Life extension by compounds in Caenorhabditis Elegans

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Name of
Formulation

Dose

Avg/Med Lifespan Change (%) -96267.9

Max Lifespan Change (%) -94.993


Strain

Significance
(Yes: Y, No: N)

Reference

Hydrogen
Sulphide

50 ppm

74


N2

Y

18077331

Nitrophenyl
piperazine containing compound 1

50 µM

72.5


N2

Y

27220516

Caffeine

5 mM

65


N2

Y

26696878

Resveratrol

50 µM

60.23


N2

Y

30320257

Carbonylcyanide-3-chlorophenylhydrazone

10 µM

60


N2

Y

19442682

Thioflavin
T

50-100 µM

60

78


N2

Y

21451522

Bacitracin

0.01

58.5

74


N2

Y

22114686

Paraquat

0.1 mM

58

48


N2

Y

21151885

Metformin

25 mM

57.3


N2

Y

24889636

Rifampicin

30 µM

56.1


N2

Y

25720500

Alaskan
Blueberry Extract

60 µg/mL

56


N2

ND

27486399

Salicylamine

500 µM

56


N2

Y

27514077

Rifampicin

50 µM

55.8


N2

Y

25720500

EUK-134

0.5 mM

54


N2

Y

10968795

EUK-134

5 mM

52


N2

Y

10968795

EUK-134

10 mM

52


N2

Y

10968795

Minocycline

100 µM

51


N2

Y

30479271

Taxifolin

820 µM

51


N2

Y

18755260

Resveratrol

50 µM

50.8

29.2


N2

Y

17460219

Rifampicin

20 µM

50.8


N2

Y

25720500

N-acetylglucosamine

10 mM

50


N2

Y

24630720

Rifampicin

100 µM

49.2


N2

Y

25720500

Acetaminophen

0.10%

48.6

66


N2

Y

22114686

Minocycline

100 µM

48


N2

Y

30479271

Vitamin D3

250 µM

47.95


N2

Y

27783938

Alpha-ketoglutarate

8 mM

47.9


Y

26190651

Metformin

25 mM

47.4


N2

Y

24889636

Shengmai
yin

48.0 g/L

47.3


N2

Y

24952637

Trimethadione

4 mg/ml

47

57


N2

Y

15653505

Fructose

100 mM

45.66


N2

Y

27680107

Rifampicin

50 µM

45.4


N2

Y

25720500

Urolithin A

50 µM

45.4


N2

Y

27400265

Rifampicin

10 µM

45.3


N2

Y

25720500

Baicalein

100 µM

45

24


N2

ND

23339711

Pyrroloquinoline
quinone

1 mM

44.44


N2

Y

27090484

Blueberry
extract

200 mg/mL

44.42

24


N2

Y

30238944

Metformin

25 mM

44


N2

Y

24889636

Metformin

50 mM

43.65


N2

Y

29027899

Rifampicin

200 µM

43.4


N2

Y

25720500

Loxapine
succinate

88 µM

43


Y

24134630

Minocycline

200 µM

43


N2

Y

30479271

Minocycline

50 µM

43


N2

Y

30479271

TPEN

200 µM

43


N2

Y

27078872

(R)-2-hydroxyglutarate

8 mM

42.9


Y

26190651

Rifampicin

5 µM

42.6


N2

Y

25720500

EUK-134

5 mM

42


N2

Y

10968795

Psora-4

88 µM

42


Y

24134630

Selenocysteine

5 mM

41.9


N2

Y

30365103

Ciclopirox
olamine

0.0001

41

52


N2

Y

22114686

Electrolyzed
reduced water

41

0


N2

Y

20944427

Trimethadione

4 mg/ml

41

23


N2

Y

15653505

Urolithin A

30 µM

40.7


N2

Y

27400265

Urolithin A

30 µM

40.7


N2

Y

27400265

Sodium
Chloride

250 mM

40.53

44.44


N2

Y

26854551

Sodium
Chloride

350 mM

40.53

44.44


N2

Y

26854551

Metformin

50 mM

40

0


N2

Y

20090912

Sorbitol

500 mM

39.35

57.89


N2

Y

26854551

Acacetin
7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside

25 µM

39


N2

Y

26433219

Curcumin

20 µM

39


N2

Y

21855561

Trimethadione

4 mg/ml

39

33


N2

Y

15653505

Whole apple
extract

10 mg/ml

39

25


N2

Y

23878618

Protocatechuic
acid

200 µM

38.9

40


N2

Y

23780797

Huanshao
dan

6.8 g/L

38.3


N2

Y

24952637

Amperozide
hydrochloride

13 µM

38


Y

24134630

EUK-134

0.5 mM

38


N2

Y

10968795

EUK-134

0.05 mM

38


N2

Y

10968795

EUK-8

0.5 mM

38


N2

Y

10968795

Octoclothepin
maleate

13 µM

38


Y

24134630

Rifampicin

50 µM

37.9


N2

Y

25720500

Glucose

4%

37.5

7.14


N2

Y

26764305

Urolithin A

50 µM

37.5


N2

Y

27400265

Electrolyzed
reduced water

37.4


N2

Y

21737933

Crude BB
extract (Vaccinium angustifolium)

1.5 mg/mL

37


fem-1(hc17)

Y

16441844

Pergolide
methanesulfonate

13 µM

37


Y

24134630

Baicalein

0.001

36.7

52


N2

Y

22114686

Caffeine

10 mM

36.7


N2

Y

24764514

Proanthocycanidin

67 µg/ml

36.6


N2

Y

22509764

Urolithin B

50 µM

36.6


N2

Y

27400265

Urolithin B

50 µM

36.6


N2

Y

27400265

Blueberry
extract

100 mg/mL

36.52

20


N2

Y

30238944

Doxycycline

30 µg/ml

36.48


N2

Y

23698443

guarana
ethanolic extract

500 µg/mL

36.36

28.57


N2

Y

29972429

guarana
ethanolic extract

1000 µg/mL

36.36

28.57


N2

Y

29972429

Lithium
Chloride

10 mM

36


N2

Y

17959600

Minocycline

100 µM

36


N2

Y

30479271

Urolithin C

50 µM

36


N2

Y

27400265

Urolithin C

50 µM

36


N2

Y

27400265

Ganoderma
lucidum extract

7.5 mg/mL

35.83

11.76


N2

Y

30476533

α‐ketoisovalerate

10 mM

35.02


N2

Y

26729005

Caffeine

5 mM

35


N2

Y

26696878

Ethosuximide

4 mg/ml

35

37


N2

Y

15653505

Ethosuximide

4 mg/ml

35

37


N2

Y

15653505

N-(2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl)-3-methoxybenzamide

33 µM

35


Y

24134630

Reishi
polysaccharide

100 ppm

35


N2

Y

19837596

Valproic
acid

6 mM

35

42


N2

Y

18248662

Rifampicin

1 µM

34.8


N2

Y

25720500

Ampicillin

100 µg/ml

34


fem-1(hc17)

Y

16441844

Captopril

2.54 mM

34

16


N2

Y

26918946

Dihydroergocristine
methanesulfonate

176 µM

34


Y

24134630

LY-367,265

33 µM

34


Y

24134630

Sulfamethoxazole

100 µM

34

0


N2

Y

24034891

Royalactin

1.6 µg/ml

33.9


N2

Y

25456847

Glycerol

500 mM

33.55

31.58


N2

Y

26854551

Pyrroloquinoline
quinone

500 µM

33.33


N2

Y

27090484

Amoxapine

88 µM

33


Y

24134630

Chlorprothixene
hydrochloride

13 µM

33


Y

24134630

Dimethyl
formamide

0.0075

33

54


N2

Y

23313473

EUK-8

0.05 mM

33


N2

Y

10968795

EUK-8

5 mM

33


N2

Y

10968795

LY-165,163

33 µM

33


Y

24134630

Minocycline

100 µM

33


N2

Y

30479271

Minocycline

50 µM

33


N2

Y

30479271

Myricetin

100 µM

32.9


N2

Y

23736695

Sorbitol

2.50%

32.7


N2

Y

26579191

Cranberry
extract

2 mg/mL

32.5


N2

Y

22864793

ursolic
acid

25 µM

32.48


N2

Y

27773812

Electrolyzed
reduced water

32.3


N2

Y

21737933

Myxothiazol

10 µM

32.3

28.6


N2

Y

18221415

Mianserin

50 µM

32


Y

24134630

Promethazine
hydrochloride

176 µM

32


Y

24134630

Salicylamine

100 µM

32


N2

Y

27514077

Trehalose

5 mM

32


N2

Y

20477758

(S)-2-hydroxyglutarate

8 mM

31.8


Y

26190651

East Indian
sandalwood oil

24 µ/mL

31.32

30.43


N2

Y

30319772

ursolic
acid

25 µM

31.3


N2

Y

28673026

Glucose

2%

31.25

14.29


N2

Y

26764305

Pyrroloquinoline
quinone

5 mM

31.25

12.5


N2

Y

28676501

Oxyresveratrol

1 mM

31.1


N2

Y

27190265

3,3-diethyl-2-pyrrolidinone

2 mg/ml

31

49


N2

Y

15653505

3,3-diethyl-2-pyrrolidinone

2 mg/ml

31

49


N2

Y

15653505

Mianserin

50 µM

31


N2

Y

18033297

Reserpine

30 µM

31


N2

Y

18409080

Thioridazine
hydrochloride

33 µM

31


Y

24134630

Trolox

3 mM

31


N2

Y

18755260

Astragalus
polysaccharide

600 µg/ml

30.8


N2

Y

25186652

Metformin

25 mM

30.6


N2

Y

24889636

N-acetyl-L-cysteine

5 mM

30.5

47.1


N2 CGCb
strain

Y

26039957

Resveratrol

1 mM

30.4


N2

Y

27190265

Damnacanthus
officinarum root extract

1200 µg/mL

30.3


N2

Y

22370553

Ethidium
bromide

5 µg/ml

30.1


N2

Y

23698443

4-phenyl-3-furoxancarbonitrile

88 µM

30


Y

24134630

Cis-(Z)-Flupenthixol
dihydrochloride

33 µM

30


Y

24134630

Minocycline

100 µM

30


N2

Y

30479271

Minocycline

200 µM

30


N2

Y

30479271

Otophylloside
B

50 µM

30


N2

Y

26112394

Polydatin

1 mM

30


N2

Y

24305800

Reserpine

60 uM

30


N2

Y

22212533

Mussel
peptides

2 mg/ml

29.9


N2

Y

29796528

Metformin

25 mM

29.7


N2

Y

24889636

Withanolide
A

5 µM

29.65

45.33


N2

Y

26956478

Alpha-ketoglutarate

8 mM

29.4


N2

Y

24828042

Royalactin

0.4 µg/ml

29.1


N2

Y

25456847

Dafadine-A

50 µM

29


N2

Y

22057127

Dimethyl
sulfoxide

0.005

29

18.6


N2

Y

20828537

EUK-134

0.05 mM

29


N2

Y

10968795

EUK-8

10 mM

29


N2

Y

10968795

EUK-8

5 mM

29


N2

Y

10968795

Juglone

40 µm

29


N2

Y

19597959

Minocycline
hydrochloride

88 µM

29


Y

24134630

Phenformin

4.5 mM

29


N2

Y

23540700

Vitamin D3

50 µM

28.77


N2

Y

27783938

α‐linolenic
acid

5 mM

28.67

8.7


N2

Y

28772063

α‐linolenic
acid

5 mM

28.67

8.7


N2

Y

28772063

Astaxanthin

1 mM

28.6

21.7


N2

Y

22013497

Caffeine

5 mM

28.5


N2

Y

24764514

Mianserin

50 µM

28.3

46


N2

Y

26255886

N-acetyl-L-cysteine

1 mM

28.1

17.6


N2 CGCb
strain

Y

26039957

Methylergonovine
maleate

88 µM

28


Y

24134630

Sulfamethoxazole

200 µM

28

0


N2

Y

24034891

Tamarixetin

NA

28


ND

16872777

Genistein

100 µM

27.9


N2

Y

25593647

FCCP

50 µM

27.8

21.4


N2

Y

18221415

Sorbitol

5%

27.12


N2

Y

26579191

N-acetyl-L-cysteine

2 mM

27.1

23.5


N2 CGCb
strain

Y

26039957

Kenpaullone

88 µM

27


Y

24134630

LFM-A13

88 µM

27


Y

24134630

Trequinsin
hydrochloride

88 µM

27


Y

24134630

Royalactin

0.04 µg/ml

26.8


N2

Y

25456847

Dauer-inducing
Pheromone

10% in
food

26.7


N2

ND

16377915

Paxilline

10 nM

26.62


N2

Y

30613772

Folic acid

25 µM

26.6


N2

Y

26546011

Platycladus
orientalis seed extract

500 µg/ml

26.5


N2

Y

23523941

East Indian
sandalwood oil

24 µ/mL

26.36

34.78


N2

Y

30319772

2-deoxy-D-glucose

5 mM

26.21

11.27


N2

Y

28992589

D-beta-hydroxybutyrate

20 mM

26


N2

Y

25127866

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