Life extension by compounds in Caenorhabditis Elegans

Part 1 Part 2 Part 3 Part 4
Name of Formulation Dose

Avg/Med Lifespan Change (%) -96267.9

Max Lifespan Change (%) -94.993

Strain Significance (Yes: Y, No: N) Reference
Hydrogen Sulphide 50 ppm

74

N2 Y 18077331
Nitrophenyl piperazine containing compound 1 50 µM

72.5

N2 Y 27220516
Caffeine 5 mM

65

N2 Y 26696878
Resveratrol 50 µM

60.23

N2 Y 30320257
Carbonylcyanide-3-chlorophenylhydrazone 10 µM

60

N2 Y 19442682
Thioflavin T 50-100 µM

60

78

N2 Y 21451522
Bacitracin 0.01

58.5

74

N2 Y 22114686
Paraquat 0.1 mM

58

48

N2 Y 21151885
Metformin 25 mM

57.3

N2 Y 24889636
Rifampicin 30 µM

56.1

N2 Y 25720500
Alaskan Blueberry Extract 60 µg/mL

56

N2 ND 27486399
Salicylamine 500 µM

56

N2 Y 27514077
Rifampicin 50 µM

55.8

N2 Y 25720500
EUK-134 0.5 mM

54

N2 Y 10968795
EUK-134 5 mM

52

N2 Y 10968795
EUK-134 10 mM

52

N2 Y 10968795
Minocycline 100 µM

51

N2 Y 30479271
Taxifolin 820 µM

51

N2 Y 18755260
Resveratrol 50 µM

50.8

29.2

N2 Y 17460219
Rifampicin 20 µM

50.8

N2 Y 25720500
N-acetylglucosamine 10 mM

50

N2 Y 24630720
Rifampicin 100 µM

49.2

N2 Y 25720500
Acetaminophen 0.10%

48.6

66

N2 Y 22114686
Minocycline 100 µM

48

N2 Y 30479271
Vitamin D3 250 µM

47.95

N2 Y 27783938
Alpha-ketoglutarate 8 mM

47.9

Y 26190651
Metformin 25 mM

47.4

N2 Y 24889636
Shengmai yin 48.0 g/L

47.3

N2 Y 24952637
Trimethadione 4 mg/ml

47

57

N2 Y 15653505
Fructose 100 mM

45.66

N2 Y 27680107
Rifampicin 50 µM

45.4

N2 Y 25720500
Urolithin A 50 µM

45.4

N2 Y 27400265
Rifampicin 10 µM

45.3

N2 Y 25720500
Baicalein 100 µM

45

24

N2 ND 23339711
Pyrroloquinoline quinone 1 mM

44.44

N2 Y 27090484
Blueberry extract 200 mg/mL

44.42

24

N2 Y 30238944
Metformin 25 mM

44

N2 Y 24889636
Metformin 50 mM

43.65

N2 Y 29027899
Rifampicin 200 µM

43.4

N2 Y 25720500
Loxapine succinate 88 µM

43

Y 24134630
Minocycline 200 µM

43

N2 Y 30479271
Minocycline 50 µM

43

N2 Y 30479271
TPEN 200 µM

43

N2 Y 27078872
(R)-2-hydroxyglutarate 8 mM

42.9

Y 26190651
Rifampicin 5 µM

42.6

N2 Y 25720500
EUK-134 5 mM

42

N2 Y 10968795
Psora-4 88 µM

42

Y 24134630
Selenocysteine 5 mM

41.9

N2 Y 30365103
Ciclopirox olamine 0.0001

41

52

N2 Y 22114686
Electrolyzed reduced water

41

0

N2 Y 20944427
Trimethadione 4 mg/ml

41

23

N2 Y 15653505
Urolithin A 30 µM

40.7

N2 Y 27400265
Urolithin A 30 µM

40.7

N2 Y 27400265
Sodium Chloride 250 mM

40.53

44.44

N2 Y 26854551
Sodium Chloride 350 mM

40.53

44.44

N2 Y 26854551
Metformin 50 mM

40

0

N2 Y 20090912
Sorbitol 500 mM

39.35

57.89

N2 Y 26854551
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside 25 µM

39

N2 Y 26433219
Curcumin 20 µM

39

N2 Y 21855561
Trimethadione 4 mg/ml

39

33

N2 Y 15653505
Whole apple extract 10 mg/ml

39

25

N2 Y 23878618
Protocatechuic acid 200 µM

38.9

40

N2 Y 23780797
Huanshao dan 6.8 g/L

38.3

N2 Y 24952637
Amperozide hydrochloride 13 µM

38

Y 24134630
EUK-134 0.5 mM

38

N2 Y 10968795
EUK-134 0.05 mM

38

N2 Y 10968795
EUK-8 0.5 mM

38

N2 Y 10968795
Octoclothepin maleate 13 µM

38

Y 24134630
Rifampicin 50 µM

37.9

N2 Y 25720500
Glucose 4%

37.5

7.14

N2 Y 26764305
Urolithin A 50 µM

37.5

N2 Y 27400265
Electrolyzed reduced water

37.4

N2 Y 21737933
Crude BB extract (Vaccinium angustifolium) 1.5 mg/mL

37

fem-1(hc17) Y 16441844
Pergolide methanesulfonate 13 µM

37

Y 24134630
Baicalein 0.001

36.7

52

N2 Y 22114686
Caffeine 10 mM

36.7

N2 Y 24764514
Proanthocycanidin 67 µg/ml

36.6

N2 Y 22509764
Urolithin B 50 µM

36.6

N2 Y 27400265
Urolithin B 50 µM

36.6

N2 Y 27400265
Blueberry extract 100 mg/mL

36.52

20

N2 Y 30238944
Doxycycline 30 µg/ml

36.48

N2 Y 23698443
guarana ethanolic extract 500 µg/mL

36.36

28.57

N2 Y 29972429
guarana ethanolic extract 1000 µg/mL

36.36

28.57

N2 Y 29972429
Lithium Chloride 10 mM

36

N2 Y 17959600
Minocycline 100 µM

36

N2 Y 30479271
Urolithin C 50 µM

36

N2 Y 27400265
Urolithin C 50 µM

36

N2 Y 27400265
Ganoderma lucidum extract 7.5 mg/mL

35.83

11.76

N2 Y 30476533
α‐ketoisovalerate 10 mM

35.02

N2 Y 26729005
Caffeine 5 mM

35

N2 Y 26696878
Ethosuximide 4 mg/ml

35

37

N2 Y 15653505
Ethosuximide 4 mg/ml

35

37

N2 Y 15653505
N-(2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl)-3-methoxybenzamide 33 µM

35

Y 24134630
Reishi polysaccharide 100 ppm

35

N2 Y 19837596
Valproic acid 6 mM

35

42

N2 Y 18248662
Rifampicin 1 µM

34.8

N2 Y 25720500
Ampicillin 100 µg/ml

34

fem-1(hc17) Y 16441844
Captopril 2.54 mM

34

16

N2 Y 26918946
Dihydroergocristine methanesulfonate 176 µM

34

Y 24134630
LY-367,265 33 µM

34

Y 24134630
Sulfamethoxazole 100 µM

34

0

N2 Y 24034891
Royalactin 1.6 µg/ml

33.9

N2 Y 25456847
Glycerol 500 mM

33.55

31.58

N2 Y 26854551
Pyrroloquinoline quinone 500 µM

33.33

N2 Y 27090484
Amoxapine 88 µM

33

Y 24134630
Chlorprothixene hydrochloride 13 µM

33

Y 24134630
Dimethyl formamide 0.0075

33

54

N2 Y 23313473
EUK-8 0.05 mM

33

N2 Y 10968795
EUK-8 5 mM

33

N2 Y 10968795
LY-165,163 33 µM

33

Y 24134630
Minocycline 100 µM

33

N2 Y 30479271
Minocycline 50 µM

33

N2 Y 30479271
Myricetin 100 µM

32.9

N2 Y 23736695
Sorbitol 2.50%

32.7

N2 Y 26579191
Cranberry extract 2 mg/mL

32.5

N2 Y 22864793
ursolic acid 25 µM

32.48

N2 Y 27773812
Electrolyzed reduced water

32.3

N2 Y 21737933
Myxothiazol 10 µM

32.3

28.6

N2 Y 18221415
Mianserin 50 µM

32

Y 24134630
Promethazine hydrochloride 176 µM

32

Y 24134630
Salicylamine 100 µM

32

N2 Y 27514077
Trehalose 5 mM

32

N2 Y 20477758
(S)-2-hydroxyglutarate 8 mM

31.8

Y 26190651
East Indian sandalwood oil 24 µ/mL

31.32

30.43

N2 Y 30319772
ursolic acid 25 µM

31.3

N2 Y 28673026
Glucose 2%

31.25

14.29

N2 Y 26764305
Pyrroloquinoline quinone 5 mM

31.25

12.5

N2 Y 28676501
Oxyresveratrol 1 mM

31.1

N2 Y 27190265
3,3-diethyl-2-pyrrolidinone 2 mg/ml

31

49

N2 Y 15653505
3,3-diethyl-2-pyrrolidinone 2 mg/ml

31

49

N2 Y 15653505
Mianserin 50 µM

31

N2 Y 18033297
Reserpine 30 µM

31

N2 Y 18409080
Thioridazine hydrochloride 33 µM

31

Y 24134630
Trolox 3 mM

31

N2 Y 18755260
Astragalus polysaccharide 600 µg/ml

30.8

N2 Y 25186652
Metformin 25 mM

30.6

N2 Y 24889636
N-acetyl-L-cysteine 5 mM

30.5

47.1

N2 CGCb strain Y 26039957
Resveratrol 1 mM

30.4

N2 Y 27190265
Damnacanthus officinarum root extract 1200 µg/mL

30.3

N2 Y 22370553
Ethidium bromide 5 µg/ml

30.1

N2 Y 23698443
4-phenyl-3-furoxancarbonitrile 88 µM

30

Y 24134630
Cis-(Z)-Flupenthixol dihydrochloride 33 µM

30

Y 24134630
Minocycline 100 µM

30

N2 Y 30479271
Minocycline 200 µM

30

N2 Y 30479271
Otophylloside B 50 µM

30

N2 Y 26112394
Polydatin 1 mM

30

N2 Y 24305800
Reserpine 60 uM

30

N2 Y 22212533
Mussel peptides 2 mg/ml

29.9

N2 Y 29796528
Metformin 25 mM

29.7

N2 Y 24889636
Withanolide A 5 µM

29.65

45.33

N2 Y 26956478
Alpha-ketoglutarate 8 mM

29.4

N2 Y 24828042
Royalactin 0.4 µg/ml

29.1

N2 Y 25456847
Dafadine-A 50 µM

29

N2 Y 22057127
Dimethyl sulfoxide 0.005

29

18.6

N2 Y 20828537
EUK-134 0.05 mM

29

N2 Y 10968795
EUK-8 10 mM

29

N2 Y 10968795
EUK-8 5 mM

29

N2 Y 10968795
Juglone 40 µm

29

N2 Y 19597959
Minocycline hydrochloride 88 µM

29

Y 24134630
Phenformin 4.5 mM

29

N2 Y 23540700
Vitamin D3 50 µM

28.77

N2 Y 27783938
α‐linolenic acid 5 mM

28.67

8.7

N2 Y 28772063
α‐linolenic acid 5 mM

28.67

8.7

N2 Y 28772063
Astaxanthin 1 mM

28.6

21.7

N2 Y 22013497
Caffeine 5 mM

28.5

N2 Y 24764514
Mianserin 50 µM

28.3

46

N2 Y 26255886
N-acetyl-L-cysteine 1 mM

28.1

17.6

N2 CGCb strain Y 26039957
Methylergonovine maleate 88 µM

28

Y 24134630
Sulfamethoxazole 200 µM

28

0

N2 Y 24034891
Tamarixetin NA

28

ND 16872777
Genistein 100 µM

27.9

N2 Y 25593647
FCCP 50 µM

27.8

21.4

N2 Y 18221415
Sorbitol 5%

27.12

N2 Y 26579191
N-acetyl-L-cysteine 2 mM

27.1

23.5

N2 CGCb strain Y 26039957
Kenpaullone 88 µM

27

Y 24134630
LFM-A13 88 µM

27

Y 24134630
Trequinsin hydrochloride 88 µM

27

Y 24134630
Royalactin 0.04 µg/ml

26.8

N2 Y 25456847
Dauer-inducing Pheromone 10% in food

26.7

N2 ND 16377915
Paxilline 10 nM

26.62

N2 Y 30613772
Folic acid 25 µM

26.6

N2 Y 26546011
Platycladus orientalis seed extract 500 µg/ml

26.5

N2 Y 23523941
East Indian sandalwood oil 24 µ/mL

26.36

34.78

N2 Y 30319772
2-deoxy-D-glucose 5 mM

26.21

11.27

N2 Y 28992589
D-beta-hydroxybutyrate 20 mM

26

N2 Y 25127866