Life extension by compounds in Caenorhabditis Elegans – Part 3

Aging
* Reviews

Anti-longevity
* Caenorhabditis elegans
* Drosophila melanogaster
* Mus musculus
* Saccharomyces cerevisiae

Aging
* Humans
* Homo Sapiens
* Mus Musculus

Senescence
* Overexpressed
* Underexpressed

Induced Senescence
* Oncogene
* Replicative
* Stress

Inhibiting Senescence
* Oncogene
* Replicative
* Stress

Variants of longevity
* Human

Pro-longevity
* Caenorhabditis elegans
* Drosophila melanogaster
* Mus musculus
* Saccharomyces cerevisiae
Fitness
* Saccharomyces cerevisiae

Dietary restriction
* Overexpressed
* Underexpressed

Dietary restriction
* Caenorhabditis elegans
* Drosophila melanogaster
* Mus Musculus
* Saccharomyces cerevisiae
* Schizosaccharomyces pombe

Dietary restriction
* Overexpressed
* Underexpressed
* Overexpressed- Underexpressed
Life extension
* Caenorhabditis elegans
* Drosophila Melanogaster
* Mus Musculus
* Other Species
* Rattus Norvegicus
* Saccharomyces cerevisiae

Post-radiation SASP (Day 10)
* Renal Epithelial Cells
* Human Fibroblasts
* Exosome SASP - Human Fibroblasts

Post-Atazanivir SASP (Day 14)
* Human Fibroblasts

RAS induced SASP (Day 7)
* Fibroblasts
* Exosome SASP - Fibroblasts
Part 1 Part 2 Part 3 Part 4
Ethosuximide 4 mg/ml

14

-2

N2 Y 15653505
Fucoxanthin 5 µM

14

24

N2 Y 26292053
Glutamate 1 mM

14

N2 Y 25643626
L-theanine 100 µM

14

N2 Y 25643626
Malate 10 mM

14

N2 Y 23472183
Matairesinol 10 µM

14

N2 Y 26141518
Methionine 10 mM

14

N2 Y 25643626
Minocycline 200 µM

14

N2 Y 30479271
Naftopidil dihydrochloride 33 µM

14

Y 24134630
Naphthazarin 500 µM

14

8

N2 Y 21765926
Phosphatidylinositol ether lipid analogue 24 1 µM

14

N2 Y 23543623
Quercetin 22 µg/mL

14

N2 Y 21563825
Resveratrol 0.5 mM

14

N2 Y 16256736
Tryptophan 1 mM

14

N2 Y 25643626
Chlorophyll 80 µg/ml

13.9

N2 Y 27077003
Salicylic acid 1 µM

13.9

N2 Y 22866967
Sodium pyruvate 2.5 mM

13.9

N2 Y 21040400
Celastrol 7 µmol/l

13.8

N2 Y 24416295
Huperzine A 300 µM

13.8

N2 Y 23523941
Metformin 20 mM

13.79

N2 Y 29263362
Arctigenin 100 µM

13.7

N2 Y 26141518
Echinacoside 200 µM

13.64

N2 Y 29185166
Silymarin 50 µM

13.64

N2 Y 28039083
Chlorophyll 1 µg/ml

13.54

N2 Y 27077003
Paraquat 100 µM

13.53

N2 Y 28054425
Naringin 1 µM

13.5

4.08

N2 Y 29375370
Resveratrol 100 µM

13.5

N2 Y 29874838
Epigallocatechin-3-gallate 100 µM

13.44

-2.29

N2 Y 28992589
Dauer-inducing Pheromone 5% in food

13.3

N2 ND 16377915
Sesame Cake Peptides 25 µg/ml

13.29

3.57

N2 Y 27381188
Phaseolus vulgaris Extract 150 µg / mL

13.2

N2 Y 20455573
cis-vaccenic acid 800 µM

13.06

N2 Y 28379943
3,4-dichloroisocoumarin 88 µM

13

Y 24134630
Beta-alanine 1 mM

13

N2 Y 25643626
Bezafibrate 10 µM

13

N2 Y 23603800
Catechin 200 µm

13

N2 Y 19501612
Colanic acid

13

N2 Y 28622510
Colanic acid

13

N2 Y 28622510
Danazol 33 µM

13

Y 24134630
Diallyl trisulfide 10 µM

13

TJ1060 Y 21296648
DL-isocitrate 5 mM

13

N2 Y 25643626
Ethosuximide 2 mg/ml

13

24

N2 Y 15653505
Homocysteine 1 mM

13

N2 Y 25643626
Ketanserin tartrate 176 µM

13

Y 24134630
Metformin 12.5 mM

13

N2 Y 24889636
Oxoline 1 mM

13

18

N2 Y 21765926
Valine 1 mM

13

N2 N 25643626
2-deoxy-D-glucose 5 mM

12.93

56.49

N2 Y 17908557
Cranberry extract 2 mg/ml

12.8

N2 Y 24566444
Dehydroabietic acid 10 µM

12.8

20

N2 Y 25976661
Resveratrol 10 µM

12.8

9.1

N2 Y 25976661
ethanol extract of Agrimonia procera herba 100 µg/mL

12.7

N2 Y 30558122
Damaurone D 10 µM

12.6

N2 Y 29992572
Liuwei dihuang wan 4.2 g/L

12.6

N2 Y 24952637
Naringin 5 µM

12.57

4.08

N2 Y 29375370
β-Santalol 16 µM

12.56

25

N2 Y 30319772
2,3-Dehydrosilybin A 10 µM

12.55

N2 Y 28039083
N-acetyl-L-cysteine 6 mM

12.53

12

N2 Y 27683245
Glucose 1%

12.5

0

N2 N 26764305
HuminFeed 400 µM

12.5

N2 Y 22529848
Lappaol F 100 µM

12.5

N2 Y 26141518
4‐methyl‐2‐oxovalerate 10 mM

12.44

N2 Y 26729005
Tyrosine-Alanine Dipeptide 10 mM

12.43

13.04

N2 Y 26987062
Epigallocatechin-3-gallate NA

12.2

N2 Y 19085685
Lonicera japonica 100 µg/mL

12.13

N2 N 30266681
Doxycycline 6 µg/ml

12.1

SJ4101 Y 23698443
Electrolyzed reduced water

12.1

N2 Y 21737933
Procyanidins 65 µg/ml

12.1

N2 Y 20717869
1,2,4-triazolo[1,5-a]pyridine 500 nM

12

N2 Y 22509764
Apple polyphenols 100 µg/ml

12

N2 Y 20717869
Colanic acid

12

N2 Y 28622510
d-Allulose 10 mM

12

N2 Y 28965946
Guanabenz acetate 88 µM

12

Y 24134630
Histidine 10 mM

12

N2 Y 25643626
Minocycline 200 µM

12

N2 Y 30479271
N-acetyl-l-histidine 1 mM

12

N2 Y 25643626
Oxoline 1 mM

12

24

N2 Y 21765926
Phosphoenolpyruvate 1 mM

12

N2 Y 25643626
Phosphoenolpyruvate 5 mM

12

N2 Y 25643626
Plumbagin 50 µM

12

12

N2 Y 21765926
Plumbagin 50 µM

12

5

N2 Y 21765926
Propyl gallate 1 mM

12

0

N2 Y 18755260
Q3'G 21 µg/mL

12

N2 Y 21563825
Quinidine sulfate 33 µM

12

Y 24134630
SQDB 100 µg/ml

12

N2 Y 20179756
Tocotrienol 259 µg

12

11

N2 Y 22484623
Vincristine sulfate 88 µM

12

Y 24134630
Arbutin 5 mM

11.89

N2 Y 29340230
Dehydroabietic acid 10 µM

11.8

18.1

N2 Y 25976661
Specioside 50 µM

11.8

N2 Y 25619942
18α-Glycyrrhetinic acid 100 µg/ml

11.76

N2 Y 26886723
Lappaol C 100 µM

11.5

N2 Y 26141518
Naringin 10 µM

11.5

6.8

N2 Y 29375370
Lappaol C 10 µM

11.3

N2 Y 26141518
Resveratrol 100 µM

11.3

N2 Y 23698443
(Iso)lappaol A 100 µM

11.2

N2 Y 26141518
Beta-caryophyllene 25 µM

11.2

N2 Y 24835194
Chlorophyll 100 µg/ml

11.18

N2 Y 27077003
Oleanolic acid 200 µM

11.18

N2 Y 26592451
Ribes fasciculatum eylacetate fraction 250 µg/mL

11.1

4.76

N2 Y 27478096
7-cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine 33 µM

11

Y 24134630
Alanine 10 mM

11

N2 Y 25643626
Alpha-ketoglutarate 5 mM

11

N2 Y 25643626
Arginine 5 mM

11

N2 Y 25643626
Caffeic acid 300 µM

11

N2 Y 21503726
Carnosine 1 mM

11

N2 Y 25643626
Colanic acid

11

N2 Y 28622510
Colanic acid

11

N2 Y 28622510
Cortexolone maleate 33 µM

11

Y 24134630
D-glucosamine 10 mM

11

8

N2 Y 24714520
Glucose 2%

11

N2 N 19883616
Glutamate 5 mM

11

N2 Y 25643626
Lithium Chloride 10 mM

11

JK1107 (glp-1) Y 24398558
Naphthazarin 100 µM

11

12

N2 Y 21765926
Plumbagin 25 µM

11

13

N2 Y 21765926
Plumbagin 25 µM

11

6

N2 Y 21765926
Quercetin 100 µM

11

25

N2 Y 19043800
Quercetin 200 µM

11

9

N2 Y 19043800
Quercetin 100 µM

11

N2 Y 22493606
Resveratrol 100 ug/ml

11

11.5

N2 ND 21364612
Succinate 1 mM

11

N2 Y 25643626
Taurine 1 mM

11

N2 Y 25643626
Tyrphostin AG 1478 33 µM

11

Y 24134630
Vitamin E 400 µg/ml

11

N2 Y 14706236
Vitamin D3 25 µM

10.98

N2 Y 27783938
CGP37157 100 µM

10.9

N2 Y 30705628
Sesamin 12.5 µg

10.9

N2 Y 24549958
Withanolide A 50 µM

10.81

15.12

N2 Y 26956478
Caffeine 5 mM

10.8

N2 Y 24764514
Sesamin 3.1 µg

10.5

N2 Y 24549958
α‐linolenic acid 2 mM

10.49

4.35

N2 Y 28772063
Soybean trypsin inhibitor 10 µM

10.4

N2 Y 25959406
Tyrosine-Alanine Dipeptide 1 mM

10.37

13.04

N2 Y 26987062
α-Santalol 32 µM

10.31

8.33

N2 Y 30319772
Dehydroabietic acid 1 µM

10.3

16.7

N2 Y 25976661
Pyrroloquinoline quinone 1 mM

10.16

3.8

N2 Y 28676501
2,3-dehydrosilybin 10 µM

10.15

N2 Y 28039083
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside 5 µM

10.1

N2 Y 26433219
Gamma-tocopherol 43 µg

10.1

12.3

N2 Y 22484623
10-hydroxy-2-decenoic Acid 25 µM

10

14

N2 Y 25789174
Alpha-ketoglutarate 100 µM

10

N2 Y 25643626
Arsenite 100 nM

10

N2 Y 23534459
BRL 15572 33 µM

10

Y 24134630
Chlorophytum borivilianum polysaccharide extract 1 ng/ml

10

CB5586 Y 28727758
Colanic acid

10

N2 Y 28622510
Gallic Acid 300 µM

10

N2 Y 21805983
Genistein 50 µM

10

N2 Y 25593647
Glycine 1 mM

10

N2 Y 25643626
Histidine 5 mM

10

N2 Y 25643626
L-theanine 5 mM

10

N2 Y 25643626
Minocycline 200 µM

10

N2 Y 30479271
N-acetyl-l-histidine 10 mM

10

N2 N 25643626
Naphthazarin 100 µM

10

12

N2 Y 21765926
Naphthazarin 200 µM

10

8

N2 Y 21765926
Oxoline 1 mM

10

24

N2 Y 21765926
Phosphatidylinositol ether lipid analogue 6 1 µM

10

N2 Y 23543623
Plumbagin 25 µM

10

2

N2 N 21765926
Putrescine 1 mM

10

N2 Y 25643626
Pyrroloquinoline quinone 15 mM

10

6

N2 Y 28676501
Quercetin 200 µM

10

-2

N2 Y 19043800
Quercetin 200 µM

10

-8

N2 N 19043800
Quercetin 100 µM

10

N2 Y 18692520
Quercetin 200 µM

10

N2 Y 18692520
Quercetin 200 µM

10

N2 Y 19043800
Quercetin 200 µM

10

N2 Y 22493606
Resveratrol 100 µm

10

N2 Y 15254550
Rosmarinic acid 200 µM

10

N2 Y 21503726
Rotenone 100 nM

10

N2 Y 24199155
Succinate 5 mM

10

N2 Y 25643626
Tannic acid 25 µM

10

N2 Y 22493606
Tyrosine 1 mM

10

N2 Y 25643626
Verminoside 5 µM

9.8

N2 Y 26189547
Emodin 50 µM

9.68

N2 Y 28831863
Fish oil 1 mg/plate

9.6

N2 Y 23526170
Korean mistletoe extract 50 µg/ml

9.6

N2 Y 24337961
Pictilisib 1 µM

9.6

N2 Y 23543623
Thapsigargin 10 nM

9.6

N2 Y 29988547
Sesamin 5.75 µg

9.55

N2 Y 28239780
L-isoleucine 5 mM

9.5

6.45

N2 Y 26620638
Echinacoside 600 µM

9.47

N2 Y 26027643
Metformin 50 mM

9.4

N2 N 24889636
Resveratrol 0.1 mM

9.3

N2 Y 16256736
M084 50 µM

9.11

N2 Y 27854075
N-acetyl-L-cysteine 3 mM

9.07

20

N2 Y 27683245
Silybin A/B 10 µM

9.04

N2 Y 28039083
Betaine 1 mM

9

N2 Y 25643626
Caffeic acid phenethylester

9

17

Y 24964141
Coenzyme Q10 150 µg/ml

9

N2 Y 14706236
Colanic acid

9

N2 Y 28622510
Cysteine 1 mM

9

N2 Y 25643626
Histidine 5 mM

9

N2 Y 25643626
L-histidine methyl ester 1 mM

9

N2 Y 25643626
Naphthazarin 500 µM

9

4

N2 N 21765926
Oxoline 100 µM

9

15

N2 N 21765926
Plumbagin 10 µM

9

2

N2 N 21765926
Quercetin 200 µM

9

0

N2 Y 19043800
Quercetin 200 µM

9

N2 Y 19043800
Quercetin 200 µM

9

N2 Y 22493606
Ribose 1 mM

9

N2 Y 25643626
Ribose 5 mM

9

N2 Y 25643626
Serine 10 mM

9

N2 Y 25643626
Tryptophan 1 mM

9

N2 Y 25643626
Vitamin E 100 µg/ml

9

N2 N 3374177
Arctiin 10 µM

8.9

N2 Y 26141518
Fish oil 0.5 mg/plate

8.9

N2 N 23526170
Specioside 5 µM

8.9

N2 Y 25619942
Caffeine 7.5 mM

8.7

N2 Y 24764514
Soybean trypsin inhibitor 5 µM

8.7

N2 Y 25959406
Tocotrienol 8 µg/ml

8.7

N2 Y 10843344
2-Selenium-bridged-beta-cyclodextrin 5 mM

8.69

4.76

N2 Y 101039
Tocotrienol 26 µg

8.6

3.5

N2 Y 22484623
East Indian sandalwood oil 6 µ/mL

8.59

8.69

N2 Y 30319772
Verminoside 50 µM

8.5

N2 Y 26189547
Dimethyl Sulfide 1 µM

8.43

N2 Y 27790859
7-methylxanthine 50 µg/mL

8.41

N2 Y 30061824
S-allylmercapto-N-acetylcysteine 0.5mM

8.38

12.5

CF512 Y 29579097
4-hydroxy-E-globularinin 2 µM

8.1

N2 Y 23000058
ethanol extract of Agrimonia procera herba 50 µg/mL

8.1

N2 Y 30558122
Resveratrol 100 µM

8.1

N2 N 17875315
Alanine 1 mM

8

N2 Y 25643626
AMN082 33 µM

8

Y 24134630
Arginine 1 mM

8

N2 Y 25643626
Caffeine 5 mM

8

N2 Y 26696878
D-aspartate 10 mM

8

N2 Y 25643626
Ginkgo biloba extract 100 µg/ml

8

N2 ND 16872777
Gluconate 1 mM

8

N2 Y 25643626
L-histidine methyl ester 100 µM

8

N2 Y 25643626
Lonidamine 5 µM

8

8

Y 21932172
L-theanine 1 mM

8

N2 Y 25643626
Lysine 5 mM

8

N2 Y 25643626
Methionine 5 mM

8

N2 Y 25643626
MPTP 10 nM

8

N2 Y 24199155
Naphthazarin 200 µM

8

14

N2 Y 21765926
Naphthazarin 100 µM

8

7

N2 Y 21765926
Ornithine 1 mM

8

N2 Y 25643626
Phosphoenolpyruvate 10 mM

8

N2 Y 25643626
Proline 5 mM

8

N2 Y 25643626
Quercetin 100 µM

8

16

N2 Y 19043800
Quercetin 100 µM

8

-3

N2 N 19043800
Serine 1 mM

8

N2 Y 25643626
Tannic acid 200 µM

8

N2 Y 22493606
Threonine 10 mM

8

N2 Y 25643626
Valine 5 mM

8

N2 Y 25643626
Vitexin 50 µM

8

5.3

N2 Y 26535084
Hon Tsai Tai Extract 2 mg/ml

7.97

N2 Y 26726147
Dichloroacetate 50 µg/ml

7.9

13.5

N2 Y 21153705
Glaucarubinone 100 nM

7.9

9

N2 Y 21264793
Isoprenol 0.1 mM

7.81

4

N2 Y 30624146
1-methyl nicotinamide 1 µM

7.7

11

N2 Y 24077178
Caffeine 0.5 mM

7.7

N2 Y 24764514
Echinacoside 150 µM

7.6

N2 Y 26027643
ethanol extract of Agrimonia procera herba 200 µg/mL

7.5

N2 Y 30558122
Recombinant buckwheat trypsin inhibitor 2.5 µM

7.5

N2 Y 25959406
Resveratrol 100 µM

7.5

N2 Y 17875315
Damaurone D 5 µM

7.49

N2 Y 29992572
Oxyresveratrol 100 µM

7.4

N2 Y 27190265
Resveratrol 100 µM

7.4

N2 Y 17875315
2-Selenium-bridged β-cyclodextrin 0.5 mM

7.24

4.76

N2 Y 101039
2-Selenium-bridged-beta-cyclodextrin 0.5 mM

7.24

4.76

N2 Y 101039
2,3-Dehydrosilybin B 10 µM

7.18

N2 Y 28039083
Epigallocatechin-3-gallate 300 µM

7.11

4

N2 Y 28992589
Platinum nanoparticles 5 ppb

7.1

N2 Y 21737933
Silychristin A/B 10 µM

7.06

N2 Y 28039083
L-Valine 5 mM

7.05

0

N2 Y 26620638
(R,R)-cis-Diethyl tetrahydro-2,8-chrysenediol 33 µM

7

Y 24134630
Alpha-ketoglutarate 10 mM

7

N2 N 25643626
Astragalus polysaccharide 50 µg/ml

7

N2 N 25186652
Beta-Estradiol 33 µM

7

Y 24134630
Caprylate 1 mM

7

N2 Y 25643626
d-Allulose 25 mM

7

N2 Y 28965946
D-aspartate 1 mM

7

N2 N 25643626
Homocysteine 5 mM

7

N2 Y 25643626
Leucine 10 mM

7

N2 Y 25643626
Lysine 1 mM

7

N2 Y 25643626
Picolinic acid 1 mM

7

N2 Y 25643626
Plumbagin 10 µM

7

3

N2 N 21765926
Tomatidine 25 µM

7

N2 Y 28397803
Naringin 0.5 µM

6.95

-0.68

N2 Y 29375370
Selenocysteine 5 mM

6.93

N2 Y 30365103
M084 1 mM

6.92

N2 Y 27854075
L-Leucine 5 mM

6.84

7.32

N2 Y 26620638
Isosilybin A/B 10 µM

6.82

N2 Y 28039083