Life extension by compounds in Caenorhabditis Elegans – Part 3

[raw]

Aging

* Reviews

Anti-longevity

* Caenorhabditis elegans

* Drosophila melanogaster

* Mus musculus

* Saccharomyces cerevisiae

Aging

* Humans

* Homo Sapiens

* Mus Musculus

Senescence

* Overexpressed

* Underexpressed

Induced Senescence

* Oncogene

* Replicative

* Stress


Inhibiting Senescence

* Oncogene

* Replicative

* Stress


Variants of longevity

* Human


Pro-longevity

* Caenorhabditis elegans

* Drosophila melanogaster

* Mus musculus

* Saccharomyces cerevisiae
Fitness

* Saccharomyces cerevisiae


Dietary restriction

* Overexpressed

* Underexpressed


Dietary restriction

* Caenorhabditis elegans

* Drosophila melanogaster

* Mus Musculus

* Saccharomyces cerevisiae

* Schizosaccharomyces pombe


Dietary restriction

* Overexpressed

* Underexpressed

* Overexpressed- Underexpressed
Life extension

* Caenorhabditis elegans

* Drosophila Melanogaster

* Mus Musculus

* Other Species

* Rattus Norvegicus

* Saccharomyces cerevisiae


Post-radiation SASP (Day 10)

* Renal Epithelial Cells

* Human Fibroblasts

* Exosome SASP – Human Fibroblasts


Post-Atazanivir SASP (Day 14)

* Human Fibroblasts


RAS induced SASP (Day 7)

* Fibroblasts

* Exosome SASP – Fibroblasts

Part 1
Part 2
Part 3
Part 4


Ethosuximide

4 mg/ml

14

-2


N2

Y

15653505

Fucoxanthin

5 µM

14

24


N2

Y

26292053

Glutamate

1 mM

14


N2

Y

25643626

L-theanine

100 µM

14


N2

Y

25643626

Malate

10 mM

14


N2

Y

23472183

Matairesinol

10 µM

14


N2

Y

26141518

Methionine

10 mM

14


N2

Y

25643626

Minocycline

200 µM

14


N2

Y

30479271

Naftopidil
dihydrochloride

33 µM

14


Y

24134630

Naphthazarin

500 µM

14

8


N2

Y

21765926

Phosphatidylinositol
ether lipid analogue 24

1 µM

14


N2

Y

23543623

Quercetin

22 µg/mL

14


N2

Y

21563825

Resveratrol

0.5 mM

14


N2

Y

16256736

Tryptophan

1 mM

14


N2

Y

25643626

Chlorophyll

80 µg/ml

13.9


N2

Y

27077003

Salicylic
acid

1 µM

13.9


N2

Y

22866967

Sodium
pyruvate

2.5 mM

13.9


N2

Y

21040400

Celastrol

7 µmol/l

13.8


N2

Y

24416295

Huperzine A

300 µM

13.8


N2

Y

23523941

Metformin

20 mM

13.79


N2

Y

29263362

Arctigenin

100 µM

13.7


N2

Y

26141518

Echinacoside

200 µM

13.64


N2

Y

29185166

Silymarin

50 µM

13.64


N2

Y

28039083

Chlorophyll

1 µg/ml

13.54


N2

Y

27077003

Paraquat

100 µM

13.53


N2

Y

28054425

Naringin

1 µM

13.5

4.08


N2

Y

29375370

Resveratrol

100 µM

13.5


N2

Y

29874838

Epigallocatechin-3-gallate

100 µM

13.44

-2.29


N2

Y

28992589

Dauer-inducing
Pheromone

5% in food

13.3


N2

ND

16377915

Sesame Cake
Peptides

25 µg/ml

13.29

3.57


N2

Y

27381188

Phaseolus
vulgaris Extract

150 µg /
mL

13.2


N2

Y

20455573

cis-vaccenic
acid

800 µM

13.06


N2

Y

28379943

3,4-dichloroisocoumarin

88 µM

13


Y

24134630

Beta-alanine

1 mM

13


N2

Y

25643626

Bezafibrate

10 µM

13


N2

Y

23603800

Catechin

200 µm

13


N2

Y

19501612

Colanic
acid

13


N2

Y

28622510

Colanic
acid

13


N2

Y

28622510

Danazol

33 µM

13


Y

24134630

Diallyl
trisulfide

10 µM

13


TJ1060

Y

21296648

DL-isocitrate

5 mM

13


N2

Y

25643626

Ethosuximide

2 mg/ml

13

24


N2

Y

15653505

Homocysteine

1 mM

13


N2

Y

25643626

Ketanserin
tartrate

176 µM

13


Y

24134630

Metformin

12.5 mM

13


N2

Y

24889636

Oxoline

1 mM

13

18


N2

Y

21765926

Valine

1 mM

13


N2

N

25643626

2-deoxy-D-glucose

5 mM

12.93

56.49


N2

Y

17908557

Cranberry
extract

2 mg/ml

12.8


N2

Y

24566444

Dehydroabietic
acid

10 µM

12.8

20


N2

Y

25976661

Resveratrol

10 µM

12.8

9.1


N2

Y

25976661

ethanol
extract of Agrimonia procera herba

100 µg/mL

12.7


N2

Y

30558122

Damaurone D

10 µM

12.6


N2

Y

29992572

Liuwei
dihuang wan

4.2 g/L

12.6


N2

Y

24952637

Naringin

5 µM

12.57

4.08


N2

Y

29375370

β-Santalol

16 µM

12.56

25


N2

Y

30319772

2,3-Dehydrosilybin
A

10 µM

12.55


N2

Y

28039083

N-acetyl-L-cysteine

6 mM

12.53

12


N2

Y

27683245

Glucose

1%

12.5

0


N2

N

26764305

HuminFeed

400 µM

12.5


N2

Y

22529848

Lappaol F

100 µM

12.5


N2

Y

26141518

4‐methyl‐2‐oxovalerate

10 mM

12.44


N2

Y

26729005

Tyrosine-Alanine
Dipeptide

10 mM

12.43

13.04


N2

Y

26987062

Epigallocatechin-3-gallate

NA

12.2


N2

Y

19085685

Lonicera
japonica

100 µg/mL

12.13


N2

N

30266681

Doxycycline

6 µg/ml

12.1


SJ4101

Y

23698443

Electrolyzed
reduced water

12.1


N2

Y

21737933

Procyanidins

65 µg/ml

12.1


N2

Y

20717869

1,2,4-triazolo[1,5-a]pyridine

500 nM

12


N2

Y

22509764

Apple
polyphenols

100 µg/ml

12


N2

Y

20717869

Colanic
acid

12


N2

Y

28622510

d-Allulose

10 mM

12


N2

Y

28965946

Guanabenz
acetate

88 µM

12


Y

24134630

Histidine

10 mM

12


N2

Y

25643626

Minocycline

200 µM

12


N2

Y

30479271

N-acetyl-l-histidine

1 mM

12


N2

Y

25643626

Oxoline

1 mM

12

24


N2

Y

21765926

Phosphoenolpyruvate

1 mM

12


N2

Y

25643626

Phosphoenolpyruvate

5 mM

12


N2

Y

25643626

Plumbagin

50 µM

12

12


N2

Y

21765926

Plumbagin

50 µM

12

5


N2

Y

21765926

Propyl
gallate

1 mM

12

0


N2

Y

18755260

Q3’G

21 µg/mL

12


N2

Y

21563825

Quinidine
sulfate

33 µM

12


Y

24134630

SQDB

100 µg/ml

12


N2

Y

20179756

Tocotrienol

259 µg

12

11


N2

Y

22484623

Vincristine
sulfate

88 µM

12


Y

24134630

Arbutin

5 mM

11.89


N2

Y

29340230

Dehydroabietic
acid

10 µM

11.8

18.1


N2

Y

25976661

Specioside

50 µM

11.8


N2

Y

25619942

18α-Glycyrrhetinic
acid

100 µg/ml

11.76


N2

Y

26886723

Lappaol C

100 µM

11.5


N2

Y

26141518

Naringin

10 µM

11.5

6.8


N2

Y

29375370

Lappaol C

10 µM

11.3


N2

Y

26141518

Resveratrol

100 µM

11.3


N2

Y

23698443

(Iso)lappaol
A

100 µM

11.2


N2

Y

26141518

Beta-caryophyllene

25 µM

11.2


N2

Y

24835194

Chlorophyll

100 µg/ml

11.18


N2

Y

27077003

Oleanolic
acid

200 µM

11.18


N2

Y

26592451

Ribes
fasciculatum eylacetate fraction

250 µg/mL

11.1

4.76


N2

Y

27478096

7-cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

33 µM

11


Y

24134630

Alanine

10 mM

11


N2

Y

25643626

Alpha-ketoglutarate

5 mM

11


N2

Y

25643626

Arginine

5 mM

11


N2

Y

25643626

Caffeic
acid

300 µM

11


N2

Y

21503726

Carnosine

1 mM

11


N2

Y

25643626

Colanic
acid

11


N2

Y

28622510

Colanic
acid

11


N2

Y

28622510

Cortexolone
maleate

33 µM

11


Y

24134630

D-glucosamine

10 mM

11

8


N2

Y

24714520

Glucose

2%

11


N2

N

19883616

Glutamate

5 mM

11


N2

Y

25643626

Lithium
Chloride

10 mM

11


JK1107
(glp-1)

Y

24398558

Naphthazarin

100 µM

11

12


N2

Y

21765926

Plumbagin

25 µM

11

13


N2

Y

21765926

Plumbagin

25 µM

11

6


N2

Y

21765926

Quercetin

100 µM

11

25


N2

Y

19043800

Quercetin

200 µM

11

9


N2

Y

19043800

Quercetin

100 µM

11


N2

Y

22493606

Resveratrol

100 ug/ml

11

11.5


N2

ND

21364612

Succinate

1 mM

11


N2

Y

25643626

Taurine

1 mM

11


N2

Y

25643626

Tyrphostin
AG 1478

33 µM

11


Y

24134630

Vitamin E

400 µg/ml

11


N2

Y

14706236

Vitamin D3

25 µM

10.98


N2

Y

27783938

CGP37157

100 µM

10.9


N2

Y

30705628

Sesamin

12.5 µg

10.9


N2

Y

24549958

Withanolide
A

50 µM

10.81

15.12


N2

Y

26956478

Caffeine

5 mM

10.8


N2

Y

24764514

Sesamin

3.1 µg

10.5


N2

Y

24549958

α‐linolenic
acid

2 mM

10.49

4.35


N2

Y

28772063

Soybean
trypsin inhibitor

10 µM

10.4


N2

Y

25959406

Tyrosine-Alanine
Dipeptide

1 mM

10.37

13.04


N2

Y

26987062

α-Santalol

32 µM

10.31

8.33


N2

Y

30319772

Dehydroabietic
acid

1 µM

10.3

16.7


N2

Y

25976661

Pyrroloquinoline
quinone

1 mM

10.16

3.8


N2

Y

28676501

2,3-dehydrosilybin

10 µM

10.15


N2

Y

28039083

Acacetin
7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside

5 µM

10.1


N2

Y

26433219

Gamma-tocopherol

43 µg

10.1

12.3


N2

Y

22484623

10-hydroxy-2-decenoic
Acid

25 µM

10

14


N2

Y

25789174

Alpha-ketoglutarate

100 µM

10


N2

Y

25643626

Arsenite

100 nM

10


N2

Y

23534459

BRL 15572

33 µM

10


Y

24134630

Chlorophytum
borivilianum polysaccharide extract

1 ng/ml

10


CB5586

Y

28727758

Colanic
acid

10


N2

Y

28622510

Gallic Acid

300 µM

10


N2

Y

21805983

Genistein

50 µM

10


N2

Y

25593647

Glycine

1 mM

10


N2

Y

25643626

Histidine

5 mM

10


N2

Y

25643626

L-theanine

5 mM

10


N2

Y

25643626

Minocycline

200 µM

10


N2

Y

30479271

N-acetyl-l-histidine

10 mM

10


N2

N

25643626

Naphthazarin

100 µM

10

12


N2

Y

21765926

Naphthazarin

200 µM

10

8


N2

Y

21765926

Oxoline

1 mM

10

24


N2

Y

21765926

Phosphatidylinositol
ether lipid analogue 6

1 µM

10


N2

Y

23543623

Plumbagin

25 µM

10

2


N2

N

21765926

Putrescine

1 mM

10


N2

Y

25643626

Pyrroloquinoline
quinone

15 mM

10

6


N2

Y

28676501

Quercetin

200 µM

10

-2


N2

Y

19043800

Quercetin

200 µM

10

-8


N2

N

19043800

Quercetin

100 µM

10


N2

Y

18692520

Quercetin

200 µM

10


N2

Y

18692520

Quercetin

200 µM

10


N2

Y

19043800

Quercetin

200 µM

10


N2

Y

22493606

Resveratrol

100 µm

10


N2

Y

15254550

Rosmarinic
acid

200 µM

10


N2

Y

21503726

Rotenone

100 nM

10


N2

Y

24199155

Succinate

5 mM

10


N2

Y

25643626

Tannic acid

25 µM

10


N2

Y

22493606

Tyrosine

1 mM

10


N2

Y

25643626

Verminoside

5 µM

9.8


N2

Y

26189547

Emodin

50 µM

9.68


N2

Y

28831863

Fish oil

1 mg/plate

9.6


N2

Y

23526170

Korean
mistletoe extract

50 µg/ml

9.6


N2

Y

24337961

Pictilisib

1 µM

9.6


N2

Y

23543623

Thapsigargin

10 nM

9.6


N2

Y

29988547

Sesamin

5.75 µg

9.55


N2

Y

28239780

L-isoleucine

5 mM

9.5

6.45


N2

Y

26620638

Echinacoside

600 µM

9.47


N2

Y

26027643

Metformin

50 mM

9.4


N2

N

24889636

Resveratrol

0.1 mM

9.3


N2

Y

16256736

M084

50 µM

9.11


N2

Y

27854075

N-acetyl-L-cysteine

3 mM

9.07

20


N2

Y

27683245

Silybin A/B

10 µM

9.04


N2

Y

28039083

Betaine

1 mM

9


N2

Y

25643626

Caffeic
acid phenethylester

9

17


Y

24964141

Coenzyme
Q10

150 µg/ml

9


N2

Y

14706236

Colanic
acid

9


N2

Y

28622510

Cysteine

1 mM

9


N2

Y

25643626

Histidine

5 mM

9


N2

Y

25643626

L-histidine
methyl ester

1 mM

9


N2

Y

25643626

Naphthazarin

500 µM

9

4


N2

N

21765926

Oxoline

100 µM

9

15


N2

N

21765926

Plumbagin

10 µM

9

2


N2

N

21765926

Quercetin

200 µM

9

0


N2

Y

19043800

Quercetin

200 µM

9


N2

Y

19043800

Quercetin

200 µM

9


N2

Y

22493606

Ribose

1 mM

9


N2

Y

25643626

Ribose

5 mM

9


N2

Y

25643626

Serine

10 mM

9


N2

Y

25643626

Tryptophan

1 mM

9


N2

Y

25643626

Vitamin E

100 µg/ml

9


N2

N

3374177

Arctiin

10 µM

8.9


N2

Y

26141518

Fish oil

0.5
mg/plate

8.9


N2

N

23526170

Specioside

5 µM

8.9


N2

Y

25619942

Caffeine

7.5 mM

8.7


N2

Y

24764514

Soybean
trypsin inhibitor

5 µM

8.7


N2

Y

25959406

Tocotrienol

8 µg/ml

8.7


N2

Y

10843344

2-Selenium-bridged-beta-cyclodextrin

5 mM

8.69

4.76


N2

Y

101039

Tocotrienol

26 µg

8.6

3.5


N2

Y

22484623

East Indian
sandalwood oil

6 µ/mL

8.59

8.69


N2

Y

30319772

Verminoside

50 µM

8.5


N2

Y

26189547

Dimethyl
Sulfide

1 µM

8.43


N2

Y

27790859

7-methylxanthine

50 µg/mL

8.41


N2

Y

30061824

S-allylmercapto-N-acetylcysteine

0.5mM

8.38

12.5


CF512

Y

29579097

4-hydroxy-E-globularinin

2 µM

8.1


N2

Y

23000058

ethanol
extract of Agrimonia procera herba

50 µg/mL

8.1


N2

Y

30558122

Resveratrol

100 µM

8.1


N2

N

17875315

Alanine

1 mM

8


N2

Y

25643626

AMN082

33 µM

8


Y

24134630

Arginine

1 mM

8


N2

Y

25643626

Caffeine

5 mM

8


N2

Y

26696878

D-aspartate

10 mM

8


N2

Y

25643626

Ginkgo
biloba extract

100 µg/ml

8


N2

ND

16872777

Gluconate

1 mM

8


N2

Y

25643626

L-histidine
methyl ester

100 µM

8


N2

Y

25643626

Lonidamine

5 µM

8

8


Y

21932172

L-theanine

1 mM

8


N2

Y

25643626

Lysine

5 mM

8


N2

Y

25643626

Methionine

5 mM

8


N2

Y

25643626

MPTP

10 nM

8


N2

Y

24199155

Naphthazarin

200 µM

8

14


N2

Y

21765926

Naphthazarin

100 µM

8

7


N2

Y

21765926

Ornithine

1 mM

8


N2

Y

25643626

Phosphoenolpyruvate

10 mM

8


N2

Y

25643626

Proline

5 mM

8


N2

Y

25643626

Quercetin

100 µM

8

16


N2

Y

19043800

Quercetin

100 µM

8

-3


N2

N

19043800

Serine

1 mM

8


N2

Y

25643626

Tannic acid

200 µM

8


N2

Y

22493606

Threonine

10 mM

8


N2

Y

25643626

Valine

5 mM

8


N2

Y

25643626

Vitexin

50 µM

8

5.3


N2

Y

26535084

Hon Tsai
Tai Extract

2 mg/ml

7.97


N2

Y

26726147

Dichloroacetate

50 µg/ml

7.9

13.5


N2

Y

21153705

Glaucarubinone

100 nM

7.9

9


N2

Y

21264793

Isoprenol

0.1 mM

7.81

4


N2

Y

30624146

1-methyl
nicotinamide

1 µM

7.7

11


N2

Y

24077178

Caffeine

0.5 mM

7.7


N2

Y

24764514

Echinacoside

150 µM

7.6


N2

Y

26027643

ethanol
extract of Agrimonia procera herba

200 µg/mL

7.5


N2

Y

30558122

Recombinant
buckwheat trypsin inhibitor

2.5 µM

7.5


N2

Y

25959406

Resveratrol

100 µM

7.5


N2

Y

17875315

Damaurone D

5 µM

7.49


N2

Y

29992572

Oxyresveratrol

100 µM

7.4


N2

Y

27190265

Resveratrol

100 µM

7.4


N2

Y

17875315

2-Selenium-bridged
β-cyclodextrin

0.5 mM

7.24

4.76


N2

Y

101039

2-Selenium-bridged-beta-cyclodextrin

0.5 mM

7.24

4.76


N2

Y

101039

2,3-Dehydrosilybin
B

10 µM

7.18


N2

Y

28039083

Epigallocatechin-3-gallate

300 µM

7.11

4


N2

Y

28992589

Platinum
nanoparticles

5 ppb

7.1


N2

Y

21737933

Silychristin
A/B

10 µM

7.06


N2

Y

28039083

L-Valine

5 mM

7.05

0


N2

Y

26620638

(R,R)-cis-Diethyl
tetrahydro-2,8-chrysenediol

33 µM

7


Y

24134630

Alpha-ketoglutarate

10 mM

7


N2

N

25643626

Astragalus
polysaccharide

50 µg/ml

7


N2

N

25186652

Beta-Estradiol

33 µM

7


Y

24134630

Caprylate

1 mM

7


N2

Y

25643626

d-Allulose

25 mM

7


N2

Y

28965946

D-aspartate

1 mM

7


N2

N

25643626

Homocysteine

5 mM

7


N2

Y

25643626

Leucine

10 mM

7


N2

Y

25643626

Lysine

1 mM

7


N2

Y

25643626

Picolinic
acid

1 mM

7


N2

Y

25643626

Plumbagin

10 µM

7

3


N2

N

21765926

Tomatidine

25 µM

7


N2

Y

28397803

Naringin

0.5 µM

6.95

-0.68


N2

Y

29375370

Selenocysteine

5 mM

6.93


N2

Y

30365103

M084

1 mM

6.92


N2

Y

27854075

L-Leucine

5 mM

6.84

7.32


N2

Y

26620638

Isosilybin
A/B

10 µM

6.82


N2

Y

28039083

[/raw]