Life extension by compounds in Caenorhabditis Elegans – Part 2

Aging
* Reviews

Anti-longevity
* Caenorhabditis elegans
* Drosophila melanogaster
* Mus musculus
* Saccharomyces cerevisiae

Aging
* Humans
* Homo Sapiens
* Mus Musculus

Senescence
* Overexpressed
* Underexpressed

Induced Senescence
* Oncogene
* Replicative
* Stress

Inhibiting Senescence
* Oncogene
* Replicative
* Stress

Variants of longevity
* Human

Pro-longevity
* Caenorhabditis elegans
* Drosophila melanogaster
* Mus musculus
* Saccharomyces cerevisiae
Fitness
* Saccharomyces cerevisiae

Dietary restriction
* Overexpressed
* Underexpressed

Dietary restriction
* Caenorhabditis elegans
* Drosophila melanogaster
* Mus Musculus
* Saccharomyces cerevisiae
* Schizosaccharomyces pombe

Dietary restriction
* Overexpressed
* Underexpressed
* Overexpressed- Underexpressed
Life extension
* Caenorhabditis elegans
* Drosophila Melanogaster
* Mus Musculus
* Other Species
* Rattus Norvegicus
* Saccharomyces cerevisiae

Post-radiation SASP (Day 10)
* Renal Epithelial Cells
* Human Fibroblasts
* Exosome SASP - Human Fibroblasts

Post-Atazanivir SASP (Day 14)
* Human Fibroblasts

RAS induced SASP (Day 7)
* Fibroblasts
* Exosome SASP - Fibroblasts
Part 1 Part 2 Part 3 Part 4
Rapamycin 100 µM

26

34.84

N2 Y 24332851
Chlorophyll 40 µg/ml

25.96

N2 Y 27077003
6-shogaol 25 µM

25.9

15.78

N2 Y 29978428
Reserpine 60 µM

25.75

N2 Y 27966489
Doxycycline 30 µg/ml

25.4

SJ4101 Y 23698443
β-Santalol 16 µM

25.38

25

N2 Y 30319772
Isoprenol 0.5 mM

25.26

28

N2 Y 30624146
Pyruvate 8 mM

25.17

N2 Y 26729005
Matairesinol 100 µM

25

N2 Y 26141518
Nitrendipine 88 µM

25

Y 24134630
Oxaloacetate 8 mM

25

13

N2 Y 19793063
Oxatomide 88 µM

25

Y 24134630
Pyrroloquinoline quinone 10 mM

25

10.3

N2 Y 28676501
Calycosin 200 µM

24.86

N2 Y 28434978
Astragalus polysaccharide 200 µg/ml

24.7

N2 Y 25186652
Paraquat 200 µM

24.6

13.58

N2 Y 28992589
N-acetyl-L-cysteine 9 mM

24.49

64

N2 Y 27683245
Metformin 50 mM

24.46

N2 Y 27984722
Selenocysteine 5 mM

24.34

10.52

N2 Y 28954009
Dimethyl Sulfide 10 µM

24.33

N2 Y 27790859
Alpha-lipoic acid 24 µM

24.2

14.3

N2 Y 17156833
Selenocysteine 1 mM

24.16

7.9

N2 Y 28954009
Caffeine 15 mM

24

N2 Y 26696878
Colanic acid

24

N2 Y 28622510
Dihydroergotamine methanesulfonate 88 µM

24

Y 24134630
Trimethadione 4 mg/ml

24

29

N2 Y 15653505
Urolithin A 10 µM

24

N2 Y 27400265
Urolithin A 10 µM

24

N2 Y 27400265
Astragalus membranaceus polysaccharide 1-2.5 mg/ml

23.8

N2 Y 21892924
Paraquat 100 µM

23.73

30.77

N2 Y 27683245
Doxycycline 60 µg/ml

23.7

SJ4101 Y 23698443
Recombinant buckwheat trypsin inhibitor 10 µM

23.7

N2 Y 25959406
Resveratrol 500 µM

23.7

N2 Y 27190265
Tanespimycin 100 µM

23.52

N2 Y 30625143
Dafachronic Acid 0.1µM

23.44

N2 Y 26691751
Chlorophyll 10 µg/ml

23.37

N2 Y 27077003
Hydralazine 100 µM

23.29

N2 Y 29263362
Vitamin D3 100 µM

23.29

N2 Y 27783938
Potassium Chloride 250 mM

23.23

31.58

N2 Y 26854551
Acetic Acid 50 ppm

23

N2 Y 19837596
Aspirin 0.5 µM

23

N2 Y 22866967
Captopril 3.18 mM

23

18

N2 Y 26918946
Cyproterone acetate 33 µM

23

Y 24134630
Metergoline 33 µM

23

Y 24134630
Nicardipine hydrochloride 176 µM

23

Y 24134630
Nitrophenyl piperazine containing compound 1 10 µM

23

N2 Y 27220516
Protocatechuic acid 100 µM

23

25

N2 Y 23780797
Vitamin D3 1000 µg/ml

23

N2 Y 24304198
Vitamin E 200 µg/ml

23

N2 Y 3374177
Astragalus polysaccharide 100 µg/ml

22.8

N2 Y 25186652
Buthus martensii Karsch Polypeptide Toxin Polypeptide DNA sequence inserted into the pGEX-4T-1 plasmid and transformed into pGEX-4T-1

22.5

29.27

N2 Y 28088444
Curcumin 100 µM

22.5

N2 Y 25959406
Mulberry leaf polyphenols 25 mg/mL

22.5

N2 Y 25323576
Ikarugamycin 5 µM

22.25

fem-1(ˆ');dal-1(ˆ') Y 29273768
Blueberry extract 50 mg/mL

22.23

16

N2 Y 30238944
Beta-caryophyllene 50 µM

22.2

N2 Y 24835194
Resveratrol 100 µM

22.2

N2 Y 27190265
Trichostatin A 100 µM

22.1

N2 Y 26676933
18α-Glycyrrhetinic acid 20 µg/mL

22

N2 Y 26886723
Naphthazarin 500 µM

22

25

N2 Y 21765926
Platinum nanoparticles 0.5 mM

22

N2 Y 18400258
Serine 10 mM

22

N2 Y 25643626
Vitamin E 200 µg/ml

22

N2 Y 3374177
Fructose 55 mM

21.96

N2 Y 27680107
Allantoin 250 µM

21.9

N2 Y 26676933
Lonicera japonica 500 µg/mL

21.87

N2 Y 30266681
Erchen wan 1.5 g/L

21.8

N2 N 24952637
Selenocysteine 2.5 mM

21.72

7.9

N2 Y 28954009
Caffeine 20 mM

21.6

N2 Y 24764514
Edetate Calcium Disodium

21.4

N2 Y 25554795
Rapamycin 100 µM

21.3

N2 Y 29874838
Alpha-lipoic acid 1 mM

21

0

N2 Y 18755260
Ascr#3 400 nM

21

N2 Y 23509272
Chicoric acid 100 µM

21

8

N2 Y 24244361
DhHP-6 200 µM

21

N2 Y 20528576
Gamma-tocopherol 200 µg/ml

21

fem-1(hc17) Y 17169403
Garlic extract 50 ppm

21

N2 Y 25940980
Glycerol 10 mM

21

N2 Y 25643626
Nortriptyline hydrochloride 88 µM

21

Y 24134630
Panax notoginseng main root polysaccharide 0.1 mg/ml

21

N2 ND 26234580
Tocotrienol 86 µg

21

18

N2 Y 22484623
Aspirin 1 µM

20.9

N2 Y 22866967
LY-294002 100 µM

20.9

N2 Y 26676933
Rifamycin SV 50 µM

20.9

N2 Y 25720500
Astaxanthin 6 µg

20.8

14.6

N2 Y 22484623
Diosgenin 50 µg/mL

20.8

N2 Y 28954389
Verminoside 25 µM

20.8

N2 Y 26189547
α‐keto‐β‐methylvalerate 10 mM

20.77

N2 Y 26729005
Astragalus polysaccharide 200 µg/ml

20.7

N2 Y 25186652
Icariin 45 µM

20.7

N2 Y 22216122
Rapamycin 1 nM

20.6

N2 Y 23698443
Vitamin E 200 µg/mL

20.6

0

N2 Y 17169403
Dimethyl Sulfide 5 µM

20.14

N2 Y 27790859
Triptolide 50 mg/L

20.1

16

N2 Y 28471052
Cranberry extract 2 mg/ml

20

N2 Y 24566444
Epigallocatechin-3-gallate 100 µM

20

13

N2 N 20513639
Ferulsinaic acid 100 µM

20

N2 Y 21749391
HF-HQ 400 µM

20

N2 Y 22529848
Pregnenolone 60 µg/mL

20

N2 Y 17266678
Propionylpromazine hydrochloride 33 µM

20

Y 24134630
Q3M 20 µg/mL

20

N2 Y 21563825
Tocotrienol NA

20

N2 ND 16872777
Tocotrienol 80 µg/ml

19.8

N2 Y 10843344
Emodin 150 µM

19.74

N2 Y 28831863
Astragalus polysaccharide 400 µg/ml

19.6

N2 Y 25186652
Caffeine 7.5 mM

19.6

N2 Y 24764514
Sodium Chloride 150 mM

19.59

16.67

N2 Y 26854551
Pyrroloquinoline quinone 3 mM

19.53

8.15

N2 Y 28676501
Isoprenol 1 mM

19.23

22.6

N2 Y 30624146
M084 500 µM

19.12

N2 Y 27854075
DhHP-6 100 µM

19.1

N2 Y 23410029
Tyrosol 250 µM

19.1

10.8

fer-15(b26) Y 22824366
Celecoxib 10 µM

19

N2 Y 21348927
Coenzyme Q10

19

clk-1 (qm30) Y 19428456
Fenofibrate 10 µM

19

N2 Y 23603800
Methyl 3,4-dihydroxybenzoate 160 mg/mL

19

N2 Y 29874838
Naphthazarin 200 µM

19

16

N2 Y 21765926
Proline 5 mM

19

N2 Y 25643626
Quercetin 100 µM

19

15

N2 Y 18024103
Rapamycin 100 µM

19

N2 Y 22560223
Tannic acid 100 µM

19

N2 Y 22493606
Urolithin D 50 µM

19

N2 Y 27400265
Urolithin D 50 µM

19

N2 Y 27400265
Rapamycin 10 µM

18.9

N2 Y 26676933
4-hydroxy-E-globularinin 20 µM

18.8

N2 Y 23000058
Damnacanthus officinarum leaf extract 1200 µg/mL

18.6

N2 Y 22370553
Polygonum multiflorum Extract 1000 µg/mL

18.6

N2 Y 30036983
5-octanoyl salicylic acid 100 µM

18.3

11.53

N2 Y 30192051
Piceatannol 50 µM

18.3

N2 Y 28128482
Piceatannol 100 µM

18.3

N2 Y 28128482
Platinum nanoparticles 2 ppb

18.2

N2 Y 21737933
guarana ethanolic extract 100 µg/mL

18.18

21.4

N2 Y 29972429
α-Santalol 32 µM

18.04

8.33

N2 Y 30319772
Acanthopanax sessiliflorus stem extract 500 mg/L

18

20

N2 Y 25324932
BRL 50481 176 µM

18

Y 24134630
Coenzyme Q10 150 µg/ml

18

N2 Y 14706236
Cyclosporin A 88 µM

18

Y 24134630
D-aspartate 5 mM

18

N2 Y 25643626
D-glutamate 5 mM

18

N2 Y 25643626
Doxycycline hydrochloride 33 µM

18

Y 24134630
Enoxacin 100 µg/mL

18

N2 Y 29986212
Loratadine 33 µM

18

Y 24134630
Proline 10 mM

18

N2 Y 25643626
Protease treated royal jelly 10 µg/ml

18

44

N2 Y 21858156
Quercetin 200 µM

18

29

N2 Y 19043800
Serine 5 mM

18

N2 Y 25643626
Sulfamethoxazole 400 µM

18

0

N2 Y 24034891
Tannic acid 100 µM

18

N2 Y 20413530
Tannic acid 100 µM

18

N2 Y 22493606
Sorbitol 1%

17.9

N2 Y 26579191
Calycosin 400 µM

17.8

N2 Y 28434978
Oxyresveratrol 500 µM

17.8

N2 Y 27190265
Resveratrol 1 mM

17.8

N2 Y 16256736
Luteolin 100 µM

17.65

14.82

N2 Y 29375370
Doxycycline 6 µg/ml

17.6

N2 Y 23698443
Electrolyzed reduced water

17.5

10.7

N2 Y 23959012
Celastrol 7 µmol/l

17.4

N2 Y 24416295
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside 25 µM

17.3

N2 Y 26433219
Electrolyzed reduced water

17.3

13.8

N2 Y 23959012
FCCP 50 µM

17.3

21.6

N2 Y 20346071
Oleic Acid 800 µM

17.29

N2 Y 28379943
Shatavarin IV 50 µM

17.26

N2 Y 29069955
Caffeine 2.5 mM

17.2

N2 Y 24764514
Vitexin 100 µM

17.2

10.5

N2 Y 26535084
East Indian sandalwood oil 12 µ/mL

17.1

21.73

N2 Y 30319772
Folic acid 10 µM

17.1

N2 Y 26546011
Palmitoleic acid 800 µM

17.09

N2 Y 28379943
Lonicera japonica 1000 µg/mL

17.07

N2 Y 30266681
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside 50 µM

17

N2 Y 26433219
Colanic acid

17

N2 Y 28622510
Ethosuximide 4 mg/ml

17

22

N2 Y 15653505
Gamma-tocopherol 20 µg/ml

17

fem-1(hc17) Y 17169403
Gluconate 5 mM

17

N2 Y 25643626
Inositol 10 mM

17

N2 Y 25643626
Metformin 6.25 mM

17

N2 Y 24889636
Proline 1 mM

17

N2 Y 25643626
Vitamin E 200 µg/ml

17

N2 Y 3374177
Vitamin E 200 µg/ml

17

N2 Y 3374177
Caffeine 10 mM

16.9

N2 Y 24764514
Damaurone D 15 µM

16.7

N2 Y 29992572
Resveratrol 250 µM

16.66

3.13

N2 Y 27683245
Oleanolic acid 300 µM

16.63

N2 Y 26592451
4-dafachronic acid 250 nM

16.6

28

N2 Y 17360327
Epigallocatechin-3-gallate 200 µM

16.6

3.14

N2 Y 28992589
Vitamin E 20 µg/mL

16.6

0

N2 Y 17169403
Ribes fasciculatum eylacetate fraction 500 µg/mL

16.3

19.05

N2 Y 27478096
Rapamycin 1 nM

16.2

N2 Y 23698443
Agmatine 1 mM

16

N2 Y 25643626
Aspirin 100 µM

16

N2 Y 23485446
Clofibrate 10 µM

16

N2 Y 23603800
Colanic acid

16

N2 Y 28622510
Cysteine 5 mM

16

N2 Y 25643626
D-alanine 10 mM

16

N2 Y 25643626
D-alanine 5 mM

16

N2 Y 25643626
Demeclocycline hydrochloride 33 µM

16

Y 24134630
Eleutherococcus senticosus root extract 250 µg/ml

16

N2 Y 18536978
Eliprodil 88 µM

16

Y 24134630
Fumarate 10 mM

16

N2 Y 23472183
Gluconate 10 mM

16

N2 Y 25643626
Glutamine 5 mM

16

N2 Y 25643626
Leucine 1 mM

16

N2 Y 25643626
Omega-6 10 µM

16

N2 Y 23392608
Sorbitol 12.50%

16

N2 Y 26579191
Tannic acid 50 µM

16

N2 Y 22493606
phenylethanoid glycosides 500 µg/mL

15.98

N2 Y 29185166
Indole 100 µM

15.91

12.3

N2 Y 28827958
Echinacoside 300 µM

15.82

N2 Y 26027643
Chloramphenicol 100 µg/ml

15.8

N2 Y 23698443
Withanolide A 25 µM

15.79

24.58

N2 Y 26956478
Calycosin 100 µM

15.64

N2 Y 28434978
Recombinant buckwheat trypsin inhibitor 5 µM

15.6

N2 Y 25959406
Sesame Cake Peptides 12.5 µg/ml

15.59

3.57

N2 Y 27381188
Dehydroabietic acid 10 µM

15.5

16.7

N2 Y 25976661
Electrolyzed reduced water

15.5

N2 Y 21737933
S-allylmercapto-N-acetylcysteine 2 mM

15.5

18.75

CF512 Y 29579097
Specioside 25 µM

15.5

N2 Y 25619942
Resveratrol 50 µM

15.4

14.3

N2 Y 25976661
Caffeine 50 µg/mL

15.39

N2 Y 30061824
Arctiin 100 µM

15.3

N2 Y 26141518
2,5-Di-tert-butylhydroquinone 250 µM

15.2

N2 Y 29988547
Lonicera japonica 200 µg/mL

15.17

N2 N 30266681
α‐linolenic acid 10 mM

15.13

-4.34

N2 Y 28772063
α‐linolenic acid 10 mM

15.13

-4.34

N2 Y 28772063
1,2,3-Triazolyl ester of ketorolac 50 nM

15

N2 Y 29760342
Alpha-ketoglutarate 1 mM

15

N2 Y 25643626
Arginine 10 mM

15

N2 Y 25643626
Cinnarizine 33 µM

15

Y 24134630
DAPH 13 µM

15

Y 24134630
Doxazosin mesylate 33 µM

15

Y 24134630
Epicatechin 100 µM

15

11

N2 N 20513639
Folic acid 25 µM

15

N2 Y 26546011
Glutamine 1 mM

15

N2 Y 25643626
Guanfacine hydrochloride 13 µM

15

Y 24134630
Hexahydro-sila-diphenidol 88 µM

15

Y 24134630
Nicotinamide adenine dinucleotide 100 µM

15

N2 ND 19370397
Oxoline 500 µM

15

14

N2 Y 21765926
Oxoline 500 µM

15

12

N2 Y 21765926
Oxoline 500 µM

15

10

N2 Y 21765926
Plumbagin 25 µM

15

5

N2 Y 21765926
Rhodiola rosea root extract 10 µg/ml

15

N2 Y 18536978
Spermidine 0.2 mM

15

N2 Y 19801973
Vinpocetine 33 µM

15

Y 24134630
Beta-caryophyllene 100 µM

14.9

N2 Y 24835194
CGP37157 50 µM

14.9

N2 Y 30705628
Hydralazine 50 µM

14.83

N2 Y 29263362
1,7-dimethylxanthine 50 µg/mL

14.75

N2 Y 30061824
Dibromoacetic acid 100 µM

14.6

N2 Y 25556763
N-acetyl-L-cysteine 5 mM

14.6

19

N2 CGCb strain N 26039957
Shiquan dabu wan 6.2 g/L

14.5

N2 Y 24952637
Cranberry extract 2 mg/ml

14.4

N2 Y 24566444
Aspirin 100 µM

14.24

N2 Y 28910305
S-allylmercapto-N-acetylcysteine 5 mM

14.24

18.75

CF512 Y 29579097
2,5-Di-tert-butylhydroquinone 350 µM

14.2

N2 Y 29988547
Sesamin 6.3 µg

14.1

N2 Y 24549958
Ascr#2 400 nM

14

N2 Y 23509272
BTCP hydrochloride 88 µM

14

Y 24134630
Colanic acid

14

N2 Y 28622510
Colanic acid

14

N2 Y 28622510
D-alanine 1 mM

14

N2 Y 25643626
D-glutamate 1 mM

14

N2 Y 25643626