Life extension by compounds in Caenorhabditis Elegans – Part 2

[raw]

Aging

* Reviews

Anti-longevity

* Caenorhabditis elegans

* Drosophila melanogaster

* Mus musculus

* Saccharomyces cerevisiae

Aging

* Humans

* Homo Sapiens

* Mus Musculus

Senescence

* Overexpressed

* Underexpressed

Induced Senescence

* Oncogene

* Replicative

* Stress


Inhibiting Senescence

* Oncogene

* Replicative

* Stress


Variants of longevity

* Human


Pro-longevity

* Caenorhabditis elegans

* Drosophila melanogaster

* Mus musculus

* Saccharomyces cerevisiae
Fitness

* Saccharomyces cerevisiae


Dietary restriction

* Overexpressed

* Underexpressed


Dietary restriction

* Caenorhabditis elegans

* Drosophila melanogaster

* Mus Musculus

* Saccharomyces cerevisiae

* Schizosaccharomyces pombe


Dietary restriction

* Overexpressed

* Underexpressed

* Overexpressed- Underexpressed
Life extension

* Caenorhabditis elegans

* Drosophila Melanogaster

* Mus Musculus

* Other Species

* Rattus Norvegicus

* Saccharomyces cerevisiae


Post-radiation SASP (Day 10)

* Renal Epithelial Cells

* Human Fibroblasts

* Exosome SASP – Human Fibroblasts


Post-Atazanivir SASP (Day 14)

* Human Fibroblasts


RAS induced SASP (Day 7)

* Fibroblasts

* Exosome SASP – Fibroblasts

Part 1
Part 2
Part 3
Part 4


Rapamycin

100 µM

26

34.84


N2

Y

24332851

Chlorophyll

40 µg/ml

25.96


N2

Y

27077003

6-shogaol

25 µM

25.9

15.78


N2

Y

29978428

Reserpine

60 µM

25.75


N2

Y

27966489

Doxycycline

30 µg/ml

25.4


SJ4101

Y

23698443

β-Santalol

16 µM

25.38

25


N2

Y

30319772

Isoprenol

0.5 mM

25.26

28


N2

Y

30624146

Pyruvate

8 mM

25.17


N2

Y

26729005

Matairesinol

100 µM

25


N2

Y

26141518

Nitrendipine

88 µM

25


Y

24134630

Oxaloacetate

8 mM

25

13


N2

Y

19793063

Oxatomide

88 µM

25


Y

24134630

Pyrroloquinoline
quinone

10 mM

25

10.3


N2

Y

28676501

Calycosin

200 µM

24.86


N2

Y

28434978

Astragalus
polysaccharide

200 µg/ml

24.7


N2

Y

25186652

Paraquat

200 µM

24.6

13.58


N2

Y

28992589

N-acetyl-L-cysteine

9 mM

24.49

64


N2

Y

27683245

Metformin

50 mM

24.46


N2

Y

27984722

Selenocysteine

5 mM

24.34

10.52


N2

Y

28954009

Dimethyl
Sulfide

10 µM

24.33


N2

Y

27790859

Alpha-lipoic
acid

24 µM

24.2

14.3


N2

Y

17156833

Selenocysteine

1 mM

24.16

7.9


N2

Y

28954009

Caffeine

15 mM

24


N2

Y

26696878

Colanic
acid

24


N2

Y

28622510

Dihydroergotamine
methanesulfonate

88 µM

24


Y

24134630

Trimethadione

4 mg/ml

24

29


N2

Y

15653505

Urolithin A

10 µM

24


N2

Y

27400265

Urolithin A

10 µM

24


N2

Y

27400265

Astragalus
membranaceus polysaccharide

1-2.5
mg/ml

23.8


N2

Y

21892924

Paraquat

100 µM

23.73

30.77


N2

Y

27683245

Doxycycline

60 µg/ml

23.7


SJ4101

Y

23698443

Recombinant
buckwheat trypsin inhibitor

10 µM

23.7


N2

Y

25959406

Resveratrol

500 µM

23.7


N2

Y

27190265

Tanespimycin

100 µM

23.52


N2

Y

30625143

Dafachronic
Acid

0.1µM

23.44


N2

Y

26691751

Chlorophyll

10 µg/ml

23.37


N2

Y

27077003

Hydralazine

100 µM

23.29


N2

Y

29263362

Vitamin D3

100 µM

23.29


N2

Y

27783938

Potassium
Chloride

250 mM

23.23

31.58


N2

Y

26854551

Acetic Acid

50 ppm

23


N2

Y

19837596

Aspirin

0.5 µM

23


N2

Y

22866967

Captopril

3.18 mM

23

18


N2

Y

26918946

Cyproterone
acetate

33 µM

23


Y

24134630

Metergoline

33 µM

23


Y

24134630

Nicardipine
hydrochloride

176 µM

23


Y

24134630

Nitrophenyl
piperazine containing compound 1

10 µM

23


N2

Y

27220516

Protocatechuic
acid

100 µM

23

25


N2

Y

23780797

Vitamin D3

1000 µg/ml

23


N2

Y

24304198

Vitamin E

200 µg/ml

23


N2

Y

3374177

Astragalus
polysaccharide

100 µg/ml

22.8


N2

Y

25186652

Buthus
martensii Karsch Polypeptide Toxin

Polypeptide
DNA sequence inserted into the pGEX-4T-1 plasmid and transformed into
pGEX-4T-1

22.5

29.27


N2

Y

28088444

Curcumin

100 µM

22.5


N2

Y

25959406

Mulberry
leaf polyphenols

25 mg/mL

22.5


N2

Y

25323576

Ikarugamycin

5 µM

22.25


fem-1(ˆ’);dal-1(ˆ’)

Y

29273768

Blueberry
extract

50 mg/mL

22.23

16


N2

Y

30238944

Beta-caryophyllene

50 µM

22.2


N2

Y

24835194

Resveratrol

100 µM

22.2


N2

Y

27190265

Trichostatin
A

100 µM

22.1


N2

Y

26676933

18α-Glycyrrhetinic
acid

20 µg/mL

22


N2

Y

26886723

Naphthazarin

500 µM

22

25


N2

Y

21765926

Platinum
nanoparticles

0.5 mM

22


N2

Y

18400258

Serine

10 mM

22


N2

Y

25643626

Vitamin E

200 µg/ml

22


N2

Y

3374177

Fructose

55 mM

21.96


N2

Y

27680107

Allantoin

250 µM

21.9


N2

Y

26676933

Lonicera
japonica

500 µg/mL

21.87


N2

Y

30266681

Erchen wan

1.5 g/L

21.8


N2

N

24952637

Selenocysteine

2.5 mM

21.72

7.9


N2

Y

28954009

Caffeine

20 mM

21.6


N2

Y

24764514

Edetate
Calcium Disodium

21.4


N2

Y

25554795

Rapamycin

100 µM

21.3


N2

Y

29874838

Alpha-lipoic
acid

1 mM

21

0


N2

Y

18755260

Ascr#3

400 nM

21


N2

Y

23509272

Chicoric
acid

100 µM

21

8


N2

Y

24244361

DhHP-6

200 µM

21


N2

Y

20528576

Gamma-tocopherol

200 µg/ml

21


fem-1(hc17)

Y

17169403

Garlic
extract

50 ppm

21


N2

Y

25940980

Glycerol

10 mM

21


N2

Y

25643626

Nortriptyline
hydrochloride

88 µM

21


Y

24134630

Panax
notoginseng main root polysaccharide

0.1 mg/ml

21


N2

ND

26234580

Tocotrienol

86 µg

21

18


N2

Y

22484623

Aspirin

1 µM

20.9


N2

Y

22866967

LY-294002

100 µM

20.9


N2

Y

26676933

Rifamycin
SV

50 µM

20.9


N2

Y

25720500

Astaxanthin

6 µg

20.8

14.6


N2

Y

22484623

Diosgenin

50 µg/mL

20.8


N2

Y

28954389

Verminoside

25 µM

20.8


N2

Y

26189547

α‐keto‐β‐methylvalerate

10 mM

20.77


N2

Y

26729005

Astragalus
polysaccharide

200 µg/ml

20.7


N2

Y

25186652

Icariin

45 µM

20.7


N2

Y

22216122

Rapamycin

1 nM

20.6


N2

Y

23698443

Vitamin E

200 µg/mL

20.6

0


N2

Y

17169403

Dimethyl
Sulfide

5 µM

20.14


N2

Y

27790859

Triptolide

50 mg/L

20.1

16


N2

Y

28471052

Cranberry
extract

2 mg/ml

20


N2

Y

24566444

Epigallocatechin-3-gallate

100 µM

20

13


N2

N

20513639

Ferulsinaic
acid

100 µM

20


N2

Y

21749391

HF-HQ

400 µM

20


N2

Y

22529848

Pregnenolone

60 µg/mL

20


N2

Y

17266678

Propionylpromazine
hydrochloride

33 µM

20


Y

24134630

Q3M

20 µg/mL

20


N2

Y

21563825

Tocotrienol

NA

20


N2

ND

16872777

Tocotrienol

80 µg/ml

19.8


N2

Y

10843344

Emodin

150 µM

19.74


N2

Y

28831863

Astragalus
polysaccharide

400 µg/ml

19.6


N2

Y

25186652

Caffeine

7.5 mM

19.6


N2

Y

24764514

Sodium
Chloride

150 mM

19.59

16.67


N2

Y

26854551

Pyrroloquinoline
quinone

3 mM

19.53

8.15


N2

Y

28676501

Isoprenol

1 mM

19.23

22.6


N2

Y

30624146

M084

500 µM

19.12


N2

Y

27854075

DhHP-6

100 µM

19.1


N2

Y

23410029

Tyrosol

250 µM

19.1

10.8


fer-15(b26)

Y

22824366

Celecoxib

10 µM

19


N2

Y

21348927

Coenzyme
Q10

19


clk-1
(qm30)

Y

19428456

Fenofibrate

10 µM

19


N2

Y

23603800

Methyl
3,4-dihydroxybenzoate

160 mg/mL

19


N2

Y

29874838

Naphthazarin

200 µM

19

16


N2

Y

21765926

Proline

5 mM

19


N2

Y

25643626

Quercetin

100 µM

19

15


N2

Y

18024103

Rapamycin

100 µM

19


N2

Y

22560223

Tannic acid

100 µM

19


N2

Y

22493606

Urolithin D

50 µM

19


N2

Y

27400265

Urolithin D

50 µM

19


N2

Y

27400265

Rapamycin

10 µM

18.9


N2

Y

26676933

4-hydroxy-E-globularinin

20 µM

18.8


N2

Y

23000058

Damnacanthus
officinarum leaf extract

1200 µg/mL

18.6


N2

Y

22370553

Polygonum
multiflorum Extract

1000 µg/mL

18.6


N2

Y

30036983

5-octanoyl
salicylic acid

100 µM

18.3

11.53


N2

Y

30192051

Piceatannol

50 µM

18.3


N2

Y

28128482

Piceatannol

100 µM

18.3


N2

Y

28128482

Platinum
nanoparticles

2 ppb

18.2


N2

Y

21737933

guarana
ethanolic extract

100 µg/mL

18.18

21.4


N2

Y

29972429

α-Santalol

32 µM

18.04

8.33


N2

Y

30319772

Acanthopanax
sessiliflorus stem extract

500 mg/L

18

20


N2

Y

25324932

BRL 50481

176 µM

18


Y

24134630

Coenzyme
Q10

150 µg/ml

18


N2

Y

14706236

Cyclosporin
A

88 µM

18


Y

24134630

D-aspartate

5 mM

18


N2

Y

25643626

D-glutamate

5 mM

18


N2

Y

25643626

Doxycycline
hydrochloride

33 µM

18


Y

24134630

Enoxacin

100 µg/mL

18


N2

Y

29986212

Loratadine

33 µM

18


Y

24134630

Proline

10 mM

18


N2

Y

25643626

Protease
treated royal jelly

10 µg/ml

18

44


N2

Y

21858156

Quercetin

200 µM

18

29


N2

Y

19043800

Serine

5 mM

18


N2

Y

25643626

Sulfamethoxazole

400 µM

18

0


N2

Y

24034891

Tannic acid

100 µM

18


N2

Y

20413530

Tannic acid

100 µM

18


N2

Y

22493606

Sorbitol

1%

17.9


N2

Y

26579191

Calycosin

400 µM

17.8


N2

Y

28434978

Oxyresveratrol

500 µM

17.8


N2

Y

27190265

Resveratrol

1 mM

17.8


N2

Y

16256736

Luteolin

100 µM

17.65

14.82


N2

Y

29375370

Doxycycline

6 µg/ml

17.6


N2

Y

23698443

Electrolyzed
reduced water

17.5

10.7


N2

Y

23959012

Celastrol

7 µmol/l

17.4


N2

Y

24416295

Acacetin
7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside

25 µM

17.3


N2

Y

26433219

Electrolyzed
reduced water

17.3

13.8


N2

Y

23959012

FCCP

50 µM

17.3

21.6


N2

Y

20346071

Oleic Acid

800 µM

17.29


N2

Y

28379943

Shatavarin
IV

50 µM

17.26


N2

Y

29069955

Caffeine

2.5 mM

17.2


N2

Y

24764514

Vitexin

100 µM

17.2

10.5


N2

Y

26535084

East Indian
sandalwood oil

12 µ/mL

17.1

21.73


N2

Y

30319772

Folic acid

10 µM

17.1


N2

Y

26546011

Palmitoleic
acid

800 µM

17.09


N2

Y

28379943

Lonicera
japonica

1000 µg/mL

17.07


N2

Y

30266681

Acacetin
7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside

50 µM

17


N2

Y

26433219

Colanic
acid

17


N2

Y

28622510

Ethosuximide

4 mg/ml

17

22


N2

Y

15653505

Gamma-tocopherol

20 µg/ml

17


fem-1(hc17)

Y

17169403

Gluconate

5 mM

17


N2

Y

25643626

Inositol

10 mM

17


N2

Y

25643626

Metformin

6.25 mM

17


N2

Y

24889636

Proline

1 mM

17


N2

Y

25643626

Vitamin E

200 µg/ml

17


N2

Y

3374177

Vitamin E

200 µg/ml

17


N2

Y

3374177

Caffeine

10 mM

16.9


N2

Y

24764514

Damaurone D

15 µM

16.7


N2

Y

29992572

Resveratrol

250 µM

16.66

3.13


N2

Y

27683245

Oleanolic
acid

300 µM

16.63


N2

Y

26592451

4-dafachronic
acid

250 nM

16.6

28


N2

Y

17360327

Epigallocatechin-3-gallate

200 µM

16.6

3.14


N2

Y

28992589

Vitamin E

20 µg/mL

16.6

0


N2

Y

17169403

Ribes fasciculatum
eylacetate fraction

500 µg/mL

16.3

19.05


N2

Y

27478096

Rapamycin

1 nM

16.2


N2

Y

23698443

Agmatine

1 mM

16


N2

Y

25643626

Aspirin

100 µM

16


N2

Y

23485446

Clofibrate

10 µM

16


N2

Y

23603800

Colanic
acid

16


N2

Y

28622510

Cysteine

5 mM

16


N2

Y

25643626

D-alanine

10 mM

16


N2

Y

25643626

D-alanine

5 mM

16


N2

Y

25643626

Demeclocycline
hydrochloride

33 µM

16


Y

24134630

Eleutherococcus
senticosus root extract

250 µg/ml

16


N2

Y

18536978

Eliprodil

88 µM

16


Y

24134630

Fumarate

10 mM

16


N2

Y

23472183

Gluconate

10 mM

16


N2

Y

25643626

Glutamine

5 mM

16


N2

Y

25643626

Leucine

1 mM

16


N2

Y

25643626

Omega-6

10 µM

16


N2

Y

23392608

Sorbitol

12.50%

16


N2

Y

26579191

Tannic acid

50 µM

16


N2

Y

22493606

phenylethanoid
glycosides

500 µg/mL

15.98


N2

Y

29185166

Indole

100 µM

15.91

12.3


N2

Y

28827958

Echinacoside

300 µM

15.82


N2

Y

26027643

Chloramphenicol

100 µg/ml

15.8


N2

Y

23698443

Withanolide
A

25 µM

15.79

24.58


N2

Y

26956478

Calycosin

100 µM

15.64


N2

Y

28434978

Recombinant
buckwheat trypsin inhibitor

5 µM

15.6


N2

Y

25959406

Sesame Cake
Peptides

12.5 µg/ml

15.59

3.57


N2

Y

27381188

Dehydroabietic
acid

10 µM

15.5

16.7


N2

Y

25976661

Electrolyzed
reduced water

15.5


N2

Y

21737933

S-allylmercapto-N-acetylcysteine

2 mM

15.5

18.75


CF512

Y

29579097

Specioside

25 µM

15.5


N2

Y

25619942

Resveratrol

50 µM

15.4

14.3


N2

Y

25976661

Caffeine

50 µg/mL

15.39


N2

Y

30061824

Arctiin

100 µM

15.3


N2

Y

26141518

2,5-Di-tert-butylhydroquinone

250 µM

15.2


N2

Y

29988547

Lonicera
japonica

200 µg/mL

15.17


N2

N

30266681

α‐linolenic
acid

10 mM

15.13

-4.34


N2

Y

28772063

α‐linolenic
acid

10 mM

15.13

-4.34


N2

Y

28772063

1,2,3-Triazolyl
ester of ketorolac

50 nM

15


N2

Y

29760342

Alpha-ketoglutarate

1 mM

15


N2

Y

25643626

Arginine

10 mM

15


N2

Y

25643626

Cinnarizine

33 µM

15


Y

24134630

DAPH

13 µM

15


Y

24134630

Doxazosin
mesylate

33 µM

15


Y

24134630

Epicatechin

100 µM

15

11


N2

N

20513639

Folic acid

25 µM

15


N2

Y

26546011

Glutamine

1 mM

15


N2

Y

25643626

Guanfacine
hydrochloride

13 µM

15


Y

24134630

Hexahydro-sila-diphenidol

88 µM

15


Y

24134630

Nicotinamide
adenine dinucleotide

100 µM

15


N2

ND

19370397

Oxoline

500 µM

15

14


N2

Y

21765926

Oxoline

500 µM

15

12


N2

Y

21765926

Oxoline

500 µM

15

10


N2

Y

21765926

Plumbagin

25 µM

15

5


N2

Y

21765926

Rhodiola
rosea root extract

10 µg/ml

15


N2

Y

18536978

Spermidine

0.2 mM

15


N2

Y

19801973

Vinpocetine

33 µM

15


Y

24134630

Beta-caryophyllene

100 µM

14.9


N2

Y

24835194

CGP37157

50 µM

14.9


N2

Y

30705628

Hydralazine

50 µM

14.83


N2

Y

29263362

1,7-dimethylxanthine

50 µg/mL

14.75


N2

Y

30061824

Dibromoacetic
acid

100 µM

14.6


N2

Y

25556763

N-acetyl-L-cysteine

5 mM

14.6

19


N2 CGCb
strain

N

26039957

Shiquan
dabu wan

6.2 g/L

14.5


N2

Y

24952637

Cranberry
extract

2 mg/ml

14.4


N2

Y

24566444

Aspirin

100 µM

14.24


N2

Y

28910305

S-allylmercapto-N-acetylcysteine

5 mM

14.24

18.75


CF512

Y

29579097

2,5-Di-tert-butylhydroquinone

350 µM

14.2


N2

Y

29988547

Sesamin

6.3 µg

14.1


N2

Y

24549958

Ascr#2

400 nM

14


N2

Y

23509272

BTCP
hydrochloride

88 µM

14


Y

24134630

Colanic
acid

14


N2

Y

28622510

Colanic
acid

14


N2

Y

28622510

D-alanine

1 mM

14


N2

Y

25643626

D-glutamate

1 mM

14


N2

Y

25643626

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