IR, RAS, ATV induced SASP

Uniprot

Genes

Protein Name

IR (fibro)

RAS

ATV

IR (epi)

P04406

GAPDH

Glyceraldehyde-3-phosphate dehydrogenase

6.78

3.83

1.91

0.94

P14618

PKM

Pyruvate kinase PKM

5.73

3.98

1.50

1.27

O43399

TPD52L2

Tumor protein D54

5.86

3.01

2.18

0.69

Q99988

GDF15

Growth/differentiation factor 15

2.54

5.07

3.08

1.96

Q16555

DPYSL2

Dihydropyrimidinase-related protein 2

6.00

2.25

1.48

0.68

Q9Y490

TLN1

Talin-1

5.13

2.92

0.91

0.79

P17096

HMGA1

High mobility group protein HMG-I/HMG-Y

2.53

3.38

3.59

1.40

P78417

GSTO1

Glutathione S-transferase omega-1

2.09

3.92

3.25

0.64

O14950;P19105

MYL12B

Myosin regulatory light chain 12B

4.93

1.53

1.63

0.65

P60709;P63261

ACTB

Actin, cytoplasmic 1

4.11

2.86

1.05

0.88

O00151

PDLIM1

PDZ and LIM domain protein 1

4.27

1.89

1.97

0.88

P46940

IQGAP1

Ras GTPase-activating-like protein IQGAP1

3.41

2.98

1.75

1.20

O00299

CLIC1

Chloride intracellular channel protein 1

2.68

3.37

1.07

1.00

A5A3E0

POTEF

POTE ankyrin domain family member F

2.94

3.01

1.29

0.62

Q15149

PLEC

Plectin

2.81

2.23

2.35

0.64

P0DMV8;P0DMV9

HSPA1A;HSPA1B

Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1B

2.96

2.40

1.45

0.67

Q562R1

ACTBL2

Beta-actin-like protein 2

2.02

2.93

0.98

0.70


Reference: A proteomic atlas of senescence-associated secretomes for aging biomarker development
Nathan Basisty,et al, PLOS Biology, 2020