Human non-Cluster of differentiation (CD) Cellular Antigens

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Antigen

Name


Other

Names


MW


Structure


Distribution


Function


4-1BB Ligand


CD137L


 


TNFSF


Bact, DC, carcinoma cell lines


T costimulation


AID


 


 


RNA-editing deaminase family


Bact, Germinal Center B


Activation-Induced Deaminase, Ig class switch recombination


AITR


TNFRSF18, GITR


 


 


Treg, Tact


costimulation


AITRL


TNFSF18, TL6, GITRL


 


 


APC


 


B7 family


see CD273-276


 


 


 


 


B7-H4


B7-S1, B7x


 


B7 family


 


may interact with BTLA (?), inhibition


BAMBI


TGFBR


29kD


TGFBR


carcinoma cell


pseudoreceptor for TGF-b (short cytoplasmic domain), growth inhibition


BCMA


see CD269


 


 


 


 


BLyS


see CD257


 


 


 


 


BR3


see CD268


 


 


 


 


BTLA


see CD272


 


 


 


 


CCR7


see CD197


 


 


 


 


c-Met


HGFR/SFR


190kD


heterodimer, PTK


epith, hematopoietic progenitors, early thymocytes


tumor growth / metastasis, Hepatocyte Growth Factor / Scatter Factor receptor, T development, hematopoiesis


CMKLR1


chemokine-like receptor 1


42kD


GPCR 7TM, chemokine receptor


pDC (CD123+), in vitro derived moDC


binds chemerin, pDC recruitment, bone development


DcR3


TR6, TNFRSF6B


 


Soluble


tumors


Fas decoy receptor, tumor evasion


 


 


 


 


 


 


DEC-205


see CD205


 


 


 


 


DR3


TRAMP, Apo-3, WSL-1, LARD, TR3


 


TNFRSF


Tact, leukocytes


lymphocyte homeostasis


 


 


 


 


 


 


DR6


TR7


 


TNFRSF


 


death, Th2 response


Fc epsilonRI alpha


high-affinity IgE receptor


 


tetramer complex


mast cells, basophils


triggers IgE-mediated allergic reactions


Foxp3


SCURFIN


50kD


Fox family forkhead


T subsets (CD4+/CD25+ subset and CD8+ subset)


transcription factor, upregulated in T regs


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


Granzyme B


Granzyme-2, CTLA-1


30kD


Peptidase S1 family


Cytotoxic T, NK


target cell apoptotic lysis, cell-mediated immune responses


HLA-ABC


 


45, 11-12kD


 


nucleated cells


cell-mediated immune response & tumor surveillance


HLA-DR


 


 


 


APC, Tact


presentation of peptides to CD4+ T lymphocytes


HVEM


TNFRSF14, TR2


60kD


TNFRSF


broad expression


receptor for LIGHT, LT-alpha, BTLA, Herpes Simplex Virus, lymphocyte activation


ICOS


see CD278


 


 


 


 


ICOSL


see CD275


 


 


 


 


IL-15R alpha


 


 


 


monoact


binds to IL-15, w/ IL-2RB and common gamma, IL-15 trans-presentation


Integrin b5


 


100kD


 


carcinoma cell lines, fibroblast lines


w/ alphav subunit, vitronectin receptor


MD-2


 


30KD


 


w/ TLR4 distribution and LPS recognition


 


MICA/MICB


 


70kD


MHC Class I-related proteins


intestinal epith, some tumors


unregulated on epith after shock, NKG2D receptors


Nanog


 


34kD


 


ES cells


transcription factor, self renewal of ES cells


 


 


 


 


 


 


NKG2D


see CD314


 


 


 


 


NOD2


CARD-15, IBD1


 


 


monocytes, intracellular


 


Notch-1


Lin-12, Tan 1


 


 


developing embryo, variety of adult tissues


cell-cell interaction, cell fate determination


OPG


TRAIL-R5, TR1, TNFRSF11B


 


 


binds TRAIL?


bone resorption


OX-40


see CD134


 


 


 


 


OX-40 Ligand


see CD252


 


 


 


 


p38


 


38kD


SAP/MAP kinase


NK, CD8+ T subset, upregulated on CD8+T


role in cytolytic activity


PD-1


see CD279


 


 


 


 


PD-L1


see CD274


 


 


 


 


PD-L2


see CD273


 


 


 


 


Perforin


 


70-75kD


 


CTL, NK


cytolytic protein


 


 


 


 


 


 


RP105


see CD180


 


 


 


 


RANK


see CD265


 


 


 


 


RANKL


see CD254


 


 


 


 


SAP


SLAM-associated protein


14kD


adaptor protein


T, NK


negatively regulates SLAM- family receptors


SLP-76


 


76kD


 


T, Blow


T cell receptor mediated signaling


SSEA-1


stage-specific embryonic antigen-1


 


 


ES cells, embryonic carcinomas, germ cells


down regulated by differentiation


SSEA-3


stage-specific embryonic antigen-3


 


 


 


 


SSEA-4


stage-specific embryonic antigen-4


 


 


 


 


Stro-1


 


 


 


BM stroma, erythroid progenitors


surface marker for immature mesenchymal cells


TACI


see CD267


 


 


 


 


T-bet


 


 


 


Th1 cells


transcription factor, T development / differentiation


TCL1


 


 


 


B cell tumors, lymphoid lineages in a developmentally controlled manner, pDC


intracellular, lymphoid proto-oncogene


TCR alpha b


 


 


 


peripheral T subset


antigen recognition


TCR gamma delta


 


 


 


T subset


antigen recognition


TLR1 – TLR4


see CD281 – CD284


 


 


 


 


TLR5


TIL3


 


TLR family


mRNA: leukocytes, prostate, ovary, liver, lung


interacts w/ microbial lipoproteins, NF-kappaB, responds to Salmonella


TLR6


 


 


TLR family


mRNA: leukocytes, ovary, lung


interacts w/ microbial lipoproteins, protein sequence similar to hTLR1; regulates TLR2 response


TLR7


 


 


TLR family


mRNA: spleen, placenta, lung; upregulated on mac


 


TLR8


 


 


TLR family


mRNA: leukocytes, lung


 


TLR9


see CD289


 


 


 


 


TLR10


 


 


TLR family


mRNA: lymphoid tissues


most closely related to TLR1 and TLR6


TNFRI


see CD120a


 


 


 


 


TRAIL


see CD253


 


 


 


 


TSLPR


 


50kD


heterodimer with IL-7Ralpha/CD127


monocytes, DC, B


binds TSLP (Thymic Stromal Lymphopoietin) to activate DC


TWEAK


TNFSF12, APO3L


 


TNFSF


activated mono


death


 


 


 


 


 


 


TWEAK Receptor


see CD266


 


 


 


 


ULBPs


 


 


MHC class I-related protiens, GPI-linked


tumors


NKG2D receptors, NK activation


ZAP-70


TCRζ-associated kinase


70kD


Syk family


Intracellular T, NK


TCR signaling & development


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