Human Cluster of differentiation (CD) Cellular Antigens

[raw]

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CD

Name


Other

Names


Molecular weight


Structure


Distribution


Function


CD1a


T6


49kD


IgSF, MHC-like


cortical thymocytes, Langerhans cells, DC


antigen presentation, with b2m


CD1b


T6


45kD


IgSF, MHC-like


cortical thymocytes, Langerhans cells, DC


antigen presentation, with b2m


CD1c


T6


43kD


IgSF, MHC-like


cortical thymocytes, Langerhans cells, DC, B subset


antigen presentation, with b2m


CD1d


 


49kD


IgSF, MHC-like


intestinal epith, B subset, monolow, DC


antigen presentation, with b2m


CD1e


 


28kD


IgSF, MHC-like


DC


antigen presentation, with b2m


CD2


T11, LFA-2, SRBC-R


50kD


IgSF


thymocytes, T, NK


CD58 ligand, adhesion, T cell activation


CD2R


T11-3


50kD


IgSF


Tact


activation-dependent form of CD2


CD3 gamma, CD3 delta


T3


 


IgSF


T, thymocyte subset


with TCR, TCR surface expression / signal transduction


CD3 epsilon


T3


20kD


IgSF


T, thymocyte subset


with TCR, TCR surface expression / signal transduction


 


 


 


 


 


 


 


 


 


 


 


 


CD4


T4


55kD


IgSF


thymocyte subset, T subset, mono, mac


MHC class II coreceptor, HIV receptor, T cell differentiation / activation


 


 


 


 


 


 


CD5


T1, Tp67


67kD


Scavenger R SF


thymocytes, T, B subset, B-CLL


CD72 receptor, TCR or BCR signaling, T-B interaction


CD6


T12


100-130kD


Scavenger R SF


thymocytes, T, B subset


CD166 receptor, T cell differentiation / costimulation


CD7


 


40kD


IgSF


hematopoietic progenitors, thymocytes, T, NK


T costimulation


CD8a


T8, Leu-2


32-34kD


IgSF


thymocyte subset, T subset, NK


MHC class I coreceptor, receptor for some mutated HIV-1, T cell differentiation / activation


 


 


 


 


 


 


 


 


 


 


 


 


CD8b


 


30-32kD


IgSF


thymocyte subset, T subset


 


CD9


p24, MRP-1


22-27kD


TM4SF


pre-B, eosinophils, basophils, platelets, Tact


cellular adhesion and migration


CD10


CALLA, NEP, gp100


100kD


type II TM


B precursors, T precursors, neutrophils


zinc-binding metalloproteinase, B cell development


CD11a


LFA-1, integrin alphaL


180kD


Integrin family


lymph, gran, mono, mac


CD11a / CD18 receptor for ICAM-1, -2,-3, intercellular adhesion, T costimulation


CD11b


Mac-1, integrin alphaM


170kD


Integrin family


myeloid cells, NK


binds CD54, ECM, iC3b


 


 


 


 


 


 


CD11c


p150, 95, CR4, integrin alphaX


150kD


Integrin family


DC, myeloid cells, NK, B, T subset


binds CD54, fibrinogen and iC3b


CD12


 


90-120kD


 


mono, gran, platelets


 


CD13


Aminopeptidase N, APN


150-170kD


type II TM


myeloid cells


zinc-binding metalloproteinase, antigen processing, receptor for corona virus strains


CD14


LPS-R


53-55kD


GPI-linked


mono, mac, Langerhans cells, granlow


receptor for LPS/LBP, LPS recognition


CD15


Lewis-x, Lex


 


CHO


neutrophils, eosinophils, mono


adhesion


CD15s


Sialyl Lewis X


 


CHO


neutrophils, eosinophils, mono, memory helper T, Tact and B, NK, HEV


CD62L and CD62P ligand, adhesion


CD15u


Sulfated Lewis X


 


CHO


myeloid subset


adhesion


CD16a


FcgammaRIIIA


50-65kD


IgSF


neutrophils, mac, NK


component of low affinity Fc receptor, phagocytosis and ADCC


CD16b


FcgammaRIIIB


48kD


IgSF


neutrophils


component of low affinity Fc receptor, phagocytosis and ADCC


CD17


 


 


 


neutrophils, mono, platelets


lactosyl ceramide


CD18


Integrin b2


95kD


Integrin family


broad, all leukocytes


with CD11a, b & c, adhesion


CD19


B4


95kD


IgSF


B, FDC


complex with CD21 and CD81, BCR coreceptor, B cell activation / differentiation


CD20


B1, Bp35


33-37kD


TM4SF


B, T subset


B cell activation


CD21


C3DR, CR2, EBV-R


145,110kD


CCRSF


B, FDC, T subset


complement C3d and EBV receptor, complex with CD19 and CD81, BCR coreceptor


CD22


BL-CAM, Siglec-2


150kD


IgSF, sialoadhesins


B


adhesion, B-mono, B-T interactions


CD23


FcepsilonRII


45kD


C-type lectin


B, activated mac, eosinophils, FDC, platelets


CD19-CD21-CD81 receptor, IgE low affinity receptor, signal transduction


CD24


BA-1


35-45kD


GPI-linked


thymocytes, erythrocytes, peripheral lymph, myeloid


binds P-selectin


CD25


Tac, p55


55kD


type I TM


Tact, Bact, lymph progenitors


IL-2Ralpha, with IL-2Rb and gamma to form high affinity complex


CD26


DPP IV


110kD


type II TM


thymocyte subset, Tact, soluble form


dipeptidyl peptidase, T costimulation, HIV entry


CD27


T14


50-55kD


TNFRSF


medullary thymocytes, T, B subset, NK subset


CD70 receptor, T costimulation


 


 


 


 


 


 


CD28


Tp44, T44


44kD


IgSF


most T, thymocytes, plasma cells


CD80, CD86 receptor, T costimulation


 


 


 


 


 


 


CD29


Integrin b1


130kD


Integrin family


lymph, mono, granlow, platelets, mast cells, fibroblasts, endoth


with CD49a (VLA-1) receptor for VCAM-1, MAdCAM-1 and ECM


CD30


Ki-1


105-120kD


TNFRSF


Bact, T and NK , Reed-Sternberg cells, anaplastic large cell lymphoma


CD153 receptor, lymph proliferation / apoptosis


CD31


PECAM-1


130-140kD


IgSF


mono, platelets, gran, endoth, lymph subset


CD38 receptor, adhesion


CD32


FcgammaRII


40kD


IgSF


mono, gran, B, platelets


low affinity Fc receptor for aggregated Ig and immune complexes


CD33


p67, Siglec-3


67kD


IgSF, sialoadhesins


myeloid progenitors, mono, gran, DC, mast cells, Tact


adhesion


 


 


 


 


 


 


CD34


 


105-120kD


Sialomucin, type I TM


hematopoietic precursors, capillary endoth, embryonic fibroblasts


stem cell marker, adhesion, CD62L receptor


CD35


CR1


250kD


CCRSF


erythrocytes, B, mono, neutrophils, eosinophils, FDC, T subset


complement receptor 1, binds C3b and C4b, adhesion, phagocytosis


CD36


GPIV


88kD


 


platelets, mono, mac, endoth, early erythrocytes


ECM receptor, adhesion, phagocytosis


CD37


 


40-52kD


TM4SF


B, Tlow, granlow


signal transduction


CD38


T10


45kD


 


variable levels on majority of hematopoietic cells, high expression on plasma cells, B and Tact


ecto-ADP-ribosyl cyclase, cell activation


CD39


 


78kD


NK, mac, Langerhans cells, DC, Bact


B cell adhesion, protects activated cells from lysis, ecto-apyrase


 


CD40


 


48kD


TNFRSF


B, mono, mac, FDC, endoth, T subset


CD154 receptor, B differentiation / costimulation, isotype-switching, rescues B cells from apoptosis


CD41


gpIIb


125/22kD


Integrin family


platelets, megakaryocytes


with CD61 forms GPIIb, binds fibrinogen, fibronectin, vWF, thrombospondin, platelet activation and aggregation


 


 


 


 


 


 


CD42a


GPIX


22kD


LRRF


platelets, megakaryocytes


complex with CD42b, c and d, receptor for vWF and thrombin, platelet adhesion to subendothelial matrices


CD42b


GPIba


145kD


LRRF


platelets, megakaryocytes


complex with CD42a, c and d, binds to vWF and thrombin, platelet adhesion / activation


CD42c


GPIbb


24kD


LRRF


platelets, megakaryocytes


complex with CD42a, b, d


CD42d


GPV


82kD


LRRF


platelets, megakaryocytes


complex with CD42a-c


CD43


Leukosialin, sialophorin


115-135kD


Sialomucin, type I TM


leukocytes, except resting B, plateletslow


inhibition of T cell interaction, CD54R, adhesion


CD44


H-CAM, Pgp-1


80-95kD


hyaladherin family


hematopoietic and non-hematopoietic cells, except platelets, hepatocytes, testis


binds hyaluronic acid, adhesion


CD44R


CD44v


 


 


CD44 variants heterogeneous expression, constitutively on epith, mono, upregulated on activated leukocytes


adhesion, metastasis


CD45


LCA, T200, B220


180-240kD


 


hematopoietic cells, multiple isoforms from alternative splicing


tyrosine phosphatase, enhanced TCR & BCR signals


 


 


 


 


 


 


CD45RA


 


205-220kD


 


B, T subset(naive), mono


exon A isoforms of CD45


 


 


 


 


 


 


CD45RB


 


190-220kD


 


T subset, B, mono, mac, gran


exon B isoforms of CD45


CD45RO


 


180kD


 


Tact, memory T, B subset, mono, mac, gran


isoform of CD45 lacking A, B, C exons


CD46


MCP


56/66kD


CCRSF


nucleated cells


membrane cofactor protein, binds C3b & C4b allowing degradation by Factor I, measles virus receptor


CD47


IAP


47-52kD


IgSF


hematopoietic cells, epith, endoth, fibroblasts, other tissues


leukocyte adhesion, migration, activation


CD47R


 


 


 


New designation for CDw149, similar distribution as CD47 but dimmer


 


CD48


Blast-1


45kD


IgSF


broad, all leukocytes


cell adhesion


CD49a


VLA-1


210kD


Integrin family


Tact, mono


integrin alpha1, adhesion, CD49a/CD29 binds collagen and laminin


CD49b


VLA-2


165kD


Integrin family


B, mono, platelets, Tact, megakaryocytes


integrin alpha2, adhesion, CD49b / CD29 binds collagen and laminin


CD49c


VLA-3


125kD


Integrin family


B and Tlow, most adhesive cell lines


integrin alpha3, adhesion, CD49c/CD29 binds laminin, fibronectin and collagen


CD49d


VLA-4


150kD


Integrin family


T, B, NK, thymocytes, mono, eosinophils, mast, DC


integrin alpha4, adhesion, CD49d/CD29 binds fibronectin, VCAM-1 & MAdCAM-1


CD49e


VLA-5


135, 25kD


Integrin family


thymocytes, T, mono, platelets, early and Bact


integrin alpha5, adhesion, CD49e/CD29 binds fibronectin


CD49f


VLA-6


125kD


Integrin family


memory T, thymocytes, mono, platelets, megakaryocytes, epith


integrin alpha6, adhesion, CD49f / CD29 binds laminin


CD50


ICAM-3


110-120kD


IgSF


hematopoietic, endoth, epidermal Langerhans cells


adhesion, costimulation


CD51


Vitronectin receptor


125, 24kD


Integrin family


plateletslow, endoth, osteoblasts, melanomas


integrin alphav, adhesion, CD51 / CD61 binds vitronectin, vWF, fibrinogen and thrombospondin


CD52


CAMPATH-1


21-28kD


 


thymocytes, T, B (not plasma cells), mono, mac


 


CD53


 


35-42kD


TM4SF


leukocytes, DC, osteoblasts, osteoclasts


signal transduction


CD54


ICAM-1


90-110kD


IgSF


endoth, mono, lymph (high upon activation)


receptor for CD11a / CD18 (LFA-1), CD11b/CD18 (Mac-1) and rhinovirus


CD55


DAF


60-70kD


GPI-linked


hematopoietic, endoth


binds C3b, complement regulation


CD56


NCAM


175-185kD


IgSF


NK, T subset, neurons, some large granular lymphocyte leukemias, myeloid leukemias


adhesion


CD57


HNK-1, Leu-7


110kD


 


NK subset, T subset


 


CD58


LFA-3


55-70kD


IgSF


hematopoietic, non-hematopoietic cells


CD2 receptor, adhesion


CD59


Protectin, MAC- inhibitor


19kD


GPI-linked


hematopoietic, non-hematopoietic cells


binds complement C8 and C9, blocks assembly of membrane attack complex


CD60a


GD3


 


CHO


T subset, platelets, thymic epith, astrocytes


costimulation


CD60b


9-O-sialyl GD3


 


CHO


T subset, Bact


 


CD60c


7-O-sialyl GD3


 


CHO


T subset


 


CD61


GPIIIa


105kD


Integrin family


platelets, megakaryocytes, mac, endoth


integrin b3, adhesion, CD41/CD61 or CD51 / CD61 mediate adhesion to ECM


CD62E


E-selectin, ELAM-1


97,107-115kD


Selectin family


endoth


binds CD15s, cell rolling, metastasis


CD62L


L-selectin, LECAM-1


74, 95kD


Selectin family


B, naïve and memory T, mono, gran, NK, thymocytes


CD34, GlyCAM, and MAdCAM-1 receptor, leukocyte homing, tethering, rolling


CD62P


P-selectin, PADGEM


140kD


Selectin family


activated platelets, endoth


CD162, CD15s receptor, adhesion, neutrophil rolling, platelet-neutrophil and platelet-mono interactions


CD63


LIMP, LAMP-3


53kD


TM4SF


activated platelets, mono, mac


lysosomal membrane protein, moves to cell surface after activation


CD64


FcgammaRI


72kD


IgSF


mono, mac, DC, Interferon or G-CSF activated gran


high affinity receptor for IgG, phagocytosis and ADCC


CD65


 


 


 


gran, mono subset, myeloid leukemias


 


CD65s


VIM2


 


 


gran, mono, myeloid leukemias


phagocytosis


CD66a


BGP-1, NCA-160


160-180kD


IgSF, CEA family


neutrophils, epith


cell adhesion


CD66b


CD67, CGM6


95-100kD


IgSF, CEA family


gran


cell adhesion, neutrophil activation


CD66c


NCA


90kD


IgSF, CEA family


neutrophils, colon carcinoma


cell adhesion


CD66d


CGM1


35kD


IgSF, CEA family


neutrophils


 


CD66e


CEA


180-200kD


IgSF, CEA family


colon epith, colon cancer


cell adhesion


CD66f


PSG, Sp-1


54-72kD


IgSF, CEA family


pregnancy specific glycoprotein, placental syncytiotrophoblasts, fetal liver


immune regulation, protects fetus from maternal immune system


CD68


Macrosialin, gp110


110kD


Sialomucin


intracellularly in mono, mac, neutrophils, basophils, large lymph, mast cells, DC, myeloid progenitors, liver


 


CD69


AIM


28, 32kD


C-type lectin


Tact, B, NK and gran, thymocytes, platelets, Langerhans cells


signal transduction


CD70


Ki-24


50, 70, 90, 160kD


TNFSF


Bact and Tact


CD27 ligand, T and B cell costimulation


CD71


T9


95kD


 


proliferating cells, reticulocytes, erythroid precursors


transferrin receptor, iron uptake


 


 


 


 


 


 


CD72


Lyb-2


42kD


C-type lectin


B, FDC


CD5, CD100 receptor, B proliferation


CD73


 


69kD


GPI-linked


B subset, T subset, FDC, epith


ecto-5’-nucleotidase, nucleoside uptake, T costimulation, lymph adhesion


CD74


Ii, invariant chain


33, 35, 41, 43kD


 


B, mac, mono, Langerhans cells, DC, Tact


MHC class II traffic and function


CD75


 


 


CHO Sialoglycan family


B subset, epith


lactosamines


CD75s


 


 


CHO Sialoglycan family


B subset, T subset


alpha-2,6-sialylated lactosamines (previously CDw75 and CDw76)


CD77


Gb3, Pk blood group


 


 


germinal center B, Burkitt’s lymphomashigh, follicular lymphomaslow


apoptosis


CD79a


Iga


33, 45kD


IgSF


B


component of BCR, BCR surface expression and signal transduction


CD79b


Igb


37kD


IgSF


B


component of BCR, BCR surface expression and signal transduction


CD80


B7, B7-1, BB1


60kD


IgSF


Bact and Tact, mac, DC


binds to CD28, CD152, T costimulation


CD81


TAPA-1


26kD


TM4SF


T, B, NK, thymocytes, DC, endoth, fibroblast, neuroblastomas, melanomas


complex with CD19 & CD21, signaling, T costimulation


CD82


R2


50-53kD


TM4SF


leukocytes


signal transduction


CD83


HB15


43kD


IgSF


Bact and Tact, DC, Langerhans cells


 


CDw84


 


73kD


 


mono, platelets, B, T subset, mac subset


 


CD85


 


110kD


IgSF, ILT/LIR family


DC, mono, B, NK, T subset


inhibition of NK, T cell cytolytic function


CD86


B70, B7-2


80kD


IgSF


mono, DC, Bact and Tact


binds to CD28, CD152, T costimulation


CD87


UPA-R


39-66kD


GPI-linked


gran, mono, NK, Tact, endoth, fibroblasts


urokinase plasminogen activator receptor, inflammatory cell invasion, metastasis


CD88


C5aR


40kD


TM7SF


gran, mono, DC


C5a receptor, granulocyte activation


CD89


FcalphaR


55-75kD


IgSF


mono, mac, gran, neutrophils, B subset, T subset


IgA receptor, phagocytosis, degranulation, respiratory burst


CD90


Thy-1


25-35kD


IgSF, GPI-linked


CD34+ hematopoietic subset, neurons


hematopoietic stem cell and neuron differentiation


CD91


 


600kD


LDLR family


mono, mac, neurons, fibroblasts


receptor for alpha-2-macroglobulin


CD92


 


70kD


 


neutrophils, mono, platelets, endoth, fibroblasts


 


CD93


 


120kD


 


neutrophils, mono, endoth


 


CD94


KP43


43kD


C-type lectin


NK, T subset


complex with NKG2, inhibits NK function


CD95


Apo-1, Fas


45kD


TNFRSF


lymph (high upon activation), mono, neutrophils


FasL (CD178) receptor, apoptosis


 


 


 


 


 


 


CD96


TACTILE


160kD


IgSF


NK, Tact


adhesion of activated T and NK


CD97


 


74, 80, 90kD


TM7SF


Bact and Tact, mono, gran


 


CD98


4F2


80, 40kD


 


T, B, NK, gran, all human cell lines


cellular activation


CD99


MIC2, E2


32kD


 


leukocytes


T cell activation, adhesion


CD99R


E2


32kD


 


T, NK, myeloid cells


isoform of CD99


CD100


 


150kD


 


hematopoietic cells except immature bone marrow cells, RBC and platelets


cell adhesion, cellular activation


CD101


V7, p126


120kD


IgSF


mono, gran, DC, Tact


T cell activation


CD102


ICAM-2


55-65kD


IgSF


lymph, mono, platelets, endoth


binds CD11a / CD18, costimulation


CD103


HML-1, alpha6, integrin alphaE


150, 25kD


Integrin family


intraepithelial lymph, lymph subset, activated lymph


with integrin b7, binds E-cadherin, lymph homing/retention


CD104


b4 integrin


220kD


Integrin family


epith, Schwann cells, keratinocytes, some tumor cells


with integrin alpha6 (CD49f), cell adhesion, differentiation, metastasis


CD105


Endoglin


95kD


homodimer


endoth, bone marrow subset, activated mac


cellular response to TGF-b1


CD106


VCAM-1


110kD


IgSF


activated endoth, FDC


VLA-4 (CD49d / CD29) receptor, leukocyte adhesion, migration, costimulation


CD107a


LAMP-1


110kD


 


activated platelets, T, endoth, metastatic tumors


a lysosomal membrane protein


CD107b


LAMP-2


120kD


 


activated platelets, T, endoth, metastatic tumors


a lysosomal membrane protein


CD108


 


80kD


 


erythrocytes, lymphoblasts, resting lymphlow


 


CD109


 


170kD


 


Tact and platelets, CD34+ subset, endoth


 


CD110


MPL, TPO-R


82-84kD


CRSF


megakaryocytes, platelets, some CD34+ stem cellslow


thrombopoietin receptor, megakaryocyte progenitor cell growth / differentiation


CD111


PRR1, Nectin-1


64-72kD


IgSF


stem cell subset, mac, neutrophils


 


CD112


PRR2, Nectin-2


64-72kD


IgSF


mono, neutrophils, CD34+ subset, megakaryocytes, endoth, epith


intercellular adhesion


CD113


PVRL3, Nectin3


83kD


IgSF


testis, placenta


adhesion molecule that interacts with afadin


CD114


G-CSFR


95, 139kD


CRSF


myeloid progenitors, endoth


myeloid differentiation / proliferation


CD115


M-CSFR, c-fms


150kD


IgSF, RTK family


mono, mac, monocytic progenitors


CSF-1R, monocytic differentiation / proliferation


CD116


GM-CSFRalpha


70-85kD


CRSF


mono, gran, DC, endoth


with common b, myeloid differentiation / proliferation


CD117


c-kit, SCFR


145kD


IgSF, RTK family


hematopoietic progenitors, mast cells


SCF receptor, hematopoietic progenitor development / differentiation


CD118


LIFR, gp190


190kD


Type I CRSF & secreted forms


epithelial cells in adult and embryo


membrane-bound involved in signal transduction, soluble form inhibits activity of LIF


CD119


IFNgammaR


90-100kD


 


mac, mono, B, T, NK, neutrophils, endoth


IFN-gamma Ralpha, with IFN-gamma AF-1, host defense


CD120a


TNFR-I


50-60kD


TNFRSF


hematopoietic, non-hematopoietic cells


receptor for both TNF-alpha and TNF-b


CD120b


TNFR-II


75-85kD


TNFRSF


hematopoietic, non-hematopoietic cells


receptor for both TNF-alpha and TNF-b


CD121a


IL-1R type I


80kD


IgSF


dimly expressed on many cells


binds IL-1alpha and IL-1b, IL-1 signaling


CD121b


IL-1R, type II


60-70kD


IgSF


B, mac, mono, T subset


binds IL-1alpha and IL-1b, negative signals


CD122


IL-2Rb


75kD


CRSF


NK, T, B, mono


IL-2Rb and IL-15Rb, signal transduction


CD123


IL-3R


70kD


CRSF


lymph subset, basophils, hematopoietic progenitors, mac, DC, megakaryocytes


IL-3Ralpha, with CDw131


CD124


IL-4R


140kD


CRSF


lymphlow, mono, hematopoietic precursors, .broblast, epith


IL-4Ralpha, with CD132 or IL-13Ralpha, T cell growth / differentiation


CD125


IL-5R


60kD


CRSF


eosinophils, basophils


IL-5Ralpha, with CDw131


CD126


IL-6R


80kD


IgSF, CRSF


Bact and plasma cells, most leukocyteslow, fibroblasts


IL-6Ralpha, with CD130


CD127


IL-7R


65-75kD


CRSF


T, pro-B


IL-7Ralpha, with CD132, B and T cell development


CD128


see CD181 & CD182


 


 


 


 


CD130


IL-6Rb, gp130


130kD


CRSF


Bact and plasma cells, most leukocyteslow, endoth


IL-6Rb, IL-6, IL-11, LIF, CNF signals


CD131


IL-3R common b


95-120kD


CRSF


mono, gran, early B


with alpha subunits of IL-3R, IL-5R, and GM-CSFR, signal transduction


CD132


Common gamma


64kD


CRSF


T, B, NK, mono, gran


subunit of IL-2R, IL-4R, IL-7R, IL-9R, and IL-15R, signal transduction


CD133


AC133, prominin-like 1


120kD


TM5SF


hematopoietic stem cell subset, epith, endoth


 


CD134


OX-40


48-50kD


TNFRSF


Tact


T cell activation, differentiation, apoptosis


CD135


Flt3/Flk2


130-150kD


RTK family


myelomonocytic, primitive B progenitors


tyrosine kinase, binds FLT3 ligand, early lymph development


CD136


MSP-R, RON


180kD


RTK family


epith, CNS, PNS, hematopoietic subset


migration, morphological change and proliferation of different target cells


CD137


4-1BB


30kD


TNFRSF


Tact


T costimulation


CD138


Syndecan-1


80-150kD


Syndecan family


plasma cells, pre-B, basolateral surface of epith, meurons


receptor for ECM, cell morphology


CD139


 


228kD


 


B, mono, gran, erythrocyteslow


 


CD140a


PDGFRalpha


180kD


RTK family


fibroblasts, smooth muscle & glial cells, chondrocytes


binds PDGF A and B


CD140b


PDGFRb


180kD


RTK family


fibroblasts, smooth muscle & glial cells, chondrocytes


binds PDGF B


CD141


Thrombomodulin


100kD


C-type lectin


mono, neutrophils, endoth, smooth muscle cells


initiation of protein C anticoagulant signal


CD142


Tissue Factor


45kD


 


mono, endoth, keratinocytes, epith


binds clotting factor VIIa, initiator of clotting


CD143


ACE


170kD


 


endoth, epith, neurons, fibroblasts, activated mac


angiotensin converting enzyme, angiotensin II & bradykinin metabolism


CD144


VE-Cadherin, Cadherin-5


130kD


Cadherin family


endoth


adhesion, cell-cell interaction


CD145


 


110, 90kD


 


endoth, some stromal cells


 


CD146


MUC18, S-endo


113-118kD


IgSF


endoth, melanomas, FDC, Tact


adhesion


CD147


Neurothelin, basoglin


 


IgSF


leukocytes, erythrocytes, platelets, endoth


adhesion


CD148


HPTP-eta


240-260kD


 


gran, mono, DC, T (high upon activation)


tyrosine phosphatase R Type III


CD150


SLAM


75-95kD


IgSF


T subset (high upon activation), B, DC, endoth


costimulation, proliferation, Ig production, measles virus receptor


CD151


PETA-3


32kD


 


endoth, megakaryocytes, platelets, epith


cell adhesion


CD152


CTLA-4


33kD


IgSF


Tact and B


CD80 and CD86 receptor, negative regulation of T cell costimulation


 


 


 


 


 


 


CD153


CD30L


40kD


TNFSF


neutrophils, B, Tact and mac


CD30 ligand, T costimulation


CD154


CD40L, gp39, TRAP


32-39kD


TNFSF


Tact


CD40 ligand, B and DC costimulation


CD155


PVR


80-90kD


IgSF


mono, mac, CD34+ thymocytes


Polio virus receptor (PVR)


CD156a


ADAM8


69kD


 


neutrophils, mono


leukocyte extravasation


CD156b


TACE / ADAM 17


100kD


 


broad


cleaves membrane proteins (TNF, TGFalpha) to generate soluble forms


CD156c


ADAM10


98kD


Peptidase M12B family


lymphoid organs, peripheral blood leukocyte, cartilage, chondrocytes and fetal liver


proteolytic cleavage of cell-surface molecules including Notch, TNF-alpha, APP and ephrin-A2


CD157


BST-1


42-45kD


 


gran, mono, B progenitors, endoth


ADP-ribosyl-cyclic ADP-ribose hydrolase activities, pre-B cell growth


CD158a


p58.1


50-58kD


IgSF, KIR family


NK subset, T subset


inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor


CD158b


p58.2


50-58kD


IgSF, KIR family


NK subset, T subset


inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor


CD159a


NKG2A


43kD


 


T subset, NK


with CD94, NK cell receptor


CD159c


NKG2C


40kD


Type II C-Type Lectin


NK


with MHC class I HLA-E molecules, forms heterodimer with CD94


CD160


BY55


27kD


IgSF


NK subset, T subset


costimulation


CD161


NKR-P1A


40kD


C-type lectin


T subset, NK


NK cell-mediated cytotoxicity


CD162


PSGL-1


120kD


Mucin family


mono, gran, most lymph


CD62P, CD62L ligand, adhesion, rolling


CD162R


PEN-5


 


CHO


NK subset


 


CD163


130kD


 


Scavenger receptor SF


mono, mac


 


CD164


MGC-24


80kD


epith, mono, lymphlow, bone marrow stromal cells, CD34+ erythroid progenitors


hematopoietic progenitor cell-stromal cell interaction


 


CD165


AD2, gp37


42kD


lymph subset, mono, immature thymocytes, platelets


adhesion, thymocyte-thymic epith interaction


 


CD166


ALCAM


105kD


IgSF


neurons, mono, epith, fibroblasts, Tact


CD6 ligand, adhesion


CD167a


DDR1


120kD


RTK family


epith, myoblasts


tyrosine kinase, adhesion to collagen


CD168


RHAMM


84-88kD


 


mono, T subset, thymocyte subset, intracellularly in breast cancer cells


adhesion, tumor migration, metastasis


CD169


sialoadhesin, Siglec-1


185kD


IgSF, sialoadhesins


tissue mac subset


adhesion, cell-cell and cell-matrix interactions, binds CD227 on breast cancer cells and CD43 on T cells


CD170


Siglec-5, CD33-like2


140kD


IgSF, sialoadhesins


Mac subset, neutrophils


adhesion


CD171


L1


200-210kD


IgSF


CNS, PNS, glial cells, mono, T subset, B, DC, several human tumor cells


kidney morphogenesis, lymph node architecture, T costimulation, neurohistogenesis, homotypic interaction, binds CD9, CD24, CD56, CD142, CD166, integrins


CD172a


SIRPgamma


110kD


 


mono, T subset, stem cells


adhesion, complex with CD47


CD172b


SIRPb, SIRB1


50kD


IgSF


mono and DC


negative regulation of RTK-coupled signaling


CD172g


SIRPgamma, SIRPB2


45-50kD


IgSF, ASV


mRNA: liver and at lower levels in many tissues


binds CD47


CD173


Blood group H type 2


 


CHO


erythrocytes, stem cell subset, platelets


 


CD174


Lewis Y


 


CHO


stem cells subset, epith


 


CD175


Tn


 


CHO


stem cells subset


 


CD175s


Sialyl-Tn


 


CHO


erythroblasts


 


CD176


Thomson Friedrenreich Ag


 


CHO


stem cell subset


 


CD177


NB1


56-62kD


 


neutrophil subset


 


CD178


FasL, CD95L


38-42kD


TNFSF


Tact, testis


CD95 ligand, apoptosis, immune privilege, soluble form in serum


CD179a


V pre B


16-18kD


IgSF


Pro- and Pre-B


B cell differentiation / signaling, with IgM


CD179b


Lambda 5


22kD


IgSF


Pro- and Pre-B


B cell differentiation / signaling, with IgM


CD180


RP-105


95-105kD


LRRF, TLR family


B subset, mono, DC


B cell activation, LPS signaling, with MD-1


CD181


CXCR1, IL-8RA


39kD


GPCR1 family


neutrophils, basophils, NK, T subset, mono


binding of IL-8 induces chemotaxis of neutrophils


CD182


CXCR2, IL-8RB


40kD


GPCR1 family


neutrophils, basophils, NK, T subset, mono


binding of IL-8 induces chemotaxis of neutrophils


CD183


CXCR3


40kD


TM7SF


eosinophils, Tact and NK, GM-CSF activated CD34+ progenitors


IP-10 , Mig and I-TAC receptor, T cell recruitment to inflammatory sites, enhancement of Th1 response


CD184


CXCR4, fusin


45kD


TM7SF


B, DC, T subset, mono, endoth


SDF-1 receptor, X4 HIV-1 coreceptor


CD185


CXCR5, BLR1


45kD


GPCR1 family


mature B and Burkitt Lymphoma cells


with chemokine BLC, possible regulatory function in Burkitt Lymphomagenesis and/or B differentiation, activation of mature B


CD186


CXCR6, BONZO


40kD


GPCR1 family


Tact


receptor for CXCL16 and coreceptor for SIV, strains of HIV-2 and m-tropic HIV-1


CD191


CCR1, MIP-1alphaR, RANTES-R


39kD


GPCR1 family


T, mono, stem cell subset


binds C-C type chemokines and transduces signal by increasing intracellular calcium ion levels


CD192


CCR2, MCP-1-R


40kD


GPCR1 family


activated NK and mononuclear phagocytes, T subset, B, endoth


binds MCP-1, MCP-3 & MCP-4, alternative coreceptor with CD4 for HIV-1 infection


CD193


CCR3, CKR3


45kD


GPCR1 family


eosinophils, lower expression in neutrophils and mono, T subset


binds eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES & MIP-1delta, alternative coreceptor with CD4 for HIV-1 infectiongg


CD195


CCR5


45kD


 


mono, T subset


MIP-1alpha, MIP-1b and RANTES receptor, R5 HIV-1 coreceptor


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


CD196


CCR6, LARC receptor, DRY6


45kD


GPCR1 family


T subset, B, DC subset


binds MIP-3alpha/LARC


CD197


CCR7


45kD


 


T subset, DC Subset


6Ckine and MIP-2b receptor


CD198


CCR8, GPRCY6, TER1


50kD


GPCR1 family


T, high expression in Th2, NK, mono


allergic inflammation, alternative coreceptor with CD4 for HIV-1 infection


CD199


CCR9, GPR-9-6


43kD


GPCR1 family


subset of memory T, lamina propria mononuclear cells


binds SCYA25/TECK, alternative coreceptor with CD4 for HIV-1 infection


CD200


OX-2


45-50kD


 


thymocytes, endoth, B, Tact


inhibition of immune response


CD201


EPC-R


50kD


 


endoth subset


activated protein C receptor


CD202b


Tie2, Tek


150kD


RTK family


stem cells, endoth


angiopoietin-1 receptor


CD203c


NPP3 / PDNP3, ENpp1, PD-1b


130-150kD


type II TM


basophils, mast cells, glioma cells, megakaryocytes


ectoenzyme, binding to and clearance of extracellular nucleotides


CD204


Macrophage scavenger-R


220kD


 


mac


endocytosis of macromolecules


CD205


DEC-205


205kD


 


DC, thymic epith


DC, thymic epith


CD206


macrophage mannose-R


180kD


 


DC subset, mac, mono


phagocytosis and pinocytosis of mannose containing molecules


CD207


Langerin


40kD


 


Langerhans cells


endocytic receptor


CD208


DC-LAMP


70-90kD


 


DCact, interdigitating DC


 


CD209


DC-SIGN


44kD


 


DC subset


ICAM-3 receptor, HIV-1 binding protein


 


 


 


 


 


 


CD210


IL-10-R


90-110kD


 


T, B, NK, mono, mac


IL-10 receptor, signal transduction


CD212


IL-12-R b1


100kD


 


Tact and NK


binds IL-12 with high affinity, associates with IL-12 receptor b2


CD213a1


IL-13-R alpha1


65kD


 


B, mono, fibroblasts, endoth


binds IL-13 with low affinity, with CD124


CD213a2


IL-13-R alpha2


65kD


 


B, mono


binds IL-13 with high affinity


CD217


IL-17-R


120kD


 


broad


IL-17 receptor


CD218a


IL-18Ralpha, IL-1Rrp


70kD


IL-1R family


T, NK, DCs


binds IL-18, activation of NF-kappaB


CD218b


IL-18Rb, IL18RAP


70kD


IL-1R family


T, NK and DCs


heterodimeric receptor with IL-18Ralpha to enhance IL-18 binding


CD220


Insulin-R


140, 70kD


 


broad


insulin receptor


CD221


IGF-1 R


140, 70kD


 


broad


binds IGF with high affinity, signaling, cell proliferation/ differentiation


CD222


IGF-II R, mannose-6 phosphate-R


250kD


Type I TM


broad, 90-95% intracellular


adhesion, tumor growth, a receptor for TGFb-LAP, plasminogen, proliferin, truncated form (220kD) found in serum


CD223


LAG-3


70kD


IgSF


Tact and NK


an MHC class II ligand


CD224


GGT


27, 68kD


 


leukocytes, stem cells


 


CD225


Leu-13


17kD


 


broad


 


CD226


DNAM-1, PTA-1, TLiSA1


65kD


IgSF


T, NK, mono, platelets, activated HUVEC


activation of cell-mediated cytotoxicity, soluble form (50kD) found in normal serum


CD227


MUC1, EMA


300kD


Mucin family, type I TM


epith, stem cell subset, FDC, mono, B subset, some myelomas


adhesion, signaling, binds CD169, CD54, & selectins


CD228


Melanotransferrin


80-95kD


 


stem cells, melanomas


 


CD229


Ly-9


95, 110kD


IgSF


T, B


adhesion


CD230


Prion protein


35kD


broad


 


 


CD231


TALLA-1, A15


30-45kD


TM4SF


T leukemias, neuroblastomas, brain neurons


marker for T cell acute lymphoblastic leukemia


CD232


VESP-R


200kD


 


broad


 


CD233


Band 3, SLC4A1


90kD


Anion exchanger family


erythrocytes


anion exchanger pump, transport of CO2, linking red cell membrane to cytoskeleton


CD234


Duffy, DARC


35-45kD


 


erythrocytes


Duffy antigen chemokine receptor


CD235a


Glycophorin A


36kD


 


erythrocytes


 


CD235ab


Glycophorin A/B


20kD


 


erythrocytes


 


CD235b


Glycophorin B


20kD


 


erythrocytes


 


CD236


Glycophorin C/D


32, 23kD


 


erythrocytes, stem cell subset


 


CD236R


Glycophorin C


32kD


 


erythrocytes, stem cell subset


 


CD238


Kell


93kD


 


erythrocytes, stem cell subset


 


CD239


B-CAM


78-85kD


 


erythrocytes, stem cell subset


 


CD240CE


Rh30CE


30-32kD


 


erythrocytes


 


CD240D


Rh30D


30-32kD


TM12SF


erythrocytes


 


CD241


RhAg, Rh50


50kD


TM12SF


erythrocytes


complex with CD47, LW, glycophorin B


CD242


ICAM-4


42kD


IgSF


erythrocytes


adhesion, Landsteiner-Wiener blood group


CD243


MDR-1, p170, P-gp


180kD


 


stem cells, small intestine, kidneystem cells, small intestine, kidney


ion pump


CD244


2B4


70kD


type II TM


T subset, mono, basophils, NK


NK activation, CD48 ligand


 


 


 


 


 


 


CD245


p220/240


220-240kD


 


T subset


 


CD246


ALK, Ki-1


80kD


 


anaplastic T cell leukemias, small intestine, testis, brain, not on normal lymph


brain development, implicated in ALK lymphomas


CD247


TCRz


16kD


RTK family


T, NK


TCR complex subunit, coupling of antigen recognition to signaling


CD248


TEM1, Endosialin


175kD


C-Type Lectin


endothelial tissue, stromal fibroblasts


tumor progression and angiogenesis


CD249


Aminopeptidase A


160kD


Peptidase M1 family


epith, endoth


renin-angiotensin system


CD252


OX-40Ligand, gp34


34kD


TNFSF


Bact, cardiac myocytes


T costimulation


CD253


TRAIL, Apo-2L, TL2, TNFSF10


 


TNFSF


Tact, many tissues


death


 


 


 


 


 


 


CD254


TRANCE, RANKL, OPGL


35kD


TNFSF


lymph node & BM stroma Tact


binds OPG and RANK, osteoclast differentiation, enhances DC to stimulate naïve-T proliferation


 


 


 


 


 


 


CD256


APRIL, TALL-2


16kD


TNFSF


mono, mac


binds TACI & BCMA, B proliferation


CD257


BLyS, BAFF, TALL-1


 


TNFSF


monoact, soluble form


B cell growth factor & costimulator of Ig production


 


 


 


 


 


 


CD258


LIGHT, HVEM-L


28kD


TNFSF


Tact, immature DC


binds LTBR, T proliferation, receptor for HVEM


CD261


TRAIL-R1, DR4


57kD


TNFRSF


Tact, peripheral blood leukocytes


contains death domain, apoptosis via FADD & caspase-8


 


 


 


 


 


 


CD262


TRAIL-R2, DR5


60kD


TNFRSF


widely expressed, peripheral blood lymphocytes


contains death domain, apoptosis via FADD and caspase-8


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


CD263


TRAIL-R3, DcR1, LIT


65kD


TNFRSF


peripheral blood lymphocytes


receptor for TRAIL but lacks death domain


 


 


 


 


 


 


CD265


RANK, TRANCE-R, ODFR


97kD


TNFRSF


broad expression


binds TRANCE, osteoclastogenesis, T-DC interactions


CD266


TWEAK-R, FGF-inducible 14


14kD


TNFRSF


heart, placenta and kidney, HUVEC


TWEAK receptor, cell-matrix interactions and endoth growth and migration


 


 


 


 


 


 


 


 


 


 


 


 


CD267


TACI, TNFR SF13B


 


 


B, Tact


binds BAFF & APRIL


 


 


 


 


 


 


CD268


BAFFR, TR13C


25kD


TNFRSF


B


binds BLyS, mature B survival


 


 


 


 


 


 


CD269


BCMA, TNFRSF13B


20kD


TNFRSF


mature B (membrane and perinuclear)


APRIL & BAFF receptor, B survival & proliferation


CD271


NGFR, p75 (NTR)


45kD


TNFRSF


neurons (schwann cells, growing neurites), BM mesencymal cells


NGF, BDNF, NT-3, & NT-4 receptor, tumor suppressor, cell survival and death


CD272


BTLA


33kD


IgSF


Tact, B , remains on Th1


HVEM receptor, inhibitory response


CD273


B7DC, PD-L2, PDCD1L2


25kD


IgSF


DC subset, mono, mac


PD-1 receptor, costimulation or suppression of T proliferation


CD274


B7-H1, PD-L1


33kD


IgSF


leukocytes, broad


PD-1 receptor, costimulation of lymphocytes


CD275


B7-H2, ICOSL, B7-RP1, GL50


60kD


B7 Family


B, DC, mono


costimulation, cytokine production


 


 


 


 


 


 


CD276


B7-H3


40-45kD


B7 Family, ASV


in vitro cultured DC and mono, Tact, mammary tissue


costimulation, T activation


CD277


BT3.1, butyrophilin SF3 A1, BTF5


56kD


B7/BT family, ASV


T, B, NK, mono, DC, endoth, CD34+ cells, tumor cell lines


T activation


CD278


ICOS, AILIM


55-60kD


CD28 family


Tact, Th2


binds ICOS-L, T costimulation


CD279


PD1, SLEB2


55kD


 


Tact and Bact


B7-H1 & B7-DC receptor, autoimmune disease and peripheral tolerance


 


 


 


 


 


 


CD280


ENDO180, UPARAP


180kD


C-type lectin SF


chondrocytes, fibroblasts, endothelial, mac


mannose receptor, collagen matrix remodeling and endocytic recycling


CD281


TLR1


90kD


TLR family


low levels in PBMC, mono and possibly DC


innate immunity, with TLR2


CD282


TLR2


90kD


TLR family


mono, neutrophil, upregulated in mac


binds dsRNA, response to bacterial lipoproteins, innate immunity


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


CD283


TLR3


100kD


TLR family, ASV


derived moDC (may be intracellular)


binds dsRNA, innate immunity


CD284


TLR4


100kD


TLR family, ASV


PBMC (weak in mono, immature DC & neutro)


binds LPS, innate immunity


 


 


 


 


 


 


CD289


TLR9


120kD


TLR family


pDC (intracellular)


binds CpG-DNA, innate immunity


CD292


BMPR1A, ALK3


57kD


Type I


bone progenitor


BMP 2 & 4 receptor, bone development


CD293


BMPR1B, ALK6


57kD


Type I, ASV


bone progenitor


BMP receptor, bone development


CD294


CRTH2. GPR44


55-70kD


GPCR-7TM


Th2, eosinophils, basophils


binds prostaglandin D2, stimulatory effects on Th2, allergic inflammation


CD295


LeptinR, LEPR


132kD


Type I cytokine-like receptor


broad


adipose metabolism, immune dysfunction in obesity


CD296


ART1, RT6, ART2


37kD


ADP- ribosyltransferase


heart and skeletal muscle, peripheral T, NK subset


modifies integrins during differentiation, ADP ribosylation of target proteins


CD297


ART4, dombrock blood group


38kD


ADP- ribosyltransferase


erythroid, monoact


ADP ribosylation of target proteins


CD298


Na+/K+-ATPase b3 subunit


52kD


 


broad


transport sodium & potassium ions across membrane


CD299


DC-SIGN-related, LSIGN, DC-SIGN2


45kD


Type II, similar to CD209, ASV


endothelial subset


binds ICAM3, HIV-1 gp120, coreceptor with DC-SIGN, HIV infection


CD300a


CMRF35H, IRC1, IRp60


60kD


IgSF, ASV


NK, mono, neutrophils, T and B subset and lymphocytic cell lines, AML


unknown


CD300c


CMRF35A, LIR


 


IgSF


mono, neutrophils, monocytic cell lines, B & T subsets


unknown


CD300e


CMRF35L


 


IgSF CMRF family


 


unknown


CD301


MGL, HML


38kD


C type lectin SF, ASV


immature DC


binds Tn antigen, uptake of glycosylated antigens


CD302


DCL1, BIMLEC


19-28kD


Type I TM C-type lectin receptor


some myeloid and Hodgkin’s cell lines


a fusion protein in Hodgkin’s lymphoma with DEC-205


CD303


BDCA2, HECL


38kD


C-type lectin SF ASV


plasmacytoid dendritic cells


inhibit IFN-alpha production


CD304


BDCA4, neuropilin 1


130kD


semaphorin family


neurons, CD4+/CD25+ Treg, DC, endothelial and tumor cells


interacts with VEGF165 & semaphorins, co-receptor with plexin, axonal guidance, angiogenesis, cell survival, migration


CD305


LAIR1


32-40kD


IgSF, ASV


NK, B, T, mono


inhibitory receptor on NK and T cells


CD306


LAIR2


 


IgSF, ASV


unknown


soluble, mucosal tolerance


CD307


IRTA2


55-105kD


IgSF (Fc receptor), ASV


B subset, B lymphoma


B cell development, translocation in some lymphomas


CD309


VEGFR2, KDR


230kD


Type III TM tyr kinase


endothelial, angiogenic precursor cells, hemangioblast


binds VEGF, regulates adhesion and cell signaling


CD312


EMR2


90kD


EGFR-7TM ASV


mono, mac, moDC, granslow


cell adhesion and migration for phagocytosis


CD314


NKG2D, KLR


42kD


Type II lectin-like receptor


NK, CD8+ activated, NK1.1+ T, some myeloid cells


binds MHC class I, MICA, MICB, Rae1 & ULBP4, activates cytolysis and cytokine production, costimulation


 


 


 


 


 


 


CD315


CD9P1, SMAP6, FPRP, PTGFRN


135kD


IgSF


B subset, monoact


with CD81 and CD9


CD316


EWI2, PGRL, CD81P3, KASP


63-75kD


IgSF8


B, T cells, low on NK cells


with CD81 & CD9; involved in cell migration


CD317


BST2, HM1.24


30-36kD


Type II


B, T, NK, mono, DC, fibroblast cell line, myeloma


pre-B cell growth, overexpressed in multiple myeloma


CD318


CDCP1, SIMA135


135kD


Type I, ASV


HSC (subset of CD34+), tumors


cell adhesion with ECM


CD319


CRACC, SLAMF7


66kD


Ig TM


T, B and DC subset, NK, upregulated in DC


regulate T and NK cells


CD320


8D6A, 8D6


30kD


LDL receptor


follicular DC, germinal centers


B proliferation, tumor formation


CD321


JAM1, F11 receptor


35kD


IgSF, Type I, ASV


platelet receptor, epithelia and endothelial, platelets


tight junctions


CD322


JAM2, VE-JAM


43kD


IgSF


HEV, other endoth


cell adhesion, lymphocyte homing to secondary lymphoid organs


CD324


E-Cadherin, Uvomorulin


120kD


cadherin SF


non-neural epith


cell adhesion, homotypic interaction & binds alphaE/b7


CD325


N-Cadherin, NCAD


140kD


cadherin SF


brain, skeletal and cardiac muscle


cell adhesion, neuronal recognition


CD326


Ep-CAM, Ly74


35-40kD


 


most epith cell membranes


growth factor receptor?


CD327


SIGLEC6


 


IgSF


placenta, spleen, B . sialic-acid dependent


adhesion, membrane- bound & secreted forms


CD328


SIGLEC7, AIRM-1


75kD


IgSF


resting and activated NK, placenta, liver, spleen, lower in gran & mono


sialic-acid dependent adhesion, inhibit NK activation, hemopoiesis


CD329


SIGLEC9


 


IgSF


neutrophils and mono


sialic-acid dependent adhesion molecule


CD331


FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM


30kD


TM tyr kinase


fibroblasts, epithelial


binds FGF, high affinity receptor for fibroblast growth factors


CD332


FGFR2, BEK, KGFR


115-135kD


TM RTK family


fibroblasts, epithelial


binds FGF, high affinity receptor for fibroblast growth factors


CD333


FGFR3, ACH, CEK2


115kD


TM RTK family


fibroblasts, epithelial


binds FGF, high affinity receptor for fibroblast growth factors


CD334


FGFR4, JTK2, TKF


110kD


TM RTK family


fibroblasts, epithelial


binds FGF, high affinity receptor for fibroblast growth factors


CD335


NKp46, Ly-94 homolog


46kD


IgSF


NK


activates NK cells upon non-MHC ligand binding


CD336


NKp44, Ly-95 homolog


44kD


IgSF


NK


activates NK cells upon non-MHC ligand binding


CD337


NKp30, Ly117


30kD


IgSF


NK


activates NK cells upon non-MHC ligand binding


CD338


ABCG2, BCRP, Bcrp1, MXR


73kD


GPCR 7TM


stem cell subset (side population)


multi-drug resistance transporter


CD339


Jagged-1, JAG1, JAGL1, hJ1


135kD


EGF TM


stromal cells, epithelial, AML


binds Notch, hematopoiesis


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