Genetic variants of human longevity

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Part 1
Part 2
Part 3
Part 4

ID

Gene/Variant

Chromosomal
Location

Population
Studied

Findings

References

94

ABCA1

9q31.1

Japanese

Non-significant
(study
details
)

Arai et al. (2003)

316

ABCC4

13q32.1

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

253

ACE

17q23.3

Greek

Significant
(study
details
)

Kolovou et al. (2014)

162

ACE

17q23.3

Chinese
(Uighur in Xinjiang)

Significant
(study
details
)

Wufuer et al. (2004)

130

ACE

17q23.3

Russian
(Novosibirsk)

Significant
(study
details
)

Shabalin et al. (2003)

98

ACE

17q23.3

Korean

Non-significant
(study
details
)

Choi et al. (2003)

126

ACE

17q23.3

Brazilian
of European and Japanese origin

Significant
(study
details
)

Da Cruz et al. (2003)

222

ACE

17q23.3

Italian
(Southern)

Significant
(study
details
)

Seripa et al. (2006)

62

ACE

17q23.3

American
(Caucasian)

Non-significant
(study
details
)

Hessner et al. (2001)

85

ACE

17q23.3

Polish

Non-significant
(study
details
)

Grzeszczak
and Misztalski (2002)

53

ACE

17q23.3

French

Non-significant
(study
details
)

Blanché et al. (2001)

90

ACE

17q23.3

Danish

Significant
(study
details
)

Frederiksen
et al. (2003)

63

ACE

17q23.3

Danish

Non-significant
(study
details
)

Tan et al. (2001)

45

ACE

17q23.3

Dutch

Non-significant
(study
details
)

Heijmans et al. (1999)

13

ACE

17q23.3

English
(Cambridge)

Significant
(study
details
)

Galinsky et al. (1997)

228

ACE

17q23.3

Italian

Non-significant
(study
details
)

Nacmias et al. (2007)

123

ACE

17q23.3

Italian,
French and Danish

Non-significant
(study
details
)

Panza et al. (2003)

18

ACE

17q23.3

Danish

Non-significant
(study
details
)

Agerholm-Larsen
et al. (1997)

288

ACE

17q23.3

Chinese

Significant
(study details)

Woo et al. (2012)

78

ACE

17q23.3

Chinese
(Uighur, Kazakh and Han in Xinjiang)

Significant
(study
details
)

Rahmutula et al. (2002)

37

ACE

17q23.3

Danish

Non-significant
(study
details
)

Bladbjerg et al. (1999)

28

ACE

17q23.3

French

Significant
(study
details
)

Faure-Delanef
et al. (1998)

225

ACE

17q23.3

Columbian

Significant
(study
details
)

Forero et al. (2006)

6

ACE

17q23.3

French

Significant
(study
details
)

Schächter et al. (1994)

340

ACTN3

11q13.2

Spanish

Non-significant
(study
details
)

Fiuza-Luces
et al. (2011)

283

ADA

20q13.12

Italian
(Central)

Significant
(study
details
)

Napolioni et al. (2011)

240

ADA2

22q11.1

Italian

Significant
(study
details
)

Napolioni
and Lucarini (2010)

G432

ADARB1

21q22.3

Italian,
Ashkenazi Jewish and Japanese

Significant
(study details,
5 variants
)

Sebastiani et al. (2009)

G433

ADARB2

10p15.3

Italian,
Ashkenazi Jewish and Japanese

Significant
(study
details, 13 variants
)

Sebastiani et al. (2009)

G549

ADIPOQ

3q27.3

Jordanian

Non-significant
(study
details, 2 variants
)

Khabour et al. (2010)

281

ADIPOQ

3q27.3

Polish

Significant
(study
details
)

Roszkowska-Gancarz
et al. (2012)

242

ADIPOQ

3q27.3

Jordanian

Significant
(study
details
)

Khabour et al. (2010)

G423

ADIPOQ

3q27.3

Ashkenazi Jewish

Non-significant
(study
details, 3 variants
)

Atzmon et al. (2008)

G472

ADRB2

5q32

Chinese

Significant
(study
details, 2 variants
)

Zhao et al. (2012)

3473

ADRB2

5q32

American
(Caucasian)

Significant
(study
details
)

Kulminski et al. (2010)

321

ADRB2

5q32

American
(Caucasian)

Non-significant
(study
details
)

Kulminski et al. (2010)

382

AGER

6p21.32

Caucasian

Significant
(study
details
)

Falcone et al. (2013)

36

AGT

1q42.2

Danish

Non-significant
(study
details
)

Bladbjerg et al. (1999)

64

AGT

1q42.2

Danish

Significant
(study
details
)

Tan et al. (2001)

G497

AGTR1

3q24

Italian
(Northern) and Japanese

Significant
(study details,
2 variants
)

Benigni et al. (2013)

100

AKAP10

17p11.2

American
(Caucasian)

Significant
(study
details
)

Kammerer et al. (2003)

255

AKT1

14q32.33

American
(Caucasian)

Significant
(study
details
)

Pawlikowska
et al. (2009)

G474

AKT1

14q32.33

Danish,
German

Non-significant
(study
details, 5 variants
)

Nygaard et al. (2013)

289

AKT1

14q32.33

Danish,
German

Significant
(study
details
)

Nygaard et al. (2013)

91

APOA1

11q23.3

Italian
(Southern)

Significant
(study
details
)

Garasto et al. (2003)

3462

APOA4

11q23.3

Italian

Significant
(study
details
)

Pepe et al. (1998)

92

APOA4

11q23.3

Italian
(Southern)

Non-significant
(study
details
)

Garasto et al. (2003)

24

APOA4

11q23.3

French

Non-significant
(study
details
)

Merched et al. (1998)

2

APOB

2p24.1

Finnish

Non-significant
(study
details
)

Louhija et al. (1994)

7

APOB

2p24.1

Finnish

Significant
(study
details
)

Kervinen et al. (1994)

10

APOB

2p24.1

Italian

Significant
(study
details
)

De
Benedictis et al. (1997)

386

APOC1

19q13.32

European

Significant
(study
details
)

Deelen et al. (2014)

12

APOC1

19q13.32

English
(Cambridge)

Significant
(study
details
)

Galinsky et al. (1997)

279

APOC1

19q13.32

European

Significant
(study
details
)

Beekman et al. (2013)

52

APOC3

11q23.3

Russian

Significant
(study
details
)

Anisimov et al. (2001)

89

APOC3

11q23.3

Italian
(Southern)

Non-significant
(study
details
)

Garasto et al. (2003)

213

APOC3

11q23.3

Ashkenazi
Jewish

Significant
(study
details
)

Atzmon et al. (2006)

4

APOC3

11q23.3

Finnish

Significant
(study
details
)

Louhija et al. (1994)

G476

APOE

19q13.32

Danish,
German, Dutch

Significant
(study
details, 3 variants
)

Soerensen et al. (2013)

171

APOE

19q13.32

Ashkenazi
Jewish (Jerusalem)

Non-significant
(study
details
)

Stessman et al. (2005)

11

APOE

19q13.32

Italian

Non-significant
(study
details
)

Ruiu et al. (1995)

G454

APOE

19q13.32

Danish

Significant
(study
details, 2 variants
)

Lindahl-Jacobsen
et al. (2013)

190

APOE

19q13.32

Chinese
(Uighur in Xinjiang)

Significant
(study
details
)

Mayila et al. (2005)

373

APOE

19q13.32

Irish (Belfast)

Significant
(study
details
)

Rea et al. (2001)

131

APOE

19q13.32

Russian
(Novosibirsk)

Significant
(study
details
)

Shabalin et al. (2003)

99

APOE

19q13.32

Korean

Non-significant
(study
details
)

Choi et al. (2003)

227

APOE

19q13.32

Columbian

Non-significant
(study
details
)

Forero et al. (2006)

328

APOE

19q13.32

Italian

Significant
(study
details
)

Malovini et al. (2011)

8

APOE

19q13.32

Finnish

Significant
(study
details
)

Kervinen et al. (1994)

374

APOE

19q13.32

Chinese
(Han)

Significant
(study
details
)

Jian-Gang et al. (1998)

86

APOE

19q13.32

Brazilian

Non-significant
(study
details
)

Schwanke et al. (2002)

68

APOE

19q13.32

Chinese
(Uighur in Xinjiang)

Significant
(study
details
)

Wang et al. (2001)

9

APOE

19q13.32

Swedish

Significant
(study
details
)

Eggertsen et al. (1993)

224

APOE

19q13.32

Italian
(Southern)

Significant
(study
details
)

Seripa et al. (2006)

55

APOE

19q13.32

French

Significant
(study
details
)

Blanché et al. (2001)

14

APOE

19q13.32

English
(Cambridge)

Non-significant
(study
details
)

Galinsky et al. (1997)

5

APOE

19q13.32

Finnish

Significant
(study
details
)

Louhija et al. (1994)

229

APOE

19q13.32

Greek

Significant
(study
details
)

Stakias et al. (2006)

51

APOE

19q13.32

Finnish

Significant
(study
details
)

Frisoni et al. (2001)

248

APOE

19q13.32

American
(Georgia and Louisiana populations from African and European origin)

Significant
(study
details
)

Jazwinski et al. (2010)

G480

APOE

19q13.32

European
and American (Caucasian)

Significant
(study
details, 2 variants
)

McKay et al. (2011)

3476

APOE

19q13.32

French

Significant
(study
details
)

Schächter et al. (1994)

323

ATM

11q22.3

Chinese
(Han)

Significant
(study
details
)

Chen et al. (2010)

357

ATM

11q22.3

Italian

Significant
(study
details
)

Piaceri et al. (2013)

348

ATP8

Mt

Japanese

Significant
(study
details
)

Tanaka et al. (1998)

297

ATRIP

3p21.31

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

77

BRCA1

17q21.31

American
(Caucasians) and Italian

Non-significant
(study
details
)

Vijg et al. (2001)

308

BTBD9

6p21.2

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

33

C3

19p13.3

Italian

Non-significant
(study
details
)

Bellavia et al. (1999)

35

C4A

6p21.33

Italian

Non-significant
(study
details
)

Bellavia et al. (1999)

302

C7orf50

7p22.3

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

300

CACNA1C

12p13.33

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

326

CAMK4

5q22.1

Italian

Significant
(study
details
)

Malovini et al. (2011)

299

CARS

11p15.4

American
(Caucasian)

Significant
(study details)

Yashin et al. (2012)

359

CASP5

11q22.3

Russian

Significant
(study
details
)

Ulybina et al. (2010)

153

CAT

11p13

Danish

Non-significant
(study
details
)

Christiansen
et al. (2004)

G503

CCL5

17q12

Spanish

Significant
(study
details, 2 variants
)

Laplana and
Fibla (2012)

339

CCR5

3p21.31

Spanish

Non-significant
(study
details
)

Laplana and
Fibla (2012)

294

CDH4

20q13.33

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

G434

CDKN1A

6p21.2

Italian

Significant
(study
details, 2 variants
)

Gravina et al. (2009)

G430

CEP128

14q31.1

Ashkenazi
Jewish

Significant
(study
details, 2 variants
)

Atzmon et al. (2009)

185

CETP

16q13

Italian

Non-significant
(study
details
)

Cellini et al. (2005)

G477

CETP

16q13

Danish,
German, Dutch

Significant
(study
details, 8 variants
)

Soerensen et al. (2013)

369

CETP

16q13

Ashkenazi
Jewish

Significant
(study
details
)

Atzmon et al. (2005)

95

CETP

16q13

Japanese

Non-significant
(study
details
)

Arai et al. (2003)

128

CETP

16q13

Ashkenazi
Jewish

Significant
(study
details
)

Barzilai et al. (2003)

385

CETP

16q13

Chinese

Non-significant
(study
details
)

Sun et al. (2014)

G521

CETP

16q13

American
of Japanese origin

Non-significant
(study
details, 2 variants
)

Koropatnick
et al. (2008)

34

CFB

6p21.33

Italian

Non-significant
(study
details
)

Bellavia et al. (1999)

236

CHIT1

1q32.1

Mediterranean
(Italian, Greek and Tunisian)

Significant
(study
details
)

Malaguarnera
et al. (2010)

317

CLSTN2

3q23

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

223

CNDP1

18q22.3

German

Non-significant
(study
details
)

Zschocke et al. (2006)

186

CPB2

13q14.13

American
(Caucasian)

Significant
(study
details
)

Reiner et al. (2005)

113

CXCL8

4q13.3

Irish

Non-significant
(study
details
)

Ross et al. (2003)

249

CYP19A1

15q21.2

Italian
(Salerno)

Significant
(study
details
)

Corbo et al. (2011)

48

CYP1A1

15q24.1

Italian
(Northern)

Non-significant
(study
details
)

Taioli et al. (2001)

G411

CYP1A1

15q24.1

German

Non-significant
(study
details, 2 variants
)

Pesch et al. (2004)

145

CYP1B1

2p22.2

German

Significant
(study
details
)

Pesch et al. (2004)

20

CYP2D6

22q13.2

Spanish

Non-significant
(study
details
)

Agúndez et al. (1997)

G400

CYP2D6

22q13.2

French

Non-significant
(study
details, 2 variants
)

Muiras et al. (1998)

22

CYP2E1

10q26.3

Spanish

Non-significant
(study
details
)

Agúndez et al. (1997)

293

DRD4

11p15.5

American (Caucasian)

Significant
(study
details
)

Grady et al. (2013)

G494

EGFR

7p11.2

Korean

Significant
(study
details, 4 variants
)

Park et al. (2009)

234

ERCC2

19q13.32

Polish

Significant
(study
details
)

Polosak et al. (2010)

250

ESR1

6q25.1-q25.2

Italian
(Salerno)

Significant
(study
details
)

Corbo et al. (2011)

G427

EXO1

1q43

German

Significant
(study
details, 3 variants
)

Nebel et al. (2009)

61

F2

11p11.2

American
(Caucasian)

Non-significant
(study
details
)

Hessner et al. (2001)

65

F2

11p11.2

Danish

Non-significant
(study
details
)

Tan et al. (2001)

38

F2

11p11.2

Danish

Non-significant
(study
details
)

Bladbjerg et al. (1999)

56

F5

1q24.2

American
(Caucasian)

Non-significant
(study
details
)

Hessner et al. (2001)

66

F7

13q34

Danish

Non-significant
(study
details
)

Tan et al. (2001)

39

F7

13q34

Danish

Non-significant
(study
details
)

Bladbjerg et al. (1999)

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