Genetic variants of human longevity – Part 4

Part 1 Part 2 Part 3 Part 4

204

TNF

6p21.33

Japanese

Non-significant (study details)

Okayama et al. (2005)

140

TNF

6p21.33

Bulgarian

Non-significant (study details)

Naumova et al. (2004)

118

TNF

6p21.33

Irish (Belfast)

Non-significant (study details)

Ross et al. (2003)

247

TNF

6p21.33

Jordanian

Non-significant (study details)

Khabour and Barnawi (2010)

198

TNF

6p21.33

Mexican

Significant (study details)

Soto-Vega et al. (2005)

102

TNF

6p21.33

Italian

Non-significant (study details)

Lio et al. (2003)

331

TOMM40

19q13.32

Polish

Significant (study details)

Maruszak et al. (2012)

355

TOMM40

19q13.32

Danish, American

Significant (study details)

Schupf et al. (2013)

282

TOMM40

19q13.32

American (Caucasian)

Significant (study details)

Sebastiani et al. (2012)

360

TOMM40

19q13.32

American, English, Irish

Significant (study details)

Shi et al. (2012)

285

TP53

17p13.1

Italian (Central)

Significant (study details)

Di Pietro et al. (2013)

381

TP53

17p13.1

Danish

Significant (study details)

Bojesen and Nordestgaard (2008)

276

TP53

17p13.1

European

Significant (study details)

Beekman et al. (2013)

322

TP53

17p13.1

Chinese (Guangxi Bama)

Non-significant (study details)

Yang et al. (2012)

290

TP53

17p13.1

Chinese

Non-significant (study details)

Cai et al. (2009)

G522

TP53

17p13.1

Irish

Significant (study details, 2 variants)

Ross et al. (2001)

295

TP53

17p13.1

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

391

TP53

17p13.1

Japanese

Significant (study details)

Pinós et al. (2014)

277

TP53

17p13.1

European

Significant (study details)

Beekman et al. (2013)

387

TP53

17p13.1

Spanish

Significant (study details)

Pinós et al. (2014)

G523

TP53

17p13.1

Irish

Non-significant (study details, 2 variants)

Ross et al. (2001)

314

TP53

17p13.1

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

383

TP53

17p13.1

European (Danish, Finnish, South Italian and Greek)

Significant (study details)

Raule et al. (2014)

278

TP53

17p13.1

European

Significant (study details)

Beekman et al. (2013)

342

TP53

17p13.1

American (Utah)

Non-significant (study details)

Kerber et al. (2012)

3474

TP53

17p13.1

American (Caucasian)

Non-significant (study details)

Boyden and Kunkel (2010)

347

TP53

17p13.1

American (Utah)

Non-significant (study details)

Kerber et al. (2012)

361

TP53

17p13.1

Chinese (Han)

Non-significant (study details)

Pan et al. (2011)

320

TP53

17p13.1

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

256

TP53

17p13.1

American (Caucasian)

Significant (study details)

Boyden and Kunkel (2010)

375

TP53

17p13.1

Italian

Significant (study details)

De Benedictis et al. (1999)

343

TP53

17p13.1

American (Utah)

Non-significant (study details)

Kerber et al. (2012)

366

TP53

17p13.1

Japanese

Significant (study details)

Bilal et al. (2008)

3475

TP53

17p13.1

American (Caucasian)

Non-significant (study details)

Boyden and Kunkel (2010)

284

TP53

17p13.1

American (Caucasian)

Significant (study details)

Puca et al. (2001)

380

TP53

17p13.1

Italian (Northern)

Significant (study details)

Emanuele et al. (2010)

371

TP53

17p13.1

Finnish

Significant (study details)

Niemi et al. (2003)

307

TP53

17p13.1

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

330

TP53

17p13.1

English (Newcastle)

Non-significant (study details)

Collerton et al. (2013)

257

TP53

17p13.1

American (Caucasian)

Non-significant (study details)

Boyden and Kunkel (2010)

280

TP53

17p13.1

European

Significant (study details)

Beekman et al. (2013)

344

TP53

17p13.1

American (Utah)

Non-significant (study details)

Kerber et al. (2012)

312

TP53

17p13.1

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

235

TSHB

1p13.2

Ashkenazi Jewish

Non-significant (study details)

Atzmon et al. (2009)

G531

TTR

18q12.1

Danish

Significant (study details, 2 variants)

Hornstrup et al. (2013)

269

TXNRD1

12q23.3

Danish

Significant (study details)

Soerensen et al. (2012)

G544

TXNRD1

12q23.3

Danish

Significant (study details, 15 variants)

Dato et al. (2014)

3472

UBE4B

1p36.22

Chinese

Significant (study details)

Sun et al. (2014)

384

UBE4B

1p36.22

Spanish

Significant (study details)

Garatachea et al. (2014)

G499

UCP1

4q31.1

Italian (Southern)

Significant (study details, 2 variants)

Rose et al. (2011)

332

UCP2

11q13.4

Italian (Southern)

Significant (study details)

Rose et al. (2011)

182

UCP2

11q13.4

Dutch

Non-significant (study details)

van Heemst et al. (2005)

G500

UCP3

11q13.4

Italian (Southern)

Significant (study details, 2 variants)

Rose et al. (2011)

G479

UCP3

11q13.4

Danish

Significant (study details, 2 variants)

Dato et al. (2012)

G534

UCP3

11q13.4

Danish

Significant (study details, 4 variants)

Dato et al. (2014)

G548

UCP3

11q13.4

Danish

Non-significant (study details, 2 variants)

Dato et al. (2012)

G437

VDR

12q13.11

Spanish

Non-significant (study details, 5 variants)

Laplana et al. (2010)

367

VEGFA

6p21.1

Italian (Northern)

Significant (study details)

Del Bo et al. (2008)

G416

WRN

8p12

Dutch

Non-significant (study details, 3 variants)

Kuningas et al. (2006)

G403

WRN

8p12

Finnish and Mexican

Non-significant (study details, 2 variants)

Castro et al. (2000)

32

WRN

8p12

Finnish, American, Mexican and Japanese

Non-significant (study details)

Castro et al. (1999)

266

WRN

8p12

Danish

Significant (study details)

Soerensen et al. (2012)

270

XDH

2p23.1

Danish

Significant (study details)

Soerensen et al. (2012)

G418

XRCC1

19q13.31

English

Non-significant (study details, 2 variants)

Wilding et al. (2006)

208

XRCC3

14q32.33

English

Non-significant (study details)

Wilding et al. (2006)

209

XRCC4

5q14.2

English

Non-significant (study details)

Wilding et al. (2006)

210

XRCC5

2q35

English

Non-significant (study details)

Wilding et al. (2006)

275

XRCC5

2q35

Danish

Significant (study details)

Soerensen et al. (2012)

252

XRCC6

22q13.2

American (Caucasian)

Non-significant (study details)

Kim et al. (2012)

218

YTHDF2

1p35.3

Italian

Significant (study details)

Cardelli et al. (2006)

G457

10 genes

Multiple

Dutch

Significant (study details, 10 variants)

Deelen et al. (2013)

G492

10 genes

Multiple

Korean

Non-significant (study details, 11 variants)

Park et al. (2009)

G508

119 genes

Multiple

Italian (Southern)

Non-significant (study details, 316 variants)

Di Cianni et al. (2013)

G475

12 genes

Multiple

Danish, German, Dutch

Non-significant (study details, 68 variants)

Soerensen et al. (2013)

G463

14 genes

Multiple

European

Non-significant (study details, 14 variants)

Walter et al. (2011)

G501

16 genes

Multiple

Italian (Southern)

Non-significant (study details, 38 variants)

Campa et al. (2012)

G469

164 genes

Multiple

American (Caucasian)

Significant (study details, 281 variants)

Sebastiani et al. (2012)

G519

2 genes

Multiple

American (Caucasian), French

Non-significant (study details, 6 variants)

Geesaman et al. (2003)

G471

2 genes

Multiple

Italian (Central)

Significant (study details, 3 variants)

Napolioni et al. (2011)

G425

2 genes

Multiple

German

Significant (study details, 16 variants)

Flachsbart et al. (2009)

G498

2 genes

Multiple

Italian (Northern) and Japanese

Non-significant (study details, 8 variants)

Benigni et al. (2013)

G450

2 genes

Multiple

German

Significant (study details, 2 variants)

Nebel et al. (2011)

G554

2 genes

Multiple

American (Georgia and Louisiana populations from African and European origin)

Non-significant (study details, 2 variants)

Jazwinski et al. (2010)

G535

2 genes

Multiple

Spanish

Non-significant (study details, 2 variants)

Garatachea et al. (2014)

G452

2 genes

Multiple

German

Non-significant (study details, 2 variants)

Nebel et al. (2011)

G504

2 genes

Multiple

American (Caucasian), Ashkenazi Jewish

Non-significant (study details, 2 variants)

Terry et al. (2006)

G421

2 genes

Multiple

Ashkenazi Jewish

Non-significant (study details, 2 variants)

Terry et al. (2006)

G440

2 genes

Multiple

American (Caucasians), Italian (Southern), French, Ashkenazi Jewish

Significant (study details, 4 variants)

Conneely et al. (2012)

G447

2 genes

Multiple

Greek

Non-significant (study details, 3 variants)

Kolovou et al. (2014)

G446

2 genes

Multiple

Ashkenazi Jewish

Non-significant (study details, 2 variants)

Han et al. (2013)

G545

2 genes

Multiple

Italian (Southern)

Non-significant (study details, 9 variants)

Rose et al. (2015)

G470

2 genes

Multiple

American (Caucasian)

Non-significant (study details, 20 variants)

Heckman et al. (2012)

G458

2 genes

Multiple

Dutch

Significant (study details, 3 variants)

Deelen et al. (2011)

G412

2 genes

Multiple

Italian (Northern)

Significant (study details, 2 variants)

Gaspari et al. (2003)

G456

20 genes

Multiple

Dutch

Non-significant (study details, 30 variants)

Beekman et al. (2010)

G459

21 genes

Multiple

Dutch

Non-significant (study details, 57 variants)

Deelen et al. (2011)

G511

22 genes

Multiple

American, English, Irish

Non-significant (study details, 41 variants)

Shi et al. (2012)

G453

25 genes

Multiple

German

Non-significant (study details, 32 variants)

Nebel et al. (2011)

G550

3 genes

Multiple

Italian

Non-significant (study details, 31 variants)

Gravina et al. (2009)

G486

3 genes

Multiple

Germany, Italian, Chinese (Han)

Non-significant (study details, 32 variants)

Kleindorp et al. (2011)

G438

3 genes

Multiple

American (Georgia and Louisiana populations from African and European origin)

Significant (study details, 3 variants)

Jazwinski et al. (2010)

G536

3 genes

Multiple

Italian

Significant (study details, 3 variants)

Garatachea et al. (2014)

G537

3 genes

Multiple

Japanese

Significant (study details, 3 variants)

Garatachea et al. (2014)

G466

3 genes

Multiple

European

Non-significant (study details, 6 variants)

Lescai et al. (2009)

G468

3 genes

Multiple

German

Non-significant (study details, 3 variants)

Flachsbart et al. (2010)

G462

3 genes

Multiple

Dutch

Non-significant (study details, 3 variants)

Noordam et al. (2012)

G436

3 genes

Multiple

Danish

Significant (study details, 3 variants)

Singh et al. (2010)

G431

3 genes

Multiple

Chinese (Uighur in Xinjiang)

Significant (study details, 3 variants)

Li et al. (2009)

G490

3 genes

Multiple

Italian

Significant (study details, 4 variants)

Barbieri et al. (2012)

G539

3 genes

Multiple

American

Significant (study details, 10 variants)

Kim et al. (2015)

G455

3 genes

Multiple

Danish

Non-significant (study details, 6 variants)

Soerensen et al. (2012)

G502

3 genes

Multiple

Italian (Southern)

Non-significant (study details, 5 variants)

Montesanto et al. (2013)

G507

3 genes

Multiple

American (Amish)

Non-significant (study details, 23 variants)

Edwards et al. (2013)

G441

3 genes

Multiple

American (Caucasians), Italian (Southern), French, Ashkenazi Jewish

Non-significant (study details, 12 variants)

Conneely et al. (2012)

G467

3 genes

Multiple

European

Non-significant (study details, 10 variants)

Lescai et al. (2009)

G491

36 genes

Multiple

Italian

Non-significant (study details, 66 variants)

Malovini et al. (2011)

G482

4 genes

Multiple

American (Caucasian)

Non-significant (study details, 9 variants)

Lunetta et al. (2007)

G473

4 genes

Multiple

Chinese

Non-significant (study details, 14 variants)

Zhao et al. (2012)

G443

4 genes

Multiple

American of Japanese origin

Non-significant (study details, 12 variants)

Willcox et al. (2008)

G509

4 genes

Multiple

Ashkenazi Jewish

Significant (study details, 4 variants)

Huffman et al. (2012)

G506

4 genes

Multiple

Spanish

Non-significant (study details, 4 variants)

Santiago et al. (2013)

G465

4 genes

Multiple

European

Non-significant (study details, 4 variants)

Lescai et al. (2009)

G526

4 genes

Multiple

American (Caucasian and African-American)

Non-significant (study details, 10 variants)

Reiner et al. (2013)

G547

40 genes

Multiple

Danish

Non-significant (study details, 282 variants)

Dato et al. (2014)

G461

40 genes

Multiple

Dutch

Significant (study details, 40 variants)

Passtoors et al. (2013)

G485

5 genes

Multiple

German

Non-significant (study details, 56 variants)

Flachsbart et al. (2011)

G444

5 genes

Multiple

American of Japanese origin

Non-significant (study details, 15 variants)

Morris et al. (2014)

G541

5 genes

Multiple

American of Japanese origin

Non-significant (study details, 78 variants)

Morris et al. (2015)

G435

58 genes

Multiple

Caucasians

Non-significant (study details, 287 variants)

Newman et al. (2010)

G451

7 genes

Multiple

German

Non-significant (study details, 16 variants)

Nebel et al. (2011)

G484

7 genes

Multiple

American (Caucasian)

Non-significant (study details, 21 variants)

Lunetta et al. (2007)

G449

7 genes

Multiple

American (Caucasian)

Non-significant (study details, 16 variants)

Pawlikowska et al. (2009)

G483

8 genes

Multiple

American (Caucasian)

Non-significant (study details, 16 variants)

Lunetta et al. (2007)

G464

8 genes

Multiple

European

Non-significant (study details, 8 variants)

Walter et al. (2011)

G510

9 genes

Multiple

American, English, Irish

Non-significant (study details, 9 variants)

Shi et al. (2012)

G546

91 genes

Multiple

Danish

Non-significant (study details, 592 variants)

Debrabant et al. (2014)