Genetic variants of human longevity – Part 4

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Part 4

204

TNF

6p21.33

Japanese

Non-significant
(study
details
)

Okayama et al. (2005)

140

TNF

6p21.33

Bulgarian

Non-significant
(study
details
)

Naumova et al. (2004)

118

TNF

6p21.33

Irish
(Belfast)

Non-significant
(study
details
)

Ross et al. (2003)

247

TNF

6p21.33

Jordanian

Non-significant
(study
details
)

Khabour and
Barnawi (2010)

198

TNF

6p21.33

Mexican

Significant
(study
details
)

Soto-Vega et al. (2005)

102

TNF

6p21.33

Italian

Non-significant
(study
details
)

Lio et al. (2003)

331

TOMM40

19q13.32

Polish

Significant
(study
details
)

Maruszak et al. (2012)

355

TOMM40

19q13.32

Danish,
American

Significant
(study
details
)

Schupf et al. (2013)

282

TOMM40

19q13.32

American
(Caucasian)

Significant
(study
details
)

Sebastiani et al. (2012)

360

TOMM40

19q13.32

American,
English, Irish

Significant
(study
details
)

Shi et al. (2012)

285

TP53

17p13.1

Italian
(Central)

Significant
(study
details
)

Di Pietro et al. (2013)

381

TP53

17p13.1

Danish

Significant
(study
details
)

Bojesen and
Nordestgaard (2008)

276

TP53

17p13.1

European

Significant
(study details)

Beekman et al. (2013)

322

TP53

17p13.1

Chinese
(Guangxi Bama)

Non-significant
(study
details
)

Yang et al. (2012)

290

TP53

17p13.1

Chinese

Non-significant
(study
details
)

Cai et al. (2009)

G522

TP53

17p13.1

Irish

Significant
(study
details, 2 variants
)

Ross et al. (2001)

295

TP53

17p13.1

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

391

TP53

17p13.1

Japanese

Significant
(study
details
)

Pinós et al. (2014)

277

TP53

17p13.1

European

Significant
(study
details
)

Beekman et al. (2013)

387

TP53

17p13.1

Spanish

Significant
(study
details
)

Pinós et al. (2014)

G523

TP53

17p13.1

Irish

Non-significant
(study
details, 2 variants
)

Ross et al. (2001)

314

TP53

17p13.1

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

383

TP53

17p13.1

European
(Danish, Finnish, South Italian and Greek)

Significant
(study
details
)

Raule et al. (2014)

278

TP53

17p13.1

European

Significant
(study
details
)

Beekman et al. (2013)

342

TP53

17p13.1

American
(Utah)

Non-significant
(study
details
)

Kerber et al. (2012)

3474

TP53

17p13.1

American
(Caucasian)

Non-significant
(study
details
)

Boyden and
Kunkel (2010)

347

TP53

17p13.1

American
(Utah)

Non-significant
(study
details
)

Kerber et al. (2012)

361

TP53

17p13.1

Chinese
(Han)

Non-significant
(study
details
)

Pan et al. (2011)

320

TP53

17p13.1

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

256

TP53

17p13.1

American
(Caucasian)

Significant
(study
details
)

Boyden and
Kunkel (2010)

375

TP53

17p13.1

Italian

Significant
(study
details
)

De
Benedictis et al. (1999)

343

TP53

17p13.1

American
(Utah)

Non-significant
(study
details
)

Kerber et al. (2012)

366

TP53

17p13.1

Japanese

Significant
(study
details
)

Bilal et al. (2008)

3475

TP53

17p13.1

American
(Caucasian)

Non-significant
(study
details
)

Boyden and
Kunkel (2010)

284

TP53

17p13.1

American
(Caucasian)

Significant
(study
details
)

Puca et al. (2001)

380

TP53

17p13.1

Italian
(Northern)

Significant
(study
details
)

Emanuele et al. (2010)

371

TP53

17p13.1

Finnish

Significant
(study
details
)

Niemi et al. (2003)

307

TP53

17p13.1

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

330

TP53

17p13.1

English
(Newcastle)

Non-significant
(study
details
)

Collerton et al. (2013)

257

TP53

17p13.1

American
(Caucasian)

Non-significant
(study
details
)

Boyden and
Kunkel (2010)

280

TP53

17p13.1

European

Significant
(study
details
)

Beekman et al. (2013)

344

TP53

17p13.1

American
(Utah)

Non-significant
(study
details
)

Kerber et al. (2012)

312

TP53

17p13.1

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

235

TSHB

1p13.2

Ashkenazi
Jewish

Non-significant
(study
details
)

Atzmon et al. (2009)

G531

TTR

18q12.1

Danish

Significant
(study
details, 2 variants
)

Hornstrup et al. (2013)

269

TXNRD1

12q23.3

Danish

Significant
(study
details
)

Soerensen et al. (2012)

G544

TXNRD1

12q23.3

Danish

Significant
(study
details, 15 variants
)

Dato et al. (2014)

3472

UBE4B

1p36.22

Chinese

Significant
(study
details
)

Sun et al. (2014)

384

UBE4B

1p36.22

Spanish

Significant
(study
details
)

Garatachea et al. (2014)

G499

UCP1

4q31.1

Italian
(Southern)

Significant
(study
details, 2 variants
)

Rose et al. (2011)

332

UCP2

11q13.4

Italian
(Southern)

Significant
(study
details
)

Rose et al. (2011)

182

UCP2

11q13.4

Dutch

Non-significant
(study
details
)

van Heemst et al. (2005)

G500

UCP3

11q13.4

Italian
(Southern)

Significant
(study
details, 2 variants
)

Rose et al. (2011)

G479

UCP3

11q13.4

Danish

Significant
(study
details, 2 variants
)

Dato et al. (2012)

G534

UCP3

11q13.4

Danish

Significant
(study
details, 4 variants
)

Dato et al. (2014)

G548

UCP3

11q13.4

Danish

Non-significant
(study
details, 2 variants
)

Dato et al. (2012)

G437

VDR

12q13.11

Spanish

Non-significant
(study
details, 5 variants
)

Laplana et al. (2010)

367

VEGFA

6p21.1

Italian
(Northern)

Significant
(study
details
)

Del Bo et al. (2008)

G416

WRN

8p12

Dutch

Non-significant
(study
details, 3 variants
)

Kuningas et al. (2006)

G403

WRN

8p12

Finnish
and Mexican

Non-significant
(study
details, 2 variants
)

Castro et al. (2000)

32

WRN

8p12

Finnish,
American, Mexican and Japanese

Non-significant
(study
details
)

Castro et al. (1999)

266

WRN

8p12

Danish

Significant
(study
details
)

Soerensen et al. (2012)

270

XDH

2p23.1

Danish

Significant
(study
details
)

Soerensen et al. (2012)

G418

XRCC1

19q13.31

English

Non-significant
(study
details, 2 variants
)

Wilding et al. (2006)

208

XRCC3

14q32.33

English

Non-significant
(study
details
)

Wilding et al. (2006)

209

XRCC4

5q14.2

English

Non-significant
(study
details
)

Wilding et al. (2006)

210

XRCC5

2q35

English

Non-significant
(study
details
)

Wilding et al. (2006)

275

XRCC5

2q35

Danish

Significant
(study
details
)

Soerensen et al. (2012)

252

XRCC6

22q13.2

American
(Caucasian)

Non-significant
(study
details
)

Kim et al. (2012)

218

YTHDF2

1p35.3

Italian

Significant
(study
details
)

Cardelli et al. (2006)

G457

10 genes

Multiple

Dutch

Significant
(study
details, 10 variants
)

Deelen et al. (2013)

G492

10 genes

Multiple

Korean

Non-significant
(study
details, 11 variants
)

Park et al. (2009)

G508

119 genes

Multiple

Italian
(Southern)

Non-significant
(study
details, 316 variants
)

Di Cianni et al. (2013)

G475

12 genes

Multiple

Danish,
German, Dutch

Non-significant
(study
details, 68 variants
)

Soerensen et al. (2013)

G463

14 genes

Multiple

European

Non-significant
(study
details, 14 variants
)

Walter et al. (2011)

G501

16 genes

Multiple

Italian
(Southern)

Non-significant
(study
details, 38 variants
)

Campa et al. (2012)

G469

164 genes

Multiple

American
(Caucasian)

Significant
(study
details, 281 variants
)

Sebastiani et al. (2012)

G519

2 genes

Multiple

American
(Caucasian), French

Non-significant
(study
details, 6 variants
)

Geesaman et al. (2003)

G471

2 genes

Multiple

Italian
(Central)

Significant
(study
details, 3 variants
)

Napolioni et al. (2011)

G425

2 genes

Multiple

German

Significant
(study
details, 16 variants
)

Flachsbart et al. (2009)

G498

2 genes

Multiple

Italian
(Northern) and Japanese

Non-significant
(study
details, 8 variants
)

Benigni et al. (2013)

G450

2 genes

Multiple

German

Significant
(study
details, 2 variants
)

Nebel et al. (2011)

G554

2 genes

Multiple

American
(Georgia and Louisiana populations from African and European origin)

Non-significant
(study
details, 2 variants
)

Jazwinski et al. (2010)

G535

2 genes

Multiple

Spanish

Non-significant
(study
details, 2 variants
)

Garatachea et al. (2014)

G452

2 genes

Multiple

German

Non-significant
(study
details, 2 variants
)

Nebel et al. (2011)

G504

2 genes

Multiple

American
(Caucasian), Ashkenazi Jewish

Non-significant
(study
details, 2 variants
)

Terry et al. (2006)

G421

2 genes

Multiple

Ashkenazi
Jewish

Non-significant
(study
details, 2 variants
)

Terry et al. (2006)

G440

2 genes

Multiple

American
(Caucasians), Italian (Southern), French, Ashkenazi Jewish

Significant
(study
details, 4 variants
)

Conneely et al. (2012)

G447

2 genes

Multiple

Greek

Non-significant
(study
details, 3 variants
)

Kolovou et al. (2014)

G446

2 genes

Multiple

Ashkenazi
Jewish

Non-significant
(study
details, 2 variants
)

Han et al. (2013)

G545

2 genes

Multiple

Italian
(Southern)

Non-significant
(study
details, 9 variants
)

Rose et al. (2015)

G470

2 genes

Multiple

American
(Caucasian)

Non-significant
(study
details, 20 variants
)

Heckman et al. (2012)

G458

2 genes

Multiple

Dutch

Significant
(study
details, 3 variants
)

Deelen et al. (2011)

G412

2 genes

Multiple

Italian
(Northern)

Significant
(study
details, 2 variants
)

Gaspari et al. (2003)

G456

20 genes

Multiple

Dutch

Non-significant
(study
details, 30 variants
)

Beekman et al. (2010)

G459

21 genes

Multiple

Dutch

Non-significant
(study
details, 57 variants
)

Deelen et al. (2011)

G511

22 genes

Multiple

American,
English, Irish

Non-significant
(study
details, 41 variants
)

Shi et al. (2012)

G453

25 genes

Multiple

German

Non-significant
(study
details, 32 variants
)

Nebel et al. (2011)

G550

3 genes

Multiple

Italian

Non-significant
(study
details, 31 variants
)

Gravina et al. (2009)

G486

3 genes

Multiple

Germany,
Italian, Chinese (Han)

Non-significant
(study
details, 32 variants
)

Kleindorp et al. (2011)

G438

3 genes

Multiple

American
(Georgia and Louisiana populations from African and European origin)

Significant
(study
details, 3 variants
)

Jazwinski et al. (2010)

G536

3 genes

Multiple

Italian

Significant
(study
details, 3 variants
)

Garatachea et al. (2014)

G537

3 genes

Multiple

Japanese

Significant
(study
details, 3 variants
)

Garatachea et al. (2014)

G466

3 genes

Multiple

European

Non-significant
(study
details, 6 variants
)

Lescai et al. (2009)

G468

3 genes

Multiple

German

Non-significant
(study
details, 3 variants
)

Flachsbart et al. (2010)

G462

3 genes

Multiple

Dutch

Non-significant
(study
details, 3 variants
)

Noordam et al. (2012)

G436

3 genes

Multiple

Danish

Significant
(study
details, 3 variants
)

Singh et al. (2010)

G431

3 genes

Multiple

Chinese
(Uighur in Xinjiang)

Significant
(study
details, 3 variants
)

Li et al. (2009)

G490

3 genes

Multiple

Italian

Significant
(study
details, 4 variants
)

Barbieri et al. (2012)

G539

3 genes

Multiple

American

Significant
(study
details, 10 variants
)

Kim et al. (2015)

G455

3 genes

Multiple

Danish

Non-significant
(study
details, 6 variants
)

Soerensen et al. (2012)

G502

3 genes

Multiple

Italian
(Southern)

Non-significant
(study
details, 5 variants
)

Montesanto et al. (2013)

G507

3 genes

Multiple

American
(Amish)

Non-significant
(study
details, 23 variants
)

Edwards et al. (2013)

G441

3 genes

Multiple

American
(Caucasians), Italian (Southern), French, Ashkenazi Jewish

Non-significant
(study
details, 12 variants
)

Conneely et al. (2012)

G467

3 genes

Multiple

European

Non-significant
(study
details, 10 variants
)

Lescai et al. (2009)

G491

36 genes

Multiple

Italian

Non-significant
(study
details, 66 variants
)

Malovini et al. (2011)

G482

4 genes

Multiple

American
(Caucasian)

Non-significant
(study
details, 9 variants
)

Lunetta et al. (2007)

G473

4 genes

Multiple

Chinese

Non-significant
(study
details, 14 variants
)

Zhao et al. (2012)

G443

4 genes

Multiple

American
of Japanese origin

Non-significant
(study
details, 12 variants
)

Willcox et al. (2008)

G509

4 genes

Multiple

Ashkenazi
Jewish

Significant
(study
details, 4 variants
)

Huffman et al. (2012)

G506

4 genes

Multiple

Spanish

Non-significant
(study
details, 4 variants
)

Santiago et al. (2013)

G465

4 genes

Multiple

European

Non-significant
(study
details, 4 variants
)

Lescai et al. (2009)

G526

4 genes

Multiple

American
(Caucasian and African-American)

Non-significant
(study
details, 10 variants
)

Reiner et al. (2013)

G547

40 genes

Multiple

Danish

Non-significant
(study
details, 282 variants
)

Dato et al. (2014)

G461

40 genes

Multiple

Dutch

Significant
(study
details, 40 variants
)

Passtoors et al. (2013)

G485

5 genes

Multiple

German

Non-significant
(study
details, 56 variants
)

Flachsbart et al. (2011)

G444

5 genes

Multiple

American
of Japanese origin

Non-significant
(study
details, 15 variants
)

Morris et al. (2014)

G541

5 genes

Multiple

American
of Japanese origin

Non-significant
(study
details, 78 variants
)

Morris et al. (2015)

G435

58 genes

Multiple

Caucasians

Non-significant
(study
details, 287 variants
)

Newman et al. (2010)

G451

7 genes

Multiple

German

Non-significant
(study
details, 16 variants
)

Nebel et al. (2011)

G484

7 genes

Multiple

American
(Caucasian)

Non-significant
(study
details, 21 variants
)

Lunetta et al. (2007)

G449

7 genes

Multiple

American
(Caucasian)

Non-significant
(study
details, 16 variants
)

Pawlikowska
et al. (2009)

G483

8 genes

Multiple

American
(Caucasian)

Non-significant
(study
details, 16 variants
)

Lunetta et al. (2007)

G464

8 genes

Multiple

European

Non-significant
(study
details, 8 variants
)

Walter et al. (2011)

G510

9 genes

Multiple

American,
English, Irish

Non-significant
(study
details, 9 variants
)

Shi et al. (2012)

G546

91 genes

Multiple

Danish

Non-significant
(study
details, 592 variants
)

Debrabant et al. (2014)

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