Genetic variants of human longevity – Part 3

[raw]
Part 1
Part 2
Part 3
Part 4

183

IRS1

2q36.3

Dutch

Non-significant
(study
details
)

van Heemst et al. (2005)

120

IRS1

2q36.3

Italian

Non-significant
(study
details
)

Bonafè et al. (2003)

238

IRS2

13q34

Italian

Significant
(study
details
)

Barbieri et al. (2010)

58

ITGA2

5q11.2

American
(Caucasian)

Non-significant
(study
details
)

Hessner et al. (2001)

59

ITGB3

17q21.32

American
(Caucasian)

Significant
(study
details
)

Hessner et al. (2001)

41

ITGB3

17q21.32

Danish

Non-significant
(study
details
)

Bladbjerg et al. (1999)

159

KIR3DL1

19q13.42

Irish

Non-significant
(study
details
)

Maxwell et al. (2004)

141

KIR3DL1

19q13.42

Irish

Non-significant
(study
details
)

Ross et al. (2004)

258

KL

13q13.1

Danish

Significant
(study
details
)

Soerensen et al. (2012)

368

KL

13q13.1

Ashkenazi
Jewish, Czechs (Bohemian)

Significant
(study
details
)

Arking et al. (2005)

233

KL

13q13.1

Italian

Significant
(study
details
)

Invidia et al. (2010)

G405

KL

13q13.1

Czechs
(Bohemian), Americans (Baltimore Caucasians and African-Americans)

Significant
(study
details, 2 variants
)

Arking et al. (2002)

298

LINC01237

2q37.3

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

389

LINC02227

5q33.3

European

Significant
(study
details
)

Deelen et al. (2014)

96

LIPC

15q21.3

Japanese

Non-significant
(study
details
)

Arai et al. (2003)

310

LOC100631378

19q13.13

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

243

LOC105375494

7q32.1

Jordanian

Significant
(study
details
)

Khabour et al. (2010)

354

LOC105378102

6q26

American
(Amish)

Significant
(study
details
)

Edwards et al. (2013)

274

LOC107987209

14q32.33

Dutch

Significant
(study
details
)

Deelen et al. (2011)

97

LPL

8p21.3

Japanese

Non-significant
(study details)

Arai et al. (2003)

117

LTA

6p21.33

Irish
(Belfast)

Non-significant
(study
details
)

Ross et al. (2003)

G496

LYN

8q12.1

Korean

Significant
(study
details, 8 variants
)

Park et al. (2009)

358

MAP3K7

6q15

Italian
(Southern)

Significant
(study
details
)

Di Cianni et al. (2013)

G505

MEFV

16p13.3

Italian
(Sicily)

Non-significant
(study
details, 3 variants
)

Grimaldi et al. (2006)

197

MEFV

16p13.3

Italian
(Sicily)

Significant
(study
details
)

Grimaldi et al. (2006)

244

MINPP1

10q23.2

Caucasians

Non-significant
(study
details
)

Newman et al. (2010)

272

MLH1

3p22.2

Danish

Significant
(study
details
)

Soerensen et al. (2012)

G417

MLH1

3p22.2

Korean

Significant
(study
details, 3 variants
)

Kim et al. (2006)

203

MMP1

11q22.2

Japanese

Non-significant
(study details)

Okayama et al. (2005)

205

MMP3

11q22.2

Japanese

Non-significant
(study
details
)

Okayama et al. (2005)

341

MSTN

2q32.2

Spanish and
Italian

Significant
(study
details
)

Garatachea et al. (2013)

G487

mt146T

 

Chinese
(Guangxi Bama)

Significant
(study
details, 2 variants
)

Yang et al. (2012)

220

MT1A

16q13

Italian

Significant
(study
details
)

Cipriano et al. (2006)

350

MT2A

16q13

Turkish

Significant
(study
details
)

Kayaaltı
et al. (2011)

363

MTHFR

1p36.22

Jordanian

Non-significant
(study
details
)

Khabour et al. (2009)

43

MTHFR

1p36.22

Danish

Non-significant
(study
details
)

Bladbjerg et al. (1999)

17

MTHFR

1p36.22

English
(Cambridge)

Non-significant
(study
details
)

Galinsky et al. (1997)

174

MTHFR

1p36.22

Ashkenazi
Jewish (Jerusalem)

Non-significant
(study
details
)

Stessman et al. (2005)

60

MTHFR

1p36.22

American
(Caucasian)

Non-significant
(study
details
)

Hessner et al. (2001)

47

MTHFR

1p36.22

Swiss

Non-significant
(study
details
)

Todesco et al. (1999)

143

MTHFR

1p36.22

Danish

Non-significant
(study
details
)

Pesch et al. (2004)

193

MTR

1q43

German

Significant
(study
details
)

Linnebank et al. (2005)

G518

MTTP

4q23

English
(Oxford)

Non-significant
(study
details, 11 variants
)

Neville et al. (2007)

G552

MTTP

4q23

Danish

Non-significant
(study
details, 2 variants
)

Bathum et al. (2005)

G414

MTTP

4q23

German

Non-significant
(study
details, 3 variants
)

Nebel et al. (2005)

G419

MTTP

4q23

Dutch

Non-significant
(study
details, 2 variants
)

Beekman et al. (2006)

G401

NAT2

8p22

French

Non-significant
(study
details, 4 variants
)

Muiras et al. (1998)

23

NAT2

8p22

Spanish

Non-significant
(study
details
)

Agúndez et al. (1997)

304

NCAM2

21q21.1

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

346

ND2

Mt

Japanese

Significant
(study
details
)

Tanaka et al. (1998)

87

ND2

Mt

Chinese

Non-significant
(study
details
)

Yao et al. (2002)

345

ND5

Mt

Chinese
(Zhuang)

Significant
(study
details
)

Feng et al. (2011)

G532

NDUFS1

2q33.3

Danish

Significant
(study
details, 5 variants
)

Dato et al. (2014)

306

NLRC5

16q13

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

338

NOS1

12q24.22

Italian
(Southern)

Significant
(study
details
)

Montesanto et al. (2013)

158

NR3C1

5q31.3

Dutch

Significant
(study
details
)

van Rossum et al. (2004)

G420

NR3C1

5q31.3

Dutch

Non-significant
(study
details, 3 variants
)

Kuningas et al. (2006)

G402

PARP1

1q42.12

French

Non-significant
(study
details, 4 variants
)

Cottet et al. (2000)

27

PARP1

1q42.12

Italian

Non-significant
(study
details
)

De
Benedictis et al. (1998)

G515

PARP1

1q42.12

American (Caucasian
and African-American), Ashkenazi Jewish

Non-significant
(study
details, 2 variants
)

Walston et al. (2009)

303

PARVG

22q13.31

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

G495

PAX4

7q32.1

Korean

Significant
(study
details, 3 variants
)

Park et al. (2009)

G493

PCSK1

5q15

Korean

Significant
(study
details, 3 variants
)

Park et al. (2009)

324

PICALM

11q14.2

Italian

Significant
(study
details
)

Piaceri et al. (2011)

121

PIK3CB

3q22.3

Italian

Non-significant
(study
details
)

Bonafè et al. (2003)

169

PIK3CB

3q22.3

Japanese

Non-significant
(study
details
)

Kojima et al. (2004)

168

PIK3CG

7q22.3

Japanese

Non-significant
(study
details
)

Kojima et al. (2004)

42

PLAT

8p11.21

Danish

Non-significant
(study
details
)

Bladbjerg et al. (1999)

267

POLB

8p11.21

Danish

Significant
(study
details
)

Soerensen et al. (2012)

84

PON1

7q21.3

Italian

Significant
(study
details
)

Bonafè et al. (2002)

122

PON1

7q21.3

French

Significant
(study
details
)

Xia et al. (2003)

151

PON1

7q21.3

Italian
(Sicily)

Significant
(study
details
)

Campo et al. (2004)

156

PON1

7q21.3

Danish

Significant
(study
details
)

Christiansen
et al. (2004)

134

PON1

7q21.3

Italian
and N. Irish

Significant
(study
details
)

Rea et al. (2004)

336

PPARG

3p25.2

Italian
(Southern)

Significant
(study
details
)

Corbo et al. (2013)

152

PPARG

3p25.2

Italian

Significant
(study
details
)

Barbieri et al. (2004)

170

PPARGC1A

4p15.2

Japanese

Non-significant
(study
details
)

Kojima et al. (2004)

315

PPP1R26-AS1

9q34.3

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

305

PPP2R2C

4p16.1

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

329

PRNP

20p13

Polish

Non-significant
(study
details
)

Golanska et al. (2013)

287

PTPN22

1p13.2

Italian
(Central)

Non-significant
(study
details
)

Napolioni et al. (2011)

265

RAD23B

9q31.2

Danish

Significant
(study
details
)

Soerensen et al. (2012)

263

RAD52

12p13.33

Danish

Significant
(study
details
)

Soerensen et al. (2012)

29

REN

1q32.1

Italian

Non-significant
(study
details
)

De
Benedictis et al. (1998)

349

RNR2

Mt

Japanese

Significant
(study
details
)

Tanaka et al. (1998)

G481

Rs10493513

 

American
(Caucasian)

(study
details, 8 variants
)

Lunetta et al. (2007)

319

RUNX3

1p36.11

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

G538

SDC4

20q13.12

Italian
(Southern)

Significant
(study
details, 2 variants
)

Rose et al. (2015)

226

SERPINE1

7q22.1

Italian
(Sicily)

Significant
(study
details
)

Listì et al. (2007)

144

SERPINE1

7q22.1

Danish

Non-significant
(study
details
)

Pesch et al. (2004)

44

SERPINE1

7q22.1

Danish

Non-significant
(study
details
)

Bladbjerg et al. (1999)

54

SERPINE1

7q22.1

German

Non-significant
(study
details
)

Lottermoser
et al. (2001)

46

SERPINE1

7q22.1

Dutch

Non-significant
(study
details
)

Heijmans et al. (1999)

188

SERPINE1

7q22.1

American
(Caucasian)

Non-significant
(study
details
)

Reiner et al. (2005)

19

SERPINE1

7q22.1

Italian

Significant
(study
details
)

Mannucci et al. (1997)

127

SHC1

1q21.3

Japanese

Non-significant
(study
details
)

Kamei et al. (2003)

132

SHC1

1q21.3

Dutch

Non-significant
(study
details
)

Mooijaart et al. (2004)

G540

SIRT1

10q21.3

Ashkenazi
Jewish

Non-significant
(study
details, 19 variants
)

Han et al. (2015)

G527

SIRT1

10q21.3

Dutch

Non-significant
(study
details, 2 variants
)

Figarska et al. (2013)

G514

SIRT1

10q21.3

Chinese
(Han)

Significant
(study
details, 2 variants
)

Zhang et al. (2010)

251

SIRT1

10q21.3

American
(Caucasian)

Significant
(study
details
)

Kim et al. (2012)

379

SIRT1

10q21.3

Dutch

Significant
(study
details
)

Figarska et al. (2013)

192

SIRT1

10q21.3

German

Non-significant
(study
details
)

Flachsbart et al. (2006)

177

SIRT3

11p15.5

Italian
(Southern)

Significant
(study
details
)

Bellizzi et al. (2005)

G528

SIRT3

11p15.5

Italian
(Northern)

Non-significant
(study
details, 3 variants
)

Albani et al. (2014)

G542

SIRT3

11p15.5

Italian
(Northern)

Significant
(study
details, 2 variants
)

Albani et al. (2014)

388

SIRT3

11p15.5

Italian
(Northern)

Non-significant
(study
details
)

Albani et al. (2014)

129

SIRT3

11p15.5

Italian
(Southern)

Significant
(study
details
)

Rose et al. (2003)

292

SIRT6

19p13.3

Danish,
German, Dutch

Significant
(study
details
)

Soerensen et al. (2013)

124

SLC13A2

17q11.2

American

Non-significant
(study
details
)

Lee et al. (2003)

334

SLC25A14

Xq26.1

Italian
(Southern)

Non-significant
(study
details
)

Rose et al. (2011)

333

SLC25A27

6p12.3

Italian
(Southern)

Significant
(study details)

Rose et al. (2011)

191

SLC6A4

17q11.2

Japanese

Significant
(study
details
)

Gondo et al. (2005)

268

SLC9A3R2

16p13.3

Danish

Significant
(study
details
)

Soerensen et al. (2012)

G529

SOD1

21q22.11

German

Non-significant
(study
details, 3 variants
)

Gentschew et al. (2013)

364

SOD2

6q25.3

Danish

Significant
(study
details
)

Soerensen et al. (2009)

31

SOD2

6q25.3

Italian

Non-significant
(study
details
)

De
Benedictis et al. (1998)

G533

SOD2

6q25.3

Danish

Significant
(study
details, 5 variants
)

Dato et al. (2014)

G543

SOD2

6q25.3

German

Non-significant
(study
details, 8 variants
)

Gentschew et al. (2013)

362

SOD2

6q25.3

Jordanian

Non-significant
(study
details
)

Khabour et al. (2009)

184

SOD2

6q25.3

Dutch

Non-significant
(study
details
)

van Heemst et al. (2005)

175

SOD2

6q25.3

Ashkenazi
Jewish (Jerusalem)

Non-significant
(study
details
)

Stessman et al. (2005)

G530

SOD3

4p15.2

German

Non-significant
(study
details, 8 variants
)

Gentschew et al. (2013)

311

SSTR3

22q13.1

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

301

STK24

13q32.2

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

26

SULT1A1

16p11.2

English
(Caucasian) and Nigerian

Significant
(study
details
)

Coughtrie et al. (1999)

296

SVEP1

9q31.3

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

337

TAS2R16

7q31.32

Italian
(Southern)

Significant
(study
details
)

Campa et al. (2012)

237

TERC

3q26.2

Ashkenazi
Jewish

Significant
(study
details
)

Atzmon et al. (2010)

286

TERT

5p15.33

Italian
(Central)

Significant
(study
details
)

Concetti et al. (2013)

239

TERT

5p15.33

Ashkenazi
Jewish

Significant
(study
details
)

Atzmon et al. (2010)

353

TFAM

10q21.1

Spanish

Non-significant
(study
details
)

Santiago et al. (2013)

313

TGFA

2p13.3

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

139

TGFB1

19q13.2

Bulgarian

Non-significant
(study
details
)

Naumova et al. (2004)

206

TGFB1

19q13.2

Japanese

Non-significant
(study
details
)

Okayama et al. (2005)

G413

TGFB1

19q13.2

Italian

Significant
(study
details, 4 variants
)

Carrieri et al. (2004)

214

TGFB2

1q41

Italian
(Sicily)

Non-significant
(study
details
)

Nuzzo et al. (2006)

30

TH

11p15.5

Italian

Significant
(study
details
)

De
Benedictis et al. (1998)

254

TH

11p15.5

German

Non-significant
(study
details
)

von
Wurmb-Schwark et al. (2011)

88

TH

11p15.5

Italian

Significant
(study
details
)

Tan et al. (2002)

231

TLR4

9q33.1

German

Non-significant
(study
details
)

Nebel et al. (2007)

164

TLR4

9q33.1

Italian

Significant
(study
details
)

Balistreri et al. (2004)

157

TNF

6p21.33

Danish

Non-significant
(study
details
)

Bruunsgaard
et al. (2004)

G517

TNF

6p21.33

Italian

Significant
(study details,
2 variants
)

Cardelli et al. (2008)

75

TNF

6p21.33

Finnish

Non-significant
(study
details
)

Wang et al. (2001)

[/raw]