Genetic variants of human longevity – Part 3

Part 1 Part 2 Part 3 Part 4

183

IRS1

2q36.3

Dutch

Non-significant (study details)

van Heemst et al. (2005)

120

IRS1

2q36.3

Italian

Non-significant (study details)

Bonafè et al. (2003)

238

IRS2

13q34

Italian

Significant (study details)

Barbieri et al. (2010)

58

ITGA2

5q11.2

American (Caucasian)

Non-significant (study details)

Hessner et al. (2001)

59

ITGB3

17q21.32

American (Caucasian)

Significant (study details)

Hessner et al. (2001)

41

ITGB3

17q21.32

Danish

Non-significant (study details)

Bladbjerg et al. (1999)

159

KIR3DL1

19q13.42

Irish

Non-significant (study details)

Maxwell et al. (2004)

141

KIR3DL1

19q13.42

Irish

Non-significant (study details)

Ross et al. (2004)

258

KL

13q13.1

Danish

Significant (study details)

Soerensen et al. (2012)

368

KL

13q13.1

Ashkenazi Jewish, Czechs (Bohemian)

Significant (study details)

Arking et al. (2005)

233

KL

13q13.1

Italian

Significant (study details)

Invidia et al. (2010)

G405

KL

13q13.1

Czechs (Bohemian), Americans (Baltimore Caucasians and African-Americans)

Significant (study details, 2 variants)

Arking et al. (2002)

298

LINC01237

2q37.3

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

389

LINC02227

5q33.3

European

Significant (study details)

Deelen et al. (2014)

96

LIPC

15q21.3

Japanese

Non-significant (study details)

Arai et al. (2003)

310

LOC100631378

19q13.13

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

243

LOC105375494

7q32.1

Jordanian

Significant (study details)

Khabour et al. (2010)

354

LOC105378102

6q26

American (Amish)

Significant (study details)

Edwards et al. (2013)

274

LOC107987209

14q32.33

Dutch

Significant (study details)

Deelen et al. (2011)

97

LPL

8p21.3

Japanese

Non-significant (study details)

Arai et al. (2003)

117

LTA

6p21.33

Irish (Belfast)

Non-significant (study details)

Ross et al. (2003)

G496

LYN

8q12.1

Korean

Significant (study details, 8 variants)

Park et al. (2009)

358

MAP3K7

6q15

Italian (Southern)

Significant (study details)

Di Cianni et al. (2013)

G505

MEFV

16p13.3

Italian (Sicily)

Non-significant (study details, 3 variants)

Grimaldi et al. (2006)

197

MEFV

16p13.3

Italian (Sicily)

Significant (study details)

Grimaldi et al. (2006)

244

MINPP1

10q23.2

Caucasians

Non-significant (study details)

Newman et al. (2010)

272

MLH1

3p22.2

Danish

Significant (study details)

Soerensen et al. (2012)

G417

MLH1

3p22.2

Korean

Significant (study details, 3 variants)

Kim et al. (2006)

203

MMP1

11q22.2

Japanese

Non-significant (study details)

Okayama et al. (2005)

205

MMP3

11q22.2

Japanese

Non-significant (study details)

Okayama et al. (2005)

341

MSTN

2q32.2

Spanish and Italian

Significant (study details)

Garatachea et al. (2013)

G487

mt146T

 

Chinese (Guangxi Bama)

Significant (study details, 2 variants)

Yang et al. (2012)

220

MT1A

16q13

Italian

Significant (study details)

Cipriano et al. (2006)

350

MT2A

16q13

Turkish

Significant (study details)

Kayaaltı et al. (2011)

363

MTHFR

1p36.22

Jordanian

Non-significant (study details)

Khabour et al. (2009)

43

MTHFR

1p36.22

Danish

Non-significant (study details)

Bladbjerg et al. (1999)

17

MTHFR

1p36.22

English (Cambridge)

Non-significant (study details)

Galinsky et al. (1997)

174

MTHFR

1p36.22

Ashkenazi Jewish (Jerusalem)

Non-significant (study details)

Stessman et al. (2005)

60

MTHFR

1p36.22

American (Caucasian)

Non-significant (study details)

Hessner et al. (2001)

47

MTHFR

1p36.22

Swiss

Non-significant (study details)

Todesco et al. (1999)

143

MTHFR

1p36.22

Danish

Non-significant (study details)

Pesch et al. (2004)

193

MTR

1q43

German

Significant (study details)

Linnebank et al. (2005)

G518

MTTP

4q23

English (Oxford)

Non-significant (study details, 11 variants)

Neville et al. (2007)

G552

MTTP

4q23

Danish

Non-significant (study details, 2 variants)

Bathum et al. (2005)

G414

MTTP

4q23

German

Non-significant (study details, 3 variants)

Nebel et al. (2005)

G419

MTTP

4q23

Dutch

Non-significant (study details, 2 variants)

Beekman et al. (2006)

G401

NAT2

8p22

French

Non-significant (study details, 4 variants)

Muiras et al. (1998)

23

NAT2

8p22

Spanish

Non-significant (study details)

Agúndez et al. (1997)

304

NCAM2

21q21.1

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

346

ND2

Mt

Japanese

Significant (study details)

Tanaka et al. (1998)

87

ND2

Mt

Chinese

Non-significant (study details)

Yao et al. (2002)

345

ND5

Mt

Chinese (Zhuang)

Significant (study details)

Feng et al. (2011)

G532

NDUFS1

2q33.3

Danish

Significant (study details, 5 variants)

Dato et al. (2014)

306

NLRC5

16q13

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

338

NOS1

12q24.22

Italian (Southern)

Significant (study details)

Montesanto et al. (2013)

158

NR3C1

5q31.3

Dutch

Significant (study details)

van Rossum et al. (2004)

G420

NR3C1

5q31.3

Dutch

Non-significant (study details, 3 variants)

Kuningas et al. (2006)

G402

PARP1

1q42.12

French

Non-significant (study details, 4 variants)

Cottet et al. (2000)

27

PARP1

1q42.12

Italian

Non-significant (study details)

De Benedictis et al. (1998)

G515

PARP1

1q42.12

American (Caucasian and African-American), Ashkenazi Jewish

Non-significant (study details, 2 variants)

Walston et al. (2009)

303

PARVG

22q13.31

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

G495

PAX4

7q32.1

Korean

Significant (study details, 3 variants)

Park et al. (2009)

G493

PCSK1

5q15

Korean

Significant (study details, 3 variants)

Park et al. (2009)

324

PICALM

11q14.2

Italian

Significant (study details)

Piaceri et al. (2011)

121

PIK3CB

3q22.3

Italian

Non-significant (study details)

Bonafè et al. (2003)

169

PIK3CB

3q22.3

Japanese

Non-significant (study details)

Kojima et al. (2004)

168

PIK3CG

7q22.3

Japanese

Non-significant (study details)

Kojima et al. (2004)

42

PLAT

8p11.21

Danish

Non-significant (study details)

Bladbjerg et al. (1999)

267

POLB

8p11.21

Danish

Significant (study details)

Soerensen et al. (2012)

84

PON1

7q21.3

Italian

Significant (study details)

Bonafè et al. (2002)

122

PON1

7q21.3

French

Significant (study details)

Xia et al. (2003)

151

PON1

7q21.3

Italian (Sicily)

Significant (study details)

Campo et al. (2004)

156

PON1

7q21.3

Danish

Significant (study details)

Christiansen et al. (2004)

134

PON1

7q21.3

Italian and N. Irish

Significant (study details)

Rea et al. (2004)

336

PPARG

3p25.2

Italian (Southern)

Significant (study details)

Corbo et al. (2013)

152

PPARG

3p25.2

Italian

Significant (study details)

Barbieri et al. (2004)

170

PPARGC1A

4p15.2

Japanese

Non-significant (study details)

Kojima et al. (2004)

315

PPP1R26-AS1

9q34.3

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

305

PPP2R2C

4p16.1

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

329

PRNP

20p13

Polish

Non-significant (study details)

Golanska et al. (2013)

287

PTPN22

1p13.2

Italian (Central)

Non-significant (study details)

Napolioni et al. (2011)

265

RAD23B

9q31.2

Danish

Significant (study details)

Soerensen et al. (2012)

263

RAD52

12p13.33

Danish

Significant (study details)

Soerensen et al. (2012)

29

REN

1q32.1

Italian

Non-significant (study details)

De Benedictis et al. (1998)

349

RNR2

Mt

Japanese

Significant (study details)

Tanaka et al. (1998)

G481

Rs10493513

 

American (Caucasian)

(study details, 8 variants)

Lunetta et al. (2007)

319

RUNX3

1p36.11

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

G538

SDC4

20q13.12

Italian (Southern)

Significant (study details, 2 variants)

Rose et al. (2015)

226

SERPINE1

7q22.1

Italian (Sicily)

Significant (study details)

Listì et al. (2007)

144

SERPINE1

7q22.1

Danish

Non-significant (study details)

Pesch et al. (2004)

44

SERPINE1

7q22.1

Danish

Non-significant (study details)

Bladbjerg et al. (1999)

54

SERPINE1

7q22.1

German

Non-significant (study details)

Lottermoser et al. (2001)

46

SERPINE1

7q22.1

Dutch

Non-significant (study details)

Heijmans et al. (1999)

188

SERPINE1

7q22.1

American (Caucasian)

Non-significant (study details)

Reiner et al. (2005)

19

SERPINE1

7q22.1

Italian

Significant (study details)

Mannucci et al. (1997)

127

SHC1

1q21.3

Japanese

Non-significant (study details)

Kamei et al. (2003)

132

SHC1

1q21.3

Dutch

Non-significant (study details)

Mooijaart et al. (2004)

G540

SIRT1

10q21.3

Ashkenazi Jewish

Non-significant (study details, 19 variants)

Han et al. (2015)

G527

SIRT1

10q21.3

Dutch

Non-significant (study details, 2 variants)

Figarska et al. (2013)

G514

SIRT1

10q21.3

Chinese (Han)

Significant (study details, 2 variants)

Zhang et al. (2010)

251

SIRT1

10q21.3

American (Caucasian)

Significant (study details)

Kim et al. (2012)

379

SIRT1

10q21.3

Dutch

Significant (study details)

Figarska et al. (2013)

192

SIRT1

10q21.3

German

Non-significant (study details)

Flachsbart et al. (2006)

177

SIRT3

11p15.5

Italian (Southern)

Significant (study details)

Bellizzi et al. (2005)

G528

SIRT3

11p15.5

Italian (Northern)

Non-significant (study details, 3 variants)

Albani et al. (2014)

G542

SIRT3

11p15.5

Italian (Northern)

Significant (study details, 2 variants)

Albani et al. (2014)

388

SIRT3

11p15.5

Italian (Northern)

Non-significant (study details)

Albani et al. (2014)

129

SIRT3

11p15.5

Italian (Southern)

Significant (study details)

Rose et al. (2003)

292

SIRT6

19p13.3

Danish, German, Dutch

Significant (study details)

Soerensen et al. (2013)

124

SLC13A2

17q11.2

American

Non-significant (study details)

Lee et al. (2003)

334

SLC25A14

Xq26.1

Italian (Southern)

Non-significant (study details)

Rose et al. (2011)

333

SLC25A27

6p12.3

Italian (Southern)

Significant (study details)

Rose et al. (2011)

191

SLC6A4

17q11.2

Japanese

Significant (study details)

Gondo et al. (2005)

268

SLC9A3R2

16p13.3

Danish

Significant (study details)

Soerensen et al. (2012)

G529

SOD1

21q22.11

German

Non-significant (study details, 3 variants)

Gentschew et al. (2013)

364

SOD2

6q25.3

Danish

Significant (study details)

Soerensen et al. (2009)

31

SOD2

6q25.3

Italian

Non-significant (study details)

De Benedictis et al. (1998)

G533

SOD2

6q25.3

Danish

Significant (study details, 5 variants)

Dato et al. (2014)

G543

SOD2

6q25.3

German

Non-significant (study details, 8 variants)

Gentschew et al. (2013)

362

SOD2

6q25.3

Jordanian

Non-significant (study details)

Khabour et al. (2009)

184

SOD2

6q25.3

Dutch

Non-significant (study details)

van Heemst et al. (2005)

175

SOD2

6q25.3

Ashkenazi Jewish (Jerusalem)

Non-significant (study details)

Stessman et al. (2005)

G530

SOD3

4p15.2

German

Non-significant (study details, 8 variants)

Gentschew et al. (2013)

311

SSTR3

22q13.1

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

301

STK24

13q32.2

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

26

SULT1A1

16p11.2

English (Caucasian) and Nigerian

Significant (study details)

Coughtrie et al. (1999)

296

SVEP1

9q31.3

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

337

TAS2R16

7q31.32

Italian (Southern)

Significant (study details)

Campa et al. (2012)

237

TERC

3q26.2

Ashkenazi Jewish

Significant (study details)

Atzmon et al. (2010)

286

TERT

5p15.33

Italian (Central)

Significant (study details)

Concetti et al. (2013)

239

TERT

5p15.33

Ashkenazi Jewish

Significant (study details)

Atzmon et al. (2010)

353

TFAM

10q21.1

Spanish

Non-significant (study details)

Santiago et al. (2013)

313

TGFA

2p13.3

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

139

TGFB1

19q13.2

Bulgarian

Non-significant (study details)

Naumova et al. (2004)

206

TGFB1

19q13.2

Japanese

Non-significant (study details)

Okayama et al. (2005)

G413

TGFB1

19q13.2

Italian

Significant (study details, 4 variants)

Carrieri et al. (2004)

214

TGFB2

1q41

Italian (Sicily)

Non-significant (study details)

Nuzzo et al. (2006)

30

TH

11p15.5

Italian

Significant (study details)

De Benedictis et al. (1998)

254

TH

11p15.5

German

Non-significant (study details)

von Wurmb-Schwark et al. (2011)

88

TH

11p15.5

Italian

Significant (study details)

Tan et al. (2002)

231

TLR4

9q33.1

German

Non-significant (study details)

Nebel et al. (2007)

164

TLR4

9q33.1

Italian

Significant (study details)

Balistreri et al. (2004)

157

TNF

6p21.33

Danish

Non-significant (study details)

Bruunsgaard et al. (2004)

G517

TNF

6p21.33

Italian

Significant (study details, 2 variants)

Cardelli et al. (2008)

75

TNF

6p21.33

Finnish

Non-significant (study details)

Wang et al. (2001)