Genetic variants of human longevity – Part 2

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Part 1
Part 2
Part 3
Part 4

172

F7

13q34

Ashkenazi
Jewish (Jerusalem)

Non-significant
(study
details
)

Stessman et al. (2005)

G404

F7

13q34

Danish

Significant
(study
details, 2 variants
)

Tan et al. (2001)

15

F7

13q34

Italian

Non-significant
(study details)

Mannucci et al. (1997)

318

FAM19A5

22q13.32

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

82

FAS

10q23.31

Italian
(Northern)

Non-significant
(study
details
)

Pinti et al. (2002)

83

FASLG

1q24.3

Italian
(Northern)

Non-significant
(study
details
)

Pinti et al. (2002)

221

FCGR2A

1q23.3

German

Non-significant
(study
details
)

Flesch et al. (2006)

16

FGB

4q31.3

Italian

Non-significant
(study
details
)

Mannucci et al. (1997)

67

FGB

4q31.3

Danish

Non-significant
(study
details
)

Tan et al. (2001)

40

FGB

4q31.3

Danish

Non-significant
(study
details
)

Bladbjerg et al. (1999)

187

FGB

4q31.3

American
(Caucasian)

Non-significant
(study
details
)

Reiner et al. (2005)

G488

FOXO1

13q14.11

Chinese
(Han)

Significant
(study
details, 2 variants
)

Zeng et al. (2010)

119

FOXO1

13q14.11

Italian

Non-significant
(study
details
)

Bonafè et al. (2003)

G428

FOXO1

13q14.11

Chinese
(Han)

Significant
(study
details, 2 variants
)

Li et al. (2009)

166

FOXO1

13q14.11

Japanese

Non-significant
(study
details
)

Kojima et al. (2004)

G513

FOXO3

6q21

Danish

Non-significant
(study
details, 6 variants
)

Soerensen et al. (2010)

G445

FOXO3

6q21

American
of Japanese origin

Non-significant
(study
details, 39 variants
)

Donlon et al. (2012)

G426

FOXO3

6q21

Italian (Southern)

Significant
(study
details, 4 variants
)

Anselmi et al. (2009)

G460

FOXO3

6q21

Dutch

Non-significant
(study
details, 21 variants
)

Deelen et al. (2011)

G442

FOXO3

6q21

American
of Japanese origin

Significant
(study
details, 3 variants
)

Willcox et al. (2008)

G489

FOXO3

6q21

Chinese
(Han)

Significant
(study
details, 3 variants
)

Zeng et al. (2010)

G448

FOXO3

6q21

American
(Caucasian)

Significant
(study
details, 2 variants
)

Pawlikowska
et al. (2009)

G512

FOXO3

6q21

Danish

Significant
(study
details, 8 variants
)

Soerensen et al. (2010)

G429

FOXO3

6q21

Chinese
(Han)

Significant
(study
details, 3 variants
)

Li et al. (2009)

335

FSHR

2p16.3

Italian
(Southern)

(study
details
)

Corbo et al. (2013)

178

GH1

17q23.3

Dutch

Significant
(study
details
)

van Heemst et al. (2005)

180

GHRHR

7p14.3

Dutch

Non-significant
(study
details
)

van Heemst et al. (2005)

260

GHRHR

7p14.3

Danish

Significant
(study
details
)

Soerensen et al. (2012)

271

GHRL

3p25.3

Danish

Significant
(study
details
)

Soerensen et al. (2012)

262

GHSR

3q26.31

Danish

Significant
(study
details
)

Soerensen et al. (2012)

142

GP1BA

17p13.2

Danish

Non-significant
(study
details
)

Pesch et al. (2004)

365

GPX1

3p21.31

Danish

Significant
(study
details
)

Soerensen et al. (2009)

259

GSR

8p12

Danish

Significant
(study
details
)

Soerensen et al. (2012)

25

GSTM1

1p13.3

French

Non-significant
(study
details
)

Muiras et al. (1998)

49

GSTM1

1p13.3

Italian
(Northern)

Non-significant
(study
details
)

Taioli et al. (2001)

146

GSTM1

1p13.3

German

Non-significant
(study
details
)

Pesch et al. (2004)

211

GSTM1

1p13.3

Danish

Non-significant
(study
details
)

Christiansen
et al. (2006)

147

GSTP1

11q13.2

German

Non-significant
(study
details
)

Pesch et al. (2004)

212

GSTT1

22q11.23

Danish

Significant
(study
details
)

Christiansen
et al. (2006)

148

GSTT1

22q11.23

German

Non-significant
(study
details
)

Pesch et al. (2004)

50

GSTT1

22q11.23

Italian
(Northern)

Significant
(study
details
)

Taioli et al. (2001)

356

GSTZ1

14q24.3

Italian
(Southern)

Significant
(study
details
)

Di Cianni et al. (2013)

273

H2AFX

11q23.3

Danish

Significant
(study
details
)

Soerensen et al. (2012)

G406

HFE

6p22.2

Italian
(Sardinia)

Non-significant
(study
details, 3 variants
)

Carru et al. (2003)

81

HFE

6p22.2

Italian
(Sicily)

Significant
(study
details
)

Lio et al. (2002)

370

HFE

6p22.2

Italian
(Sicily)

Significant
(study
details
)

Lio et al. (2002)

G520

HFE

6p22.2

Italian
(Sicily)

Non-significant
(study
details, 2 variants
)

Lio et al. (2002)

114

HLA-A

6p22.1

Irish
(Belfast)

Non-significant
(study
details
)

Ross et al. (2003)

133

HLA-A

6p22.1

Bulgarian

Non-significant
(study
details
)

Naumova et al. (2004)

116

HLA-B

6p21.33

Irish
(Belfast)

Non-significant
(study
details
)

Ross et al. (2003)

135

HLA-B

6p21.33

Bulgarian

Non-significant
(study
details
)

Naumova et al. (2004)

195

HLA-B

6p21.33

Mexican

Non-significant
(study
details
)

Soto-Vega et al. (2005)

3

HLA-B

6p21.33

Dutch

Non-significant
(study details)

Lagaay et al. (1991)

136

HLA-C

6p21.33

Bulgarian

Non-significant
(study
details
)

Naumova et al. (2004)

196

HLA-DQA1

6p21.32

Mexican

Non-significant
(study
details
)

Soto-Vega et al. (2005)

215

HLA-DQA1

6p21.32

Italian
(Sardinia)

Non-significant
(study
details
)

Scola et al. (2006)

376

HLA-DQA1

6p21.32

Japanese

Significant
(study
details
)

Takata et al. (1987)

G397

HLA-DQA1

6p21.32

Japanese
(Okinawa)

Significant
(study
details, 2 variants
)

Akisaka et al. (1997)

G398

HLA-DQB1

6p21.32

Japanese
(Okinawa)

Significant
(study
details, 2 variants
)

Akisaka et al. (1997)

G408

HLA-DQB1

6p21.32

Bulgarian

Non-significant
(study
details, 2 variants
)

Naumova et al. (2004)

216

HLA-DQB1

6p21.32

Italian
(Sardinia)

Non-significant
(study
details
)

Scola et al. (2006)

194

HLA-DRB1

6p21.32

Mexican

Non-significant
(study
details
)

Soto-Vega et al. (2005)

377

HLA-DRB1

6p21.32

Japanese

Significant
(study
details
)

Takata et al. (1987)

245

HLA-DRB1

6p21.32

Italian
(Palermo)

Significant
(study
details
)

Listì et al. (2010)

21

HLA-DRB1

6p21.32

French

Significant
(study details)

Ivanova et al. (1998)

G399

HLA-DRB1

6p21.32

Japanese
(Okinawa)

Significant
(study
details, 3 variants
)

Akisaka et al. (1997)

G409

HLA-DRB1

6p21.32

Bulgarian

Non-significant
(study
details, 2 variants
)

Naumova et al. (2004)

115

HLA-DRB3

6p21.3

Irish
(Belfast)

Non-significant
(study
details
)

Ross et al. (2003)

1

HLA-DRB5

6p21.32

Dutch

Non-significant
(study
details
)

Lagaay et al. (1991)

93

HMOX1

22q12.3

Japanese

Significant
(study
details
)

Yamaya et al. (2003)

352

HP

16q22.2

Italian
(Central)

Significant
(study
details
)

Napolioni et al. (2011)

309

HPCAL1

2p25.1

American
(Caucasian)

Significant
(study
details
)

Yashin et al. (2012)

G478

HSPA14

10p13

Danish,
German, Dutch

Significant
(study
details, 4 variants
)

Soerensen et al. (2013)

125

HSPA1A

6p21.33

Italian
(Southern)

Significant
(study
details
)

Altomare et al. (2003)

217

HSPA1A

6p21.33

Danish

Significant
(study
details
)

Singh et al. (2006)

149

HSPA1A

6p21.33

Danish

Significant
(study
details
)

Singh et al. (2004)

219

HSPA1B

6p21.33

Danish

Significant
(study
details
)

Singh et al. (2006)

378

HSPA1L

6p21.33

Irish

Significant
(study
details
)

Ross et al. (2003)

150

HSPA1L

6p21.33

Danish

Non-significant
(study
details
)

Singh et al. (2004)

106

HSPA1L

6p21.33

Irish

Significant
(study
details
)

Ross et al. (2003)

372

IFNG

12q15

Italian

Significant
(study
details
)

Lio et al. (2002)

108

IFNG

12q15

Irish

Non-significant
(study
details
)

Ross et al. (2003)

137

IFNG

12q15

Bulgarian

Non-significant
(study
details
)

Naumova et al. (2004)

160

IFNG

12q15

Italian
(Sardinia)

Non-significant
(study
details
)

Pes et al. (2004)

79

IFNG

12q15

Italian

Significant
(study
details
)

Lio et al. (2002)

241

IGF1

12q23.2

Chinese
(Han)

Non-significant
(study
details
)

Xie et al. (2010)

232

IGF1

12q23.2

Ashkenazi
Jewish

Non-significant
(study
details
)

Suh et al. (2008)

179

IGF1

12q23.2

Dutch

Non-significant
(study
details
)

van Heemst et al. (2005)

G424

IGF1

12q23.2

Chinese
(Han)

Non-significant
(study
details, 3 variants
)

Xie et al. (2008)

G407

IGF1R

15q26.3

Italian

Significant
(study
details, 2 variants
)

Bonafè et al. (2003)

G422

IGF1R

15q26.3

Ashkenazi
Jewish

Significant
(study
details, 2 variants
)

Suh et al. (2008)

325

IGF1R

15q26.3

Italian

Significant
(study
details
)

Albani et al. (2011)

173

IGF2

11p15.5

Ashkenazi
Jewish (Jerusalem)

Significant
(study
details
)

Stessman et al. (2005)

73

IGF2

11p15.5

Italian

Non-significant
(study
details
)

De Luca et al. (2001)

264

IGF2R

6q25.3

Danish

Significant
(study
details
)

Soerensen et al. (2012)

G410

IL10

1q32.1

Bulgarian

Non-significant
(study
details, 3 variants
)

Naumova et al. (2004)

80

IL10

1q32.1

Italian

Significant
(study
details
)

Lio et al. (2002)

199

IL10

1q32.1

Japanese

Significant
(study
details
)

Okayama et al. (2005)

246

IL10

1q32.1

Jordanian

Significant
(study
details
)

Khabour and
Barnawi (2010)

109

IL10

1q32.1

Irish

Non-significant
(study
details
)

Ross et al. (2003)

69

IL10

1q32.1

Finnish

Non-significant
(study
details
)

Wang et al. (2001)

101

IL10

1q32.1

Italian

Significant
(study
details
)

Lio et al. (2003)

161

IL10

1q32.1

Italian
(Sardinia)

Non-significant
(study
details
)

Pes et al. (2004)

110

IL12A

3q25.33

Irish

Non-significant
(study
details
)

Ross et al. (2003)

200

IL18

11q23.1

Japanese

Non-significant
(study
details
)

Okayama et al. (2005)

230

IL18

11q23.1

Italian

Significant
(study
details
)

Frayling et al. (2007)

71

IL1A

2q14.1

Finnish

Non-significant
(study
details
)

Wang et al. (2001)

105

IL1A

2q14.1

Italian
(Nothern and Central)

Non-significant
(study
details
)

Cavallone et al. (2003)

103

IL1B

2q14.1

Italian
(Northern and Central)

Non-significant
(study
details
)

Cavallone et al. (2003)

201

IL1B

2q14.1

Japanese

Non-significant
(study
details
)

Okayama et al. (2005)

70

IL1B

2q14.1

Finnish

Non-significant
(study
details
)

Wang et al. (2001)

72

IL1RN

2q14.1

Finnish

Non-significant
(study
details
)

Wang et al. (2001)

104

IL1RN

2q14.1

Italian
(Northern and Central)

Non-significant
(study
details
)

Cavallone et al. (2003)

111

IL2

4q27

Irish

Non-significant
(study
details
)

Ross et al. (2003)

207

IL2

4q27

Italian
(Central and Southern)

Non-significant
(study
details
)

Scola et al. (2005)

189

IL6

7p15.3

American
(Caucasian)

Non-significant
(study
details
)

Reiner et al. (2005)

107

IL6

7p15.3

Irish
(Northern)

Non-significant
(study
details
)

Rea et al. (2003)

57

IL6

7p15.3

Italian

Significant
(study
details
)

Bonafè et al. (2001)

112

IL6

7p15.3

Irish

Non-significant
(study
details
)

Ross et al. (2003)

176

IL6

7p15.3

Finnish

Significant
(study
details
)

Hurme et al. (2005)

327

IL6

7p15.3

Italian

Non-significant
(study
details
)

Albani et al. (2011)

163

IL6

7p15.3

Italian
(Sardinia)

Non-significant
(study details)

Pes et al. (2004)

291

IL6

7p15.3

Danish,
German, Dutch

Non-significant
(study
details
)

Soerensen et al. (2013)

154

IL6

7p15.3

Italian
(Southern)

Non-significant
(study
details
)

Capurso et al. (2004)

351

IL6

7p15.3

Turkish

Significant
(study
details
)

Kayaaltı
et al. (2011)

G524

IL6

7p15.3

Danish

Significant
(study
details, 2 variants
)

Christiansen
et al. (2004)

155

IL6

7p15.3

Danish

Significant
(study
details
)

Christiansen
et al. (2004)

74

IL6

7p15.3

Finnish

Non-significant
(study
details
)

Wang et al. (2001)

202

IL6

7p15.3

Japanese

Non-significant
(study
details
)

Okayama et al. (2005)

138

IL6

7p15.3

Bulgarian

Non-significant
(study
details
)

Naumova et al. (2004)

G525

IL6

7p15.3

Danish

Non-significant
(study
details, 2 variants
)

Christiansen
et al. (2004)

G516

IL6R

1q21.3

American
(Caucasian and African-American), Ashkenazi Jewish

Non-significant
(study
details, 7 variants
)

Walston et al. (2009)

181

INS

11p15.5

Dutch

Non-significant
(study
details
)

van Heemst et al. (2005)

76

INS

11p15.5

Italian

Non-significant
(study
details
)

De Luca et al. (2001)

261

INS

11p15.5

Danish

Significant
(study
details
)

Soerensen et al. (2012)

165

INSR

19p13.2

Japanese

Significant
(study
details
)

Kojima et al. (2004)

167

IRS1

2q36.3

Japanese

Non-significant
(study
details
)

Kojima et al. (2004)

[/raw]