Genetic variants of human longevity – Part 2

Part 1 Part 2 Part 3 Part 4

172

F7

13q34

Ashkenazi Jewish (Jerusalem)

Non-significant (study details)

Stessman et al. (2005)

G404

F7

13q34

Danish

Significant (study details, 2 variants)

Tan et al. (2001)

15

F7

13q34

Italian

Non-significant (study details)

Mannucci et al. (1997)

318

FAM19A5

22q13.32

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

82

FAS

10q23.31

Italian (Northern)

Non-significant (study details)

Pinti et al. (2002)

83

FASLG

1q24.3

Italian (Northern)

Non-significant (study details)

Pinti et al. (2002)

221

FCGR2A

1q23.3

German

Non-significant (study details)

Flesch et al. (2006)

16

FGB

4q31.3

Italian

Non-significant (study details)

Mannucci et al. (1997)

67

FGB

4q31.3

Danish

Non-significant (study details)

Tan et al. (2001)

40

FGB

4q31.3

Danish

Non-significant (study details)

Bladbjerg et al. (1999)

187

FGB

4q31.3

American (Caucasian)

Non-significant (study details)

Reiner et al. (2005)

G488

FOXO1

13q14.11

Chinese (Han)

Significant (study details, 2 variants)

Zeng et al. (2010)

119

FOXO1

13q14.11

Italian

Non-significant (study details)

Bonafè et al. (2003)

G428

FOXO1

13q14.11

Chinese (Han)

Significant (study details, 2 variants)

Li et al. (2009)

166

FOXO1

13q14.11

Japanese

Non-significant (study details)

Kojima et al. (2004)

G513

FOXO3

6q21

Danish

Non-significant (study details, 6 variants)

Soerensen et al. (2010)

G445

FOXO3

6q21

American of Japanese origin

Non-significant (study details, 39 variants)

Donlon et al. (2012)

G426

FOXO3

6q21

Italian (Southern)

Significant (study details, 4 variants)

Anselmi et al. (2009)

G460

FOXO3

6q21

Dutch

Non-significant (study details, 21 variants)

Deelen et al. (2011)

G442

FOXO3

6q21

American of Japanese origin

Significant (study details, 3 variants)

Willcox et al. (2008)

G489

FOXO3

6q21

Chinese (Han)

Significant (study details, 3 variants)

Zeng et al. (2010)

G448

FOXO3

6q21

American (Caucasian)

Significant (study details, 2 variants)

Pawlikowska et al. (2009)

G512

FOXO3

6q21

Danish

Significant (study details, 8 variants)

Soerensen et al. (2010)

G429

FOXO3

6q21

Chinese (Han)

Significant (study details, 3 variants)

Li et al. (2009)

335

FSHR

2p16.3

Italian (Southern)

(study details)

Corbo et al. (2013)

178

GH1

17q23.3

Dutch

Significant (study details)

van Heemst et al. (2005)

180

GHRHR

7p14.3

Dutch

Non-significant (study details)

van Heemst et al. (2005)

260

GHRHR

7p14.3

Danish

Significant (study details)

Soerensen et al. (2012)

271

GHRL

3p25.3

Danish

Significant (study details)

Soerensen et al. (2012)

262

GHSR

3q26.31

Danish

Significant (study details)

Soerensen et al. (2012)

142

GP1BA

17p13.2

Danish

Non-significant (study details)

Pesch et al. (2004)

365

GPX1

3p21.31

Danish

Significant (study details)

Soerensen et al. (2009)

259

GSR

8p12

Danish

Significant (study details)

Soerensen et al. (2012)

25

GSTM1

1p13.3

French

Non-significant (study details)

Muiras et al. (1998)

49

GSTM1

1p13.3

Italian (Northern)

Non-significant (study details)

Taioli et al. (2001)

146

GSTM1

1p13.3

German

Non-significant (study details)

Pesch et al. (2004)

211

GSTM1

1p13.3

Danish

Non-significant (study details)

Christiansen et al. (2006)

147

GSTP1

11q13.2

German

Non-significant (study details)

Pesch et al. (2004)

212

GSTT1

22q11.23

Danish

Significant (study details)

Christiansen et al. (2006)

148

GSTT1

22q11.23

German

Non-significant (study details)

Pesch et al. (2004)

50

GSTT1

22q11.23

Italian (Northern)

Significant (study details)

Taioli et al. (2001)

356

GSTZ1

14q24.3

Italian (Southern)

Significant (study details)

Di Cianni et al. (2013)

273

H2AFX

11q23.3

Danish

Significant (study details)

Soerensen et al. (2012)

G406

HFE

6p22.2

Italian (Sardinia)

Non-significant (study details, 3 variants)

Carru et al. (2003)

81

HFE

6p22.2

Italian (Sicily)

Significant (study details)

Lio et al. (2002)

370

HFE

6p22.2

Italian (Sicily)

Significant (study details)

Lio et al. (2002)

G520

HFE

6p22.2

Italian (Sicily)

Non-significant (study details, 2 variants)

Lio et al. (2002)

114

HLA-A

6p22.1

Irish (Belfast)

Non-significant (study details)

Ross et al. (2003)

133

HLA-A

6p22.1

Bulgarian

Non-significant (study details)

Naumova et al. (2004)

116

HLA-B

6p21.33

Irish (Belfast)

Non-significant (study details)

Ross et al. (2003)

135

HLA-B

6p21.33

Bulgarian

Non-significant (study details)

Naumova et al. (2004)

195

HLA-B

6p21.33

Mexican

Non-significant (study details)

Soto-Vega et al. (2005)

3

HLA-B

6p21.33

Dutch

Non-significant (study details)

Lagaay et al. (1991)

136

HLA-C

6p21.33

Bulgarian

Non-significant (study details)

Naumova et al. (2004)

196

HLA-DQA1

6p21.32

Mexican

Non-significant (study details)

Soto-Vega et al. (2005)

215

HLA-DQA1

6p21.32

Italian (Sardinia)

Non-significant (study details)

Scola et al. (2006)

376

HLA-DQA1

6p21.32

Japanese

Significant (study details)

Takata et al. (1987)

G397

HLA-DQA1

6p21.32

Japanese (Okinawa)

Significant (study details, 2 variants)

Akisaka et al. (1997)

G398

HLA-DQB1

6p21.32

Japanese (Okinawa)

Significant (study details, 2 variants)

Akisaka et al. (1997)

G408

HLA-DQB1

6p21.32

Bulgarian

Non-significant (study details, 2 variants)

Naumova et al. (2004)

216

HLA-DQB1

6p21.32

Italian (Sardinia)

Non-significant (study details)

Scola et al. (2006)

194

HLA-DRB1

6p21.32

Mexican

Non-significant (study details)

Soto-Vega et al. (2005)

377

HLA-DRB1

6p21.32

Japanese

Significant (study details)

Takata et al. (1987)

245

HLA-DRB1

6p21.32

Italian (Palermo)

Significant (study details)

Listì et al. (2010)

21

HLA-DRB1

6p21.32

French

Significant (study details)

Ivanova et al. (1998)

G399

HLA-DRB1

6p21.32

Japanese (Okinawa)

Significant (study details, 3 variants)

Akisaka et al. (1997)

G409

HLA-DRB1

6p21.32

Bulgarian

Non-significant (study details, 2 variants)

Naumova et al. (2004)

115

HLA-DRB3

6p21.3

Irish (Belfast)

Non-significant (study details)

Ross et al. (2003)

1

HLA-DRB5

6p21.32

Dutch

Non-significant (study details)

Lagaay et al. (1991)

93

HMOX1

22q12.3

Japanese

Significant (study details)

Yamaya et al. (2003)

352

HP

16q22.2

Italian (Central)

Significant (study details)

Napolioni et al. (2011)

309

HPCAL1

2p25.1

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

G478

HSPA14

10p13

Danish, German, Dutch

Significant (study details, 4 variants)

Soerensen et al. (2013)

125

HSPA1A

6p21.33

Italian (Southern)

Significant (study details)

Altomare et al. (2003)

217

HSPA1A

6p21.33

Danish

Significant (study details)

Singh et al. (2006)

149

HSPA1A

6p21.33

Danish

Significant (study details)

Singh et al. (2004)

219

HSPA1B

6p21.33

Danish

Significant (study details)

Singh et al. (2006)

378

HSPA1L

6p21.33

Irish

Significant (study details)

Ross et al. (2003)

150

HSPA1L

6p21.33

Danish

Non-significant (study details)

Singh et al. (2004)

106

HSPA1L

6p21.33

Irish

Significant (study details)

Ross et al. (2003)

372

IFNG

12q15

Italian

Significant (study details)

Lio et al. (2002)

108

IFNG

12q15

Irish

Non-significant (study details)

Ross et al. (2003)

137

IFNG

12q15

Bulgarian

Non-significant (study details)

Naumova et al. (2004)

160

IFNG

12q15

Italian (Sardinia)

Non-significant (study details)

Pes et al. (2004)

79

IFNG

12q15

Italian

Significant (study details)

Lio et al. (2002)

241

IGF1

12q23.2

Chinese (Han)

Non-significant (study details)

Xie et al. (2010)

232

IGF1

12q23.2

Ashkenazi Jewish

Non-significant (study details)

Suh et al. (2008)

179

IGF1

12q23.2

Dutch

Non-significant (study details)

van Heemst et al. (2005)

G424

IGF1

12q23.2

Chinese (Han)

Non-significant (study details, 3 variants)

Xie et al. (2008)

G407

IGF1R

15q26.3

Italian

Significant (study details, 2 variants)

Bonafè et al. (2003)

G422

IGF1R

15q26.3

Ashkenazi Jewish

Significant (study details, 2 variants)

Suh et al. (2008)

325

IGF1R

15q26.3

Italian

Significant (study details)

Albani et al. (2011)

173

IGF2

11p15.5

Ashkenazi Jewish (Jerusalem)

Significant (study details)

Stessman et al. (2005)

73

IGF2

11p15.5

Italian

Non-significant (study details)

De Luca et al. (2001)

264

IGF2R

6q25.3

Danish

Significant (study details)

Soerensen et al. (2012)

G410

IL10

1q32.1

Bulgarian

Non-significant (study details, 3 variants)

Naumova et al. (2004)

80

IL10

1q32.1

Italian

Significant (study details)

Lio et al. (2002)

199

IL10

1q32.1

Japanese

Significant (study details)

Okayama et al. (2005)

246

IL10

1q32.1

Jordanian

Significant (study details)

Khabour and Barnawi (2010)

109

IL10

1q32.1

Irish

Non-significant (study details)

Ross et al. (2003)

69

IL10

1q32.1

Finnish

Non-significant (study details)

Wang et al. (2001)

101

IL10

1q32.1

Italian

Significant (study details)

Lio et al. (2003)

161

IL10

1q32.1

Italian (Sardinia)

Non-significant (study details)

Pes et al. (2004)

110

IL12A

3q25.33

Irish

Non-significant (study details)

Ross et al. (2003)

200

IL18

11q23.1

Japanese

Non-significant (study details)

Okayama et al. (2005)

230

IL18

11q23.1

Italian

Significant (study details)

Frayling et al. (2007)

71

IL1A

2q14.1

Finnish

Non-significant (study details)

Wang et al. (2001)

105

IL1A

2q14.1

Italian (Nothern and Central)

Non-significant (study details)

Cavallone et al. (2003)

103

IL1B

2q14.1

Italian (Northern and Central)

Non-significant (study details)

Cavallone et al. (2003)

201

IL1B

2q14.1

Japanese

Non-significant (study details)

Okayama et al. (2005)

70

IL1B

2q14.1

Finnish

Non-significant (study details)

Wang et al. (2001)

72

IL1RN

2q14.1

Finnish

Non-significant (study details)

Wang et al. (2001)

104

IL1RN

2q14.1

Italian (Northern and Central)

Non-significant (study details)

Cavallone et al. (2003)

111

IL2

4q27

Irish

Non-significant (study details)

Ross et al. (2003)

207

IL2

4q27

Italian (Central and Southern)

Non-significant (study details)

Scola et al. (2005)

189

IL6

7p15.3

American (Caucasian)

Non-significant (study details)

Reiner et al. (2005)

107

IL6

7p15.3

Irish (Northern)

Non-significant (study details)

Rea et al. (2003)

57

IL6

7p15.3

Italian

Significant (study details)

Bonafè et al. (2001)

112

IL6

7p15.3

Irish

Non-significant (study details)

Ross et al. (2003)

176

IL6

7p15.3

Finnish

Significant (study details)

Hurme et al. (2005)

327

IL6

7p15.3

Italian

Non-significant (study details)

Albani et al. (2011)

163

IL6

7p15.3

Italian (Sardinia)

Non-significant (study details)

Pes et al. (2004)

291

IL6

7p15.3

Danish, German, Dutch

Non-significant (study details)

Soerensen et al. (2013)

154

IL6

7p15.3

Italian (Southern)

Non-significant (study details)

Capurso et al. (2004)

351

IL6

7p15.3

Turkish

Significant (study details)

Kayaaltı et al. (2011)

G524

IL6

7p15.3

Danish

Significant (study details, 2 variants)

Christiansen et al. (2004)

155

IL6

7p15.3

Danish

Significant (study details)

Christiansen et al. (2004)

74

IL6

7p15.3

Finnish

Non-significant (study details)

Wang et al. (2001)

202

IL6

7p15.3

Japanese

Non-significant (study details)

Okayama et al. (2005)

138

IL6

7p15.3

Bulgarian

Non-significant (study details)

Naumova et al. (2004)

G525

IL6

7p15.3

Danish

Non-significant (study details, 2 variants)

Christiansen et al. (2004)

G516

IL6R

1q21.3

American (Caucasian and African-American), Ashkenazi Jewish

Non-significant (study details, 7 variants)

Walston et al. (2009)

181

INS

11p15.5

Dutch

Non-significant (study details)

van Heemst et al. (2005)

76

INS

11p15.5

Italian

Non-significant (study details)

De Luca et al. (2001)

261

INS

11p15.5

Danish

Significant (study details)

Soerensen et al. (2012)

165

INSR

19p13.2

Japanese

Significant (study details)

Kojima et al. (2004)

167

IRS1

2q36.3

Japanese

Non-significant (study details)

Kojima et al. (2004)