Genes that inhibit stress induced senescence

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Entrez ID

Symbol

Method Used To Cause Senescence

Cell type

Cell line

Cancer Line

231

AKR1B1

Knockdown, Overexpression

Keratinocyte

HaCat

Yes

55729

ATF7IP

Knockdown

Lung fibroblast

IMR-90

No

644

BLVRA

Knockdown

Fibroblast

Primary cell

No

672

BRCA1

Mutation

Breast cancer

HBL100, HCC1937, MCF-7

Yes

2146

EZH2

Knockdown

Gastric cancer

SGC-7901

Yes

3309

HSPA5

Knockout, Overexpression

Ovarian cancer

A2780

Yes

3316

HSPB2

Knockdown, Overexpression

Breast epithelial

MCF-10A, MCF-7

No

3768

KCNJ12

Knockout

Breast cancer, Gastric cancer, Prostate cancer

DU145, LNCaP, MCF-7, MKN74, PC-3, SK-BR3, SNU-484, SNU-638, SNU-668, T47D

Yes

4170

MCL1

Knockdown, Overexpression

Colon cancer

HCT116

Yes

59277

NTN4

Knockdown, Overexpression

Glioma

T98G, U-251MG, U-87MG, U-U118MG

Yes

6714

SRC

Overexpression

Fibrosarcoma

HT1080

Yes

10460

TACC3

Knockout

Breast cancer

MCF-7

Yes

Reference: HAGR
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