Genes that induce stress induced senescence

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Entrez ID


Symbol


Method Used To Cause Senescence


Cell type


Cell line


Cancer Line


1051


CEBPB

Knockdown, Overexpression


Prostate cancer


LNCaP


Yes


1111


CHEK1

Knockout


Colon cancer


HCT116


Yes


3400


ID4

Overexpression


Prostate cancer


DU145


Yes


3486


IGFBP3

Knockdown


Lung fibroblast


WI-38


No


50618


ITSN2

Knockdown, Overexpression


Foreskin fibroblast, Lung fibroblast


Hs68, WI-38


No


4854


NOTCH3

Knockdown


Breast cancer, Fibroblast, Foreskin fibroblast, Glioma, Melanoma


A375P, BJ, LF1, MDA-MB-231, T98G, WS1


Yes


5037


PEBP1

Knockdown, Overexpression


Colon cancer, Gastric cancer, Lung cancer, Prostate cancer


A549, HCT116, MKN45, PC-3


Yes


5824


PEX19

Overexpression


Osteosarcoma


U2OS


Yes


5583


PRKCH

Knockdown, Overexpression


Breast cancer


MCF-7


Yes


5925


RB1

Knockdown


Osteoblast


Primary cell


No


54739


XAF1

Knockdown, Overexpression


Dermal microvascular endothelial cells


Primary cell


No


83719


YPEL3

Knockdown, Overexpression


Breast cancer


MCF-7


Yes

Reference: HAGR
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