Genes that induce replicative senescence

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Entrez ID


Symbol


Method Used To
Cause Senescence


Cell type


Cell line


Cancer Line


22848


AAK1

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


51225


ABI3

Overexpression


Colon cancer, Thyroid cancer


ARO, WRO


Yes


203054


ADCK5

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


183


AGT

Knockout, Overexpression


Vascular smooth muscle


Primary cell


No


247


ALOX15B

Overexpression


Prostate epithelial


Primary cell


No


367


AR

Knockdown, Overexpression


Hair follicular keratinocyte


Primary cell


No


10095


ARPC1B

Overexpression


Osteosarcoma


SaOs-2


Yes


558


AXL

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


640


BLK

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


29117


BRD7

Knockdown


Foreskin fibroblast


BJ


No


857


CAV1

Knockdown


Fibroblast


Primary cell


No


284119


CAVIN1

Knockdown, Overexpression


Cervical cancer, Lung fibroblast


HeLa, IMR-90, WI-38


No


595


CCND1

Overexpression


Fibroblast


Hs68, WI-38


No


5129


CDK18

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


1026


CDKN1A

Knockout


Fibroblast


LF1


No


1027


CDKN1B

Overexpression


Lung fibroblast


TIG-3


No


1028


CDKN1C

Overexpression


Liver cancer


HepG2, SNU-398


Yes


1029


CDKN2A

Overexpression


Lung fibroblast


TIG-3


No


55602


CDKN2AIP

Overexpression


Lung fibroblast


MRC-5, TIG-1


No


1030


CDKN2B

Overexpression


Glioblastoma


T98G, U-251MG, U-373MG


Yes


1152


CKB

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


64506


CPEB1

Knockout, Overexpression


Foreskin fibroblast, Lung fibroblast


Primary cell, WI-38


No


3576


CXCL8

Overexpression


Foreskin fibroblast, Lung fibroblast


BJ, IMR-90, WI-38


No


3491


CYR61

Overexpression


Foreskin fibroblast, Lung fibroblast


BJ, IMR-90


No


1869


E2F1

Overexpression


Lung fibroblast


WI-38


No


26298


EHF

Overexpression


Lung fibroblast


WI-38


No


54206


ERRFI1

Overexpression


Lung fibroblast


WI-38


No


2130


EWSR1

Knockout


Hematopoietic stem


Primary cell


No


10922


FASTK

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


79791


FBXO31

Overexpression


Breast cancer


MCF-7


Yes


56287


GKN1

Overexpression


Gastric cancer


AGS, MKN1


Yes


2791


GNG11

Knockout, Overexpression


Lung fibroblast


TIG-7


No


2870


GRK6

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


3065


HDAC1

Overexpression


Cervical cancer


HeLa


Yes


220296


HEPACAM

Overexpression


Breast cancer


MCF-7


Yes


3101


HK3

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


3458


IFNG

Overexpression


Umbilical vein endothelial


Primary cell


No


3484


IGFBP1

Overexpression


Breast cancer


MCF-7


Yes


3488


IGFBP5

Knockout, Overexpression


Umbilical vein endothelial


Primary cell


No


3552


IL1A

Knockout


Umbilical vein endothelial


Primary cell


No


3621


ING1

Overexpression


Foreskin fibroblast


Hs68


No


3622


ING2

Knockout, Overexpression


Lung fibroblast


MRC-5


No


3661


IRF3

Overexpression


Foreskin fibroblast


BJ


No


3663


IRF5

Overexpression


Li Fraumeni syndrome fibroblast


MDAH041


Yes


3665


IRF7

Overexpression


Li Fraumeni syndrome fibroblast


MDAH041


Yes


3691


ITGB4

Knockdown


Umbilical vein endothelial


Primary cell


No


3705


ITPK1

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


3707


ITPKB

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


3984


LIMK1

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


5604


MAP2K1

Overexpression


Intestinal epithelial


HIEC-6


No


5608


MAP2K6

Overexpression


Osteosarcoma


U2OS


Yes


5609


MAP2K7

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


9064


MAP3K6

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


6885


MAP3K7

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


6300


MAPK12

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


22983


MAST1

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


4145


MATK

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


10445


MCRS1

Overexpression


Foreskin fibroblast, Lung fibroblast, Mammary epithelial


H184B5F5/M10, Hs68, IMR-90


No


126308


MOB3A

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


23515


MORC3

Overexpression


Lung fibroblast


WI-38


No


10934


MORF4

Overexpression


Fibrosarcoma


A9, HT1080


Yes


4598


MVK

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


10608


MXD4

Overexpression


Lung fibroblast


WI-38


No


65220


NADK

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


10397


NDRG1

Knockdown


Liver cancer


Hep3B, HepG2, Huh7, PLC/PRF/5


Yes


4814


NINJ1

Overexpression


Hepatoma


Huh7


Yes


50507


NOX4

Knockdown, Overexpression


Breast epithelial, Lung fibroblast


MCF-12A, TIG-3


No


9891


NUAK1

Knockout, Overexpression


Lung fibroblast


WI-38


No


5015


OTX2

Overexpression


Medulloblastoma


D283, D341, D425, D458, D556, DAOY, MED8A, UW228-2


Yes


10298


PAK4

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


55193


PBRM1

Knockdown


Foreskin fibroblast


BJ


No


7703


PCGF2

Knockout, Overexpression


Foreskin fibroblast, Lung fibroblast


BJ, MRC-5, WI-38


No


149420


PDIK1L

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


5170


PDPK1

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


23037


PDZD2

Overexpression


Breast cancer, Liver cancer, Prostate cancer


DU145


Yes


51588


PIAS4

Overexpression


Lung fibroblast


WI-38


No


23533


PIK3R5

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


5315


PKM

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


22925


PLA2R1

Knockout, Overexpression


Lung fibroblast


IMR-90, WI-38


No


10654


PMVK

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


87178


PNPT1

Overexpression


Melanoma


FO-1, HO-1, MeWo


Yes


5460


POU5F1

Overexpression


Mesenchymal stromal


Primary cell


No


5580


PRKCD

Knockdown, Overexpression


Lung fibroblast


TIG-1


No


5629


PROX1

Overexpression


Liver cancer


Hep3B, HepG2, Mahlavu, SK-HEP1


Yes


9232


PTTG1

Overexpression


Foreskin fibroblast, Lung fibroblast


BJ, IMR-90, WI-38


No


6041


RNASEL

Knockout, Overexpression


Lung fibroblast


WI-38


No


27330


RPS6KA6

Knockdown, Overexpression


Colon cancer, Lung fibroblast


IMR-90


No


861


RUNX1

Overexpression


Foreskin fibroblast


Hs68


No


5054


SERPINE1

Knockdown


Foreskin fibroblast


BJ, Primary cell


No


150094


SIK1

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


23309


SIN3B

Knockout, Overexpression


Lung fibroblast


IMR-90


No


64849


SLC13A3

Overexpression


Lung fibroblast, Renal tubular


MRC-5, WI-38


No


6598


SMARCB1

Overexpression


Malignant rhabdoid tumor


G-401


Yes


64750


SMURF2

Overexpression


Foreskin fibroblast, Lung fibroblast, Skin fibroblast


BJ, WI-38, WS1


No


8470


SORBS2

Overexpression


Fibroblast, Keratinocyte


Primary cell


No


6657


SOX2

Overexpression


Colon cancer, Embryonic kidney


HCT116, HEK293T, WiDr


Yes


6667


SP1

Overexpression


Lung fibroblast


2BS


No


10927


SPIN1

Overexpression


Cervical cancer


HeLa


Yes


8405


SPOP

Knockdown, Overexpression


Lung fibroblast


IMR-90


No


6720


SREBF1

Overexpression


Fibroblast


Primary cell


No


6777


STAT5B

Overexpression


Lung fibroblast


IMR-90


No


282974


STK32C

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


83931


STK40

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


6850


SYK

Overexpression


Melanoma


501-mel, A375, SK-MEL-28


Yes


7023


TFAP4

Overexpression


Breast cancer, Retinal pigment epithelial


hTERT-RPE, MCF-7


Yes


7041


TGFB1I1

Knockout, Overexpression


Fibroblast


KMST-6, SUSM-1


No


7098


TLR3

Overexpression


Fibroblast, Keratinocyte


Primary cell


No


9966


TNFSF15

Knockout, Overexpression


Endothelial progenitor


Primary cell


No


7150


TOP1

Knockout


Lung fibroblast


IMR-90, WI-38


No


8626


TP63

Knockout


Foreskin fibroblast


BJ


No


7297


TYK2

Overexpression


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


27287


VENTX

Knockdown, Overexpression


Cervical cancer, Embryonic kidney, Lung fibroblast, Lymphoblastic leukemia, Osteosarcoma


HEK293T, HeLa, IMR-90, Nalm16, U2OS


Yes


51384


WNT16

Knockdown


Lung fibroblast


MRC-5


No


7538


ZFP36

Overexpression


Cervical cancer


HeLa


Yes


8553


BHLHE40

Overexpression


Breast cancer, Esophageal cancer


EC9706, MCF-7


Yes


2626


GATA4

Knockdown, Overexpression


Foreskin fibroblast, Lung fibroblast


BJ, IMR-90


No


1432


MAPK14

Knockout


Lung fibroblast


MRC-5, WI-38


No


6787


NEK4

Knockdown


Foreskin fibroblast


BJ


No


7157


TP53

Overexpression


Bladder cancer


EJ


Yes


80019


UBTD1

Overexpression


Breast cancer, Colorectal cancer, Gastric cancer, Gastric epithelial, Lung fibroblast, Prostate cancer


AGS, GES-1, KATO-III, LoVo, MCF-7, MKN28, MKN45, MRC-5, NCI-N87, PC-3, SGC-7901, SNU-1, SNU-16


Yes

Reference: HAGR
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