Genes that induce oncogene induced senescence

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Entrez ID


Symbol


Method Used To Cause Senescence


Cell type


Cell line


Cancer Line


207


AKT1

Overexpression


Aortic endothelial, Dermal microvascular endothelial cells, Umbilical vein endothelial


Primary cell


No


673


BRAF

Overexpression


Foreskin fibroblast, Melanocyte


BJ, Primary cell


No


2919


CXCL1

Overexpression


Ovarian fibroblast


Gro-1


No


1643


DDB2

Knockout


Lung fibroblast


IMR-90


No


1718


DHCR24

Mutation


Lung fibroblast


WI-38


No


2113


ETS1

Overexpression


Foreskin fibroblast, Lung fibroblast


Hs68, TIG-3


No


2114


ETS2

Overexpression


Foreskin fibroblast, Lung fibroblast


Hs68, TIG-3


No


3265


HRAS

Overexpression


Lung fibroblast


IMR-90, WI-38


No


5605


MAP2K2

Overexpression


Lung fibroblast


IMR-90


No


8550


MAPKAPK5

Knockout


Foreskin fibroblast


BJ


No


5371


PML

Overexpression


Lung fibroblast


WI-38


No


5894


RAF1

Overexpression


Lung fibroblast


IMR-90


No


2810


SFN

Overexpression


Melanoma


SK-MEL-147, SK-MEL-19, SK-MEL-29


Yes


6660


SOX5

Overexpression


Glioma


U-1242MG, U-178MG, U-251MG, U-343MG, U-343MGa


Yes


6426


SRSF1

Overexpression


Foreskin fibroblast


BJ


No


10155


TRIM28

Knockout


Lung fibroblast


IMR-90


No


25842


ASF1A

Knockout, Overexpression


Lung fibroblast


Primary cell


No


11235


PDCD10

Knockout


Coronary artery endothelial, Lung fibroblast


IMR-90, Primary cell


No


5292


PIM1

Knockdown, Overexpression


Foreskin fibroblast, Lung fibroblast


2BS, BJ, WI-38


No


8651


SOCS1

Knockdown, Overexpression


Lung fibroblast


IMR-90


No


10628


TXNIP

Knockout, Overexpression


Lung fibroblast


2BS


No

Reference: HAGR
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