Genes inhibiting senescence

Entrez Id

Gene Symbol

Method

Senescence Type

Effect on senescence

Cell Types

Cell Lines

Cancer Line

6714

SRC

Overexpression

Stress-induced

Inhibition

Fibrosarcoma

HT1080

Yes

604

BCL6

Overexpression

Replicative

Inhibition

B-cell

Primary cell

No

57332

CBX8

Overexpression

Replicative

Inhibition

Fibroblast

TIG-3

No

1019

CDK4

Overexpression

Replicative

Inhibition

Foreskin fibroblast

BJ

No

1021

CDK6

Overexpression

Replicative

Inhibition

Foreskin fibroblast

BJ

No

7913

DEK

Overexpression

Replicative

Inhibition

Foreskin keratinocyte

Primary cell

No

1746

DLX2

Overexpression

Replicative

Inhibition

Foreskin fibroblast, Lung fibroblast

BJ, IMR-90

No

2353

FOS

Overexpression

Replicative

Inhibition

Lung fibroblast

WI-38

No

3397

ID1

Overexpression

Replicative

Inhibition

Dermal endothelial, Umbilical vein endothelial

Primary cell

No

79923

NANOG

Overexpression

Replicative

Inhibition

Dermal fibroblast, Fibroblast

NIH3T3, Oct4-GiP

Yes

10783

NEK6

Overexpression

Replicative

Inhibition

Bladder cancer, Lung cancer

EJ, NCI-H1299

Yes

8493

PPM1D

Overexpression

Replicative

Inhibition

Mesenchymal stem

Primary cell

No

27339

PRPF19

Overexpression

Replicative

Inhibition

Dermal fibroblast, Umbilical vein endothelial

Primary cell

No

5693

PSMB5

Overexpression

Replicative

Inhibition

Multipotent bone marrow stromal

Primary cell

No

6446

SGK1

Overexpression

Replicative

Inhibition

Umbilical vein endothelial

Primary cell

No

23411

SIRT1

Overexpression

Replicative

Inhibition

Lung fibroblast

2BS

No

7015

TERT

Overexpression

Replicative

Inhibition

Foreskin fibroblast, Retinal pigment epithelial

BJ, RPE-340

No

7114

TMSB4X

Overexpression

Replicative

Inhibition

Nucleus pulposus

Primary cell

No

7422

VEGFA

Overexpression

Replicative

Inhibition

Dermal endothelial

Primary cell

No

4101

MAGEA2

Overexpression

Oncogene-induced

Inhibition

Foreskin fibroblast

BJ

No

9759

HDAC4

Knockout, Overexpression

Replicative

Inhibition

Lung fibroblast

2BS

No

3309

HSPA5

Knockout, Overexpression

Stress-induced

Inhibition

Ovarian cancer

A2780

Yes

648

BMI1

Knockout, Overexpression

Replicative

Inhibition

Foreskin fibroblast, Lung fibroblast, Skin fibroblast

82-6, BJ, WI-38

No

672

BRCA1

Mutation

Stress-induced

Inhibition

Breast cancer

HBL100, HCC1937, MCF-7

Yes

47

ACLY

Knockout

Replicative

Inhibition

Dermal fibroblast

Primary cell

No

472

ATM

Knockout

Replicative

Inhibition

Foreskin fibroblast, Lung fibroblast

BJ, MRC-5, WI-38

No

84661

DPY30

Knockout

Replicative

Inhibition

Lung fibroblast

IMR-90

No

2539

G6PD

Knockout

Replicative

Inhibition

Foreskin fibroblast

Primary cell

No

3768

KCNJ12

Knockout

Stress-induced

Inhibition

Breast cancer, Gastric cancer, Prostate cancer

DU145, LNCaP, MCF-7, MKN74, PC-3, SK-BR3, SNU-484, SNU-638, SNU-668, T47D

Yes

4609

MYC

Knockout

Oncogene-induced

Inhibition

Fibroblast

LF1

No

4780

NFE2L2

Knockout

Replicative

Inhibition

Lung fibroblast

HFL-1

No

5948

RBP2

Knockout

Replicative

Inhibition

Cervical cancer, Gastric cancer

AGS, BGC-823, HeLa, HGC-27, KATO-III, SiHa

Yes

6829

SUPT5H

Knockout

Oncogene-induced

Inhibition

Cervical cancer

HeLa

Yes

10460

TACC3

Knockout

Stress-induced

Inhibition

Breast cancer

MCF-7

Yes

7014

TERF2

Knockout

Replicative

Inhibition

Neuroblastoma

SH-SY5Y

Yes

7490

WT1

Knockout

Oncogene-induced

Inhibition

Lung cancer

NCI-A549, NCI-H1299, NCI-H1437, NCI-H1568, NCI-H1650, NCI-H1975, NCI-H2009, NCI-H2126, NCI-H23, NCI-H358, NCI-H441, NCI-H460, NCI-H522, NCI-H727

Yes

7707

ZNF148

Knockout

Replicative

Inhibition

Lung cancer

NCI-H460

Yes

231

AKR1B1

Knockdown, Overexpression

Stress-induced

Inhibition

Keratinocyte

HaCat

Yes

23492

CBX7

Knockdown, Overexpression

Replicative

Inhibition

Keratinocyte, Lung fibroblast

Primary cell, WI-38

No

8087

FXR1

Knockdown, Overexpression

Replicative

Inhibition

Laryngeal cancer, Tongue cancer

CAL27, SCC25, SCC4, SCC9, UMSCC-11A, UMSCC-11B, UMSCC-74A, UMSCC-74B

Yes

55355

HJURP

Knockdown, Overexpression

Replicative

Inhibition

Dermal fibroblast, Umbilical vein endothelial

Primary cell

No

3316

HSPB2

Knockdown, Overexpression

Stress-induced

Inhibition

Breast epithelial

MCF-10A, MCF-7

No

3489

IGFBP6

Knockdown, Overexpression

Replicative

Inhibition

Fibroblast

Primary cell

No

4170

MCL1

Knockdown, Overexpression

Stress-induced

Inhibition

Colon cancer

HCT116

Yes

59277

NTN4

Knockdown, Overexpression

Stress-induced

Inhibition

Glioma

T98G, U-251MG, U-87MG, U-U118MG

Yes

23598

PATZ1

Knockdown, Overexpression

Replicative

Inhibition

Umbilical vein endothelial

Primary cell

No

11059

WWP1

Knockdown, Overexpression

Replicative

Inhibition

Lung fibroblast

2BS, WI-38

No

444

ASPH

Knockdown

Replicative

Inhibition

Liver cancer

FOCUS, HepG2, Huh7

Yes

55729

ATF7IP

Knockdown

Stress-induced

Inhibition

Lung fibroblast

IMR-90

No

6790

AURKA

Knockdown

Replicative

Inhibition

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

9531

BAG3

Knockdown

Replicative

Inhibition

Glioma, Laryngeal cancer

A172, HEp2

Yes

644

BLVRA

Knockdown

Stress-induced

Inhibition

Fibroblast

Primary cell

No

10950

BTG3

Knockdown

Replicative

Inhibition

Lung fibroblast

IMR-90, WI-38

No

983

CDK1

Knockdown

Replicative

Inhibition

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

8099

CDK2AP1

Knockdown

Replicative

Inhibition

Dermal fibroblast

Primary cell

No

1058

CENPA

Knockdown

Replicative

Inhibition

Lung fibroblast

TIG-3

No

1452

CSNK1A1

Knockdown

Replicative

Inhibition

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

1457

CSNK2A1

Knockdown

Replicative

Inhibition

Lung fibroblast

IMR-90

No

8727

CTNNAL1

Knockdown

Replicative

Inhibition

Lung cancer, Squamous carcinoma

A549, OC2

Yes

54487

DGCR8

Knockdown

Replicative

Inhibition

Lung fibroblast

IMR-90

No

1660

DHX9

Knockdown

Replicative

Inhibition

Lung fibroblast

MRC-5

No

80824

DUSP16

Knockdown

Replicative

Inhibition

Embryonic kidney, Liver cancer

HEK293FT, HepG2, PLC/PRF/5

Yes

1845

DUSP3

Knockdown

Replicative

Inhibition

Cervical cancer

HeLa

Yes

2021

ENDOG

Knockdown

Replicative

Inhibition

Endothelial

Primary cell

No

2042

EPHA3

Knockdown

Replicative

Inhibition

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

2146

EZH2

Knockdown

Stress-induced

Inhibition

Gastric cancer

SGC-7901

Yes

2305

FOXM1

Knockdown

Replicative

Inhibition

Gallbladder cancer

GBC-SD

Yes

2309

FOXO3

Knockdown

Replicative

Inhibition

Dermal fibroblast

Primary cell

No

2597

GAPDH

Knockdown

Replicative

Inhibition

Lung cancer

A549

Yes

2720

GLB1

Knockdown

Replicative

Inhibition

Foreskin fibroblast

Primary cell

No

3096

HIVEP1

Knockdown

Replicative

Inhibition

Foreskin fibroblast

Primary cell

No

3146

HMGB1

Knockdown

Replicative

Inhibition

Lung cancer, Melanoma

A375, G361, NCI-H1299, SK-MEL-28

Yes

10765

KDM5B

Knockdown

Replicative

Inhibition

Colon cancer

Colo201, DLD1, HCT116

Yes

57650

KIAA1524

Knockdown

Replicative

Inhibition

Gastric cancer

AGS, BGC-823, HGC-27, KATO-III

Yes

9365

KL

Knockdown

Replicative

Inhibition

Lung fibroblast

MRC-5, WI-38

No

9113

LATS1

Knockdown

Replicative

Inhibition

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

3958

LGALS3

Knockdown

Replicative

Inhibition

Gastric cancer

AGS, KATO-III, MKN28, SNU-1, SNU-16, SNU-216, SNU-5, SNU-601, SNU-638, SNU-668, SNU-719, YCC-2

Yes

51474

LIMA1

Knockdown

Replicative, Stress-induced

Inhibition

Lung fibroblast

IMR-90

No

4085

MAD2L1

Knockdown

Replicative

Inhibition

Breast epithelial, Lung fibroblast

IMR-90, MCF-10A

No

4116

MAGOH

Knockdown

Replicative, Stress-induced

Inhibition

Lung fibroblast

IMR-90

No

55110

MAGOHB

Knockdown

Replicative, Stress-induced

Inhibition

Lung fibroblast

IMR-90

No

5606

MAP2K3

Knockdown

Replicative

Inhibition

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

11184

MAP4K1

Knockdown

Replicative

Inhibition

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

54708

5-Mar

Knockdown

Replicative

Inhibition

Cervical cancer

HeLa

Yes

4190

MDH1

Knockdown

Replicative

Inhibition

Dermal fibroblast, Lung fibroblast

IMR-90, Primary cell

No

4204

MECP2

Knockdown

Replicative

Inhibition

Mesenchymal stem

Primary cell

No

4318

MMP9

Knockdown

Replicative

Inhibition

Medulloblastoma

DAOY

Yes

4638

MYLK

Knockdown

Replicative

Inhibition

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

4750

NEK1

Knockdown

Replicative

Inhibition

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

64175

P3H1

Knockdown

Replicative, Stress-induced

Inhibition

Lung fibroblast

IMR-90

No

25913

POT1

Knockdown

Replicative

Inhibition

Lung fibroblast

IMR-90

No

5495

PPM1B

Knockdown

Replicative

Inhibition

Lung fibroblast

IMR-90

No

55170

PRMT6

Knockdown

Replicative

Inhibition

Breast cancer, Breast epithelial

MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3

Yes

10213

PSMD14

Knockdown

Replicative

Inhibition

Breast cancer, Cervical cancer, Colorectal cancer, Glioma, Lung cancer, Melanoma, Ovarian cancer, Pancreatic cancer, Prostate cancer

A427, A549, BTS49-SK-OV-3, DU145, HCC1937, HCT116, HeLa, Mia PaCa-2, NCI-H1299, NCI-H23, NCI-H460, NCI-H522, SK-BR-3, SK-LU-1, SK-MEL-2, SNB-75

Yes

5885

RAD21

Knockdown

Replicative

Inhibition

Breast cancer

MDA-MB-231

No

9978

RBX1

Knockdown

Replicative

Inhibition

Glioblastoma, Lung cancer

U87

Yes

10856

RUVBL2

Knockdown

Replicative

Inhibition

Kidney cancer

A498, KRC/Y

Yes

280636

SELENOH

Knockdown

Replicative

Inhibition

Lung fibroblast

MRC-5

No

29843

SENP1

Knockdown

Replicative

Inhibition

Foreskin fibroblast

Primary cell

No

59343

SENP2

Knockdown

Replicative

Inhibition

Foreskin fibroblast

Primary cell

No

57337

SENP7

Knockdown

Replicative

Inhibition

Foreskin fibroblast

Primary cell

No

51548

SIRT6

Knockdown

Replicative

Inhibition

Chondrocyte

NHAC-kn

No

6495

SIX1

Knockdown

Replicative

Inhibition

Lung fibroblast

IMR-90

No

9194

SLC16A7

Knockdown

Replicative

Inhibition

Colon cancer, Gastric cancer

DLD1, HCT116, HCT8, HT29, LoVo, MKN45, MKN74, SW480

Yes

6597

SMARCA4

Knockdown

Replicative

Inhibition

Mesenchymal stem

Primary cell

No

23049

SMG1

Knockdown

Replicative

Inhibition

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

6615

SNAI1

Knockdown

Replicative

Inhibition

Prostate cancer

LNCaP, PC-3

Yes

6647

SOD1

Knockdown

Replicative

Inhibition

Lung fibroblast

WI-38, WI38-SV40

No

6909

TBX2

Knockdown

Replicative

Inhibition

Melanoma

B16

Yes

7012

TERC

Knockdown

Replicative

Inhibition

Cervical cancer

HeLa

Yes

7027

TFDP1

Knockdown

Replicative

Inhibition

Cervical cancer, Lung cancer, Lung fibroblast

A549, HeLa, WI-38

Yes

8741

TNFSF13

Knockdown

Replicative

Inhibition

Colon cancer

SW480

Yes

7175

TPR

Knockdown

Replicative

Inhibition

Cervical cancer, Melanoma, Osteosarcoma

A375, HeLa, U2OS

Yes

79054

TRPM8

Knockdown

Replicative

Inhibition

Pancreatic cancer

BxPC-3, PANC-1

Yes

7295

TXN

Knockdown

Replicative

Inhibition

Foreskin fibroblast

BJ, BJE-LT

No

7398

USP1

Knockdown

Oncogene-induced

Inhibition

Foreskin fibroblast, Lung fibroblast

BJ, WI-38

No

7472

WNT2

Knockdown

Replicative

Inhibition

Lung fibroblast

WI-38

No

7486

WRN

Knockdown

Oncogene-induced

Inhibition

Fibroblast, WRN syndrome fibroblast

AG00780, AG03141

Yes

10413

YAP1

Knockdown

Replicative

Inhibition

Foreskin fibroblast, Lung fibroblast

BJ, IMR-90, WI-38

No

64393

ZMAT3

Knockdown

Replicative

Inhibition

Breast cancer, Dermal fibroblast, Embryonic kidney, Osteosarcoma

HEK293T, MCF-7, U2OS

Yes

Reference: HAGR