Genes inhibiting senescence

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Entrez Id


Gene Symbol


Method


Senescence Type


Effect on senescence


Cell Types


Cell Lines


Cancer Line


6714


SRC


Overexpression


Stress-induced


Inhibition


Fibrosarcoma


HT1080


Yes


604


BCL6


Overexpression


Replicative


Inhibition


B-cell


Primary cell


No


57332


CBX8


Overexpression


Replicative


Inhibition


Fibroblast


TIG-3


No


1019


CDK4


Overexpression


Replicative


Inhibition


Foreskin fibroblast


BJ


No


1021


CDK6


Overexpression


Replicative


Inhibition


Foreskin fibroblast


BJ


No


7913


DEK


Overexpression


Replicative


Inhibition


Foreskin keratinocyte


Primary cell


No


1746


DLX2


Overexpression


Replicative


Inhibition


Foreskin fibroblast, Lung fibroblast


BJ, IMR-90


No


2353


FOS


Overexpression


Replicative


Inhibition


Lung fibroblast


WI-38


No


3397


ID1


Overexpression


Replicative


Inhibition


Dermal endothelial, Umbilical vein endothelial


Primary cell


No


79923


NANOG


Overexpression


Replicative


Inhibition


Dermal fibroblast, Fibroblast


NIH3T3, Oct4-GiP


Yes


10783


NEK6


Overexpression


Replicative


Inhibition


Bladder cancer, Lung cancer


EJ, NCI-H1299


Yes


8493


PPM1D


Overexpression


Replicative


Inhibition


Mesenchymal stem


Primary cell


No


27339


PRPF19


Overexpression


Replicative


Inhibition


Dermal fibroblast, Umbilical vein endothelial


Primary cell


No


5693


PSMB5


Overexpression


Replicative


Inhibition


Multipotent bone marrow stromal


Primary cell


No


6446


SGK1


Overexpression


Replicative


Inhibition


Umbilical vein endothelial


Primary cell


No


23411


SIRT1


Overexpression


Replicative


Inhibition


Lung fibroblast


2BS


No


7015


TERT


Overexpression


Replicative


Inhibition


Foreskin fibroblast, Retinal pigment epithelial


BJ, RPE-340


No


7114


TMSB4X


Overexpression


Replicative


Inhibition


Nucleus pulposus


Primary cell


No


7422


VEGFA


Overexpression


Replicative


Inhibition


Dermal endothelial


Primary cell


No


4101


MAGEA2


Overexpression


Oncogene-induced


Inhibition


Foreskin fibroblast


BJ


No


9759


HDAC4


Knockout, Overexpression


Replicative


Inhibition


Lung fibroblast


2BS


No


3309


HSPA5


Knockout, Overexpression


Stress-induced


Inhibition


Ovarian cancer


A2780


Yes


648


BMI1


Knockout, Overexpression


Replicative


Inhibition


Foreskin fibroblast, Lung fibroblast, Skin fibroblast


82-6, BJ, WI-38


No


672


BRCA1


Mutation


Stress-induced


Inhibition


Breast cancer


HBL100, HCC1937, MCF-7


Yes


47


ACLY


Knockout


Replicative


Inhibition


Dermal fibroblast


Primary cell


No


472


ATM


Knockout


Replicative


Inhibition


Foreskin fibroblast, Lung fibroblast


BJ, MRC-5, WI-38


No


84661


DPY30


Knockout


Replicative


Inhibition


Lung fibroblast


IMR-90


No


2539


G6PD


Knockout


Replicative


Inhibition


Foreskin fibroblast


Primary cell


No


3768


KCNJ12


Knockout


Stress-induced


Inhibition


Breast cancer, Gastric cancer, Prostate cancer


DU145, LNCaP, MCF-7, MKN74, PC-3, SK-BR3, SNU-484, SNU-638, SNU-668, T47D


Yes


4609


MYC


Knockout


Oncogene-induced


Inhibition


Fibroblast


LF1


No


4780


NFE2L2


Knockout


Replicative


Inhibition


Lung fibroblast


HFL-1


No


5948


RBP2


Knockout


Replicative


Inhibition


Cervical cancer, Gastric cancer


AGS, BGC-823, HeLa, HGC-27, KATO-III, SiHa


Yes


6829


SUPT5H


Knockout


Oncogene-induced


Inhibition


Cervical cancer


HeLa


Yes


10460


TACC3


Knockout


Stress-induced


Inhibition


Breast cancer


MCF-7


Yes


7014


TERF2


Knockout


Replicative


Inhibition


Neuroblastoma


SH-SY5Y


Yes


7490


WT1


Knockout


Oncogene-induced


Inhibition


Lung cancer


NCI-A549, NCI-H1299, NCI-H1437, NCI-H1568, NCI-H1650, NCI-H1975, NCI-H2009, NCI-H2126, NCI-H23, NCI-H358, NCI-H441, NCI-H460, NCI-H522, NCI-H727


Yes


7707


ZNF148


Knockout


Replicative


Inhibition


Lung cancer


NCI-H460


Yes


231


AKR1B1


Knockdown, Overexpression


Stress-induced


Inhibition


Keratinocyte


HaCat


Yes


23492


CBX7


Knockdown, Overexpression


Replicative


Inhibition


Keratinocyte, Lung fibroblast


Primary cell, WI-38


No


8087


FXR1


Knockdown, Overexpression


Replicative


Inhibition


Laryngeal cancer, Tongue cancer


CAL27, SCC25, SCC4, SCC9, UMSCC-11A, UMSCC-11B, UMSCC-74A, UMSCC-74B


Yes


55355


HJURP


Knockdown, Overexpression


Replicative


Inhibition


Dermal fibroblast, Umbilical vein endothelial


Primary cell


No


3316


HSPB2


Knockdown, Overexpression


Stress-induced


Inhibition


Breast epithelial


MCF-10A, MCF-7


No


3489


IGFBP6


Knockdown, Overexpression


Replicative


Inhibition


Fibroblast


Primary cell


No


4170


MCL1


Knockdown, Overexpression


Stress-induced


Inhibition


Colon cancer


HCT116


Yes


59277


NTN4


Knockdown, Overexpression


Stress-induced


Inhibition


Glioma


T98G, U-251MG, U-87MG, U-U118MG


Yes


23598


PATZ1


Knockdown, Overexpression


Replicative


Inhibition


Umbilical vein endothelial


Primary cell


No


11059


WWP1


Knockdown, Overexpression


Replicative


Inhibition


Lung fibroblast


2BS, WI-38


No


444


ASPH


Knockdown


Replicative


Inhibition


Liver cancer


FOCUS, HepG2, Huh7


Yes


55729


ATF7IP


Knockdown


Stress-induced


Inhibition


Lung fibroblast


IMR-90


No


6790


AURKA


Knockdown


Replicative


Inhibition


Embryonic kidney, Retinal pigment epithelial


HEK293T, hTERT-RPE1


Yes


9531


BAG3


Knockdown


Replicative


Inhibition


Glioma, Laryngeal cancer


A172, HEp2


Yes


644


BLVRA


Knockdown


Stress-induced


Inhibition


Fibroblast


Primary cell


No


10950


BTG3


Knockdown


Replicative


Inhibition


Lung fibroblast


IMR-90, WI-38


No


983


CDK1


Knockdown


Replicative


Inhibition


Embryonic kidney, Retinal pigment epithelial


HEK293T, hTERT-RPE1


Yes


8099


CDK2AP1


Knockdown


Replicative


Inhibition


Dermal fibroblast


Primary cell


No


1058


CENPA


Knockdown


Replicative


Inhibition


Lung fibroblast


TIG-3


No


1452


CSNK1A1


Knockdown


Replicative


Inhibition


Embryonic kidney, Retinal pigment epithelial


HEK293T, hTERT-RPE1


Yes


1457


CSNK2A1


Knockdown


Replicative


Inhibition


Lung fibroblast


IMR-90


No


8727


CTNNAL1


Knockdown


Replicative


Inhibition


Lung cancer, Squamous carcinoma


A549, OC2


Yes


54487


DGCR8


Knockdown


Replicative


Inhibition


Lung fibroblast


IMR-90


No


1660


DHX9


Knockdown


Replicative


Inhibition


Lung fibroblast


MRC-5


No


80824


DUSP16


Knockdown


Replicative


Inhibition


Embryonic kidney, Liver cancer


HEK293FT, HepG2, PLC/PRF/5


Yes


1845


DUSP3


Knockdown


Replicative


Inhibition


Cervical cancer


HeLa


Yes


2021


ENDOG


Knockdown


Replicative


Inhibition


Endothelial


Primary cell


No


2042


EPHA3


Knockdown


Replicative


Inhibition


Embryonic kidney, Retinal pigment epithelial


HEK293T, hTERT-RPE1


Yes


2146


EZH2


Knockdown


Stress-induced


Inhibition


Gastric cancer


SGC-7901


Yes


2305


FOXM1


Knockdown


Replicative


Inhibition


Gallbladder cancer


GBC-SD


Yes


2309


FOXO3


Knockdown


Replicative


Inhibition


Dermal fibroblast


Primary cell


No


2597


GAPDH


Knockdown


Replicative


Inhibition


Lung cancer


A549


Yes


2720


GLB1


Knockdown


Replicative


Inhibition


Foreskin fibroblast


Primary cell


No


3096


HIVEP1


Knockdown


Replicative


Inhibition


Foreskin fibroblast


Primary cell


No


3146


HMGB1


Knockdown


Replicative


Inhibition


Lung cancer, Melanoma


A375, G361, NCI-H1299, SK-MEL-28


Yes


10765


KDM5B


Knockdown


Replicative


Inhibition


Colon cancer


Colo201, DLD1, HCT116


Yes


57650


KIAA1524


Knockdown


Replicative


Inhibition


Gastric cancer


AGS, BGC-823, HGC-27, KATO-III


Yes


9365


KL


Knockdown


Replicative


Inhibition


Lung fibroblast


MRC-5, WI-38


No


9113


LATS1


Knockdown


Replicative


Inhibition


Embryonic kidney, Retinal pigment epithelial


HEK293T, hTERT-RPE1


Yes


3958


LGALS3


Knockdown


Replicative


Inhibition


Gastric cancer


AGS, KATO-III, MKN28, SNU-1, SNU-16, SNU-216, SNU-5, SNU-601, SNU-638, SNU-668, SNU-719, YCC-2


Yes


51474


LIMA1


Knockdown


Replicative, Stress-induced


Inhibition


Lung fibroblast


IMR-90


No


4085


MAD2L1


Knockdown


Replicative


Inhibition


Breast epithelial, Lung fibroblast


IMR-90, MCF-10A


No


4116


MAGOH


Knockdown


Replicative, Stress-induced


Inhibition


Lung fibroblast


IMR-90


No


55110


MAGOHB


Knockdown


Replicative, Stress-induced


Inhibition


Lung fibroblast


IMR-90


No


5606


MAP2K3


Knockdown


Replicative


Inhibition


Embryonic kidney, Retinal pigment epithelial


HEK293T, hTERT-RPE1


Yes


11184


MAP4K1


Knockdown


Replicative


Inhibition


Embryonic kidney, Retinal pigment epithelial


HEK293T, hTERT-RPE1


Yes


54708


5-Mar


Knockdown


Replicative


Inhibition


Cervical cancer


HeLa


Yes


4190


MDH1


Knockdown


Replicative


Inhibition


Dermal fibroblast, Lung fibroblast


IMR-90, Primary cell


No


4204


MECP2


Knockdown


Replicative


Inhibition


Mesenchymal stem


Primary cell


No


4318


MMP9


Knockdown


Replicative


Inhibition


Medulloblastoma


DAOY


Yes


4638


MYLK


Knockdown


Replicative


Inhibition


Embryonic kidney, Retinal pigment epithelial


HEK293T, hTERT-RPE1


Yes


4750


NEK1


Knockdown


Replicative


Inhibition


Embryonic kidney, Retinal pigment epithelial


HEK293T, hTERT-RPE1


Yes


64175


P3H1


Knockdown


Replicative, Stress-induced


Inhibition


Lung fibroblast


IMR-90


No


25913


POT1


Knockdown


Replicative


Inhibition


Lung fibroblast


IMR-90


No


5495


PPM1B


Knockdown


Replicative


Inhibition


Lung fibroblast


IMR-90


No


55170


PRMT6


Knockdown


Replicative


Inhibition


Breast cancer, Breast epithelial


MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3


Yes


10213


PSMD14


Knockdown


Replicative


Inhibition


Breast cancer, Cervical cancer, Colorectal cancer, Glioma, Lung cancer, Melanoma, Ovarian cancer, Pancreatic cancer, Prostate cancer


A427, A549, BTS49-SK-OV-3, DU145, HCC1937, HCT116, HeLa, Mia PaCa-2, NCI-H1299, NCI-H23, NCI-H460, NCI-H522, SK-BR-3, SK-LU-1, SK-MEL-2, SNB-75


Yes


5885


RAD21


Knockdown


Replicative


Inhibition


Breast cancer


MDA-MB-231


No


9978


RBX1


Knockdown


Replicative


Inhibition


Glioblastoma, Lung cancer


U87


Yes


10856


RUVBL2


Knockdown


Replicative


Inhibition


Kidney cancer


A498, KRC/Y


Yes


280636


SELENOH


Knockdown


Replicative


Inhibition


Lung fibroblast


MRC-5


No


29843


SENP1


Knockdown


Replicative


Inhibition


Foreskin fibroblast


Primary cell


No


59343


SENP2


Knockdown


Replicative


Inhibition


Foreskin fibroblast


Primary cell


No


57337


SENP7


Knockdown


Replicative


Inhibition


Foreskin fibroblast


Primary cell


No


51548


SIRT6


Knockdown


Replicative


Inhibition


Chondrocyte


NHAC-kn


No


6495


SIX1


Knockdown


Replicative


Inhibition


Lung fibroblast


IMR-90


No


9194


SLC16A7


Knockdown


Replicative


Inhibition


Colon cancer, Gastric cancer


DLD1, HCT116, HCT8, HT29, LoVo, MKN45, MKN74, SW480


Yes


6597


SMARCA4


Knockdown


Replicative


Inhibition


Mesenchymal stem


Primary cell


No


23049


SMG1


Knockdown


Replicative


Inhibition


Embryonic kidney, Retinal pigment epithelial


HEK293T, hTERT-RPE1


Yes


6615


SNAI1


Knockdown


Replicative


Inhibition


Prostate cancer


LNCaP, PC-3


Yes


6647


SOD1


Knockdown


Replicative


Inhibition


Lung fibroblast


WI-38, WI38-SV40


No


6909


TBX2


Knockdown


Replicative


Inhibition


Melanoma


B16


Yes


7012


TERC


Knockdown


Replicative


Inhibition


Cervical cancer


HeLa


Yes


7027


TFDP1


Knockdown


Replicative


Inhibition


Cervical cancer, Lung cancer, Lung fibroblast


A549, HeLa, WI-38


Yes


8741


TNFSF13


Knockdown


Replicative


Inhibition


Colon cancer


SW480


Yes


7175


TPR


Knockdown


Replicative


Inhibition


Cervical cancer, Melanoma, Osteosarcoma


A375, HeLa, U2OS


Yes


79054


TRPM8


Knockdown


Replicative


Inhibition


Pancreatic cancer


BxPC-3, PANC-1


Yes


7295


TXN


Knockdown


Replicative


Inhibition


Foreskin fibroblast


BJ, BJE-LT


No


7398


USP1


Knockdown


Oncogene-induced


Inhibition


Foreskin fibroblast, Lung fibroblast


BJ, WI-38


No


7472


WNT2


Knockdown


Replicative


Inhibition


Lung fibroblast


WI-38


No


7486


WRN


Knockdown


Oncogene-induced


Inhibition


Fibroblast, WRN syndrome fibroblast


AG00780, AG03141


Yes


10413


YAP1


Knockdown


Replicative


Inhibition


Foreskin fibroblast, Lung fibroblast


BJ, IMR-90, WI-38


No


64393


ZMAT3


Knockdown


Replicative


Inhibition


Breast cancer, Dermal fibroblast, Embryonic kidney, Osteosarcoma


HEK293T, MCF-7, U2OS


Yes

Reference: HAGR


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