Genes inducing senescence

[raw]











































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































Entrez Id


Gene Symbol


Method


Senescence Type


Effect on senescence


Cell Types


Cell Lines


Cancer Line


3400


ID4


Overexpression


Stress-induced


Induction


Prostate cancer


DU145


Yes


5824


PEX19


Overexpression


Stress-induced


Induction


Osteosarcoma


U2OS


Yes


8553


BHLHE40


Overexpression


Replicative, Stress-induced


Induction


Breast cancer, Esophageal cancer


EC9706, MCF-7


Yes


7157


TP53


Overexpression


Replicative, Stress-induced


Induction


Bladder cancer


EJ


Yes


80019


UBTD1


Overexpression


Replicative, Stress-induced


Induction


Breast cancer, Colorectal cancer, Gastric cancer, Gastric epithelial, Lung fibroblast, Prostate cancer


AGS, GES-1, KATO-III, LoVo, MCF-7, MKN28, MKN45, MRC-5, NCI-N87, PC-3, SGC-7901, SNU-1, SNU-16


Yes


51225


ABI3


Overexpression


Replicative


Induction


Colon cancer, Thyroid cancer


ARO, WRO


Yes


203054


ADCK5


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


247


ALOX15B


Overexpression


Replicative


Induction


Prostate epithelial


Primary cell


No


10095


ARPC1B


Overexpression


Replicative


Induction


Osteosarcoma


SaOs-2


Yes


558


AXL


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


640


BLK


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


595


CCND1


Overexpression


Replicative


Induction


Fibroblast


Hs68, WI-38


No


5129


CDK18


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


1027


CDKN1B


Overexpression


Replicative


Induction


Lung fibroblast


TIG-3


No


1028


CDKN1C


Overexpression


Replicative


Induction


Liver cancer


HepG2, SNU-398


Yes


1029


CDKN2A


Overexpression


Replicative


Induction


Lung fibroblast


TIG-3


No


55602


CDKN2AIP


Overexpression


Replicative


Induction


Lung fibroblast


MRC-5, TIG-1


No


1030


CDKN2B


Overexpression


Replicative


Induction


Glioblastoma


T98G, U-251MG, U-373MG


Yes


1152


CKB


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


3576


CXCL8


Overexpression


Replicative


Induction


Foreskin fibroblast, Lung fibroblast


BJ, IMR-90, WI-38


No


3491


CYR61


Overexpression


Replicative


Induction


Foreskin fibroblast, Lung fibroblast


BJ, IMR-90


No


1869


E2F1


Overexpression


Replicative


Induction


Lung fibroblast


WI-38


No


26298


EHF


Overexpression


Replicative


Induction


Lung fibroblast


WI-38


No


54206


ERRFI1


Overexpression


Replicative


Induction


Lung fibroblast


WI-38


No


10922


FASTK


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


79791


FBXO31


Overexpression


Replicative


Induction


Breast cancer


MCF-7


Yes


56287


GKN1


Overexpression


Replicative


Induction


Gastric cancer


AGS, MKN1


Yes


2870


GRK6


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


3065


HDAC1


Overexpression


Replicative


Induction


Cervical cancer


HeLa


Yes


220296


HEPACAM


Overexpression


Replicative


Induction


Breast cancer


MCF-7


Yes


3101


HK3


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


3458


IFNG


Overexpression


Replicative


Induction


Umbilical vein endothelial


Primary cell


No


3484


IGFBP1


Overexpression


Replicative


Induction


Breast cancer


MCF-7


Yes


3621


ING1


Overexpression


Replicative


Induction


Foreskin fibroblast


Hs68


No


3661


IRF3


Overexpression


Replicative


Induction


Foreskin fibroblast


BJ


No


3663


IRF5


Overexpression


Replicative


Induction


Li Fraumeni syndrome fibroblast


MDAH041


Yes


3665


IRF7


Overexpression


Replicative


Induction


Li Fraumeni syndrome fibroblast


MDAH041


Yes


3705


ITPK1


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


3707


ITPKB


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


3984


LIMK1


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


5604


MAP2K1


Overexpression


Replicative


Induction


Intestinal epithelial


HIEC-6


No


5608


MAP2K6


Overexpression


Replicative


Induction


Osteosarcoma


U2OS


Yes


5609


MAP2K7


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


9064


MAP3K6


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


6885


MAP3K7


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


6300


MAPK12


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


22983


MAST1


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


4145


MATK


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


10445


MCRS1


Overexpression


Replicative


Induction


Foreskin fibroblast, Lung fibroblast, Mammary epithelial


H184B5F5/M10, Hs68, IMR-90


No


126308


MOB3A


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


23515


MORC3


Overexpression


Replicative


Induction


Lung fibroblast


WI-38


No


10934


MORF4


Overexpression


Replicative


Induction


Fibrosarcoma


A9, HT1080


Yes


4598


MVK


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


10608


MXD4


Overexpression


Replicative


Induction


Lung fibroblast


WI-38


No


65220


NADK


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


4814


NINJ1


Overexpression


Replicative


Induction


Hepatoma


Huh7


Yes


5015


OTX2


Overexpression


Replicative


Induction


Medulloblastoma


D283, D341, D425, D458, D556, DAOY, MED8A, UW228-2


Yes


10298


PAK4


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


149420


PDIK1L


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


5170


PDPK1


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


23037


PDZD2


Overexpression


Replicative


Induction


Breast cancer, Liver cancer, Prostate cancer


DU145


Yes


51588


PIAS4


Overexpression


Replicative


Induction


Lung fibroblast


WI-38


No


23533


PIK3R5


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


5315


PKM


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


10654


PMVK


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


87178


PNPT1


Overexpression


Replicative


Induction


Melanoma


FO-1, HO-1, MeWo


Yes


5460


POU5F1


Overexpression


Replicative


Induction


Mesenchymal stromal


Primary cell


No


5629


PROX1


Overexpression


Replicative


Induction


Liver cancer


Hep3B, HepG2, Mahlavu, SK-HEP1


Yes


9232


PTTG1


Overexpression


Replicative


Induction


Foreskin fibroblast, Lung fibroblast


BJ, IMR-90, WI-38


No


861


RUNX1


Overexpression


Replicative


Induction


Foreskin fibroblast


Hs68


No


150094


SIK1


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


64849


SLC13A3


Overexpression


Replicative


Induction


Lung fibroblast, Renal tubular


MRC-5, WI-38


No


6598


SMARCB1


Overexpression


Replicative


Induction


Malignant rhabdoid tumor


G-401


Yes


64750


SMURF2


Overexpression


Replicative


Induction


Foreskin fibroblast, Lung fibroblast, Skin fibroblast


BJ, WI-38, WS1


No


8470


SORBS2


Overexpression


Replicative


Induction


Fibroblast, Keratinocyte


Primary cell


No


6657


SOX2


Overexpression


Replicative


Induction


Colon cancer, Embryonic kidney


HCT116, HEK293T, WiDr


Yes


6667


SP1


Overexpression


Replicative


Induction


Lung fibroblast


2BS


No


10927


SPIN1


Overexpression


Replicative


Induction


Cervical cancer


HeLa


Yes


6720


SREBF1


Overexpression


Replicative


Induction


Fibroblast


Primary cell


No


6777


STAT5B


Overexpression


Replicative


Induction


Lung fibroblast


IMR-90


No


282974


STK32C


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


83931


STK40


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


6850


SYK


Overexpression


Replicative


Induction


Melanoma


501-mel, A375, SK-MEL-28


Yes


7023


TFAP4


Overexpression


Replicative


Induction


Breast cancer, Retinal pigment epithelial


hTERT-RPE, MCF-7


Yes


7098


TLR3


Overexpression


Replicative


Induction


Fibroblast, Keratinocyte


Primary cell


No


7297


TYK2


Overexpression


Replicative


Induction


Embryonic kidney, Lung fibroblast


HEK293T, IMR-90, MRC-5


No


7538


ZFP36


Overexpression


Replicative


Induction


Cervical cancer


HeLa


Yes


207


AKT1


Overexpression


Oncogene-induced


Induction


Aortic endothelial, Dermal microvascular endothelial cells, Umbilical vein endothelial


Primary cell


No


673


BRAF


Overexpression


Oncogene-induced


Induction


Foreskin fibroblast, Melanocyte


BJ, Primary cell


No


2919


CXCL1


Overexpression


Oncogene-induced


Induction


Ovarian fibroblast


Gro-1


No


2113


ETS1


Overexpression


Oncogene-induced


Induction


Foreskin fibroblast, Lung fibroblast


Hs68, TIG-3


No


2114


ETS2


Overexpression


Oncogene-induced


Induction


Foreskin fibroblast, Lung fibroblast


Hs68, TIG-3


No


3265


HRAS


Overexpression


Oncogene-induced


Induction


Lung fibroblast


IMR-90, WI-38


No


5605


MAP2K2


Overexpression


Oncogene-induced


Induction


Lung fibroblast


IMR-90


No


5371


PML


Overexpression


Oncogene-induced


Induction


Lung fibroblast


WI-38


No


5894


RAF1


Overexpression


Oncogene-induced


Induction


Lung fibroblast


IMR-90


No


2810


SFN


Overexpression


Oncogene-induced


Induction


Melanoma


SK-MEL-147, SK-MEL-19, SK-MEL-29


Yes


6660


SOX5


Overexpression


Oncogene-induced


Induction


Glioma


U-1242MG, U-178MG, U-251MG, U-343MG, U-343MGa


Yes


6426


SRSF1


Overexpression


Oncogene-induced


Induction


Foreskin fibroblast


BJ


No


1718


DHCR24


Mutation


Oncogene-induced


Induction


Lung fibroblast


WI-38


No


183


AGT


Knockout, Overexpression


Replicative


Induction


Vascular smooth muscle


Primary cell


No


25842


ASF1A


Knockout, Overexpression


Oncogene-induced, Replicative


Induction


Lung fibroblast


Primary cell


No


64506


CPEB1


Knockout, Overexpression


Replicative


Induction


Foreskin fibroblast, Lung fibroblast


Primary cell, WI-38


No


2791


GNG11


Knockout, Overexpression


Replicative


Induction


Lung fibroblast


TIG-7


No


3488


IGFBP5


Knockout, Overexpression


Replicative


Induction


Umbilical vein endothelial


Primary cell


No


3622


ING2


Knockout, Overexpression


Replicative


Induction


Lung fibroblast


MRC-5


No


9891


NUAK1


Knockout, Overexpression


Replicative


Induction


Lung fibroblast


WI-38


No


7703


PCGF2


Knockout, Overexpression


Replicative


Induction


Foreskin fibroblast, Lung fibroblast


BJ, MRC-5, WI-38


No


22925


PLA2R1


Knockout, Overexpression


Replicative


Induction


Lung fibroblast


IMR-90, WI-38


No


6041


RNASEL


Knockout, Overexpression


Replicative


Induction


Lung fibroblast


WI-38


No


26156


RSL1D1


Knockout, Overexpression


Replicative


Induction


Lung fibroblast


2BS


No


23309


SIN3B


Knockout, Overexpression


Replicative


Induction


Lung fibroblast


IMR-90


No


7041


TGFB1I1


Knockout, Overexpression


Replicative


Induction


Fibroblast


KMST-6, SUSM-1


No


9966


TNFSF15


Knockout, Overexpression


Replicative


Induction


Endothelial progenitor


Primary cell


No


10628


TXNIP


Knockout, Overexpression


Oncogene-induced, Replicative


Induction


Lung fibroblast


2BS


No


1026


CDKN1A


Knockout


Replicative


Induction


Fibroblast


LF1


No


1111


CHEK1


Knockout


Stress-induced


Induction


Colon cancer


HCT116


Yes


1643


DDB2


Knockout


Oncogene-induced


Induction


Lung fibroblast


IMR-90


No


2130


EWSR1


Knockout


Replicative


Induction


Hematopoietic stem


Primary cell


No


3552


IL1A


Knockout


Replicative


Induction


Umbilical vein endothelial


Primary cell


No


1432


MAPK14


Knockout


Replicative, Stress-induced


Induction


Lung fibroblast


MRC-5, WI-38


No


8550


MAPKAPK5


Knockout


Oncogene-induced


Induction


Foreskin fibroblast


BJ


No


11235


PDCD10


Knockout


Oncogene-induced, Replicative


Induction


Coronary artery endothelial, Lung fibroblast


IMR-90, Primary cell


No


7150


TOP1


Knockout


Replicative


Induction


Lung fibroblast


IMR-90, WI-38


No


8626


TP63


Knockout


Replicative


Induction


Foreskin fibroblast


BJ


No


10155


TRIM28


Knockout


Oncogene-induced


Induction


Lung fibroblast


IMR-90


No


367


AR


Knockdown, Overexpression


Replicative


Induction


Hair follicular keratinocyte


Primary cell


No


284119


CAVIN1


Knockdown, Overexpression


Replicative


Induction


Cervical cancer, Lung fibroblast


HeLa, IMR-90, WI-38


No


1051


CEBPB


Knockdown, Overexpression


Stress-induced


Induction


Prostate cancer


LNCaP


Yes


2626


GATA4


Knockdown, Overexpression


Replicative, Stress-induced


Induction


Foreskin fibroblast, Lung fibroblast


BJ, IMR-90


No


50618


ITSN2


Knockdown, Overexpression


Stress-induced


Induction


Foreskin fibroblast, Lung fibroblast


Hs68, WI-38


No


50507


NOX4


Knockdown, Overexpression


Replicative


Induction


Breast epithelial, Lung fibroblast


MCF-12A, TIG-3


No


5037


PEBP1


Knockdown, Overexpression


Stress-induced


Induction


Colon cancer, Gastric cancer, Lung cancer, Prostate cancer


A549, HCT116, MKN45, PC-3


Yes


5292


PIM1


Knockdown, Overexpression


Oncogene-induced, Replicative


Induction


Foreskin fibroblast, Lung fibroblast


2BS, BJ, WI-38


No


5580


PRKCD


Knockdown, Overexpression


Replicative


Induction


Lung fibroblast


TIG-1


No


5583


PRKCH


Knockdown, Overexpression


Stress-induced


Induction


Breast cancer


MCF-7


Yes


27330


RPS6KA6


Knockdown, Overexpression


Replicative


Induction


Colon cancer, Lung fibroblast


IMR-90


No


8651


SOCS1


Knockdown, Overexpression


Oncogene-induced, Replicative


Induction


Lung fibroblast


IMR-90


No


8405


SPOP


Knockdown, Overexpression


Replicative


Induction


Lung fibroblast


IMR-90


No


27287


VENTX


Knockdown, Overexpression


Replicative


Induction


Cervical cancer, Embryonic kidney, Lung fibroblast, Lymphoblastic leukemia, Osteosarcoma


HEK293T, HeLa, IMR-90, Nalm16, U2OS


Yes


54739


XAF1


Knockdown, Overexpression


Stress-induced


Induction


Dermal microvascular endothelial cells


Primary cell


No


83719


YPEL3


Knockdown, Overexpression


Stress-induced


Induction


Breast cancer


MCF-7


Yes


29117


BRD7


Knockdown


Replicative


Induction


Foreskin fibroblast


BJ


No


857


CAV1


Knockdown


Replicative


Induction


Fibroblast


Primary cell


No


3486


IGFBP3


Knockdown


Stress-induced


Induction


Lung fibroblast


WI-38


No


3691


ITGB4


Knockdown


Replicative


Induction


Umbilical vein endothelial


Primary cell


No


10397


NDRG1


Knockdown


Replicative


Induction


Liver cancer


Hep3B, HepG2, Huh7, PLC/PRF/5


Yes


6787


NEK4


Knockdown


Replicative, Stress-induced


Induction


Foreskin fibroblast


BJ


No


4854


NOTCH3


Knockdown


Stress-induced


Induction


Breast cancer, Fibroblast, Foreskin fibroblast, Glioma, Melanoma


A375P, BJ, LF1, MDA-MB-231, T98G, WS1


Yes


55193


PBRM1


Knockdown


Replicative


Induction


Foreskin fibroblast


BJ


No


5925


RB1


Knockdown


Stress-induced


Induction


Osteoblast


Primary cell


No


5054


SERPINE1


Knockdown


Replicative


Induction


Foreskin fibroblast


BJ, Primary cell


No


51384


WNT16


Knockdown


Replicative


Induction


Lung fibroblast


MRC-5


No


Reference: HAGR


[/raw]