Genes inducing senescence

Entrez Id

Gene Symbol

Method

Senescence Type

Effect on senescence

Cell Types

Cell Lines

Cancer Line

3400

ID4

Overexpression

Stress-induced

Induction

Prostate cancer

DU145

Yes

5824

PEX19

Overexpression

Stress-induced

Induction

Osteosarcoma

U2OS

Yes

8553

BHLHE40

Overexpression

Replicative, Stress-induced

Induction

Breast cancer, Esophageal cancer

EC9706, MCF-7

Yes

7157

TP53

Overexpression

Replicative, Stress-induced

Induction

Bladder cancer

EJ

Yes

80019

UBTD1

Overexpression

Replicative, Stress-induced

Induction

Breast cancer, Colorectal cancer, Gastric cancer, Gastric epithelial, Lung fibroblast, Prostate cancer

AGS, GES-1, KATO-III, LoVo, MCF-7, MKN28, MKN45, MRC-5, NCI-N87, PC-3, SGC-7901, SNU-1, SNU-16

Yes

51225

ABI3

Overexpression

Replicative

Induction

Colon cancer, Thyroid cancer

ARO, WRO

Yes

203054

ADCK5

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

247

ALOX15B

Overexpression

Replicative

Induction

Prostate epithelial

Primary cell

No

10095

ARPC1B

Overexpression

Replicative

Induction

Osteosarcoma

SaOs-2

Yes

558

AXL

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

640

BLK

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

595

CCND1

Overexpression

Replicative

Induction

Fibroblast

Hs68, WI-38

No

5129

CDK18

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

1027

CDKN1B

Overexpression

Replicative

Induction

Lung fibroblast

TIG-3

No

1028

CDKN1C

Overexpression

Replicative

Induction

Liver cancer

HepG2, SNU-398

Yes

1029

CDKN2A

Overexpression

Replicative

Induction

Lung fibroblast

TIG-3

No

55602

CDKN2AIP

Overexpression

Replicative

Induction

Lung fibroblast

MRC-5, TIG-1

No

1030

CDKN2B

Overexpression

Replicative

Induction

Glioblastoma

T98G, U-251MG, U-373MG

Yes

1152

CKB

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

3576

CXCL8

Overexpression

Replicative

Induction

Foreskin fibroblast, Lung fibroblast

BJ, IMR-90, WI-38

No

3491

CYR61

Overexpression

Replicative

Induction

Foreskin fibroblast, Lung fibroblast

BJ, IMR-90

No

1869

E2F1

Overexpression

Replicative

Induction

Lung fibroblast

WI-38

No

26298

EHF

Overexpression

Replicative

Induction

Lung fibroblast

WI-38

No

54206

ERRFI1

Overexpression

Replicative

Induction

Lung fibroblast

WI-38

No

10922

FASTK

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

79791

FBXO31

Overexpression

Replicative

Induction

Breast cancer

MCF-7

Yes

56287

GKN1

Overexpression

Replicative

Induction

Gastric cancer

AGS, MKN1

Yes

2870

GRK6

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

3065

HDAC1

Overexpression

Replicative

Induction

Cervical cancer

HeLa

Yes

220296

HEPACAM

Overexpression

Replicative

Induction

Breast cancer

MCF-7

Yes

3101

HK3

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

3458

IFNG

Overexpression

Replicative

Induction

Umbilical vein endothelial

Primary cell

No

3484

IGFBP1

Overexpression

Replicative

Induction

Breast cancer

MCF-7

Yes

3621

ING1

Overexpression

Replicative

Induction

Foreskin fibroblast

Hs68

No

3661

IRF3

Overexpression

Replicative

Induction

Foreskin fibroblast

BJ

No

3663

IRF5

Overexpression

Replicative

Induction

Li Fraumeni syndrome fibroblast

MDAH041

Yes

3665

IRF7

Overexpression

Replicative

Induction

Li Fraumeni syndrome fibroblast

MDAH041

Yes

3705

ITPK1

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

3707

ITPKB

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

3984

LIMK1

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

5604

MAP2K1

Overexpression

Replicative

Induction

Intestinal epithelial

HIEC-6

No

5608

MAP2K6

Overexpression

Replicative

Induction

Osteosarcoma

U2OS

Yes

5609

MAP2K7

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

9064

MAP3K6

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

6885

MAP3K7

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

6300

MAPK12

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

22983

MAST1

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

4145

MATK

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

10445

MCRS1

Overexpression

Replicative

Induction

Foreskin fibroblast, Lung fibroblast, Mammary epithelial

H184B5F5/M10, Hs68, IMR-90

No

126308

MOB3A

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

23515

MORC3

Overexpression

Replicative

Induction

Lung fibroblast

WI-38

No

10934

MORF4

Overexpression

Replicative

Induction

Fibrosarcoma

A9, HT1080

Yes

4598

MVK

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

10608

MXD4

Overexpression

Replicative

Induction

Lung fibroblast

WI-38

No

65220

NADK

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

4814

NINJ1

Overexpression

Replicative

Induction

Hepatoma

Huh7

Yes

5015

OTX2

Overexpression

Replicative

Induction

Medulloblastoma

D283, D341, D425, D458, D556, DAOY, MED8A, UW228-2

Yes

10298

PAK4

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

149420

PDIK1L

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

5170

PDPK1

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

23037

PDZD2

Overexpression

Replicative

Induction

Breast cancer, Liver cancer, Prostate cancer

DU145

Yes

51588

PIAS4

Overexpression

Replicative

Induction

Lung fibroblast

WI-38

No

23533

PIK3R5

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

5315

PKM

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

10654

PMVK

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

87178

PNPT1

Overexpression

Replicative

Induction

Melanoma

FO-1, HO-1, MeWo

Yes

5460

POU5F1

Overexpression

Replicative

Induction

Mesenchymal stromal

Primary cell

No

5629

PROX1

Overexpression

Replicative

Induction

Liver cancer

Hep3B, HepG2, Mahlavu, SK-HEP1

Yes

9232

PTTG1

Overexpression

Replicative

Induction

Foreskin fibroblast, Lung fibroblast

BJ, IMR-90, WI-38

No

861

RUNX1

Overexpression

Replicative

Induction

Foreskin fibroblast

Hs68

No

150094

SIK1

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

64849

SLC13A3

Overexpression

Replicative

Induction

Lung fibroblast, Renal tubular

MRC-5, WI-38

No

6598

SMARCB1

Overexpression

Replicative

Induction

Malignant rhabdoid tumor

G-401

Yes

64750

SMURF2

Overexpression

Replicative

Induction

Foreskin fibroblast, Lung fibroblast, Skin fibroblast

BJ, WI-38, WS1

No

8470

SORBS2

Overexpression

Replicative

Induction

Fibroblast, Keratinocyte

Primary cell

No

6657

SOX2

Overexpression

Replicative

Induction

Colon cancer, Embryonic kidney

HCT116, HEK293T, WiDr

Yes

6667

SP1

Overexpression

Replicative

Induction

Lung fibroblast

2BS

No

10927

SPIN1

Overexpression

Replicative

Induction

Cervical cancer

HeLa

Yes

6720

SREBF1

Overexpression

Replicative

Induction

Fibroblast

Primary cell

No

6777

STAT5B

Overexpression

Replicative

Induction

Lung fibroblast

IMR-90

No

282974

STK32C

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

83931

STK40

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

6850

SYK

Overexpression

Replicative

Induction

Melanoma

501-mel, A375, SK-MEL-28

Yes

7023

TFAP4

Overexpression

Replicative

Induction

Breast cancer, Retinal pigment epithelial

hTERT-RPE, MCF-7

Yes

7098

TLR3

Overexpression

Replicative

Induction

Fibroblast, Keratinocyte

Primary cell

No

7297

TYK2

Overexpression

Replicative

Induction

Embryonic kidney, Lung fibroblast

HEK293T, IMR-90, MRC-5

No

7538

ZFP36

Overexpression

Replicative

Induction

Cervical cancer

HeLa

Yes

207

AKT1

Overexpression

Oncogene-induced

Induction

Aortic endothelial, Dermal microvascular endothelial cells, Umbilical vein endothelial

Primary cell

No

673

BRAF

Overexpression

Oncogene-induced

Induction

Foreskin fibroblast, Melanocyte

BJ, Primary cell

No

2919

CXCL1

Overexpression

Oncogene-induced

Induction

Ovarian fibroblast

Gro-1

No

2113

ETS1

Overexpression

Oncogene-induced

Induction

Foreskin fibroblast, Lung fibroblast

Hs68, TIG-3

No

2114

ETS2

Overexpression

Oncogene-induced

Induction

Foreskin fibroblast, Lung fibroblast

Hs68, TIG-3

No

3265

HRAS

Overexpression

Oncogene-induced

Induction

Lung fibroblast

IMR-90, WI-38

No

5605

MAP2K2

Overexpression

Oncogene-induced

Induction

Lung fibroblast

IMR-90

No

5371

PML

Overexpression

Oncogene-induced

Induction

Lung fibroblast

WI-38

No

5894

RAF1

Overexpression

Oncogene-induced

Induction

Lung fibroblast

IMR-90

No

2810

SFN

Overexpression

Oncogene-induced

Induction

Melanoma

SK-MEL-147, SK-MEL-19, SK-MEL-29

Yes

6660

SOX5

Overexpression

Oncogene-induced

Induction

Glioma

U-1242MG, U-178MG, U-251MG, U-343MG, U-343MGa

Yes

6426

SRSF1

Overexpression

Oncogene-induced

Induction

Foreskin fibroblast

BJ

No

1718

DHCR24

Mutation

Oncogene-induced

Induction

Lung fibroblast

WI-38

No

183

AGT

Knockout, Overexpression

Replicative

Induction

Vascular smooth muscle

Primary cell

No

25842

ASF1A

Knockout, Overexpression

Oncogene-induced, Replicative

Induction

Lung fibroblast

Primary cell

No

64506

CPEB1

Knockout, Overexpression

Replicative

Induction

Foreskin fibroblast, Lung fibroblast

Primary cell, WI-38

No

2791

GNG11

Knockout, Overexpression

Replicative

Induction

Lung fibroblast

TIG-7

No

3488

IGFBP5

Knockout, Overexpression

Replicative

Induction

Umbilical vein endothelial

Primary cell

No

3622

ING2

Knockout, Overexpression

Replicative

Induction

Lung fibroblast

MRC-5

No

9891

NUAK1

Knockout, Overexpression

Replicative

Induction

Lung fibroblast

WI-38

No

7703

PCGF2

Knockout, Overexpression

Replicative

Induction

Foreskin fibroblast, Lung fibroblast

BJ, MRC-5, WI-38

No

22925

PLA2R1

Knockout, Overexpression

Replicative

Induction

Lung fibroblast

IMR-90, WI-38

No

6041

RNASEL

Knockout, Overexpression

Replicative

Induction

Lung fibroblast

WI-38

No

26156

RSL1D1

Knockout, Overexpression

Replicative

Induction

Lung fibroblast

2BS

No

23309

SIN3B

Knockout, Overexpression

Replicative

Induction

Lung fibroblast

IMR-90

No

7041

TGFB1I1

Knockout, Overexpression

Replicative

Induction

Fibroblast

KMST-6, SUSM-1

No

9966

TNFSF15

Knockout, Overexpression

Replicative

Induction

Endothelial progenitor

Primary cell

No

10628

TXNIP

Knockout, Overexpression

Oncogene-induced, Replicative

Induction

Lung fibroblast

2BS

No

1026

CDKN1A

Knockout

Replicative

Induction

Fibroblast

LF1

No

1111

CHEK1

Knockout

Stress-induced

Induction

Colon cancer

HCT116

Yes

1643

DDB2

Knockout

Oncogene-induced

Induction

Lung fibroblast

IMR-90

No

2130

EWSR1

Knockout

Replicative

Induction

Hematopoietic stem

Primary cell

No

3552

IL1A

Knockout

Replicative

Induction

Umbilical vein endothelial

Primary cell

No

1432

MAPK14

Knockout

Replicative, Stress-induced

Induction

Lung fibroblast

MRC-5, WI-38

No

8550

MAPKAPK5

Knockout

Oncogene-induced

Induction

Foreskin fibroblast

BJ

No

11235

PDCD10

Knockout

Oncogene-induced, Replicative

Induction

Coronary artery endothelial, Lung fibroblast

IMR-90, Primary cell

No

7150

TOP1

Knockout

Replicative

Induction

Lung fibroblast

IMR-90, WI-38

No

8626

TP63

Knockout

Replicative

Induction

Foreskin fibroblast

BJ

No

10155

TRIM28

Knockout

Oncogene-induced

Induction

Lung fibroblast

IMR-90

No

367

AR

Knockdown, Overexpression

Replicative

Induction

Hair follicular keratinocyte

Primary cell

No

284119

CAVIN1

Knockdown, Overexpression

Replicative

Induction

Cervical cancer, Lung fibroblast

HeLa, IMR-90, WI-38

No

1051

CEBPB

Knockdown, Overexpression

Stress-induced

Induction

Prostate cancer

LNCaP

Yes

2626

GATA4

Knockdown, Overexpression

Replicative, Stress-induced

Induction

Foreskin fibroblast, Lung fibroblast

BJ, IMR-90

No

50618

ITSN2

Knockdown, Overexpression

Stress-induced

Induction

Foreskin fibroblast, Lung fibroblast

Hs68, WI-38

No

50507

NOX4

Knockdown, Overexpression

Replicative

Induction

Breast epithelial, Lung fibroblast

MCF-12A, TIG-3

No

5037

PEBP1

Knockdown, Overexpression

Stress-induced

Induction

Colon cancer, Gastric cancer, Lung cancer, Prostate cancer

A549, HCT116, MKN45, PC-3

Yes

5292

PIM1

Knockdown, Overexpression

Oncogene-induced, Replicative

Induction

Foreskin fibroblast, Lung fibroblast

2BS, BJ, WI-38

No

5580

PRKCD

Knockdown, Overexpression

Replicative

Induction

Lung fibroblast

TIG-1

No

5583

PRKCH

Knockdown, Overexpression

Stress-induced

Induction

Breast cancer

MCF-7

Yes

27330

RPS6KA6

Knockdown, Overexpression

Replicative

Induction

Colon cancer, Lung fibroblast

IMR-90

No

8651

SOCS1

Knockdown, Overexpression

Oncogene-induced, Replicative

Induction

Lung fibroblast

IMR-90

No

8405

SPOP

Knockdown, Overexpression

Replicative

Induction

Lung fibroblast

IMR-90

No

27287

VENTX

Knockdown, Overexpression

Replicative

Induction

Cervical cancer, Embryonic kidney, Lung fibroblast, Lymphoblastic leukemia, Osteosarcoma

HEK293T, HeLa, IMR-90, Nalm16, U2OS

Yes

54739

XAF1

Knockdown, Overexpression

Stress-induced

Induction

Dermal microvascular endothelial cells

Primary cell

No

83719

YPEL3

Knockdown, Overexpression

Stress-induced

Induction

Breast cancer

MCF-7

Yes

29117

BRD7

Knockdown

Replicative

Induction

Foreskin fibroblast

BJ

No

857

CAV1

Knockdown

Replicative

Induction

Fibroblast

Primary cell

No

3486

IGFBP3

Knockdown

Stress-induced

Induction

Lung fibroblast

WI-38

No

3691

ITGB4

Knockdown

Replicative

Induction

Umbilical vein endothelial

Primary cell

No

10397

NDRG1

Knockdown

Replicative

Induction

Liver cancer

Hep3B, HepG2, Huh7, PLC/PRF/5

Yes

6787

NEK4

Knockdown

Replicative, Stress-induced

Induction

Foreskin fibroblast

BJ

No

4854

NOTCH3

Knockdown

Stress-induced

Induction

Breast cancer, Fibroblast, Foreskin fibroblast, Glioma, Melanoma

A375P, BJ, LF1, MDA-MB-231, T98G, WS1

Yes

55193

PBRM1

Knockdown

Replicative

Induction

Foreskin fibroblast

BJ

No

5925

RB1

Knockdown

Stress-induced

Induction

Osteoblast

Primary cell

No

5054

SERPINE1

Knockdown

Replicative

Induction

Foreskin fibroblast

BJ, Primary cell

No

51384

WNT16

Knockdown

Replicative

Induction

Lung fibroblast

MRC-5

No

Reference: HAGR