Anti-longevity genes in Saccharomyces Cerevisiae

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Name


Symbol


Entrez ID


Max average lifespan change


Acyl-CoA-Binding


ACB1


852925


Upregulated


Adenine AminoHydrolase


AAH1


855581


Upregulated


Adenine PhosphoribosylTransferase


APT1


854986


Upregulated


Adenine requiring


ADE1


851272


Upregulated


Adenine requiring


ADE12


855501


Upregulated


Adenine requiring


ADE2


854295


Upregulated


Adenine requiring


ADE4


855346


Upregulated


Adenine requiring


ADE5,7


852617


Upregulated


Adenine requiring


ADE6


852952


Upregulated


Adenylate cyclase


CYR1


853452


90%  Upregulated


Adenylyl-sulfate kinase


MET14


853869


Upregulated


ADP/ATP Carrier


AAC3


852380


15%  Upregulated


Alcohol DeHydrogenase


ADH1


854068


20%  Upregulated


ALdehyde Dehydrogenase


ALD4


854556


50%  Upregulated


Aldehyde dehydrogenase (NADP(+)) ALD6


ALD6


856044


Upregulated


Alpha-1,2-mannosyltransferase MNN2


MNN2


852303


16%  Upregulated


Alpha-1,3-mannosyltransferase MNN1


MNN1


856718


15%  Upregulated


AMP Deaminase


AMD1


854973


Upregulated


Arginine permease CAN1


CAN1


856646


30%  Upregulated


Ark family Kinase-Like protein


AKL1


852351


20%  Upregulated


Aromatic amino acid transmembrane transporter TAT2


TAT2


854139


23%  Upregulated


Asparagine-Linked Glycosylation


ALG12


855764


25%  Upregulated


Asparagine-Linked Glycosylation


ALG5


855874


50%  Upregulated


Aspartate-Glutamate Carrier


AGC1


856132


30%  Upregulated


ATP synthase


ATP3


852327


50%  Upregulated


ATPase Family Gene


AFG3


856737


20%  Upregulated


BASal


BAS1


853974


30%  Upregulated


Bem1 (One) Interacting protein


BOI2


856850


25%  Upregulated


Bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17


MET17


851010


100%  Upregulated


Bile Pigment Transporter


BPT1


850645


20%  Upregulated


Biosynthesis of Nicotinic Acid


BNA2


853541


Upregulated


Bst1p


BST1


850519


25%  Upregulated


Bypass of Stop Codon


BSC2


851868


20%  Upregulated


Bypass of Stop Codon


BSC1


851524


20%  Upregulated


CaRnitine Carrier


CRC1


854267


25%  Upregulated


Casein Kinase Alpha’ subunit


CKA2


854227


Upregulated


CaTalase A


CTA1


851843


Upregulated and Downregulated


Cbp6p


CBP6


852417


25%  Upregulated


Cbs1p


CBS1


851491


37%  Upregulated


Cdc25p


CDC25


851019


50%  Upregulated


Cell division cycle


CDC6


853244


20%  Upregulated


Ceramide synthase component


LAG1


856386


50%  Upregulated


Chromosome STability


CST26


852330


40%  Upregulated


Cln3p


CLN3


851191


Downregulated


Csr2p


CSR2


856142


Upregulated


CYStathionine beta-synthase


CYS4


853059


50%  Upregulated


Cysteine-Three-Histidine


CTH1


851729


20%  Upregulated


Cytoplasmic pre-60S factor


REI1


852569


40%  Upregulated


Dead Box Protein


DBP3


852802


35%  Upregulated


Defective Cell Wall


DCW1


853820


Upregulated


Deficient in Utilization of Glutathione


DUG1


850605


Upregulated


Der1p


DER1


852500


16%  Upregulated


Derepression of ITR1 Expression


DIE2


853142


50%  Upregulated


Dls1p


DLS1


853381


20%  Upregulated


Dnm1p


DNM1


850686


Upregulated


dolichyl-diphosphooligosaccharide–protein glycotransferase OST3


OST3


854252


20%  Upregulated


dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase


ALG6


854163


15%  Upregulated


dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase


ALG3


852196


10%  Upregulated


Drs2 Neo1 Family


DNF1


856913


50%  Upregulated


Dst1-delta 6-Azauracil Sensitivity


DAS2


851583


25%  Upregulated


ELongator Protein


ELP3


856019


Upregulated


ELongator Protein


ELP4


856002


30%  Upregulated


Eos1p


EOS1


855644


24%  Upregulated


ER oxidoreductin


ERO1


854909


28%  Upregulated


Essential for Respiration and Viability


ERV2


856152


Upregulated


Factor ARrest


FAR10


850939


Upregulated


Factor ARrest


FAR8


855044


Upregulated


Ferric REductase 6


FRE6


850675


14%  Upregulated


Five Zinc Fingers


FZF1


852638


66%  Upregulated


FluoroCYtosine resistance


FCY2


856783


Upregulated


FluoroCYtosine resistance


FCY21


856788


Upregulated


FluoroCYtosine resistance


FCY1


856175


Upregulated


Fob1p


FOB1


851688


50%  Upregulated


Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for gluc


FBP1


851092


Downregulated


GDP/GTP exchange protein (GEP) for Rho1p and Rho2p


ROM2


851086


50%  Upregulated


GIg1-2 Suppressor


GIS1


851670


25%  Upregulated


gluconokinase


YDR248C


851835


20%  Upregulated


glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2


TDH2


853465


29%  Upregulated


Gpr1p


GPR1


851527


50%  Upregulated


GTPase involved in G-protein signaling in the adenylate cyclase activating pathway


RAS1


854268


23%  Upregulated


Hes1p


HES1


854412


25%  Downregulated


hexokinase 2


HXK2


852639


50%  Upregulated


high-Affinity Glutamine Permease


AGP1


850333


Upregulated


Histone deacetylase


RPD3


855386


41%  Upregulated


Histone DeAcetylase


HDA1


855710


Upregulated


HnRNP MethylTransferase


HMT1


852322


50%  Upregulated


homolog of S. pombe SDS23


SDS23


852824


Upregulated


Homologous to RAD4


RAD34


851909


30%  Upregulated


Hsp70 family ATPase SSC1


SSC1


853503


40%  Upregulated


Hyper-resistance to Nitrogen Mustard


HNM1


852803


Upregulated


hypothetical protein


YBR238C


852540


30%  Upregulated


hypothetical protein


YLR422W


851141


25%  Upregulated


hypothetical protein


YMR018W


855032


35%  Upregulated


hypothetical protein


YGR130C


853031


30%  Upregulated


hypothetical protein


YOR012W


854177


Upregulated


hypothetical protein


YER186C


856935


30%  Upregulated


hypothetical protein


YER187W


856937


30%  Upregulated


hypothetical protein


YMR010W


855022


30%  Upregulated


Hypothetical RNA-Binding protein


HRB1


855728


20%  Upregulated


Hypoxanthine guanine PhosphoribosylTransferase


HPT1


852008


Upregulated


Idh2p


IDH2


854303


30%  Upregulated


INositol polyphosphate 5-Phosphatase


INP51


854815


10%  Upregulated


Inositol Polyphosphate Kinase


IPK1


851910


40%  Upregulated


Insensitive to KIller toxin


IKI3


851100


Upregulated


Iron-sulfur cluster assembly factor for Biotin synthase and Aconitase-like mitochondrial proteins


IBA57


853586


50%  Upregulated


Isocitrate dehydrogenase


LYS12


854714


Upregulated


Isocitrate DeHydrogenase


IDH1


855691


15%  Upregulated


Isocitrate Dehydrogenase, NADP-specific


IDP1


851493


15%  Upregulated


Isw2p


ISW2


854480


24%  Upregulated


Itc1p


ITC1


852744


18%  Upregulated


KARyogamy


KAR3


856263


55%  Upregulated


Las Seventeen Binding protein


LSB3


850580


40%  Upregulated


Las Seventeen Binding protein


LSB1


853037


30%  Upregulated


Las Seventeen Binding protein


LSB6


853345


50%  Upregulated


LEUcine biosynthesis


LEU2


850342


Upregulated


LEUcine biosynthesis


LEU3


851172


Upregulated


LINk


LIN1


856561


40%  Upregulated


LOCalization of ASH1 mRNA


LOC1


850551


40%  Upregulated


Long Chronological Lifespan


LCL1


856051


Upregulated


Long Chronological Lifespan 2


LCL2


850794


Upregulated


Long Chronological Lifespan 3


LCL3


852795


Upregulated


Long-Chain Base


LCB3


853307


Upregulated


lysine–tRNA ligase MSK1


MSK1


855651


12%  Upregulated


mannosyltransferase YUR1


YUR1


853302


19%  Upregulated


Mep2p


MEP2


855580


Upregulated


Mep3p


MEP3


856260


Upregulated


Methylene Tetrahydrafolate Dehydrogenase


MTD1


853955


Upregulated


Mir1p


MIR1


853540


25%  Upregulated


mitochondrial 54S ribosomal protein IMG1


IMG1


850413


23%  Upregulated


mitochondrial 54S ribosomal protein IMG2


IMG2


850434


28%  Upregulated


mitochondrial 54S ribosomal protein YmL33


MRPL33


855330


16%  Upregulated


mitochondrial 54S ribosomal protein YmL40


MRPL40


855930


21%  Upregulated


mitochondrial 54S ribosomal protein YmL49


MRPL49


853349


25%  Upregulated


Mitotic Arrest-Deficient


MAD2


853422


50%  Upregulated


Mns1p


MNS1


853595


Upregulated


Mub1p


MUB1


855126


29%  Upregulated


MUddled Meiosis


MUM2


852348


Upregulated


N-Myristoyl Transferase


NMT1


850892


50%  Upregulated


Nat4p


NAT4


855091


21%  Upregulated


Nitrogen Network Kinase


NNK1


853683


Upregulated


OligoPeptide Transporter 2


OPT2


856324


23%  Upregulated


Outer Membrane


OM45


854670


Upregulated


p53 Regulatory Kinase


PRK1


854713


30%  Upregulated


Pachytene CHeckpoint


PCH2


852484


50%  Upregulated


PaXillin-Like protein


PXL1


853965


Upregulated


PEroXisome related


PEX25


855991


Upregulated


Pet127p


PET127


854182


35%  Upregulated


Pet309p


PET309


850756


25%  Upregulated


Pho85 CycLin


PCL7


854761


Upregulated


PHOsphate metabolism


PHO89


852599


50%  Upregulated


PhosphatidylInositol(3)-phosphate Binding


PIB1


851908


25%  Upregulated


phosphoadenylyl-sulfate reductase (thioredoxin)


MET16


856296


Upregulated


PhosphoRibosylpyrophosphate Synthetase


PRS3


856375


50%  Upregulated


PIK-related protein kinase and rapamycin target


TOR1


853529


30%  Upregulated


Pkb-activating Kinase Homolog


PKH1


852101


15%  Upregulated


Pkb-activating Kinase Homolog


PKH3


852077


10%  Upregulated


Pkb-activating Kinase Homolog


PKH2


854053


20%  Upregulated


Plasma Membrane ATPase Related


PMR1


852709


40%  Upregulated


Pleiotropic Drug Resistance


PDR18


855807


Upregulated


Pmt7p


PMT7


851902


30%  Upregulated


protein disulfide isomerase MPD1


MPD1


854462


17%  Upregulated


Protein kinase activator found in a complex containing Snf1p and members of the Sip1p/Sip2p/Gal83p f


SNF4


852763


20%  Upregulated


Protein kinase that regulates signal transduction activity and G1 progression


SCH9


856612


300%  Upregulated


PseudoHyphal Determinant


PHD1


853823


20%  Upregulated


Psi+ INducibility


PIN3


856277


15%  Upregulated


Pst2p


PST2


851596


36%  Upregulated


putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5


PMT5


851464


21%  Upregulated


putative mitochondrial 54S ribosomal protein


MRX14


851692


12%  Upregulated


putative ubiquitin-protein ligase UBR2


UBR2


850711


67%  Upregulated


PyriDoXine auxotrophy


PDX3


852323


50%  Upregulated


Rcm1p


RCM1


855709


Upregulated


Rcy1p


RCY1


853226


Upregulated


Rec8p


REC8


856115


20%  Upregulated


Regulator of heterotrimeric G protein Signaling


RGS2


854274


35%  Upregulated


Replication In Mitochondria


RIM1


850395


20%  Upregulated


Resistance to Congo Red 2


RCR2


851566


18%  Upregulated


Restores Glucose Transport


RGT1


853828


Upregulated


Restores Glucose Transport


RGT2


851417


Upregulated


Rfx1p


RFX1


850873


20%  Upregulated


ribosomal 40S subunit protein S10B


RPS10B


855270


Upregulated


ribosomal 40S subunit protein S12


RPS12


854551


38%  Upregulated


ribosomal 40S subunit protein S18A


RPS18A


852061


15%  Upregulated


ribosomal 40S subunit protein S18B


RPS18B


854982


15%  Upregulated


ribosomal 40S subunit protein S6B


RPS6B


852479


45%  Upregulated


ribosomal 60S subunit protein L10


RPL10


850764


24%  Upregulated


ribosomal 60S subunit protein L16B


RPL16B


855655


23%  Upregulated


ribosomal 60S subunit protein L26A


RPL26A


851058


22%  Upregulated


ribosomal 60S subunit protein L2B


RPL2B


854794


38%  Upregulated


ribosomal 60S subunit protein L35A


RPL35A


851336


41%  Upregulated


ribosomal 60S subunit protein L6B


RPL6B


851169


40%  Upregulated


Ribosomal Protein of the Large subunit


RPL33B


854409


15%  Upregulated


Ribosomal Protein of the Large subunit


RPL35B


851419


25%  Upregulated


Ribosomal Protein of the Large subunit


RPL8B


850682


25%  Upregulated


Ribosomal Protein of the Large subunit


RPL12A


856656


35%  Upregulated


Ribosomal Protein of the Large subunit


RPL37B


852111


35%  Upregulated


Ribosomal Protein of the Large subunit


RPL19A


852379


50%  Upregulated


Ribosomal Protein of the Large subunit


RPL9A


852730


30%  Upregulated


Ribosomal Protein of the Large subunit


RPL9B


855658


30%  Upregulated


Ribosomal Protein of the Large subunit


RPL20B


854489


50%  Upregulated


Ribosomal Protein of the Large subunit


RPL19B


852254


20%  Upregulated


Ribosomal Protein of the Large subunit


RPL12B


852026


20%  Upregulated


Ribosomal Protein of the Large subunit


RPL1B


852742


20%  Upregulated


Ribosomal Protein of the Large subunit


RPL4A


852319


20%  Upregulated


Ribosomal Protein of the Large subunit


RPL21B


856026


50%  Upregulated


Ribosomal Protein of the Large subunit


RPL22A


850750


90%  Upregulated


Ribosomal Protein of the Large subunit


RPL23A


852191


40%  Upregulated


Ribosomal Protein of the Large subunit


RPL29


850592


35%  Upregulated


Ribosomal Protein of the Large subunit


RPL34B


854759


60%  Upregulated


Ribosomal Protein of the Large subunit


RPL43B


853557


30%  Upregulated


Ribosomal Protein of the Large subunit


RPL7A


852804


40%  Upregulated


Ribosomal Protein of the Large subunit


RPL13A


851477


30%  Upregulated


Ribosomal Protein of the Large subunit


RPL21A


852489


30%  Upregulated


Ribosomal Protein of the Small subunit


RPS11A


851589


30%  Upregulated


Ribosomal Protein of the Small subunit


RPS6A


856015


30%  Upregulated


Ribosomal Protein of the Small subunit


RPS26B


856868


20%  Upregulated


Ribosomal Protein P1 Beta


RPP1B


851427


40%  Upregulated


Ribosomal Protein P2 Beta


RPP2B


851990


55%  Upregulated


Rieske Iron-sulfur Protein


RIP1


856689


15%  Upregulated


RNase H


RNH201


855652


50%  Upregulated


RPO31


RPO31


854283


Upregulated


Rtg3p


RTG3


852171


Upregulated


S-AdenosylMethionine requiring


SAM1


850877


20%  Upregulated


SAGA histone acetyltransferase complex subunit SGF11


SGF11


856060


26%  Upregulated


Scp1p


SCP1


854549


65%  Upregulated


SECretory


SEC28


854734


20%  Upregulated


Silent information regulator


SIR4


851813


Upregulated and Downregulated


similar to the mammalian TPA Induced Sequence gene family


TIS11


850827


30%  Upregulated


SIt4 Suppressor


SIS2


853946


50%  Upregulated


Sna3p


SNA3


853290


27%  Upregulated


Something About Silencing


SAS3


852228


Upregulated


Something About Silencing


SAS4


851762


Upregulated


Sorting NeXin


SNX3


854539


Upregulated


Sorting NeXin


SNX41


852035


Upregulated


Sov1p


SOV1


855088


30%  Upregulated


SPOrulation


SPO22


854737


Upregulated


SPorulation Specific


SPS1


852135


25%  Upregulated


Stability of Eisosomes Guaranteed


SEG2


853756


20%  Upregulated


Stress-inducible Dual specificity Phosphatase


SDP1


854693


25%  Upregulated


Stress-Seventy subfamily A


SSA3


852203


50%  Upregulated


succinate dehydrogenase assembly factor SDH5


SDH5


854083


28%  Upregulated


succinate dehydrogenase flavoprotein subunit SDH1


SDH1


853709


25%  Upregulated


succinate dehydrogenase iron-sulfur protein subunit SDH2


SDH2


850685


21%  Upregulated


Sucrose NonFermenting


SNF3


851333


Upregulated


Suppressor gene for FLocculation


SFL1


854307


Upregulated


Suppressor Of Kinase


SOK1


851569


50%  Upregulated


Suppressor of Kre Null


SKN1


853045


60%  Upregulated


SuPpressor of Ty’s


SPT4


852955


40%  Upregulated


Suv3p


SUV3


856078


25%  Upregulated


SWItching deficient


SWI5


851724


20%  Upregulated


Tcb3p


TCB3


854903


18%  Upregulated


Temperature dependent Organization in Mitotic nucleus


TOM1


852068


30%  Upregulated


Tpk2p


TPK2


855898


25%  Upregulated


TransALdolase


TAL1


851068


20%  Upregulated


transcription factor MIG1


MIG1


852848


Downregulated


Translation Initiation Factor


TIF4631


853071


20%  Upregulated


Translation Initiation Factor


TIF4632


852833


20%  Upregulated


Translation Machinery Associated


TMA19


853809


30%  Upregulated


TriacylGlycerol Lipase


TGL3


855361


Upregulated


trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))


GRE3


856504


100%  Upregulated


TRna Methyltransferase


TRM9


854994


Upregulated


UBiquitin-Conjugating


UBC12


851015


50%  Upregulated


Ubx2p


UBX2


854995


24%  Upregulated


Up in StarVation


USV1


855871


Upregulated


Upstream Activation Factor subunit


UAF30


854470


Upregulated


Ure2p


URE2


855492


20%  Upregulated


URidine Hydrolase


URH1


852009


24%  Upregulated


Uth1p


UTH1


853916


15%  Upregulated


Utilization of GAba


UGA1


852902


50%  Upregulated


Utilization of GAba


UGA3


851384


75%  Upregulated


Vacuolar Basic Amino acid transporter


VBA5


853980


Upregulated


Vacuolar Protein Sorting


VPS5


854235


Upregulated


Vacuolar Protein Sorting


VPS70


853590


Upregulated


Vacuolar Protein Sorting


VPS75


855475


Upregulated


Yeast Protein Two


YPT6


850966


30%  Upregulated


Yeast Tat-binding Analog


YTA7


853186


50%  Upregulated


Yeast vaccinia virus VH1 Homolog


YVH1


854844


50%  Upregulated


Ysc84p


YSC84


856409


25%  Upregulated


Zds1p


ZDS1


855316


37%  Upregulated


ZWischenFerment


ZWF1


855480


Upregulated

Reference: HAGR
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