Anti-longevity genes in Drosophila Melanogaster

Name

Symbol

Entrez ID

Max average lifespan change

5-hydroxytryptamine (serotonin) receptor 2A

5-HT2A

40575

90% 

Adenosylhomocysteinase like 1

AhcyL1

38342

13% 

Adenosylhomocysteinase like 2

AhcyL2

42043

21% 

Alpha Mannosidase I

alpha-Man-I

31957

39% 

ATP citrate lyase

ATPCL

36760

32% 

Baboon

babo

35900

16% 

Bmcp

Bmcp

39322

CG12317-PA

JhI-21

34624

32% 

CG17367 gene product from transcript CG17367-RC

Lnk

43130

33% 

CG17856 gene product from transcript CG17856-RA

CG17856

43369

18% 

CG18809 gene product from transcript CG18809-RA

CG18809

59170

19% 

CG2789

CG2789

33231

27% 

CG31196 gene product from transcript CG31196-RA

14-3-3epsilon

42186

49% 

CG33336-PA

p53

2768677

58% 

CG3810 gene product from transcript CG3810-RC

Edem1

31154

30% 

CG3962 gene product from transcript CG3962-RA

Keap1

42062

10% 

CG42358

CG42358

7354421

CG5389 gene product from transcript CG5389-RA

CG5389

39761

11% 

CG6824-PA

ovo

31429

50% 

CG7471-PA

Rpd3

38565

52% 

CG9172 gene product from transcript CG9172-RA

CG9172

32565

46% 

Chameau

chm

43928

24% 

Coenzyme Q biosynthesis protein 2

Coq2

40988

31% 

crooked legs

crol

34592

27% 

dawdle

daw

33474

35% 

diminutive

dm

31310

47% 

DNA polymerase Gamma

DNApol-gamma35

3772064

52% 

dunce

dnc

31309

Ecdysone receptor

EcR

35540

50% 

Enhancer of zeste

E(z)

39203

76% 

enigma

Egm

36242

escargot

esg

34903

21% 

extra sexcombs

esc

34595

59% 

Glycerol 3 phosphate dehydrogenase

Gpdh

33824

20% 

Glycogen phosphorylase

GlyP

33386

17% 

Glycogen synthase

GlyS

41823

10% 

Gustatory receptor 63a

Gr63a

38453

30% 

Hexokinase A

Hex-A

45875

10% 

Hexokinase C

Hex-C

44008

I'm not dead yet protein

Indy

40049

92% 

Insulin receptor substrate-1

chico

64880

48% 

Insulin-like 1 receptor

InR

42549

85% 

Insulin-related peptide

Ilp2

39150

47% 

Integrin linked kinase

Ilk

53573

63% 

Juvenile hormone esterase binding protein 29 (DmP29)

CG3776

37996

43% 

krasavietz

kra

40680

25% 

kugelkern

kuk

42063

l(3)neo18

l(3)neo18

46260

24% 

Lamin B receptor

LBR

37482

lethal (3) DTS3

l(3)DTS3

249462

42% 

locomotion defects

loco

42672

mir-184 stem loop

mir-184

12798434

mir-277 stem loop

mir-277

12798086

70% 

mushroom-body expressed

mub

40436

21% 

myospheroid

mys

44885

44% 

NADH:ubiquinone reductase 75kD subunit precursor

ND75

31762

15% 

neuropeptide F

NPF

42018

25% 

Odorant receptor co-receptor

Orco

40650

56% 

pickpocket 23

ppk23

32731

4% 

pickpocket 28

ppk28

32671

44% 

puckered

puc

40958

retinal degeneration A

rdgA

31826

44% 

Ribose-5-phosphate isomerase

Rpi

246599

38% 

RNA polymerase III subunit C53

RpIIIC53

40002

11% 

RPS6-p70-protein kinase

S6k

38654

Smad on X

Smox

31738

10% 

snazarus (sorting nexin lazarus)

snz

31704

85% 

Stunted

sun

44046

surfeit gene 1

Surf1

44498

Target of rapamycin

Tor

47396

Tequila

teq

39048

31% 

Tetraspanin 42Ef

Tsp42Ef

35615

18% 

trachealess

trh

38065

90% 

Reference: HAGR