Age induced SASP

UniprotIds

Genes

Protein Names

New Plasma SASP Protein

Q13740

ALCAM

CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)

YES

P21810

BGN

Biglycan (Bone/cartilage proteoglycan I) (PG-S1)

YES

Q14019

COTL1

Coactosin-like protein

YES

P01034

CST3

Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin)

YES

P07858

CTSB

Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]

NO

P07339

CTSD

Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain]

YES

Q9UBR2

CTSZ

Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X)

YES

P02751

FN1

Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]

YES

Q99988

GDF15

Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)

YES

P06396

GSN

Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)

YES

P09211

GSTP1

Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1)

YES

P0DMV8

HSPA1A

Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1)

YES

P11142

HSPA8

Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)

YES

P18065

IGFBP2

Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2)

NO

Q16270

IGFBP7

Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (IGFBP-rP1) (MAC25 protein) (PGI2-stimulating factor) (Prostacyclin-stimulating factor) (Tumor-derived adhesion factor) (TAF)

NO

P03956

MMP1

Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]

YES

P08253

MMP2

72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]

YES

Q99497

PARK7

Protein/nucleic acid deglycase DJ-1 (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase) (Oncogene DJ1) (Parkinson disease protein 7) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1)

YES

P00558

PGK1

Phosphoglycerate kinase 1 (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2)

YES

Q15063

POSTN

Periostin (PN) (Osteoblast-specific factor 2) (OSF-2)

YES

P05155

SERPING1

Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1)

YES

P52823

STC1

Stanniocalcin-1 (STC-1)

YES

P01033

TIMP1

Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)

NO

P16035

TIMP2

Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)

NO

P27348

YWHAQ

14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)

YES

Reference: A proteomic atlas of senescence-associated secretomes for aging biomarker development
Nathan Basisty,et al, PLOS Biology, 2020