Age induced SASP

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UniprotIds


Genes


Protein Names


New Plasma SASP Protein


Q13740


ALCAM


CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)


YES


P21810


BGN


Biglycan (Bone/cartilage proteoglycan I) (PG-S1)


YES


Q14019


COTL1


Coactosin-like protein


YES


P01034


CST3


Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin)


YES


P07858


CTSB


Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]


NO


P07339


CTSD


Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain]


YES


Q9UBR2


CTSZ


Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X)


YES


P02751


FN1


Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]


YES


Q99988


GDF15


Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)


YES


P06396


GSN


Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)


YES


P09211


GSTP1


Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1)


YES


P0DMV8


HSPA1A


Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1)


YES


P11142


HSPA8


Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)


YES


P18065


IGFBP2


Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2)


NO


Q16270


IGFBP7


Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (IGFBP-rP1) (MAC25 protein) (PGI2-stimulating factor) (Prostacyclin-stimulating factor) (Tumor-derived adhesion factor) (TAF)


NO


P03956


MMP1


Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]


YES


P08253


MMP2


72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]


YES


Q99497


PARK7


Protein/nucleic acid deglycase DJ-1 (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase) (Oncogene DJ1) (Parkinson disease protein 7) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1)


YES


P00558


PGK1


Phosphoglycerate kinase 1 (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2)


YES


Q15063


POSTN


Periostin (PN) (Osteoblast-specific factor 2) (OSF-2)


YES


P05155


SERPING1


Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1)


YES


P52823


STC1


Stanniocalcin-1 (STC-1)


YES


P01033


TIMP1


Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)


NO


P16035


TIMP2


Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)


NO


P27348


YWHAQ


14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)


YES


Reference: A proteomic atlas of senescence-associated secretomes for aging biomarker development
Nathan Basisty,et al, PLOS Biology, 2020

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