Age induced gene changes – Homo Sapiens – Part 2

Part 1 Part 2 Part 3 Part 4
Gene Symbol (Name) Description Change gender Age change starts Age change ends Tissues Percentage change P value References
CXorf57 (chromosome X open reading frame 57)   Male and Female 20 75 Skeletal Muscle 35.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CXorf57 (chromosome X open reading frame 57) Using a linear mixed model, differential expression with age was identified in CXorf57 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CXXC1 (CXXC finger protein 1) Using a linear mixed model, differential expression with age was identified in CXXC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYB561A3 (cytochrome b561 family, member A3) Using a linear mixed model, differential expression with age was identified in CYB561A3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYB561D2 (cytochrome b561 family, member D2) Using a linear mixed model, differential expression with age was identified in CYB561D2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYB5A (cytochrome b5 type A (microsomal)) Using a linear mixed model, differential expression with age was identified in CYB5A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYC1 (cytochrome c-1)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CYC1 (cytochrome c-1) Using a linear mixed model, differential expression with age was identified in CYC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYCS (cytochrome c, somatic)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CYFIP2 (cytoplasmic FMR1 interacting protein 2) mRNA editing of CYFIP2, a p53 inducible protein thought to be involved in synaptic maintenance, decreases with age. No changes with age in mRNA editing were observed for GABRA3. Male and Female -1 -1 Frontal Lobe 0.0   2900: Nicholas et al. (2010) "Age-related gene-specific changes of A-to-I mRNA editing in the human brain." Mech. Ageing Dev. 131(6):445-447 (20538013)
CYFIP2 (cytoplasmic FMR1 interacting protein 2)   Male and Female 27 92 Kidney -11.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
CYGB (cytoglobin) Using a linear mixed model, differential expression with age was identified in CYGB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2) Using a linear mixed model, differential expression with age was identified in CYP1A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1) Using a linear mixed model, differential expression with age was identified in CYP1B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYP27A1 (cytochrome P450, family 27, subfamily A, polypeptide 1) Using a linear mixed model, differential expression with age was identified in CYP27A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cyp2c39 (cytochrome P450, family 2, subfamily c, polypeptide 39)   Male and Female 6 22 Liver -8.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
CYP2J2 (cytochrome P450, family 2, subfamily J, polypeptide 2)   Male and Female 26 106 Brain 9.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CYP3A5 (cytochrome P450, family 3, subfamily A, polypeptide 5) Using a linear mixed model, differential expression with age was identified in CYP3A5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYP4F12 (cytochrome P450, family 4, subfamily F, polypeptide 12) Using a linear mixed model, differential expression with age was identified in CYP4F12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYP4F22 (cytochrome P450, family 4, subfamily F, polypeptide 22) Using a linear mixed model, differential expression with age was identified in CYP4F22 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1)   Male and Female 20 75 Skeletal Muscle 12.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) Using a linear mixed model, differential expression with age was identified in CYP4X1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) Using a linear mixed model, differential expression with age was identified in CYP4X1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1)   Male and Female 3 23 Hematological System 35.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
Cysltr2 (cysteinyl leukotriene receptor 2)   Male and Female 3 23 Hematological System 17.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
CYTL1 (cytokine-like 1) Using a linear mixed model, differential expression with age was identified in CYTL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
D030056L22Rik (RIKEN cDNA D030056L22 gene)   Male and Female 5 25 Skeletal Muscle -7.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
D0H4S114 (DNA segment, human D4S114)   Male and Female 2 26 Lung -12.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
D0H4S114 (DNA segment, human D4S114)   Male and Female 2 15 Hippocampus -5.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
D10627 (cDNA sequence D10627)   Male and Female 5 25 Skeletal Muscle -8.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
D1Ertd705e (DNA segment, Chr 1, ERATO Doi 705, expressed)   Male and Female 3 23 Hematological System 61.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
D4Bwg0951e (DNA segment, Chr 4, Brigham & Women's Genetics 0951 expressed)   Male and Female 2 26 Lung -5.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
D630004K10Rik (RIKEN cDNA D630004K10 gene)   Male and Female 3 23 Hematological System -16.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
DAAM2 (dishevelled associated activator of morphogenesis 2)   Male and Female 22 73 Skeletal Muscle -8.0 <0.001 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100)
DAAM2 (dishevelled associated activator of morphogenesis 2)   Male and Female 20 75 Skeletal Muscle -5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DAB2 (Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)) Using a linear mixed model, differential expression with age was identified in DAB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DACT2 (dishevelled-binding antagonist of beta-catenin 2) Using a linear mixed model, differential expression with age was identified in DACT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DAD1 (defender against cell death 1) Using a linear mixed model, differential expression with age was identified in DAD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DAP (death-associated protein) Using a linear mixed model, differential expression with age was identified in DAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Dap3 (death associated protein 3)   Male and Female 5 25 Skeletal Muscle -3.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
DBN1 (drebrin 1) Using a linear mixed model, differential expression with age was identified in DBN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DBNDD1 (dysbindin (dystrobrevin binding protein 1) domain containing 1) Using a linear mixed model, differential expression with age was identified in DBNDD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DBNL (drebrin-like) Using a linear mixed model, differential expression with age was identified in DBNL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DCAF15 (DDB1 and CUL4 associated factor 15) Using a linear mixed model, differential expression with age was identified in DCAF15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DCBLD2 (discoidin, CUB and LCCL domain containing 2) Using a linear mixed model, differential expression with age was identified in DCBLD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DCLK1 (doublecortin-like kinase 1) Using a linear mixed model, differential expression with age was identified in DCLK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DCP2 (decapping mRNA 2) Using a linear mixed model, differential expression with age was identified in DCP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DCST1 (DC-STAMP domain containing 1) Using a linear mixed model, differential expression with age was identified in DCST1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DCTN1 (dynactin 1 (p150, glued homolog, Drosophila))   Male and Female 26 106 Brain -9.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
DCTN2 (dynactin 2 (p50)) Using a linear mixed model, differential expression with age was identified in DCTN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Dctn2 (dynactin 2)   Male and Female 5 25 Skeletal Muscle 9.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
Dctpp1 (dCTP pyrophosphatase 1)   Male and Female 5 30 Anatomical System -7.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
DCTPP1 (dCTP pyrophosphatase 1) Using a linear mixed model, differential expression with age was identified in DCTPP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DCXR (dicarbonyl/L-xylulose reductase) Using a linear mixed model, differential expression with age was identified in DCXR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ddah2 (dimethylarginine dimethylaminohydrolase 2)   Male and Female 8 24 Muscle -3.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
Ddah2 (dimethylarginine dimethylaminohydrolase 2)   Male and Female 2 15 Hippocampus -3.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
DDB2 (damage-specific DNA binding protein 2, 48kDa) Using a linear mixed model, differential expression with age was identified in DDB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ddi2 (DNA-damage inducible protein 2)   Male and Female 5 22 Brain -3.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
DDN (dendrin)   Male and Female 26 106 Brain -9.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
DDR1 (discoidin domain receptor tyrosine kinase 1)   Male and Female 26 106 Brain 9.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
DDRGK1 (DDRGK domain containing 1) Using a linear mixed model, differential expression with age was identified in DDRGK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DDT (D-dopachrome tautomerase)   Male and Female 22 73 Skeletal Muscle -3.0 <0.001 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100)
DDX19B (DEAD (Asp-Glu-Ala-As) box polypeptide 19B)   Male and Female 26 106 Brain -9.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
DDX24 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 24)   Male and Female 20 75 Skeletal Muscle 3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DDX26B (DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B) Using a linear mixed model, differential expression with age was identified in DDX26B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DDX27 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 27) Using a linear mixed model, differential expression with age was identified in DDX27 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DDX39 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 39)   Male and Female 26 106 Brain 8.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
DDX39B (DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B) Using a linear mixed model, differential expression with age was identified in DDX39B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ddx3y (DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked)   Male and Female 8 24 Muscle 8.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
DDX42 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 42)   Male and Female 20 75 Skeletal Muscle 3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DDX55 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 55) Using a linear mixed model, differential expression with age was identified in DDX55 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DDX59 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 59)   Male and Female 20 75 Skeletal Muscle 3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DDX59 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 59) Using a linear mixed model, differential expression with age was identified in DDX59 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DEFB1 (defensin, beta 1)   Male and Female 27 92 Kidney -8.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
DEGS2 (delta(4)-desaturase, sphingolipid 2) Using a linear mixed model, differential expression with age was identified in DEGS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DES (desmin) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of DES and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
DESI1 (desumoylating isopeptidase 1) Using a linear mixed model, differential expression with age was identified in DESI1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
destrin-2 pseudogene   Male and Female 26 106 Brain -15.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
DFNA5 (deafness, autosomal dominant 5) Using a linear mixed model, differential expression with age was identified in DFNA5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DFNB59 (deafness, autosomal recessive 59) Using a linear mixed model, differential expression with age was identified in DFNB59 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DGAT2 (diacylglycerol O-acyltransferase 2) Using a linear mixed model, differential expression with age was identified in DGAT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DGKB (diacylglycerol kinase, beta 90kDa)   Male and Female 26 106 Brain -7.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
DHCR24 (24-dehydrocholesterol reductase) Using a linear mixed model, differential expression with age was identified in DHCR24 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Dhcr7 (7-dehydrocholesterol reductase)   Male and Female 6 22 Liver 19.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
DHCR7 (7-dehydrocholesterol reductase) Using a linear mixed model, differential expression with age was identified in DHCR7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DHRS11 (dehydrogenase/reductase (SDR family) member 11) Using a linear mixed model, differential expression with age was identified in DHRS11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DHRS11 (dehydrogenase/reductase (SDR family) member 11) Using a linear mixed model, differential expression with age was identified in DHRS11 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DHRS3 (dehydrogenase/reductase (SDR family) member 3) Comparison of DNA methylation showed a significantly decreased methylation level of DHRS3 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -15.8 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
DHRS3 (dehydrogenase/reductase (SDR family) member 3) Comparison of DNA methylation showed a significantly decreased methylation level of DHRS3 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell -18.6 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
DHRS7B (dehydrogenase/reductase (SDR family) member 7B) Using a linear mixed model, differential expression with age was identified in DHRS7B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DHRS9 (dehydrogenase/reductase (SDR family) member 9) Using a linear mixed model, differential expression with age was identified in DHRS9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DHX15 (DEAH (Asp-Glu-Ala-His) box helicase 15) Using a linear mixed model, differential expression with age was identified in DHX15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Dhx40 (DEAH (Asp-Glu-Ala-His) box polypeptide 40)   Male and Female 3 23 Hematological System 12.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
DIDO1 (death inducer-obliterator 1) Using a linear mixed model, differential expression with age was identified in DIDO1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Dip2b (DIP2 disco-interacting protein 2 homolog B (Drosophila))   Male and Female 5 25 Skeletal Muscle -1.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
DIRAS3 (DIRAS family, GTP-binding RAS-like 3) Using a linear mixed model, differential expression with age was identified in DIRAS3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DKK1 (dickkopf 1 homolog (Xenopus laevis)) Comparison of DNA methylation showed a significantly increased methylation level of DKK1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis 16.2 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
DKK1 (dickkopf 1 homolog (Xenopus laevis)) Using a linear mixed model, differential expression with age was identified in DKK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DKKL1 (dickkopf-like 1)   Male and Female 0 102 Cerebellum 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
DKKL1 (dickkopf-like 1)   Male and Female 0 102 Pons 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
DKKL1 (dickkopf-like 1)   Male and Female 0 102 Temporal Lobe 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
DKKL1 (dickkopf-like 1)   Male and Female 0 102 Frontal Lobe 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
DLAT (dihydrolipoamide S-acetyltransferase)   Male and Female 20 75 Skeletal Muscle -6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DLC1 (DLC1 Rho GTPase activating protein) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of DLC1 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
DLEC1 (deleted in lung and esophageal cancer 1) Using a linear mixed model, differential expression with age was identified in DLEC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DLG5 (discs, large homolog 5 (Drosophila))   Male and Female 20 75 Skeletal Muscle 4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DLGAP1 (discs, large (Drosophila) homolog-associated protein 1)   Male and Female 26 106 Brain -11.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
DLK2 (delta-like 2 homolog (Drosophila)) Using a linear mixed model, differential expression with age was identified in DLK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DLL1 (delta-like 1 (Drosophila)) Using a linear mixed model, differential expression with age was identified in DLL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DLX5 (distal-less homeobox 5) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of DLX5 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Dmbt1 (deleted in malignant brain tumors 1)   Male and Female 4 15 Cochlea 1.0 <0.001 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326)
DMBX1 (diencephalon/mesencephalon homeobox 1) Using a linear mixed model, differential expression with age was identified in DMBX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DMD (dystrophin)   Male and Female 20 75 Skeletal Muscle 3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DMD (dystrophin) Using a linear mixed model, differential expression with age was identified in DMD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DMRT2 (doublesex and mab-3 related transcription factor 2)   Male and Female 20 75 Skeletal Muscle -12.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Dmrtc1a (DMRT-like family C1a)   Male and Female 3 23 Hematological System 13.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
DMTF1 (cyclin D binding myb-like transcription factor 1) Using a linear mixed model, differential expression with age was identified in DMTF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DNAH17 (dynein, axonemal, heavy chain 17) Using a linear mixed model, differential expression with age was identified in DNAH17 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DNAH8 (dynein, axonemal, heavy chain 8) Using a linear mixed model, differential expression with age was identified in DNAH8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Dnaja1 (DnaJ (Hsp40) homolog, subfamily A, member 1)   Male and Female 2 26 Lung -6.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
DNAJA1 (DnaJ (Hsp40) homolog, subfamily A, member 1)   Male and Female 26 106 Brain -9.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Dnajb1 (DnaJ (Hsp40) homolog, subfamily B, member 1)   Male and Female 2 26 Lung -10.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
DNAJC1 (DnaJ (Hsp40) homolog, subfamily C, member 1)   Male and Female 20 75 Skeletal Muscle 5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DNAJC15 (DnaJ (Hsp40) homolog, subfamily C, member 15)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DNASE1L2 (deoxyribonuclease I-like 2) Using a linear mixed model, differential expression with age was identified in DNASE1L2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DNM1L (dynamin 1-like)   Male and Female 26 106 Brain -14.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
DNM2 (dynamin 2) Using a linear mixed model, differential expression with age was identified in DNM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Dnm3 (dynamin 3)   Male and Female 3 23 Hematological System 18.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
Dnmt3a (DNA methyltransferase 3A) Dnmt3a mRNA content in heart of mice decrease from age 2 to 22 month. Male 2 22 Heart     2715: Dzitoyeva et al. (2009) "5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice." Neural Plast. 2009:209596 (20052386)
DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta) Using a linear mixed model, differential expression with age was identified in DNMT3B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DOCK11 (dedicator of cytokinesis 11)   Male and Female 27 92 Kidney 24.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
DOCK2 (dedicator of cytokinesis 2) Using a linear mixed model, differential expression with age was identified in DOCK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DOCK3 (dedicator of cytokinesis 3) Using a linear mixed model, differential expression with age was identified in DOCK3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Dok1 (docking protein 1)   Male and Female 5 25 Skeletal Muscle -12.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
DOLK (dolichol kinase) Using a linear mixed model, differential expression with age was identified in DOLK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DONSON (downstream neighbor of SON) Using a linear mixed model, differential expression with age was identified in DONSON in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DOPEY1 (dopey family member 1)   Male and Female 22 73 Skeletal Muscle 9.0 <0.001 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100)
DPCD (deleted in primary ciliary dyskinesia homolog (mouse)) Using a linear mixed model, differential expression with age was identified in DPCD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DPH5 (DPH5 homolog (S. cerevisiae))   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DPM3 (dolichyl-phosphate mannosyltransferase polypeptide 3) Using a linear mixed model, differential expression with age was identified in DPM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DPP8 (dipeptidyl-peptidase 8)   Male and Female 0 102 Cerebellum 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
DPP8 (dipeptidyl-peptidase 8)   Male and Female 0 102 Pons 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
DPP8 (dipeptidyl-peptidase 8)   Male and Female 0 102 Temporal Lobe 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
DPP8 (dipeptidyl-peptidase 8)   Male and Female 0 102 Frontal Lobe 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
DPT (dermatopontin) Using a linear mixed model, differential expression with age was identified in DPT in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DPYSL3 (dihydropyrimidinase-like 3)   Male and Female 26 106 Brain 12.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Dram1 (DNA-damage regulated autophagy modulator 1)   Male and Female 3 23 Hematological System -12.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
Dram2 (VDNA-damage regulated autophagy modulator 2)   Male and Female 5 25 Skeletal Muscle 16.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
DST (dystonin) Using a linear mixed model, differential expression with age was identified in DST in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DUOXA1 (dual oxidase maturation factor 1) Using a linear mixed model, differential expression with age was identified in DUOXA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DUS1L (dihydrouridine synthase 1-like (S. cerevisiae)) Using a linear mixed model, differential expression with age was identified in DUS1L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DUSP13 (dual specificity phosphatase 13)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DUSP16 (dual specificity phosphatase 16) Using a linear mixed model, differential expression with age was identified in DUSP16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Dusp22 (dual specificity phosphatase 22)   Male and Female 3 23 Hematological System -18.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
DUSP3 (dual specificity phosphatase 3)   Male and Female 26 106 Brain -6.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
DUSP3 (dual specificity phosphatase 3)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
DUSP5 (dual specificity phosphatase 5) Using a linear mixed model, differential expression with age was identified in DUSP5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Dusp6 (dual specificity phosphatase 6)   Male and Female 2 15 Hippocampus -3.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
Dut (deoxyuridine triphosphatase)   Male and Female 5 30 Anatomical System -25.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
DUT (deoxyuridine triphosphatase) Using a linear mixed model, differential expression with age was identified in DUT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DVL3 (dishevelled segment polarity protein 3) Using a linear mixed model, differential expression with age was identified in DVL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
DYSF (dysferlin) Using a linear mixed model, differential expression with age was identified in DYSF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
E2F2 (E2F transcription factor 2) Using a linear mixed model, differential expression with age was identified in E2F2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ear5 (eosinophil-associated, ribonuclease A family, member 5)   Male and Female 5 22 Brain 3385.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
EBI3 (Epstein-Barr virus induced 3) Using a linear mixed model, differential expression with age was identified in EBI3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ebi3 (Epstein-Barr virus induced gene 3)   Male and Female 3 23 Hematological System -27.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
EBP (emopamil binding protein (sterol isomerase)) Using a linear mixed model, differential expression with age was identified in EBP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ECEL1 (endothelin converting enzyme-like 1) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of ECEL1 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
ECM1 (extracellular matrix protein 1) Using a linear mixed model, differential expression with age was identified in ECM1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ECM2 (extracellular matrix protein 2, Female organ and adipocyte specific)   Male and Female 26 106 Brain 13.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ECSIT (ECSIT homolog (Drosophila))   Male and Female 20 75 Skeletal Muscle -5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
EDARADD (EDAR-associated death domain) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of EDARADD and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
EDNRB (endothelin receptor type B) Using a linear mixed model, differential expression with age was identified in EDNRB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EDRF1 (erythroid differentiation regulatory factor 1) Using a linear mixed model, differential expression with age was identified in EDRF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EEF1A2 (eukaryotic translation elongation factor 1 alpha 2) Using a linear mixed model, differential expression with age was identified in EEF1A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EEF2K (eukaryotic elongation factor-2 kinase) Using a linear mixed model, differential expression with age was identified in EEF2K in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EFCAB1 (EF-hand calcium binding domain 1) Using a linear mixed model, differential expression with age was identified in EFCAB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EFCAB7 (EF-hand calcium binding domain 7)   Male and Female 20 75 Skeletal Muscle 12.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
EFEMP1 (EGF-containing fibulin-like extracellular matrix protein 1)   Male and Female 26 106 Brain 34.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
EFEMP1 (EGF-containing fibulin-like extracellular matrix protein 1) Using a linear mixed model, differential expression with age was identified in EFEMP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EFEMP2 (EGF-containing fibulin-like extracellular matrix protein 2)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
EFEMP2 (EGF-containing fibulin-like extracellular matrix protein 2)   Male and Female 26 106 Brain 10.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
EFHC1 (EF-hand domain (C-terminal) containing 1) Using a linear mixed model, differential expression with age was identified in EFHC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EFHD1 (EF-hand domain family, member D1)   Male and Female 27 92 Kidney -9.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
EFNA1 (ephrin-A1) Using a linear mixed model, differential expression with age was identified in EFNA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EGF (epidermal growth factor (beta-urogastrone))   Male and Female 27 92 Kidney -25.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
EGFR (epidermal growth factor receptor) Using a linear mixed model, differential expression with age was identified in EGFR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EHD1 (EH-domain containing 1)   Male and Female 26 106 Brain 4.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Ehd3 (EH-domain containing 3)   Male and Female 3 23 Hematological System 33.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
EHD4 (EH-domain containing 4) Using a linear mixed model, differential expression with age was identified in EHD4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EI24 (etoposide induced 2.4) Using a linear mixed model, differential expression with age was identified in EI24 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha)   Male and Female 5 25 Skeletal Muscle -3.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)   Male and Female 26 106 Brain -3.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Eif4a2 (eukaryotic translation initiation factor 4A2)   Male and Female 5 25 Skeletal Muscle 5.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
EIF4E2 (eukaryotic translation initiation factor 4E family member 2) Using a linear mixed model, differential expression with age was identified in EIF4E2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EIF4H (eukaryotic translation initiation factor 4H)   Male and Female 20 75 Skeletal Muscle 2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ELAVL1 (ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R))   Male and Female 26 106 Brain -69.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ELAVL2 (ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B))   Male and Female 26 106 Brain -10.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Ell2 (elongation factor RNA polymerase II 2)   Male and Female 8 24 Muscle 7.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
ELMO1 (engulfment and cell motility 1) Using a linear mixed model, differential expression with age was identified in ELMO1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ELOVL1 (ELOVL fatty acid elongase 1) Using a linear mixed model, differential expression with age was identified in ELOVL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ELOVL3 (ELOVL fatty acid elongase 3) Using a linear mixed model, differential expression with age was identified in ELOVL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ELOVL4 (ELOVL fatty acid elongase 4) Using a linear mixed model, differential expression with age was identified in ELOVL4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ELOVL5 (ELOVL fatty acid elongase 5) Using a linear mixed model, differential expression with age was identified in ELOVL5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ELOVL6 (ELOVL fatty acid elongase 6) Using a linear mixed model, differential expression with age was identified in ELOVL6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ELP3 (elongator acetyltransferase complex subunit 3) Gene expression showed a significant (p<E-3) decrease in the expression of ELP3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -54.13 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
EMCN (endomucin)   Male and Female 20 75 Skeletal Muscle -6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
EMILIN2 (elastin microfibril interfacer 2) Using a linear mixed model, differential expression with age was identified in EMILIN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EMILIN3 (elastin microfibril interfacer 3) Using a linear mixed model, differential expression with age was identified in EMILIN3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EML1 (echinoderm microtubule associated protein like 1) Gene expression showed a significant (p<E-3) decrease in the expression of EML1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -87.79 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
EML1 (echinoderm microtubule associated protein like 1) Using a linear mixed model, differential expression with age was identified in EML1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EML4 (echinoderm microtubule associated protein like 4) Using a linear mixed model, differential expression with age was identified in EML4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EMP3 (epithelial membrane protein 3) Using a linear mixed model, differential expression with age was identified in EMP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EMX1 (empty spiracles homeobox 1) Gene expression showed a significant (p<E-3) increase in the expression of EMX1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary 80.0 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
En1 (engrailed 1)   Male and Female 8 24 Muscle 8.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
EN1 (engrailed homeobox 1) Comparison of DNA methylation showed a significantly increased methylation level of EN1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis 18.8 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
ENC1 (ectodermal-neural cortex (with BTB-like domain))   Male and Female 26 106 Brain -5.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ENO2 (enolase 2 (gamma, neuronal)) Using a linear mixed model, differential expression with age was identified in ENO2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ENO3 (enolase 3 (beta, muscle))   Male and Female 26 106 Brain -38.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ENOSF1 (enolase superfamily member 1) Using a linear mixed model, differential expression with age was identified in ENOSF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ENOX1 (ecto-NOX disulfide-thiol exchanger 1) Ageing related cell surface oxidase (arNOX) specific activity increases between age 30 and age 50 to 65. arNOX generates superoxide at cell surfaces and in the circulation. Male 30 60 Skin     2646: Morré et al. (2008) "Age-related ENOX protein (arNOX) activity correlated with oxidative skin damage in the elderly." Biofactors 34(3):237-244 (19734125)
ENSA (endosulfine alpha)   Male and Female 26 106 Brain -9.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2)   Male and Female 6 22 Liver 23.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
Entpd7 (ectonucleoside triphosphate diphosphohydrolase 7)   Male and Female 8 24 Muscle -9.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
EP300 (E1A binding protein p300) Gene expression showed a significant (p<E-3) decrease in the expression of EP300 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -69.23 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
EP400 (E1A binding protein p400) Using a linear mixed model, differential expression with age was identified in EP400 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Epb4.1l3 (erythrocyte protein band 4.1-like 3)   Male and Female 8 24 Muscle 4.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
EPB41 (erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)) Gene expression showed a significant (p<E-3) decrease in the expression of EPB41 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -42.2 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
EPB41L2 (erythrocyte membrane protein band 4.1-like 2)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
EPB41L5 (erythrocyte membrane protein band 4.1 like 5) Using a linear mixed model, differential expression with age was identified in EPB41L5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EPB42 (erythrocyte membrane protein band 4.2) Using a linear mixed model, differential expression with age was identified in EPB42 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Epc1 (enhancer of polycomb homolog 1 (Drosophila))   Male and Female 6 22 Liver 2.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
EPHB1 (EPH receptor B1) Using a linear mixed model, differential expression with age was identified in EPHB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EPHB4 (EPH receptor B4) Using a linear mixed model, differential expression with age was identified in EPHB4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EPHX1 (epoxide hydrolase 1, microsomal (xenobiotic)) Using a linear mixed model, differential expression with age was identified in EPHX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EPHX2 (epoxide hydrolase 2, cytoplasmic) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of EPHX2 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
EPHX3 (epoxide hydrolase 3) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of EPHX3 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Eps8l1 (EPS8-like 1)   Male and Female 5 22 Brain 152.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
EPS8L1 (EPS8-like 1) Using a linear mixed model, differential expression with age was identified in EPS8L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Eral1 (Era (G-protein)-like 1 (E. coli))   Male and Female 5 25 Skeletal Muscle -2.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
Erbb3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian))   Male and Female 5 30 Anatomical System 8.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
ERCC1 (excision repair cross-complementation group 1) Using a linear mixed model, differential expression with age was identified in ERCC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ERCC5 (excision repair cross-complementation group 5) Using a linear mixed model, differential expression with age was identified in ERCC5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ERGIC3 (ERGIC and golgi 3) Using a linear mixed model, differential expression with age was identified in ERGIC3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ERI1 (exoribonuclease 1)   Male and Female 20 75 Skeletal Muscle 4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)
ERICH1 (glutamate-rich 1) Gene expression showed a significant (p<E-3) increase in the expression of ERICH1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary 59.0   2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
ERMP1 (endoplasmic reticulum metallopeptidase 1) Using a linear mixed model, differential expression with age was identified in ERMP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ERN1 (endoplasmic reticulum to nucleus signaling 1) Using a linear mixed model, differential expression with age was identified in ERN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ERP29 (endoplasmic reticulum protein 29) Using a linear mixed model, differential expression with age was identified in ERP29 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ERV3-1 (endogenous retrovirus group 3, member 1) Using a linear mixed model, differential expression with age was identified in ERV3-1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ESR2 (estrogen receptor 2 (ER beta))   Male and Female 22 73 Skeletal Muscle 5.0 <0.001 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100)
ESRP2 (epithelial splicing regulatory protein 2) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of ESRP2 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
ESRRA (estrogen-related receptor alpha)   Male and Female 20 75 Skeletal Muscle -5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Etf1 (eukaryotic translation termination factor 1)   Male and Female 5 25 Skeletal Muscle 2.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
Etv1 (ets variant gene 1)   Male and Female 3 23 Hematological System -35.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
ETV4 (ets variant 4) Using a linear mixed model, differential expression with age was identified in ETV4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ETV6 (ets variant 6) Using a linear mixed model, differential expression with age was identified in ETV6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EVA1B (eva-1 homolog B (C. elegans)) Using a linear mixed model, differential expression with age was identified in EVA1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EWSR1 (EWS RNA-binding protein 1) Using a linear mixed model, differential expression with age was identified in EWSR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Exoc6b (exocyst complex component 6B)   Male and Female 3 23 Hematological System 11.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
EXOC7 (exocyst complex component 7) Using a linear mixed model, differential expression with age was identified in EXOC7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EXOSC10 (exosome component 10)   Male and Female 20 75 Skeletal Muscle 7.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
EXOSC10 (exosome component 10) Using a linear mixed model, differential expression with age was identified in EXOSC10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
EXOSC4 (exosome component 4) Using a linear mixed model, differential expression with age was identified in EXOSC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Exosc7 (exosome component 7)   Male and Female 8 24 Muscle -7.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
Ext1 (exostoses (multiple) 1)   Male and Female 2 26 Lung -3.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Extl1 (exostoses (multiple)-like 1)   Male and Female 8 24 Muscle -7.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
F13a1 (coagulation factor XIII, A1 subunit)   Male and Female 2 26 Lung 8.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
F5 (coagulation factor V (proaccelerin, labile factor)) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of F5 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
FA2H (fatty acid 2-hydroxylase) Using a linear mixed model, differential expression with age was identified in FA2H in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fabp4 (fatty acid binding protein 4, adipocyte)   Male and Female 2 24 Visual Apparatus 188.0 <0.001 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767)
Fabp5 (fatty acid binding protein 5, epidermal)   Male and Female 2 24 Visual Apparatus 259.0 <0.001 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767)
FABP9 (fatty acid binding protein 9, testis) Using a linear mixed model, differential expression with age was identified in FABP9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FADS1 (fatty acid desaturase 1)   Male and Female 26 106 Brain 7.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
FADS1 (fatty acid desaturase 1) Using a linear mixed model, differential expression with age was identified in FADS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FADS3 (fatty acid desaturase 3) Using a linear mixed model, differential expression with age was identified in FADS3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAH (fumarylacetoacetate hydrolase (fumarylacetoacetase))   Male and Female 26 106 Brain 10.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
FAIM2 (Fas apoptotic inhibitory molecule 2) Using a linear mixed model, differential expression with age was identified in FAIM2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM111A (family with sequence similarity 111, member A) Using a linear mixed model, differential expression with age was identified in FAM111A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fam114a1 (family with sequence similarity 114, member A1)   Male and Female 2 26 Lung -3.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
FAM124B (family with sequence similarity 124B) Using a linear mixed model, differential expression with age was identified in FAM124B in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM127A (family with sequence similarity 127, member A) Using a linear mixed model, differential expression with age was identified in FAM127A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM129B (family with sequence similarity 129, member B) Using a linear mixed model, differential expression with age was identified in FAM129B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM131A (family with sequence similarity 131, member A)   Male and Female 26 106 Brain -10.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
FAM131A (family with sequence similarity 131, member A) Using a linear mixed model, differential expression with age was identified in FAM131A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fam132a (family with sequence similarity 132, member A)   Male and Female 5 30 Anatomical System -7.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
FAM133B (family with sequence similarity 133, member B) Using a linear mixed model, differential expression with age was identified in FAM133B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM135A (family with sequence similarity 135, member A) Using a linear mixed model, differential expression with age was identified in FAM135A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fam13b (family with sequence similarity 13, member B)   Male and Female 5 25 Skeletal Muscle 4.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
FAM160B1 (family with sequence similarity 160, member B1) Using a linear mixed model, differential expression with age was identified in FAM160B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM162A (family with sequence similarity 162, member A)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Fam162b (family with sequence similarity 162, member B)   Male and Female 2 26 Lung -14.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
FAM173A (family with sequence similarity 173, member A) Using a linear mixed model, differential expression with age was identified in FAM173A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM174B (family with sequence similarity 174, member B)   Male and Female 20 75 Skeletal Muscle 9.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Fam176b (family with sequence similarity 176, member B)   Male and Female 5 22 Brain -9.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
FAM189A2 (family with sequence similarity 189, member A2) Using a linear mixed model, differential expression with age was identified in FAM189A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fam19a5 (family with sequence similarity 19, member A5)   Male and Female 8 24 Muscle 9.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
FAM209B (family with sequence similarity 209, member B) Using a linear mixed model, differential expression with age was identified in FAM209B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM24B (family with sequence similarity 24, member B) Using a linear mixed model, differential expression with age was identified in FAM24B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM43B (family with sequence similarity 43, member B) Using a linear mixed model, differential expression with age was identified in FAM43B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM46B (family with sequence similarity 46, member B) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of FAM46B and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
FAM46C (family with sequence similarity 46, member C) Using a linear mixed model, differential expression with age was identified in FAM46C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM49A (family with sequence similarity 49, member A)   Male and Female 26 106 Brain -16.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
FAM63A (family with sequence similarity 63, member A) Using a linear mixed model, differential expression with age was identified in FAM63A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM69A (family with sequence similarity 69, member A) Using a linear mixed model, differential expression with age was identified in FAM69A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM69C (family with sequence similarity 69, member C) Using a linear mixed model, differential expression with age was identified in FAM69C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM71E1 (family with sequence similarity 71, member E1) Using a linear mixed model, differential expression with age was identified in FAM71E1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM83A (family with sequence similarity 83, member A) Using a linear mixed model, differential expression with age was identified in FAM83A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fam83h (family with sequence similarity 83, member H)   Male and Female 5 25 Skeletal Muscle -3.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
FAM84B (family with sequence similarity 84, member B) Using a linear mixed model, differential expression with age was identified in FAM84B in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM89B (family with sequence similarity 89, member B) Using a linear mixed model, differential expression with age was identified in FAM89B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAM96A (family with sequence similarity 96, member A)   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
FANCD2 (Fanconi anemia, complementation group D2) Using a linear mixed model, differential expression with age was identified in FANCD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAR2 (fatty acyl CoA reductase 2) Using a linear mixed model, differential expression with age was identified in FAR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FASTK (Fas-activated serine/threonine kinase)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
FASTK (Fas-activated serine/threonine kinase) Using a linear mixed model, differential expression with age was identified in FASTK in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAT2 (FAT atypical cadherin 2) Using a linear mixed model, differential expression with age was identified in FAT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAXDC2 (fatty acid hydroxylase domain containing 2) Using a linear mixed model, differential expression with age was identified in FAXDC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FAXDC2 (fatty acid hydroxylase domain containing 2) Using a linear mixed model, differential expression with age was identified in FAXDC2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FBLN1 (fibulin 1) Using a linear mixed model, differential expression with age was identified in FBLN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FBLN5 (fibulin 5) Using a linear mixed model, differential expression with age was identified in FBLN5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fbn2 (fibrillin 2)   Male and Female 8 24 Muscle -31.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
FBP1 (fructose-1,6-bisphosphatase 1) Using a linear mixed model, differential expression with age was identified in FBP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FBP2 (fructose-1,6-bisphosphatase 2) Using a linear mixed model, differential expression with age was identified in FBP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FBXL16 (F-box and leucine-rich repeat protein 16) Gene expression showed a significant (p<E-3) decrease in the expression of FBXL16 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -51.69 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
FBXL6 (F-box and leucine-rich repeat protein 6) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of FBXL6 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
FBXO11 (F-box protein 11) Using a linear mixed model, differential expression with age was identified in FBXO11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FBXO22 (F-box protein 22) Using a linear mixed model, differential expression with age was identified in FBXO22 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FBXO31 (F-box protein 31)   Male and Female 20 75 Skeletal Muscle 7.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
FBXW12 (F-box and WD repeat domain containing 12)   Male and Female 20 75 Skeletal Muscle 9.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Fbxw4 (F-box and WD-40 domain protein 4)   Male and Female 3 23 Hematological System -12.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
FBXW7 (F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase) Using a linear mixed model, differential expression with age was identified in FBXW7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 144.23 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 342.83 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 187.24 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 105.27 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 98.14 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 222.59 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 177.42 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 111.38 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGBP (Fc fragment of IgG binding protein) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGBP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 138.31 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGBP (Fc fragment of IgG binding protein) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGBP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 290.6 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGBP (Fc fragment of IgG binding protein) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGBP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 212.37 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64)) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe FCGR1A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 150.96 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64)) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGR1A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 423.11 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64)) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGR1A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 157.35 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64)) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGR1A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 207.57 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64)) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe FCGR1B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 166.0 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64)) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGR1B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 434.19 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64)) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGR1B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 225.53 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64)) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGR1B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 170.41 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe FCGR2A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 124.01 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGR2A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 316.44 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGR2A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 141.5 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGR2A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 104.3 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR3A (Fc fragment of IgG, low affinity IIIa, receptor (CD16a)) CD16 is a receptor for the Fc part of immunoglobulin G (IgG). Its expression was reduced in neutrophils from elderly donors. Male and Female -1 -1 Neutrophil     2850: Butcher et al. (2001) "Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans." J. Leukoc. Biol. 70(6):881-886 (11739550)
FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 647.0 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 404.56 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 261.05 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 80.84 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 131.12 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 52.13 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGRT (Fc fragment of IgG, receptor, transporter, alpha) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGRT from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 76.72 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCGRT (Fc fragment of IgG, receptor, transporter, alpha) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGRT from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 89.34 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
FCN1 (ficolin (collagen/fibrinogen domain containing) 1) Using a linear mixed model, differential expression with age was identified in FCN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FDFT1 (farnesyl-diphosphate farnesyltransferase 1) Using a linear mixed model, differential expression with age was identified in FDFT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FDPS (farnesyl diphosphate synthase) Using a linear mixed model, differential expression with age was identified in FDPS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fdps (farnesyl diphosphate synthetase)   Male and Female 8 24 Muscle -7.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
FDX1 (ferredoxin 1)   Male and Female 20 75 Skeletal Muscle -6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Fermt3 (fermitin family homolog 3 (Drosophila))   Male and Female 2 26 Lung 14.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
FETUB (fetuin B) Using a linear mixed model, differential expression with age was identified in FETUB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FEV (FEV (ETS oncogene family)) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of FEV and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
FEZ1 (fasciculation and elongation protein zeta 1 (zygin I)) Using a linear mixed model, differential expression with age was identified in FEZ1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FEZ2 (fasciculation and elongation protein zeta 2 (zygin II))   Male and Female 22 73 Skeletal Muscle 5.0 <0.001 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100)
FGF1 (fibroblast growth factor 1 (acidic))   Male and Female 26 106 Brain 20.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
FGF12 (fibroblast growth factor 12)   Male and Female 26 106 Brain -29.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Fgf13 (fibroblast growth factor 13)   Male and Female 2 26 Lung 28.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
FGF13 (fibroblast growth factor 13)   Male and Female 26 106 Brain -28.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
FGF2 (fibroblast growth factor 2 (basic))   Male and Female 26 106 Brain 12.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
FGF8 (fibroblast growth factor 8 (androgen-induced)) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of FGF8 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
FGFR3 (fibroblast growth factor receptor 3)   Male and Female 26 106 Brain 13.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
FGFR3 (fibroblast growth factor receptor 3) Using a linear mixed model, differential expression with age was identified in FGFR3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fggy (FGGY carbohydrate kinase domain containing)   Male and Female 5 25 Skeletal Muscle 17.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
FGL2 (fibrinogen-like 2) Using a linear mixed model, differential expression with age was identified in FGL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FGL2 (fibrinogen-like 2) Using a linear mixed model, differential expression with age was identified in FGL2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FH (fumarate hydratase)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Fhod1 (formin homology 2 domain containing 1)   Male and Female 2 26 Lung -8.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
FIGN (fidgetin) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of FIGN and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
FILIP1 (filamin A interacting protein 1) Using a linear mixed model, differential expression with age was identified in FILIP1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FIP1L1 (factor interacting with PAPOLA and CPSF1) Using a linear mixed model, differential expression with age was identified in FIP1L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FIS1 (fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)) Using a linear mixed model, differential expression with age was identified in FIS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FJX1 (four jointed box 1 (Drosophila)) Using a linear mixed model, differential expression with age was identified in FJX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FKBP1A (FK506 binding protein 1A, 12kDa)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
FLNB (filamin B, beta) Using a linear mixed model, differential expression with age was identified in FLNB in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FLT1 (fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor recep)   Male and Female 20 75 Skeletal Muscle -6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
FLT4 (fms-related tyrosine kinase 4) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of FLT4 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Fmc1 (formation of mitochondrial complexes 1 homolog (S. cerevisiae))   Male and Female 5 30 Anatomical System -1.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
FMO3 (flavin containing monooxygenase 3) Using a linear mixed model, differential expression with age was identified in FMO3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FMO3 (flavin containing monooxygenase 3) Using a linear mixed model, differential expression with age was identified in FMO3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FNDC4 (fibronectin type III domain containing 4) Using a linear mixed model, differential expression with age was identified in FNDC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FNDC5 (fibronectin type III domain containing 5) Using a linear mixed model, differential expression with age was identified in FNDC5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FOCAD (focadhesin) Using a linear mixed model, differential expression with age was identified in FOCAD in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FOLR2 (folate receptor 2 (fetal)) Using a linear mixed model, differential expression with age was identified in FOLR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fosb (FBJ osteosarcoma oncogene B)   Male and Female 2 26 Lung -13.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Fosl2 (fos-like antigen 2)   Male and Female 6 22 Liver -40.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
Foxa3 (forkhead box A3)   Male and Female 6 22 Liver 13.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
FOXC1 (forkhead box C1) Using a linear mixed model, differential expression with age was identified in FOXC1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FOXJ3 (forkhead box J3) Using a linear mixed model, differential expression with age was identified in FOXJ3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Foxl1 (forkhead box L1)   Male and Female 5 25 Skeletal Muscle -1.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
FOXO1 (forkhead box O1)   Male and Female 20 75 Skeletal Muscle 6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
FOXP1 (forkhead box P1) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of FOXP1 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
FOXQ1 (forkhead box Q1) Using a linear mixed model, differential expression with age was identified in FOXQ1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Foxred2 (FAD-dependent oxidoreductase domain containing 2)   Male and Female 2 26 Lung 89.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
FRMD3 (FERM domain containing 3)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
FRMPD4 (FERM and PDZ domain containing 4)   Male and Female 26 106 Brain -22.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Fryl (furry homolog-like (Drosophila))   Male and Female 8 24 Muscle 4.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
Frzb (frizzled-related protein)   Male and Female 8 24 Muscle -12.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
FST (follistatin)   Male and Female 20 75 Skeletal Muscle 8.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
FSTL1 (follistatin-like 1) Expression level of miR-198 is significantly increased in foreskin cells from elderly when compared with younger controls. Male -1 -1 Foreskin 74.25246561 <0.001 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119)
FTO (fat mass and obesity associated) Using a linear mixed model, differential expression with age was identified in FTO in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FTSJ1 (FtsJ RNA methyltransferase homolog 1 (E. coli)) Using a linear mixed model, differential expression with age was identified in FTSJ1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FUK (fucokinase) Using a linear mixed model, differential expression with age was identified in FUK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
FUT3 (fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of FUT3 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Fut9 (fucosyltransferase 9)   Male and Female 5 22 Brain -2.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
FXYD2 (FXYD domain containing ion transport regulator 2)   Male and Female 27 92 Kidney -5.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
FXYD6 (FXYD domain containing ion transport regulator 6) Using a linear mixed model, differential expression with age was identified in FXYD6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Fzd2 (frizzled homolog 2 (Drosophila))   Male and Female 2 26 Lung -6.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
FZD9 (frizzled class receptor 9) Using a linear mixed model, differential expression with age was identified in FZD9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
G6PC3 (glucose 6 phosphatase, catalytic, 3) Using a linear mixed model, differential expression with age was identified in G6PC3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
G6PD (glucose-6-phosphate dehydrogenase) Using a linear mixed model, differential expression with age was identified in G6PD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gab1 (growth factor receptor bound protein 2-associated protein 1)   Male and Female 8 24 Muscle -3.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
GABBR2 (gamma-aminobutyric acid (GABA) B receptor, 2) Using a linear mixed model, differential expression with age was identified in GABBR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gabra3 (gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3)   Male and Female 5 30 Anatomical System 5.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
Gabra4 (gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4)   Male and Female 3 23 Hematological System 252.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
GABRB3 (gamma-aminobutyric acid (GABA) A receptor, beta 3)   Male and Female 26 106 Brain -31.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GABRD (gamma-aminobutyric acid (GABA) A receptor, delta)   Male and Female 26 106 Brain -9.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GABRE (gamma-aminobutyric acid (GABA) A receptor, epsilon) Using a linear mixed model, differential expression with age was identified in GABRE in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gad1 (glutamic acid decarboxylase 1)   Male and Female 5 30 Anatomical System 1.0   2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
GAD2 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of GAD2 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
GADD45A (growth arrest and DNA-damage-inducible, alpha)   Male and Female 20 75 Skeletal Muscle 19.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
GALNT16 (polypeptide N-acetylgalactosaminyltransferase 16) Using a linear mixed model, differential expression with age was identified in GALNT16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GALNT16 (polypeptide N-acetylgalactosaminyltransferase 16) Using a linear mixed model, differential expression with age was identified in GALNT16 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GAP43 (growth associated protein 43) Using a linear mixed model, differential expression with age was identified in GAP43 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GAP43 (growth associated protein 43) Using a linear mixed model, differential expression with age was identified in GAP43 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gapdhs (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic)   Male and Female 6 22 Liver -14.0   1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
Gas2l2 (growth arrest-specific 2 like 2)   Male and Female 2 26 Lung 15.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Gas2l3 (growth arrest-specific 2 like 3)   Male and Female 3 23 Hematological System 14.0   2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
GAS2L3 (growth arrest-specific 2 like 3)   Male and Female 0 102 Cerebellum 0.0   2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
GAS2L3 (growth arrest-specific 2 like 3)   Male and Female 0 102 Frontal Lobe 0.0   2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
GAS2L3 (growth arrest-specific 2 like 3)   Male and Female 0 102 Pons 0.0   2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
GAS2L3 (growth arrest-specific 2 like 3)   Male and Female 0 102 Temporal Lobe 0.0   2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
Gas5 (growth arrest specific 5)   Male and Female 2 15 Hippocampus 2.0   2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
GAS6 (growth arrest-specific 6) Using a linear mixed model, differential expression with age was identified in GAS6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GATM (glycine amidinotransferase (L-arginine:glycine amidinotransferase))   Male and Female 26 106 Brain 8.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GBP1 (guanylate binding protein 1, interferon-inducible) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of GBP1 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
GBP4 (guanylate binding protein 4) Using a linear mixed model, differential expression with age was identified in GBP4 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gcat (glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase))   Male and Female 5 25 Skeletal Muscle 10.0   2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
GCDH (glutaryl-CoA dehydrogenase) Using a linear mixed model, differential expression with age was identified in GCDH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GCHFR (GTP cyclohydrolase I feedback regulator) Using a linear mixed model, differential expression with age was identified in GCHFR in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gclc (glutamate-cysteine ligase, catalytic subunit) The apparent Km for cysteine and glutamine of the glutamate-cysteine ligase (GCL) were, respectively, 300 and 450 mM in the young (6-month-old) and 800 and 710 mM in the old mice (24-month-old). Male and Female 6 12 Liver     2825: Rebrin and Sohal (2008) "Pro-oxidant shift in glutathione redox state during aging." Adv. Drug Deliv. Rev. 60(13-14):1545-1552 (18652861)|2851: Toroser et al. (2006) "Mechanisms of gamma-glutamylcysteine ligase regulation." Biochim. Biophys. Acta 1760(2):233-244 (16324789)
GCM2 (glial cells missing homolog 2 (Drosophila)) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of GCM2 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Gcsh (glycine cleavage system protein H (aminomethyl carrier))   Male and Female 8 24 Muscle 4.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
GCSH (glycine cleavage system protein H (aminomethyl carrier))   Male and Female 20 75 Skeletal Muscle -4.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
GDA (guanine deaminase)   Male and Female 20 75 Skeletal Muscle 8.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
GDE1 (glycerophosphodiester phosphodiesterase 1) Using a linear mixed model, differential expression with age was identified in GDE1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GDPD2 (glycerophosphodiester phosphodiesterase domain containing 2) Using a linear mixed model, differential expression with age was identified in GDPD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gdpd5 (glycerophosphodiester phosphodiesterase domain containing 5)   Male and Female 8 24 Muscle 23.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
Gem (GTP binding protein (gene overexpressed in skeletal muscle))   Male and Female 2 26 Lung -13.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Gfap (glial fibrillary acidic protein)   Male and Female 5 30 Anatomical System 11.0   2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
Gfap (glial fibrillary acidic protein)   Male and Female 2 15 Hippocampus 4.0   2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
GFPT2 (glutamine-fructose-6-phosphate transaminase 2) Using a linear mixed model, differential expression with age was identified in GFPT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GFRA2 (GDNF family receptor alpha 2)   Male and Female 26 106 Brain -6.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Gfra2 (glial cell line derived neurotrophic factor family receptor alpha 2)   Male and Female 8 24 Muscle -4.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
GGA3 (golgi-associated, gamma adaptin ear containing, ARF binding protein 3) Using a linear mixed model, differential expression with age was identified in GGA3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GGNBP2 (gametogenetin binding protein 2)   Male and Female 20 75 Skeletal Muscle 5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Ggt1 (gamma-glutamyltransferase 1)   Male and Female 2 26 Lung 7.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
GGT5 (gamma-glutamyltransferase 5) Using a linear mixed model, differential expression with age was identified in GGT5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GGT6 (gamma-glutamyltransferase 6) Using a linear mixed model, differential expression with age was identified in GGT6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GHDC (GH3 domain containing) Using a linear mixed model, differential expression with age was identified in GHDC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GHDC (GH3 domain containing) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of GHDC and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
GHITM (growth hormone inducible transmembrane protein)   Male and Female 20 75 Skeletal Muscle -3.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
GIT1 (G protein-coupled receptor kinase interacting ArfGAP 1) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of GIT1 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Gkap1 (G kinase anchoring protein 1)   Male and Female 8 24 Muscle 8.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
GLB1 (galactosidase, beta 1) Using a linear mixed model, differential expression with age was identified in GLB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GLDC (glycine dehydrogenase (decarboxylating)) Using a linear mixed model, differential expression with age was identified in GLDC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GLG1 (golgi apparatus protein 1)   Male and Female 20 75 Skeletal Muscle 6.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
GLG1 (golgi apparatus protein 1)   Male and Female 20 75 Skeletal Muscle 4.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Glo1 (glyoxalase 1)   Male and Female 8 24 Muscle -3.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
GLRA1 (glycine receptor, alpha 1) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of GLRA1 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
GLRX2 (glutaredoxin 2)   Male and Female 20 75 Skeletal Muscle -3.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
GLRX5 (glutaredoxin 5) Using a linear mixed model, differential expression with age was identified in GLRX5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gltp (glycolipid transfer protein)   Male and Female 5 30 Anatomical System 5.0   2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
Gm11346 (predicted gene 11346)   Male and Female 2 26 Lung 55.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Gm885 (predicted gene 885)   Male and Female 5 22 Brain 674.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
GMDS (GDP-mannose 4,6-dehydratase) Using a linear mixed model, differential expression with age was identified in GMDS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gna11 (guanine nucleotide binding protein, alpha 11)   Male and Female 8 24 Muscle 2.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
GNA12 (guanine nucleotide binding protein (G protein) alpha 12) Using a linear mixed model, differential expression with age was identified in GNA12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GNAI2 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2) Gene expression showed a significant (p<E-3) increase in the expression of GNAI2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary 58.0   2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
GNB1 (guanine nucleotide binding protein (G protein), beta polypeptide 1)   Male and Female 26 106 Brain -4.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GNB5 (guanine nucleotide binding protein (G protein), beta 5)   Male and Female 26 106 Brain -17.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GNG11 (guanine nucleotide binding protein (G protein), gamma 11)   Male and Female 26 106 Brain 23.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GNG12 (guanine nucleotide binding protein (G protein), gamma 12)   Male and Female 26 106 Brain 19.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GNG2 (guanine nucleotide binding protein (G protein), gamma 2) Gene expression showed a significant (p<E-3) decrease in the expression of GNG2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -45.65   2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
GNG5 (guanine nucleotide binding protein (G protein), gamma 5)   Male and Female 20 75 Skeletal Muscle -3.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
GNPAT (glyceronephosphate O-acyltransferase) Using a linear mixed model, differential expression with age was identified in GNPAT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GNPDA1 (glucosamine-6-phosphate deaminase 1)   Male and Female 22 73 Skeletal Muscle 3.0   2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100)
Gnpda1 (glucosamine-6-phosphate deaminase 1)   Male and Female 6 22 Liver -6.0   1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)) Using a linear mixed model, differential expression with age was identified in GNRH1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GNRH2 (gonadotropin-releasing hormone 2) Using a linear mixed model, differential expression with age was identified in GNRH2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GNRHR2 (gonadotropin-releasing hormone (type 2) receptor 2)   Male and Female 20 75 Skeletal Muscle 4.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Gns (glucosamine (N-acetyl)-6-sulfatase)   Male and Female 8 24 Muscle 3.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
GOLGB1 (golgin B1) Using a linear mixed model, differential expression with age was identified in GOLGB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GOLPH3L (golgi phosphoprotein 3-like) Using a linear mixed model, differential expression with age was identified in GOLPH3L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GOT1 (glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)) Using a linear mixed model, differential expression with age was identified in GOT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GOT1 (glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1))   Male and Female 20 75 Skeletal Muscle -6.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
GOT2 (glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2))   Male and Female 20 75 Skeletal Muscle -4.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Gp1ba (glycoprotein 1b, alpha polypeptide)   Male and Female 2 26 Lung 20.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Gp1bb (glycoprotein Ib, beta polypeptide)   Male and Female 2 26 Lung 22.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Gp5 (glycoprotein 5 (platelet))   Male and Female 2 26 Lung 15.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Gp6 (glycoprotein 6 (platelet))   Male and Female 2 26 Lung 16.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
GPC1 (glypican 1) Using a linear mixed model, differential expression with age was identified in GPC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GPC2 (glypican 2) Using a linear mixed model, differential expression with age was identified in GPC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GPC6 (glypican 6) Using a linear mixed model, differential expression with age was identified in GPC6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gpcpd1 (glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae))   Male and Female 2 26 Lung 8.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Gpd1 (glycerol-3-phosphate dehydrogenase 1 (soluble))   Male and Female 8 24 Muscle -6.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
GPHN (gephyrin) Using a linear mixed model, differential expression with age was identified in GPHN in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GPI (glucose-6-phosphate isomerase) Using a linear mixed model, differential expression with age was identified in GPI in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GPN2 (GPN-loop GTPase 2) Using a linear mixed model, differential expression with age was identified in GPN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GPR128 (G protein-coupled receptor 128) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of GPR128 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
GPR137B (G protein-coupled receptor 137B) Using a linear mixed model, differential expression with age was identified in GPR137B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GPR137B (G protein-coupled receptor 137B)   Male and Female 26 106 Brain 16.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GPR25 (G protein-coupled receptor 25) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of GPR25 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
GPRC5B (G protein-coupled receptor, family C, group 5, member B)   Male and Female 26 106 Brain 10.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GPRC5D (G protein-coupled receptor, class C, group 5, member D) Using a linear mixed model, differential expression with age was identified in GPRC5D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GPT (glutamic-pyruvate transaminase (alanine aminotransferase)) Using a linear mixed model, differential expression with age was identified in GPT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GPX3 (glutathione peroxidase 3 (plasma)) Using a linear mixed model, differential expression with age was identified in GPX3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gpx3 (glutathione peroxidase 3)   Male and Female 3 23 Hematological System 45.0   2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
GPX4 (glutathione peroxidase 4) Using a linear mixed model, differential expression with age was identified in GPX4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GRAMD2 (GRAM domain containing 2) Using a linear mixed model, differential expression with age was identified in GRAMD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GRAMD3 (GRAM domain containing 3) Using a linear mixed model, differential expression with age was identified in GRAMD3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Grcc10 (gene rich cluster, C10 gene)   Male and Female 5 30 Anatomical System 3.0   2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
GREB1 (growth regulation by estrogen in breast cancer 1) Using a linear mixed model, differential expression with age was identified in GREB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GREB1L (growth regulation by estrogen in breast cancer-like) Using a linear mixed model, differential expression with age was identified in GREB1L in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GREB1L (growth regulation by estrogen in breast cancer-like) Using a linear mixed model, differential expression with age was identified in GREB1L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GREM1 (gremlin 1, DAN family BMP antagonist) Using a linear mixed model, differential expression with age was identified in GREM1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GREM1 (gremlin 1, DAN family BMP antagonist) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of GREM1 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
GRHPR (glyoxylate reductase/hydroxypyruvate reductase)   Male and Female 20 75 Skeletal Muscle -2.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Grhpr (glyoxylate reductase/hydroxypyruvate reductase)   Male and Female 8 24 Muscle -1.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
GRIA1 (glutamate receptor, ionotropic, AMPA 1)   Male and Female 26 106 Brain -17.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GRIA2 (glutamate receptor, ionotropic, AMPA 2) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of GRIA2 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
GRIN2A (glutamate receptor, ionotropic, N-methyl D-aspartate 2A)   Male and Female 26 106 Brain -18.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GRIN2D (glutamate receptor, ionotropic, N-methyl D-aspartate 2D)   Male and Female 26 106 Brain -7.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GRP (gastrin-releasing peptide) Using a linear mixed model, differential expression with age was identified in GRP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GRTP1 (growth hormone regulated TBC protein 1) Using a linear mixed model, differential expression with age was identified in GRTP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GSDMB (gasdermin B) Using a linear mixed model, differential expression with age was identified in GSDMB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GSDMC (gasdermin C) Using a linear mixed model, differential expression with age was identified in GSDMC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gse1 (genetic suppressor element 1)   Male and Female 5 30 Anatomical System -31.0   2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
GSTA1 (glutathione S-transferase alpha 1) Using a linear mixed model, differential expression with age was identified in GSTA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GSTM2 (glutathione S-transferase mu 2 (muscle)) Using a linear mixed model, differential expression with age was identified in GSTM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GTDC1 (glycosyltransferase-like domain containing 1)   Male and Female 20 75 Skeletal Muscle -2.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Gtf2i (general transcription factor II I)   Male and Female 2 15 Hippocampus -1.0   2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
GTF3C2 (general transcription factor IIIC, polypeptide 2, beta 110kDa) Using a linear mixed model, differential expression with age was identified in GTF3C2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gtpbp2 (GTP binding protein 2)   Male and Female 8 24 Muscle -2.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
GTPBP3 (GTP binding protein 3 (mitochondrial)) Using a linear mixed model, differential expression with age was identified in GTPBP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GUCA1B (guanylate cyclase activator 1B (retina)) Using a linear mixed model, differential expression with age was identified in GUCA1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GUK1 (guanylate kinase 1)   Male and Female 26 106 Brain -5.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
GYLTL1B (glycosyltransferase-like 1B) Using a linear mixed model, differential expression with age was identified in GYLTL1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GYPC (glycophorin C (Gerbich blood group)) Using a linear mixed model, differential expression with age was identified in GYPC in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GYPC (glycophorin C (Gerbich blood group)) Using a linear mixed model, differential expression with age was identified in GYPC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GZMH (granzyme H (cathepsin G-like 2, protein h-CCPX)) Using a linear mixed model, differential expression with age was identified in GZMH in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
GZMH (granzyme H (cathepsin G-like 2, protein h-CCPX)) Using a linear mixed model, differential expression with age was identified in GZMH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Gzmm (granzyme M (lymphocyte met-ase 1))   Male and Female 2 26 Lung 16.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
H2-Aa (histocompatibility 2, class II antigen A, alpha)   Male and Female 6 22 Liver 53.0   1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
H2-Ab1 (histocompatibility 2, class II antigen A, beta 1)   Male and Female 6 22 Liver 30.0   1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
H2AFJ (H2A histone family, member J) Using a linear mixed model, differential expression with age was identified in H2AFJ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
H2AFJ (H2A histone family, member J)   Male and Female 20 75 Skeletal Muscle 6.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
H3F3B (H3 histone, family 3B (H3.3B))   Male and Female 20 75 Skeletal Muscle 5.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HABP4 (hyaluronan binding protein 4) Using a linear mixed model, differential expression with age was identified in HABP4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HADH (hydroxyacyl-CoA dehydrogenase) Using a linear mixed model, differential expression with age was identified in HADH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HAO2 (hydroxyacid oxidase 2 (long chain)) Using a linear mixed model, differential expression with age was identified in HAO2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HARS2 (histidyl-tRNA synthetase 2, mitochondrial) Using a linear mixed model, differential expression with age was identified in HARS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HAS3 (hyaluronan synthase 3) Gene expression showed a significant (p<E-3) increase in the expression of HAS3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary 60.0   2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
HAUS7 (HAUS augmin-like complex, subunit 7) Using a linear mixed model, differential expression with age was identified in HAUS7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HBEGF (heparin-binding EGF-like growth factor) Using a linear mixed model, differential expression with age was identified in HBEGF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HCCS (holocytochrome c synthase (cytochrome c heme-lyase))   Male and Female 20 75 Skeletal Muscle -4.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HCCS (holocytochrome c synthase (cytochrome c heme-lyase))   Male and Female 26 106 Brain -14.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
HCLS1 (hematopoietic cell-specific Lyn substrate 1) Using a linear mixed model, differential expression with age was identified in HCLS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HCP5 (HLA complex P5 (non-protein coding)) Using a linear mixed model, differential expression with age was identified in HCP5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HCP5 (HLA complex P5 (non-protein coding)) Using a linear mixed model, differential expression with age was identified in HCP5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HDAC4 (histone deacetylase 4)   Male and Female 20 75 Skeletal Muscle 6.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HEATR4 (HEAT repeat containing 4) Using a linear mixed model, differential expression with age was identified in HEATR4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HEY2 (hes-related family bHLH transcription factor with YRPW motif 2) Using a linear mixed model, differential expression with age was identified in HEY2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Heyl (hairy/enhancer-of-split related with YRPW motif-like)   Male and Female 8 24 Muscle -4.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
HIBCH (3-hydroxyisobutyryl-CoA hydrolase) Using a linear mixed model, differential expression with age was identified in HIBCH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HIGD1B (HIG1 hypoxia inducible domain family, member 1B) Using a linear mixed model, differential expression with age was identified in HIGD1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HILPDA (hypoxia inducible lipid droplet-associated) Using a linear mixed model, differential expression with age was identified in HILPDA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HINT1 (histidine triad nucleotide binding protein 1)   Male and Female 26 106 Brain -5.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
HIPK2 (homeodomain interacting protein kinase 2) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of HIPK2 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
HIST1H1C (histone cluster 1, H1c) Using a linear mixed model, differential expression with age was identified in HIST1H1C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Hist1h1c (histone cluster 1, H1c)   Male and Female 2 26 Lung 7.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Hist1h1c (histone cluster 1, H1c)   Male and Female 6 22 Liver 26.0   1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
HIST1H2BD (histone cluster 1, H2bd) Using a linear mixed model, differential expression with age was identified in HIST1H2BD in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HIST1H2BD (histone cluster 1, H2bd) Using a linear mixed model, differential expression with age was identified in HIST1H2BD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HIST1H2BK (histone cluster 1, H2bk) Using a linear mixed model, differential expression with age was identified in HIST1H2BK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Hist1h3a (histone cluster 1, H3a)   Male and Female 2 26 Lung 11.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
HIST1H4H (histone cluster 1, H4h) Using a linear mixed model, differential expression with age was identified in HIST1H4H in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HIST2H2BE (histone cluster 2, H2be) Using a linear mixed model, differential expression with age was identified in HIST2H2BE in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HIST3H2A (histone cluster 3, H2a) Using a linear mixed model, differential expression with age was identified in HIST3H2A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HIVEP3 (human immunodeficiency virus type I enhancer binding protein 3) Using a linear mixed model, differential expression with age was identified in HIVEP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Hjurp (Holliday junction recognition protein)   Male and Female 2 26 Lung 4.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
HLA-B (major histocompatibility complex, class I, B) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 34.98 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-B (major histocompatibility complex, class I, B) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 36.48 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-B (major histocompatibility complex, class I, B) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 43.98 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-B (major histocompatibility complex, class I, B) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 38.96 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 39.81 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 32.6 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 37.72 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 40.14 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 38.88 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 37.81 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 34.85 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 36.98 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 56.51 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 32.79 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-C (major histocompatibility complex, class I, C) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 44.0 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DMA (major histocompatibility complex, class II, DM alpha) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe HLA-DMA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 110.56 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DMA (major histocompatibility complex, class II, DM alpha) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DMA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 221.51 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DMA (major histocompatibility complex, class II, DM alpha) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DMA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 169.94 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DMA (major histocompatibility complex, class II, DM alpha) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DMA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 115.54 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DMB (major histocompatibility complex, class II, DM beta) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DMB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 90.51 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DMB (major histocompatibility complex, class II, DM beta) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DMB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 56.95 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) Using a linear mixed model, differential expression with age was identified in HLA-DPA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 210.32 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 262.92 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 124.35 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 169.04 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 97.14 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 35.77 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 153.21 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DPB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 160.52 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DPB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 13.18 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DPB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 81.55 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DPB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 76.89 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DQA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 496.71 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DQA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 203.67 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DQB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 135.36 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DQB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 105.97 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRA (major histocompatibility complex, class II, DR alpha) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 317.66 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRA (major histocompatibility complex, class II, DR alpha) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 146.66 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRA (major histocompatibility complex, class II, DR alpha) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 241.65 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRA (major histocompatibility complex, class II, DR alpha) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 146.81 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRA (major histocompatibility complex, class II, DR alpha) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 150.4 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRA (major histocompatibility complex, class II, DR alpha) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 324.53 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRA (major histocompatibility complex, class II, DR alpha) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 303.68 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRA (major histocompatibility complex, class II, DR alpha) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 135.28 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 193.49 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRB2 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 90.28 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRB3 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 82.98 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 204.16 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 111.08 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 84.78 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB4 (major histocompatibility complex, class II, DR beta 4) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRB4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 177.65 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB4 (major histocompatibility complex, class II, DR beta 4) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRB4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 100.42 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB4 (major histocompatibility complex, class II, DR beta 4) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRB4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 88.46 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB5 (major histocompatibility complex, class II, DR beta 5) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRB5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 95.76 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB5 (major histocompatibility complex, class II, DR beta 5) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRB5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 183.97 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB5 (major histocompatibility complex, class II, DR beta 5) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRB5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 64.14 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB6 (major histocompatibility complex, class II, DR beta 6 (pseudogene)) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRB6 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 150.16 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-DRB6 (major histocompatibility complex, class II, DR beta 6 (pseudogene)) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRB6 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 33.5 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-E (major histocompatibility complex, class I, E) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 76.64 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-E (major histocompatibility complex, class I, E) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 58.3 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-E (major histocompatibility complex, class I, E) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 39.23 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-E (major histocompatibility complex, class I, E) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 43.93 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-E (major histocompatibility complex, class I, E) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 34.88 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-E (major histocompatibility complex, class I, E) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 41.65 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-E (major histocompatibility complex, class I, E) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 65.73 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-E (major histocompatibility complex, class I, E) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 61.18 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-E (major histocompatibility complex, class I, E) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 76.89 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-F (major histocompatibility complex, class I, F) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-F from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 28.92 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-G (major histocompatibility complex, class I, G) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 30.56   2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-G (major histocompatibility complex, class I, G) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 30.53   2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-G (major histocompatibility complex, class I, G) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 25.96   2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLA-G (major histocompatibility complex, class I, G) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 28.42   2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
HLCS (holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)) Using a linear mixed model, differential expression with age was identified in HLCS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HLF (hepatic leukemia factor)   Male and Female 26 106 Brain -10.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
HMGB2 (high mobility group box 2) Using a linear mixed model, differential expression with age was identified in HMGB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HMGCL (3-hydroxymethyl-3-methylglutaryl-CoA lyase) Using a linear mixed model, differential expression with age was identified in HMGCL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)) Using a linear mixed model, differential expression with age was identified in HMGCS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HMGN2 (high-mobility group nucleosomal binding domain 2)   Male and Female 20 75 Skeletal Muscle 3.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HN1 (hematological and neurological expressed 1)   Male and Female 20 75 Skeletal Muscle 3.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)   Male and Female 20 75 Skeletal Muscle 2.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3)   Male and Female 20 75 Skeletal Muscle 3.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HNRNPC (heterogeneous nuclear ribonucleoprotein C (C1/C2))   Male and Female 20 75 Skeletal Muscle 3.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)) Using a linear mixed model, differential expression with age was identified in HNRNPD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa))   Male and Female 20 75 Skeletal Muscle 2.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HNRNPDL (heterogeneous nuclear ribonucleoprotein D-like) Using a linear mixed model, differential expression with age was identified in HNRNPDL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HNRNPM (heterogeneous nuclear ribonucleoprotein M)   Male and Female 20 75 Skeletal Muscle 4.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HOOK2 (hook microtubule-tethering protein 2) Using a linear mixed model, differential expression with age was identified in HOOK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HOXA9 (homeobox A9) Using a linear mixed model, differential expression with age was identified in HOXA9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HOXB1 (homeobox B1) Comparison of DNA methylation showed a significantly decreased methylation level of HOXB1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -15.6   2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
HOXB1 (homeobox B1) Comparison of DNA methylation showed a significantly decreased methylation level of HOXB1 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell -49.3   2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
Hoxb4 (homeobox B4)   Male and Female 2 26 Lung -6.0   2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
HOXB5 (homeobox B5) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of HOXB5 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
HOXB6 (homeobox B6) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of HOXB6 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
HOXB7 (homeobox B7) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of HOXB7 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
HOXB8 (homeobox B8) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of HOXB8 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
HOXC4 (homeobox C4) Using a linear mixed model, differential expression with age was identified in HOXC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)

Reference: Digital Aging Atlas