Age Associated genes in humans

HAGRID

Common name

Symbol

187

1-Acylglycerol-3-phosphate O-acyltransferase 2

AGPAT2

87

3-Phosphoinositide dependent protein kinase 1

PDPK1

78

ABL proto-oncogene 1, non-receptor tyrosine kinase

ABL1

193

Activating transcription factor 2

ATF2

255

Adenylate cyclase 5

ADCY5

139

Alpha-2-macroglobulin

A2M

137

Amyloid beta (A4) precursor protein

APP

110

Androgen receptor

AR

264

Angiotensin II receptor, type 1

AGTR1

195

APEX nuclease (multifunctional DNA repair enzyme) 1

APEX1

102

Apolipoprotein C-III

APOC3

138

Apolipoprotein E

APOE

135

Apoptosis-inducing factor, mitochondrion-associated, 1

AIFM1

95

Aprataxin

APTX

251

Aryl hydrocarbon receptor nuclear translocator-like

ARNTL

9

ATM serine/threonine kinase

ATM

146

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

ATP5O

231

ATR serine/threonine kinase

ATR

69

B-cell CLL/lymphoma 2

BCL2

278

BCL2-antagonist/killer 1

BAK1

119

BCL2-associated X protein

BAX

186

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

BSCL2

68

Bloom syndrome, RecQ helicase-like

BLM

188

BMI1 proto-oncogene, polycomb ring finger

BMI1

191

Brain-derived neurotrophic factor

BDNF

61

Breast cancer 1, early onset

BRCA1

79

Breast cancer 2, early onset

BRCA2

197

BUB1 mitotic checkpoint serine/threonine kinase B

BUB1B

240

BUB3 mitotic checkpoint protein

BUB3

133

Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

CACNA1A

192

cAMP responsive element binding protein 1

CREB1

282

Cannabinoid receptor 1 (brain)

CNR1

304

Cardiotrophin 1

CTF1

244

Casein kinase 1, epsilon

CSNK1E

107

Catalase

CAT

223

Catenin (cadherin-associated protein), beta 1, 88kDa

CTNNB1

88

CCAAT/enhancer binding protein (C/EBP), alpha

CEBPA

89

CCAAT/enhancer binding protein (C/EBP), beta

CEBPB

265

CDGSH iron sulfur domain 2

CISD2

250

Cell division cycle 42

CDC42

247

Checkpoint kinase 2

CHEK2

262

Cholesteryl ester transfer protein, plasma

CETP

252

Clock circadian regulator

CLOCK

220

Clusterin

CLU

220

Clusterin

CLU

132

Coenzyme Q7 homolog, ubiquinone (yeast)

COQ7

287

Complement component 1, q subcomponent, A chain

C1QA

206

Connective tissue growth factor

CTGF

206

Connective tissue growth factor

CTGF

64

CREB binding protein

CREBBP

177

Cyclin A2

CCNA2

201

Cyclin-dependent kinase 1

CDK1

299

Cyclin-dependent kinase 7

CDK7

284

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

CDKN1A

226

Cyclin-dependent kinase inhibitor 2A

CDKN2A

288

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

CDKN2B

225

Delta-like 3 (Drosophila)

DLL3

291

Diacylglycerol O-acyltransferase 1

DGAT1

203

DNA-damage-inducible transcript 3

DDIT3

228

Drebrin 1

DBN1

94

E1A binding protein p300

EP300

18

E2F transcription factor 1

E2F1

76

Early growth response 1

EGR1

260

EGF containing fibulin-like extracellular matrix protein 1

EFEMP1

230

Elastin

ELN

121

Emerin

EMD

48

Epidermal growth factor

EGF

40

Epidermal growth factor receptor

EGFR

267

Epidermal growth factor receptor pathway substrate 8

EPS8

41

Erb-b2 receptor tyrosine kinase 2

ERBB2

52

Erythropoietin receptor

EPOR

216

Estrogen receptor 1

ESR1

216

Estrogen receptor 1

ESR1

189

Eukaryotic translation elongation factor 1 alpha 1

EEF1A1

266

Eukaryotic translation elongation factor 1 epsilon 1

EEF1E1

103

Eukaryotic translation elongation factor 2

EEF2

289

Eukaryotic translation initiation factor 5A2

EIF5A2

149

Excision repair cross-complementation group 1

ERCC1

11

Excision repair cross-complementation group 2

ERCC2

104

Excision repair cross-complementation group 3

ERCC3

261

Excision repair cross-complementation group 4

ERCC4

109

Excision repair cross-complementation group 5

ERCC5

92

Excision repair cross-complementation group 6

ERCC6

12

Excision repair cross-complementation group 8

ERCC8

115

Fas cell surface death receptor

FAS

50

FBJ murine osteosarcoma viral oncogene homolog

FOS

293

Fibroblast growth factor 21

FGF21

259

Fibroblast growth factor 23

FGF23

169

Fibroblast growth factor receptor 1

FGFR1

114

Flap structure-specific endonuclease 1

FEN1

171

Fms-related tyrosine kinase 1

FLT1

131

Forkhead box M1

FOXM1

124

Forkhead box O1

FOXO1

123

Forkhead box O3

FOXO3

183

Forkhead box O4

FOXO4

111

General transcription factor IIH, polypeptide 2, 44kDa

GTF2H2

237

Glutamate-cysteine ligase, catalytic subunit

GCLC

238

Glutamate-cysteine ligase, modifier subunit

GCLM

153

Glutathione peroxidase 1

GPX1

257

Glutathione peroxidase 4

GPX4

154

Glutathione reductase

GSR

156

Glutathione S-transferase alpha 4

GSTA4

157

Glutathione S-transferase pi 1

GSTP1

155

Glutathione synthetase

GSS

295

Glycogen synthase kinase 3 alpha

GSK3A

97

Glycogen synthase kinase 3 beta

GSK3B

300

Granulin

GRN

309

Growth differentiation factor 11

GDF11

122

Growth factor receptor-bound protein 2

GRB2

26

Growth hormone 1

GH1

1

Growth hormone receptor

GHR

2

Growth hormone releasing hormone

GHRH

222

Growth hormone releasing hormone receptor

GHRHR

212

H2A histone family, member X

H2AFX

212

H2A histone family, member X

H2AFX

38

Harvey rat sarcoma viral oncogene homolog

HRAS

159

Heat shock 60kDa protein 1 (chaperonin)

HSPD1

160

Heat shock 70kDa protein 1A

HSPA1A

161

Heat shock 70kDa protein 1B

HSPA1B

199

Heat shock 70kDa protein 8

HSPA8

152

Heat shock 70kDa protein 9 (mortalin)

HSPA9

74

Heat shock protein 90kDa alpha (cytosolic), class A member 1

HSP90AA1

125

Heat shock transcription factor 1

HSF1

101

Helicase, lymphoid-specific

HELLS

184

HESX homeobox 1

HESX1

176

High mobility group box 1

HMGB1

178

High mobility group box 2

HMGB2

151

Histone deacetylase 1

HDAC1

207

Histone deacetylase 2

HDAC2

207

histone deacetylase 2

HDAC2

25

Histone deacetylase 3

HDAC3

196

HMG-box transcription factor 1

HBP1

213

Homeobox B7

HOXB7

213

Homeobox B7

HOXB7

214

Homeobox C4

HOXC4

214

Homeobox C4

HOXC4

294

HtrA serine peptidase 2

HTRA2

98

Huntingtin

HTT

253

Hypermethylated in cancer 1

HIC1

65

Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

HIF1A

297

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

IKBKB

30

Insulin

INS

42

Insulin receptor

INSR

32

Insulin receptor substrate 1

IRS1

34

Insulin receptor substrate 2

IRS2

28

Insulin-like growth factor 1 (somatomedin c)

IGF1

15

Insulin-like growth factor 1 receptor

IGF1R

29

Insulin-like growth factor 2

IGF2

279

Insulin-like growth factor binding protein 2, 36kDa

IGFBP2

73

Insulin-like growth factor binding protein 3

IGFBP3

308

Interferon beta

IFNB1

46

Interleukin 2

IL2

49

Interleukin 2 receptor, gamma

IL2RG

144

Interleukin 6

IL6

167

Interleukin 7

IL7

27

Interleukin 7 receptor

IL7R

215

Janus kinase 2

JAK2

215

Janus kinase 2

JAK2

45

Jun D proto-oncogene

JUND

172

Jun proto-oncogene

JUN

17

Klotho

KL

14

Lamin A/C

LMNA

181

Lamin B1

LMNB1

217

Leptin

LEP

217

Leptin

LEP

218

Leptin receptor

LEPR

218

Leptin receptor

LEPR

134

Low density lipoprotein receptor-related protein 2

LRP2

290

Macrophage migration inhibitory factor (glycosylation-inhibiting factor)

MIF

209

MAX dimerization protein 1

MXD1

209

MAX dimerization protein 1

MXD1

90

MAX interactor 1, dimerization protein

MXI1

210

MDM2 proto-oncogene, E3 ubiquitin protein ligase

MDM2

210

MDM2 proto-oncogene, E3 ubiquitin protein ligase

MDM2

221

Mechanistic target of rapamycin (serine/threonine kinase)

MTOR

221

Mechanistic target of rapamycin (serine/threonine kinase)

MTOR

173

Mediator complex subunit 1

MED1

292

Metallothionein 1E

MT1E

127

Methionine sulfoxide reductase A

MSRA

205

Microtubule-associated protein tau

MAPT

205

Microtubule-associated protein tau

MAPT

158

Mitochondrially encoded cytochrome c oxidase I

MT-CO1

168

Mitogen-activated protein kinase 14

MAPK14

175

Mitogen-activated protein kinase 3

MAPK3

163

Mitogen-activated protein kinase 8

MAPK8

174

Mitogen-activated protein kinase 9

MAPK9

179

Mitogen-activated protein kinase kinase kinase 5

MAP3K5

243

MutL homolog 1

MLH1

208

MYC associated factor X

MAX

208

MYC associated factor X

MAX

31

Nerve growth factor (beta polypeptide)

NGF

37

Nerve growth factor receptor

NGFR

24

Neuregulin 1

NRG1

44

Nibrin

NBN

229

Noggin

NOG

20

Nuclear factor of kappa light polypeptide gene enhancer in b-cells 2 (p49/p100)

NFKB2

82

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

NFKB1

219

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

NFKBIA

219

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

NFKBIA

307

Nuclear factor, erythroid 2-like 1

NFE2L1

283

Nuclear factor, erythroid 2-like 2

NFE2L2

43

Nuclear receptor corepressor 1

NCOR1

276

Nuclear receptor corepressor 2

NCOR2

75

Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

NR3C1

296

nudix (nucleoside diphosphate linked moiety X)-type motif 1

NUDT1

142

Paraoxonase 1

PON1

62

Peptidylprolyl cis/trans isomerase, NIMA-interacting 1

PIN1

141

Peroxiredoxin 1

PRDX1

58

Peroxisomal biogenesis factor 5

PEX5

55

Peroxisome proliferator-activated receptor alpha

PPARA

263

Peroxisome proliferator-activated receptor gamma

PPARG

256

Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

PPARGC1A

63

Phosphatase and tensin homolog

PTEN

36

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

PIK3CB

286

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

PIK3CA

248

Phosphoenolpyruvate carboxykinase 1 (soluble)

PCK1

185

Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

PIK3R1

57

Phospholipase C, gamma 2 (phosphatidylinositol-specific)

PLCG2

10

Plasminogen activator, urokinase

PLAU

47

Platelet-derived growth factor beta polypeptide

PDGFB

285

Platelet-derived growth factor receptor, alpha polypeptide

PDGFRA

51

Platelet-derived growth factor receptor, beta polypeptide

PDGFRB

60

Poly (ADP-ribose) polymerase 1

PARP1

204

Polymerase (DNA directed), alpha 1, catalytic subunit

POLA1

236

Polymerase (DNA directed), beta

POLB

118

Polymerase (DNA directed), delta 1, catalytic subunit

POLD1

72

Polymerase (DNA directed), gamma

POLG

268

Potassium channel, voltage gated shaker related subfamily A, member 3

KCNA3

4

POU class 1 homeobox 1

POU1F1

254

Pregnancy-associated plasma protein A, pappalysin 1

PAPPA

224

Presenilin 1

PSEN1

113

proliferating cell nuclear antigen

PCNA

242

Pro-melanin-concentrating hormone

PMCH

96

Promyelocytic leukemia

PML

5

PROP paired-like homeobox 1

PROP1

198

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

PTGS2

99

Protein kinase C, alpha

PRKCA

54

Protein kinase C, delta

PRKCD

106

Protein kinase, DNA-activated, catalytic polypeptide

PRKDC

227

Protein phosphatase 1, catalytic subunit, alpha isozyme

PPP1CA

246

Protein phosphatase, Mg2+/Mn2+ dependent, 1D

PPM1D

166

Protein tyrosine kinase 2

PTK2

165

Protein tyrosine kinase 2 beta

PTK2B

33

Protein tyrosine phosphatase, non-receptor type 1

PTPN1

19

Protein tyrosine phosphatase, non-receptor type 11

PTPN11

162

Protein-L-isoaspartate (D-aspartate) O-methyltransferase

PCMT1

280

Pyrroline-5-carboxylate reductase 1

PYCR1

84

RAD51 recombinase

RAD51

147

RAD52 homolog, DNA repair protein

RAD52

128

RecQ helicase-like 4

RECQL4

145

Regucalcin

RGN

67

Replication protein A1, 70kDa

RPA1

56

Ret proto-oncogene

RET

120

Retinoblastoma 1

RB1

249

Rho GTPase activating protein 1

ARHGAP1

241

Ribonucleic acid export 1

RAE1

303

RPTOR independent companion of MTOR, complex 2

RICTOR

70

S100 calcium binding protein B

S100B

277

Sad1 and UNC84 domain containing 1

SUN1

298

Sequestosome 1

SQSTM1

93

Serine/threonine kinase 11

STK11

301

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

SERPINE1

3

SHC (Src homology 2 domain containing) transforming protein 1

SHC1

22

Signal transducer and activator of transcription 3 (acute-phase response factor)

STAT3

23

Signal transducer and activator of transcription 5a

STAT5A

21

Signal transducer and activator of transcription 5b

STAT5B

200

SIN3 transcription regulator family member A

SIN3A

150

Sirtuin 1

SIRT1

275

Sirtuin 3

SIRT3

239

Sirtuin 6

SIRT6

269

Sirtuin 7

SIRT7

211

Small ubiquitin-like modifier 1

SUMO1

211

Small ubiquitin-like modifier 1

SUMO1

270

Solute carrier family 13 (sodium/sulfate symporter), member 1

SLC13A1

53

Somatostatin

SST

100

Somatostatin receptor 3

SSTR3

170

Sp1 transcription factor

SP1

302

SprT-like N-terminal domain

SPRTN

245

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

STUB1

182

Succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa

SDHC

130

Superoxide dismutase 1, soluble

SOD1

129

Superoxide dismutase 2, mitochondrial

SOD2

271

Suppressor of cytokine signaling 2

SOCS2

140

Synuclein, gamma (breast cancer-specific protein 1)

SNCG

180

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

TAF1

194

TATA box binding protein

TBP

8

Telomerase reverse transcriptase

TERT

7

Telomerase rna component

TERC

105

Telomeric repeat binding factor (NIMA-interacting) 1

TERF1

116

Telomeric repeat binding factor 2

TERF2

16

Thioredoxin

TXN

305

TNF receptor-associated protein 1

TRAP1

83

Topoisomerase (DNA) I

TOP1

80

Topoisomerase (DNA) II alpha

TOP2A

81

Topoisomerase (DNA) II beta

TOP2B

148

Topoisomerase (DNA) III beta

TOP3B

59

Transcription factor 3

TCF3

190

Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

TFAP2A

202

Transcription factor Dp-1

TFDP1

91

Transforming growth factor, beta 1

TGFB1

306

Transient receptor potential cation channel subfamily V member 1

TRPV1

273

Tripeptidyl peptidase II

TPP2

86

Tumor necrosis factor

TNF

6

Tumor protein p53

TP53

274

Tumor protein p53 binding protein 1

TP53BP1

234

Tumor protein p63

TP63

281

Tumor protein p73

TP73

164

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

YWHAZ

66

Ubiquitin B

UBB

136

Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

UCHL1

85

Ubiquitin-conjugating enzyme E2I

UBE2I

258

Uncoupling protein 1 (mitochondrial, proton carrier)

UCP1

235

Uncoupling protein 2 (mitochondrial, proton carrier)

UCP2

232

Uncoupling protein 3 (mitochondrial, proton carrier)

UCP3

35

V-akt murine thymoma viral oncogene homolog 1

AKT1

71

Valosin containing protein

VCP

77

Vascular endothelial growth factor A

VEGFA

39

V-myc avian myelocytomatosis viral oncogene homolog

MYC

143

v-rel avian reticuloendotheliosis viral oncogene homolog A

RELA

13

Werner syndrome, RecQ helicase-like

WRN

126

Xeroderma pigmentosum, complementation group A

XPA

112

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

XRCC5

117

X-ray repair complementing defective repair in Chinese hamster cells 6

XRCC6

233

Zinc metallopeptidase STE24

ZMPSTE24

Reference: HAGR