Life extension by compounds in Drosophila Melanogaster – Part 1

Part 1 Part 2 Part 3 Part 4

Name of Formulation Dose Avg/Med Lifespan Change (%) -96267.9 Max Lifespan Change (%) -94.993 Strain Significance (Yes: Y, No: N) Reference
Carnosine 200 mg/l D-32 N 12447464
Cocoa 100 g/l medium rosy^+5 N 19083435
Cocoa 50 g/l medium rosy^+5 Y 19083435
Curcumin 10 mM Ra N 23063786
Curcumin 200 mM Ra Y 23063786
Curcumin 0.5 mg/g Wild 1-A N 23675008
Nordihydroguaiaretic acid 1 mg/ml Oregon-R-C N 25380600
Rhodiola rosea extract 30 mg/mL every other day 28.6 ND 9825229
Rhodiola rosea extract 30 mg/mL every other day 42.9 ND 9825229
Tartaric acid 0.1M -72 Oregon R ND 110607
Sodium borate 0.01 M -69.2 Oregon R Y 7889879
Calcium lactate 0.1 M -66.1 Oregon R ND 110607
Metformin 100 mM -66 Dahomey Y 23077661
Calcium gluconate 0.1 M -56.6 Oregon R ND 110607
Sodium borate 0.05 M -51.9 Oregon R Y 7889879
Paraquat 1 mM -41.4 Dahomey Y 27076081
Rutin 800 µM -38 Canton-S Y 28389882
Lactic acid 1 M -32.7 Oregon R ND 110607
Metformin 100 mM -31 Dahomey Y 23077661
Curcumin 100 mM -23.4 Ra N 23063786
Curcumin 100 mM -23.4 Ra Y 26136617
Rutin 600 µM -23 Canton-S Y 28389882
Caffeine 0.03% -22.86 -11.6 Canton-S Y 29093334
Metformin 50 mM -22 Dahomey Y 23077661
Sodium borate 1 mM -21.2 Oregon R Y 7889879
Rotenone 100 µM -21.14 Dahomey Y 27076081
Caffeine 0.05% -17.14 -11.6 Canton-S Y 29093334
Curcumin 100 mM -17 -3 Ra Y 26136617
Curcumin 100 mM -17 3 Ra Y 23063786
Rutin 800 µM -16.66 Canton-S Y 28389882
Galactose 6.50% -15.9 -17.1 Y 15547319
Resveratrol 32 µM -15.4 Canton S N 17875315
Taurine 1.50% -14.29 -23.19 Canton-S Y 29093334
Resveratrol 32 µM -13.9 Canton S Y 17875315
Quercetin 1 µM -13.79 -14.62 Canton S Y 28066251
Rutin 600 µM -13.33 Canton-S Y 28389882
Calcium gluconate 0.01 M -13.2 Oregon R ND 110607
Galactose 6.50% -12.6 -12.9 Y 15547319
Quercetin 0.5 µM -12 -13.84 Canton S Y 28066251
Rhodiola rosea 30 mg/ml -11.9 -16.4 IF Y 24472572
Epicatechin 1 µM -11.44 -2.21 Canton S Y 28066251
Sodium butyrate 100 mM -10.9 Ra Y 23044027
Calcium lactate 0.01 M -10.7 Oregon R ND 110607
Curcumin 100 mM -10.2 Ra N 23063786
Quercetin 1 µM -10.2 -8.21 Canton S Y 28066251
Caffeine 0.01 mg/ml -10.1 Oregon R N 8326745
Resveratrol 500 µmol/L -9.9 -5.28 w1118 N 29324667
Gluconic acid 1 M -9.3 Oregon R ND 110607
Sodium butyrate 10 mM -9.1 Ra N 23044027
Rhodiola rosea 30 mg/ml -9.1 -12.2 IF Y 24472572
Epicatechin 0.3µM -9.08 -10 Canton S Y 28066251
Catechin 0.1 mg/ml -8.5 Oregon R N 8326745
Resveratrol 10 µM -8.3 Canton S Y 17875315
Resveratrol 1000 µM -8.3 Canton S N 17875315
Curcumin 100 mM -8.2 25 Ra Y 23063786
Resveratrol 10 µM -7.7 Canton S Y 17875315
Resveratrol 3.2 µM -7.4 Dahomey N 17875315
Resveratrol 32 µM -7.4 Dahomey N 17875315
Resveratrol 1000 µM -7.4 Dahomey N 17875315
Resveratrol 200 µM -7.4 Dahomey N 17875315
Metformin 25 mM -7 Dahomey Y 23077661
Resveratrol 1 µM -6.8 Canton S N 17875315
Epicatechin 0.3µM -6.49 -5.22 Canton S Y 28066251
Sodium butyrate 100 mM -6.3 Ra N 23044027
Sodium butyrate 10 mM -6.3 Ra N 23044027
Metformin 50 mM -6 Dahomey N 23077661
Metformin 10 mM -6 Dahomey N 23077661
Metformin 25 mM -6 Dahomey N 23077661
Resveratrol 1 µM -5.6 Dahomey N 17875315
Resveratrol 10 µM -5.6 Dahomey Y 17875315
Resveratrol 1000 µM -5.6 Dahomey N 17875315
Gluconic acid 0.1 M -5.2 Oregon R ND 110607
Catechin 1 mg/ml -5.1 Oregon R N 8326745
Catechin 0.01 mg/ml -5.1 Oregon R N 8326745
Quercetin 0.3µM -5.09 -8.2 Canton S Y 28066251
Quercetin 0.5 µM -4.55 -6.7 Canton S Y 28066251
Resveratrol 10 µM -4.5 Canton S N 17875315
Resveratrol 200 µM -4.5 Canton S N 17875315
Metformin 2.5 mM -4 Dahomey N 23077661
Epicatechin 1 µM -3.78 -4.48 Canton S Y 28066251
Calcium gluconate 0.001 M -3.7 Oregon R ND 110607
Resveratrol 1 µM -3.7 Dahomey N 17875315
Resveratrol 100 µM -3.7 Dahomey N 17875315
Resveratrol 10 µM -3.4 Canton S N 17875315
Resveratrol 1 µM -3.4 Canton S N 17875315
Resveratrol 32 µM -3.4 Canton S Y 17875315
Resveratrol 100 µM -3.4 Canton S N 17875315
Resveratrol 3.2 µM -3.4 Canton S N 17875315
Resveratrol 100 µM -3.4 Canton S N 17875315
Resveratrol 200 µM -3.4 Canton S N 17875315
Resveratrol 1000 µM -3.4 Canton S N 17875315
Resveratrol 3.2 µM -3.4 Dahomey N 17875315
Resveratrol 100 µM -3.4 Dahomey N 17875315
Resveratrol 32 µM -3.4 Dahomey N 17875315
Caffeine 1 mg/ml -3.3 Oregon R N 8326745
Metformin 10 mM -3 Dahomey N 23077661
Resveratrol 3.2 µM -3 Dahomey N 17875315
Tannic acid 1 mg/ml -2.9 Oregon R N 8326745
Resveratrol 3.2 µM -2.8 Canton S N 17875315
Reference: HAGR