Genetic variants of human longevity

Part 1 Part 2 Part 3 Part 4

ID

Gene/Variant

Chromosomal Location

Population Studied

Findings

References

94

ABCA1

9q31.1

Japanese

Non-significant (study details)

Arai et al. (2003)

316

ABCC4

13q32.1

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

253

ACE

17q23.3

Greek

Significant (study details)

Kolovou et al. (2014)

162

ACE

17q23.3

Chinese (Uighur in Xinjiang)

Significant (study details)

Wufuer et al. (2004)

130

ACE

17q23.3

Russian (Novosibirsk)

Significant (study details)

Shabalin et al. (2003)

98

ACE

17q23.3

Korean

Non-significant (study details)

Choi et al. (2003)

126

ACE

17q23.3

Brazilian of European and Japanese origin

Significant (study details)

Da Cruz et al. (2003)

222

ACE

17q23.3

Italian (Southern)

Significant (study details)

Seripa et al. (2006)

62

ACE

17q23.3

American (Caucasian)

Non-significant (study details)

Hessner et al. (2001)

85

ACE

17q23.3

Polish

Non-significant (study details)

Grzeszczak and Misztalski (2002)

53

ACE

17q23.3

French

Non-significant (study details)

Blanché et al. (2001)

90

ACE

17q23.3

Danish

Significant (study details)

Frederiksen et al. (2003)

63

ACE

17q23.3

Danish

Non-significant (study details)

Tan et al. (2001)

45

ACE

17q23.3

Dutch

Non-significant (study details)

Heijmans et al. (1999)

13

ACE

17q23.3

English (Cambridge)

Significant (study details)

Galinsky et al. (1997)

228

ACE

17q23.3

Italian

Non-significant (study details)

Nacmias et al. (2007)

123

ACE

17q23.3

Italian, French and Danish

Non-significant (study details)

Panza et al. (2003)

18

ACE

17q23.3

Danish

Non-significant (study details)

Agerholm-Larsen et al. (1997)

288

ACE

17q23.3

Chinese

Significant (study details)

Woo et al. (2012)

78

ACE

17q23.3

Chinese (Uighur, Kazakh and Han in Xinjiang)

Significant (study details)

Rahmutula et al. (2002)

37

ACE

17q23.3

Danish

Non-significant (study details)

Bladbjerg et al. (1999)

28

ACE

17q23.3

French

Significant (study details)

Faure-Delanef et al. (1998)

225

ACE

17q23.3

Columbian

Significant (study details)

Forero et al. (2006)

6

ACE

17q23.3

French

Significant (study details)

Schächter et al. (1994)

340

ACTN3

11q13.2

Spanish

Non-significant (study details)

Fiuza-Luces et al. (2011)

283

ADA

20q13.12

Italian (Central)

Significant (study details)

Napolioni et al. (2011)

240

ADA2

22q11.1

Italian

Significant (study details)

Napolioni and Lucarini (2010)

G432

ADARB1

21q22.3

Italian, Ashkenazi Jewish and Japanese

Significant (study details, 5 variants)

Sebastiani et al. (2009)

G433

ADARB2

10p15.3

Italian, Ashkenazi Jewish and Japanese

Significant (study details, 13 variants)

Sebastiani et al. (2009)

G549

ADIPOQ

3q27.3

Jordanian

Non-significant (study details, 2 variants)

Khabour et al. (2010)

281

ADIPOQ

3q27.3

Polish

Significant (study details)

Roszkowska-Gancarz et al. (2012)

242

ADIPOQ

3q27.3

Jordanian

Significant (study details)

Khabour et al. (2010)

G423

ADIPOQ

3q27.3

Ashkenazi Jewish

Non-significant (study details, 3 variants)

Atzmon et al. (2008)

G472

ADRB2

5q32

Chinese

Significant (study details, 2 variants)

Zhao et al. (2012)

3473

ADRB2

5q32

American (Caucasian)

Significant (study details)

Kulminski et al. (2010)

321

ADRB2

5q32

American (Caucasian)

Non-significant (study details)

Kulminski et al. (2010)

382

AGER

6p21.32

Caucasian

Significant (study details)

Falcone et al. (2013)

36

AGT

1q42.2

Danish

Non-significant (study details)

Bladbjerg et al. (1999)

64

AGT

1q42.2

Danish

Significant (study details)

Tan et al. (2001)

G497

AGTR1

3q24

Italian (Northern) and Japanese

Significant (study details, 2 variants)

Benigni et al. (2013)

100

AKAP10

17p11.2

American (Caucasian)

Significant (study details)

Kammerer et al. (2003)

255

AKT1

14q32.33

American (Caucasian)

Significant (study details)

Pawlikowska et al. (2009)

G474

AKT1

14q32.33

Danish, German

Non-significant (study details, 5 variants)

Nygaard et al. (2013)

289

AKT1

14q32.33

Danish, German

Significant (study details)

Nygaard et al. (2013)

91

APOA1

11q23.3

Italian (Southern)

Significant (study details)

Garasto et al. (2003)

3462

APOA4

11q23.3

Italian

Significant (study details)

Pepe et al. (1998)

92

APOA4

11q23.3

Italian (Southern)

Non-significant (study details)

Garasto et al. (2003)

24

APOA4

11q23.3

French

Non-significant (study details)

Merched et al. (1998)

2

APOB

2p24.1

Finnish

Non-significant (study details)

Louhija et al. (1994)

7

APOB

2p24.1

Finnish

Significant (study details)

Kervinen et al. (1994)

10

APOB

2p24.1

Italian

Significant (study details)

De Benedictis et al. (1997)

386

APOC1

19q13.32

European

Significant (study details)

Deelen et al. (2014)

12

APOC1

19q13.32

English (Cambridge)

Significant (study details)

Galinsky et al. (1997)

279

APOC1

19q13.32

European

Significant (study details)

Beekman et al. (2013)

52

APOC3

11q23.3

Russian

Significant (study details)

Anisimov et al. (2001)

89

APOC3

11q23.3

Italian (Southern)

Non-significant (study details)

Garasto et al. (2003)

213

APOC3

11q23.3

Ashkenazi Jewish

Significant (study details)

Atzmon et al. (2006)

4

APOC3

11q23.3

Finnish

Significant (study details)

Louhija et al. (1994)

G476

APOE

19q13.32

Danish, German, Dutch

Significant (study details, 3 variants)

Soerensen et al. (2013)

171

APOE

19q13.32

Ashkenazi Jewish (Jerusalem)

Non-significant (study details)

Stessman et al. (2005)

11

APOE

19q13.32

Italian

Non-significant (study details)

Ruiu et al. (1995)

G454

APOE

19q13.32

Danish

Significant (study details, 2 variants)

Lindahl-Jacobsen et al. (2013)

190

APOE

19q13.32

Chinese (Uighur in Xinjiang)

Significant (study details)

Mayila et al. (2005)

373

APOE

19q13.32

Irish (Belfast)

Significant (study details)

Rea et al. (2001)

131

APOE

19q13.32

Russian (Novosibirsk)

Significant (study details)

Shabalin et al. (2003)

99

APOE

19q13.32

Korean

Non-significant (study details)

Choi et al. (2003)

227

APOE

19q13.32

Columbian

Non-significant (study details)

Forero et al. (2006)

328

APOE

19q13.32

Italian

Significant (study details)

Malovini et al. (2011)

8

APOE

19q13.32

Finnish

Significant (study details)

Kervinen et al. (1994)

374

APOE

19q13.32

Chinese (Han)

Significant (study details)

Jian-Gang et al. (1998)

86

APOE

19q13.32

Brazilian

Non-significant (study details)

Schwanke et al. (2002)

68

APOE

19q13.32

Chinese (Uighur in Xinjiang)

Significant (study details)

Wang et al. (2001)

9

APOE

19q13.32

Swedish

Significant (study details)

Eggertsen et al. (1993)

224

APOE

19q13.32

Italian (Southern)

Significant (study details)

Seripa et al. (2006)

55

APOE

19q13.32

French

Significant (study details)

Blanché et al. (2001)

14

APOE

19q13.32

English (Cambridge)

Non-significant (study details)

Galinsky et al. (1997)

5

APOE

19q13.32

Finnish

Significant (study details)

Louhija et al. (1994)

229

APOE

19q13.32

Greek

Significant (study details)

Stakias et al. (2006)

51

APOE

19q13.32

Finnish

Significant (study details)

Frisoni et al. (2001)

248

APOE

19q13.32

American (Georgia and Louisiana populations from African and European origin)

Significant (study details)

Jazwinski et al. (2010)

G480

APOE

19q13.32

European and American (Caucasian)

Significant (study details, 2 variants)

McKay et al. (2011)

3476

APOE

19q13.32

French

Significant (study details)

Schächter et al. (1994)

323

ATM

11q22.3

Chinese (Han)

Significant (study details)

Chen et al. (2010)

357

ATM

11q22.3

Italian

Significant (study details)

Piaceri et al. (2013)

348

ATP8

Mt

Japanese

Significant (study details)

Tanaka et al. (1998)

297

ATRIP

3p21.31

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

77

BRCA1

17q21.31

American (Caucasians) and Italian

Non-significant (study details)

Vijg et al. (2001)

308

BTBD9

6p21.2

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

33

C3

19p13.3

Italian

Non-significant (study details)

Bellavia et al. (1999)

35

C4A

6p21.33

Italian

Non-significant (study details)

Bellavia et al. (1999)

302

C7orf50

7p22.3

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

300

CACNA1C

12p13.33

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

326

CAMK4

5q22.1

Italian

Significant (study details)

Malovini et al. (2011)

299

CARS

11p15.4

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

359

CASP5

11q22.3

Russian

Significant (study details)

Ulybina et al. (2010)

153

CAT

11p13

Danish

Non-significant (study details)

Christiansen et al. (2004)

G503

CCL5

17q12

Spanish

Significant (study details, 2 variants)

Laplana and Fibla (2012)

339

CCR5

3p21.31

Spanish

Non-significant (study details)

Laplana and Fibla (2012)

294

CDH4

20q13.33

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

G434

CDKN1A

6p21.2

Italian

Significant (study details, 2 variants)

Gravina et al. (2009)

G430

CEP128

14q31.1

Ashkenazi Jewish

Significant (study details, 2 variants)

Atzmon et al. (2009)

185

CETP

16q13

Italian

Non-significant (study details)

Cellini et al. (2005)

G477

CETP

16q13

Danish, German, Dutch

Significant (study details, 8 variants)

Soerensen et al. (2013)

369

CETP

16q13

Ashkenazi Jewish

Significant (study details)

Atzmon et al. (2005)

95

CETP

16q13

Japanese

Non-significant (study details)

Arai et al. (2003)

128

CETP

16q13

Ashkenazi Jewish

Significant (study details)

Barzilai et al. (2003)

385

CETP

16q13

Chinese

Non-significant (study details)

Sun et al. (2014)

G521

CETP

16q13

American of Japanese origin

Non-significant (study details, 2 variants)

Koropatnick et al. (2008)

34

CFB

6p21.33

Italian

Non-significant (study details)

Bellavia et al. (1999)

236

CHIT1

1q32.1

Mediterranean (Italian, Greek and Tunisian)

Significant (study details)

Malaguarnera et al. (2010)

317

CLSTN2

3q23

American (Caucasian)

Significant (study details)

Yashin et al. (2012)

223

CNDP1

18q22.3

German

Non-significant (study details)

Zschocke et al. (2006)

186

CPB2

13q14.13

American (Caucasian)

Significant (study details)

Reiner et al. (2005)

113

CXCL8

4q13.3

Irish

Non-significant (study details)

Ross et al. (2003)

249

CYP19A1

15q21.2

Italian (Salerno)

Significant (study details)

Corbo et al. (2011)

48

CYP1A1

15q24.1

Italian (Northern)

Non-significant (study details)

Taioli et al. (2001)

G411

CYP1A1

15q24.1

German

Non-significant (study details, 2 variants)

Pesch et al. (2004)

145

CYP1B1

2p22.2

German

Significant (study details)

Pesch et al. (2004)

20

CYP2D6

22q13.2

Spanish

Non-significant (study details)

Agúndez et al. (1997)

G400

CYP2D6

22q13.2

French

Non-significant (study details, 2 variants)

Muiras et al. (1998)

22

CYP2E1

10q26.3

Spanish

Non-significant (study details)

Agúndez et al. (1997)

293

DRD4

11p15.5

American (Caucasian)

Significant (study details)

Grady et al. (2013)

G494

EGFR

7p11.2

Korean

Significant (study details, 4 variants)

Park et al. (2009)

234

ERCC2

19q13.32

Polish

Significant (study details)

Polosak et al. (2010)

250

ESR1

6q25.1-q25.2

Italian (Salerno)

Significant (study details)

Corbo et al. (2011)

G427

EXO1

1q43

German

Significant (study details, 3 variants)

Nebel et al. (2009)

61

F2

11p11.2

American (Caucasian)

Non-significant (study details)

Hessner et al. (2001)

65

F2

11p11.2

Danish

Non-significant (study details)

Tan et al. (2001)

38

F2

11p11.2

Danish

Non-significant (study details)

Bladbjerg et al. (1999)

56

F5

1q24.2

American (Caucasian)

Non-significant (study details)

Hessner et al. (2001)

66

F7

13q34

Danish

Non-significant (study details)

Tan et al. (2001)

39

F7

13q34

Danish

Non-significant (study details)

Bladbjerg et al. (1999)