Genes that inhibit oncogene induced senescence

Entrez ID

Symbol

Method Used To Cause Senescence

Cell type

Cell line

Cancer Line

4101

MAGEA2

Overexpression

Foreskin fibroblast

BJ

No

4609

MYC

Knockout

Fibroblast

LF1

No

6829

SUPT5H

Knockout

Cervical cancer

HeLa

Yes

7398

USP1

Knockdown

Foreskin fibroblast, Lung fibroblast

BJ, WI-38

No

7486

WRN

Knockdown

Fibroblast, WRN syndrome fibroblast

AG00780, AG03141

Yes

7490

WT1

Knockout

Lung cancer

NCI-A549, NCI-H1299, NCI-H1437, NCI-H1568, NCI-H1650, NCI-H1975, NCI-H2009, NCI-H2126, NCI-H23, NCI-H358, NCI-H441, NCI-H460, NCI-H522, NCI-H727

Yes

7101

NR2E1

Knockout

Lung fibroblast, Neural Stem, Prostate epithelial

IMR-90, WI-38

No

Reference: HAGR