Genes that induce stress induced senescence

Entrez ID

Symbol

Method Used To Cause Senescence

Cell type

Cell line

Cancer Line

1051

CEBPB

Knockdown, Overexpression

Prostate cancer

LNCaP

Yes

1111

CHEK1

Knockout

Colon cancer

HCT116

Yes

3400

ID4

Overexpression

Prostate cancer

DU145

Yes

3486

IGFBP3

Knockdown

Lung fibroblast

WI-38

No

50618

ITSN2

Knockdown, Overexpression

Foreskin fibroblast, Lung fibroblast

Hs68, WI-38

No

4854

NOTCH3

Knockdown

Breast cancer, Fibroblast, Foreskin fibroblast, Glioma, Melanoma

A375P, BJ, LF1, MDA-MB-231, T98G, WS1

Yes

5037

PEBP1

Knockdown, Overexpression

Colon cancer, Gastric cancer, Lung cancer, Prostate cancer

A549, HCT116, MKN45, PC-3

Yes

5824

PEX19

Overexpression

Osteosarcoma

U2OS

Yes

5583

PRKCH

Knockdown, Overexpression

Breast cancer

MCF-7

Yes

5925

RB1

Knockdown

Osteoblast

Primary cell

No

54739

XAF1

Knockdown, Overexpression

Dermal microvascular endothelial cells

Primary cell

No

83719

YPEL3

Knockdown, Overexpression

Breast cancer

MCF-7

Yes

Reference: HAGR