Genes that induce oncogene induced senescence

Entrez ID

Symbol

Method Used To Cause Senescence

Cell type

Cell line

Cancer Line

207

AKT1

Overexpression

Aortic endothelial, Dermal microvascular endothelial cells, Umbilical vein endothelial

Primary cell

No

673

BRAF

Overexpression

Foreskin fibroblast, Melanocyte

BJ, Primary cell

No

2919

CXCL1

Overexpression

Ovarian fibroblast

Gro-1

No

1643

DDB2

Knockout

Lung fibroblast

IMR-90

No

1718

DHCR24

Mutation

Lung fibroblast

WI-38

No

2113

ETS1

Overexpression

Foreskin fibroblast, Lung fibroblast

Hs68, TIG-3

No

2114

ETS2

Overexpression

Foreskin fibroblast, Lung fibroblast

Hs68, TIG-3

No

3265

HRAS

Overexpression

Lung fibroblast

IMR-90, WI-38

No

5605

MAP2K2

Overexpression

Lung fibroblast

IMR-90

No

8550

MAPKAPK5

Knockout

Foreskin fibroblast

BJ

No

5371

PML

Overexpression

Lung fibroblast

WI-38

No

5894

RAF1

Overexpression

Lung fibroblast

IMR-90

No

2810

SFN

Overexpression

Melanoma

SK-MEL-147, SK-MEL-19, SK-MEL-29

Yes

6660

SOX5

Overexpression

Glioma

U-1242MG, U-178MG, U-251MG, U-343MG, U-343MGa

Yes

6426

SRSF1

Overexpression

Foreskin fibroblast

BJ

No

10155

TRIM28

Knockout

Lung fibroblast

IMR-90

No

25842

ASF1A

Knockout, Overexpression

Lung fibroblast

Primary cell

No

11235

PDCD10

Knockout

Coronary artery endothelial, Lung fibroblast

IMR-90, Primary cell

No

5292

PIM1

Knockdown, Overexpression

Foreskin fibroblast, Lung fibroblast

2BS, BJ, WI-38

No

8651

SOCS1

Knockdown, Overexpression

Lung fibroblast

IMR-90

No

10628

TXNIP

Knockout, Overexpression

Lung fibroblast

2BS

No

Reference: HAGR