Genes that are up or downregulated by calorie restriction

MGI Description

MGI Symbol

EntrezID

total

overexp.

underexp.

p_overexp.

ATP-binding cassette, sub-family G (WHITE), member 5 Gene

Abcg5

27409

30

9

0

3.56E-8

actin binding LIM protein family, member 3 Gene

Ablim3

319713

21

7

1

5.42E-7

ATP citrate lyase Gene

Acly

104112

60

2

8

5.49E-5

acyl-CoA thioesterase 12 Gene

Acot12

74156

32

6

0

1.31E-4

acyl-CoA thioesterase 4 Gene

Acot4

171282

30

7

0

7.78E-6

actin, gamma, cytoplasmic 1 Gene

Actg1

11465

55

1

7

2.15E-4

adenylate cyclase 1 Gene

Adcy1

432530

11

4

0

1.15E-4

alcohol dehydrogenase 1 (class I) Gene

Adh1

11522

42

12

0

3.50E-10

alanine-glyoxylate aminotransferase 2-like 1 Gene

Agxt2l1

71760

18

5

0

6.55E-5

aminolevulinic acid synthase 2, erythroid Gene

Alas2

11656

58

3

8

4.28E-5

aldehyde dehydrogenase family 1, subfamily A1 Gene

Aldh1a1

11668

56

9

2

1.05E-5

aldehyde dehydrogenase family 1, subfamily A7 Gene

Aldh1a7

26358

35

6

2

2.19E-4

angiopoietin-like 4 Gene

Angptl4

57875

37

9

2

2.64E-7

aquaporin 6 Gene

Aqp6

11831

23

6

2

1.77E-5

aquaporin 8 Gene

Aqp8

11833

34

1

6

9.56E-5

aryl hydrocarbon receptor nuclear translocator-like Gene

Arntl

11865

63

3

11

1.41E-7

arrestin domain containing 2 Gene

Arrdc2

70807

40

7

0

5.72E-5

cDNA sequence BC089597 Gene

BC089597

216454

13

4

0

2.38E-4

BCL2/adenovirus E1B interacting protein 3 Gene

Bnip3

1E+08

14

4

0

3.27E-4

complement component 4 binding protein Gene

C4bp

12269

20

0

5

6.40E-5

complement component 9 Gene

C9

12279

36

1

7

1.28E-5

carbonic anhydrase 3 Gene

Car3

12350

49

0

11

8.86E-9

cancer susceptibility candidate 5 Gene

Casc5

76464

11

1

4

7.14E-5

carbonyl reductase 1 Gene

Cbr1

12408

38

7

0

4.04E-5

CD163 antigen Gene

Cd163

93671

14

4

1

3.27E-4

CDC42 effector protein (Rho GTPase binding) 2 Gene

Cdc42ep2

104252

28

1

5

3.50E-4

claudin 1 Gene

Cldn1

12737

34

1

6

9.56E-5

Cobl-like 1 Gene

Cobll1

319876

28

8

0

3.17E-7

collagen, type XV, alpha 1 Gene

Col15a1

12819

32

1

7

5.58E-6

collagen, type III, alpha 1 Gene

Col3a1

12825

59

1

7

3.35E-4

catechol-O-methyltransferase 1 Gene

Comt1

12846

55

2

7

2.15E-4

carnitine palmitoyltransferase 1a, liver Gene

Cpt1a

12894

53

8

1

5.16E-5

cryptochrome 1 (photolyase-like) Gene

Cry1

12952

49

8

0

2.87E-5

crystallin, mu Gene

Crym

12971

15

4

0

4.37E-4

connective tissue growth factor Gene

Ctgf

14219

35

8

0

2.05E-6

chemokine (C-X-C motif) ligand 9 Gene

Cxcl9

17329

37

0

6

1.56E-4

cytochrome P450, family 2, subfamily b, polypeptide 13 Gene

Cyp2b13

13089

23

6

1

1.77E-5

cytochrome P450, family 2, subfamily e, polypeptide 1 Gene

Cyp2e1

13106

39

7

0

4.82E-5

cytochrome P450, family 2, subfamily f, polypeptide 2 Gene

Cyp2f2

13107

37

0

6

1.56E-4

cytochrome P450, family 2, subfamily j, polypeptide 5 Gene

Cyp2j5

13109

25

0

8

4.64E-8

cytochrome P450, family 2, subfamily j, polypeptide 6 Gene

Cyp2j6

13110

30

9

0

3.56E-8

cytochrome P450, family 4, subfamily a, polypeptide 14 Gene

Cyp4a14

13119

32

8

0

9.80E-7

cytochrome P450, family 7, subfamily a, polypeptide 1 Gene

Cyp7a1

13122

39

9

2

4.30E-7

DNA segment, human D4S114 Gene

D0H4S114

27528

60

0

7

3.72E-4

D site albumin promoter binding protein Gene

Dbp

13170

34

10

4

7.63E-9

2,4-dienoyl CoA reductase 1, mitochondrial Gene

Decr1

67460

37

6

0

3.01E-4

2-4-dienoyl-Coenzyme A reductase 2, peroxisomal Gene

Decr2

26378

24

6

0

2.30E-5

7-dehydrocholesterol reductase Gene

Dhcr7

13360

49

0

10

1.11E-7

deoxyribonuclease 1-like 2 Gene

Dnase1l2

1E+08

7

0

3

3.61E-4

dipeptidylpeptidase 9 Gene

Dpp9

224897

28

0

6

3.00E-5

dual specificity phosphatase 1 Gene

Dusp1

19252

36

6

0

2.57E-4

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase Gene

Ehhadh

74147

39

10

0

3.30E-8

glutamyl aminopeptidase Gene

Enpep

13809

25

5

0

3.51E-4

erythrocyte protein band 4.1 Gene

Epb4.1

269587

61

8

1

1.44E-4

esterase 31 Gene

Es31

382053

25

1

7

9.14E-7

exostoses (multiple)-like 1 Gene

Extl1

56219

24

1

5

1.63E-4

fatty acid binding protein 5, epidermal Gene

Fabp5

16592

59

3

8

4.85E-5

family with sequence similarity 107, member A Gene

Fam107a

268709

22

8

0

3.73E-8

family with sequence similarity 195, member A Gene

Fam195a

68241

20

6

0

7.23E-6

FK506 binding protein 5 Gene

Fkbp5

14229

59

11

1

2.34E-7

flavin containing monooxygenase 3 Gene

Fmo3

14262

29

8

0

4.28E-7

frizzled homolog 1 (Drosophila) Gene

Fzd1

14362

38

6

2

3.50E-4

G0/G1 switch gene 2 Gene

G0s2

14373

33

3

7

6.95E-6

glucose-6-phosphate dehydrogenase X-linked Gene

G6pdx

14381

54

2

7

1.92E-4

glucokinase Gene

Gck

103988

41

1

8

2.98E-6

growth hormone receptor Gene

Ghr

14600

65

0

8

9.82E-5

predicted gene 13768

Gm13768

627525

7

0

3

3.61E-4

predicted gene 6957 Gene

Gm6957

629219

13

5

0

1.09E-5

predicted gene 7450

Gm7450

665017

7

0

3

3.61E-4

G protein-coupled receptor 146 Gene

Gpr146

80290

31

6

0

1.08E-4

general transcription factor II I repeat domain-containing 1 Gene

Gtf2ird1

57080

27

0

5

2.93E-4

glycogen synthase 2 Gene

Gys2

232493

27

6

0

4.75E-5

2-hydroxyacyl-CoA lyase 1 Gene

Hacl1

56794

27

6

0

4.75E-5

homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Gene

Herpud1

64209

45

9

2

1.57E-6

homeodomain interacting protein kinase 2 Gene

Hipk2

15258

36

0

6

1.33E-4

hydroxysteroid (17-beta) dehydrogenase 2 Gene

Hsd17b2

15486

46

7

5

1.44E-4

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Gene

Hsd3b2

15493

24

0

5

1.63E-4

heat shock protein 5 Gene

Hspa5

14828

69

0

9

2.27E-5

heat shock protein family, member 7 (cardiovascular) Gene

Hspb7

29818

30

1

5

4.89E-4

interferon, alpha-inducible protein 27 like 2A Gene

Ifi27l2a

76933

20

0

5

6.40E-5

interferon induced with helicase C domain 1 Gene

Ifih1

71586

33

0

6

8.03E-5

interferon-related developmental regulator 1 Gene

Ifrd1

15982

45

7

0

1.25E-4

insulin-like growth factor binding protein 2 Gene

Igfbp2

16008

40

7

1

5.72E-5

inhibin beta E Gene

Inhbe

16326

42

2

6

3.20E-4

indolethylamine N-methyltransferase Gene

Inmt

21743

33

10

4

5.51E-9

insulin induced gene 1 Gene

Insig1

231070

33

1

7

6.95E-6

interferon regulatory factor 7 Gene

Irf7

54123

30

1

6

4.56E-5

immunity-related GTPase family M member 1 Gene

Irgm1

15944

28

0

6

3.00E-5

insulin receptor substrate 2 Gene

Irs2

384783

29

7

1

6.10E-6

Kruppel-like factor 10 Gene

Klf10

21847

36

6

0

2.57E-4

Kruppel-like factor 15 Gene

Klf15

66277

32

9

0

6.68E-8

Kruppel-like factor 9 Gene

Klf9

70273

14

5

0

1.67E-5

Kruppel-like factor 9 Gene

Klf9

16601

51

9

0

4.70E-6

LPS-induced TN factor Gene

Litaf

56722

60

0

7

3.72E-4

similar to acyl-CoA thioesterase

LOC100044830

1E+08

15

4

0

4.37E-4

similar to Deltex3

LOC100045005

1E+08

7

0

3

3.61E-4

similar to apolipoprotein D

LOC100047583

1E+08

5

4

0

1.96E-6

similar to WAP four-disulfide core domain 2

LOC100048733

1E+08

7

0

3

3.61E-4

similar to Ornithine decarboxylase (ODC)

LOC677259

677259

7

0

3

3.61E-4

lipin 1 Gene

Lpin1

14245

29

6

1

7.30E-5

lymphocyte antigen 6 complex, locus E Gene

Ly6e

17069

62

2

7

4.56E-4

mitogen-activated protein kinase kinase kinase 6 Gene

Map3k6

53608

26

5

0

4.25E-4

methionine adenosyltransferase I, alpha Gene

Mat1a

11720

60

8

0

1.28E-4

matrix Gla protein Gene

Mgp

17313

48

7

1

1.89E-4

matrix metallopeptidase 15 Gene

Mmp15

17388

27

0

5

2.93E-4

metallothionein 1 Gene

Mt1

17748

61

12

2

3.54E-8

metallothionein 2 Gene

Mt2

17750

59

14

5

1.85E-10

major urinary protein 4 Gene

Mup4

17843

24

0

5

1.63E-4

N-acetyltransferase 8 (GCN5-related, putative) Gene

Nat8

68396

26

9

0

8.53E-9

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Gene

Nfkbia

18035

61

8

0

1.44E-4

niacin receptor 1 Gene

Niacr1

80885

13

4

0

2.38E-4

nuclear receptor subfamily 1, group D, member 1 Gene

Nr1d1

217166

34

3

6

9.56E-5

nuclear receptor subfamily 1, group I, member 3 Gene

Nr1i3

12355

40

9

0

5.43E-7

neurotrophin 3 Gene

Ntf3

18205

42

8

0

8.79E-6

netrin 3 Gene

Ntn3

18209

15

0

4

2.75E-4

protein disulfide isomerase associated 3 Gene

Pdia3

14827

62

0

7

4.56E-4

period homolog 1 (Drosophila) Gene

Per1

18626

38

6

1

3.50E-4

period homolog 2 (Drosophila) Gene

Per2

18627

44

12

1

6.38E-10

PHD finger protein 19 Gene

Phf19

74016

27

0

5

2.93E-4

pleckstrin homology-like domain, family A, member 1 Gene

Phlda1

21664

39

1

7

2.23E-5

proviral integration site 3 Gene

Pim3

223775

57

9

0

1.21E-5

phospholipase A2, group XIIA Gene

Pla2g12a

66350

39

6

1

4.04E-4

phosphatidylinositol-specific phospholipase C, X domain containing 3 Gene

Plcxd3

239318

14

4

0

3.27E-4

perilipin 4 Gene

Plin4

57435

15

4

0

4.37E-4

perilipin 5 Gene

Plin5

66968

17

5

1

4.83E-5

P450 (cytochrome) oxidoreductase Gene

Por

18984

61

13

0

3.41E-9

peroxisome proliferator activated receptor alpha Gene

Ppara

19013

40

8

1

5.99E-6

proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Gene

Psmb8

16913

39

0

6

2.11E-4

protein tyrosine phosphatase, receptor type, J Gene

Ptprj

668629

14

1

4

2.05E-4

R3H domain containing 2 Gene

R3hdm2

71750

49

0

7

1.02E-4

retinol binding protein 7, cellular Gene

Rbp7

63954

26

5

3

4.25E-4

regulator of G-protein signaling 16 Gene

Rgs16

19734

27

6

2

4.75E-5

rhomboid domain containing 2 Gene

Rhbdd2

215160

51

7

0

2.79E-4

Rho-related BTB domain containing 1 Gene

Rhobtb1

69288

26

5

0

4.25E-4

regulatory solute carrier protein, family 1, member 1 Gene

Rsc1a1

69994

13

0

4

1.49E-4

sal-like 1 (Drosophila) Gene

Sall1

58198

25

5

0

3.51E-4

sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) Gene

Sc5d

235293

38

0

6

1.82E-4

selenocysteine lyase Gene

Scly

50880

31

1

6

5.54E-5

scratch homolog 1, zinc finger protein (Drosophila) Gene

Scrt1

170729

25

0

5

2.00E-4

serine dehydratase Gene

Sds

231691

25

8

0

1.18E-7

serine (or cysteine) peptidase inhibitor, clade H, member 1 Gene

Serpinh1

12406

63

4

8

7.83E-5

solute carrier family 10, member 2 Gene

Slc10a2

20494

39

0

6

2.11E-4

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Gene

Slc25a25

227731

41

7

0

6.74E-5

solute carrier family 25, member 42 Gene

Slc25a42

73095

25

5

1

3.51E-4

solute carrier family 37 (glucose-6-phosphate transporter), member 4 Gene

Slc37a4

14385

35

8

0

2.05E-6

solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Gene

Slc6a6

21366

60

1

12

7.66E-9

SPARC related modular calcium binding 1 Gene

Smoc1

64075

55

7

0

4.48E-4

sterol regulatory element binding transcription factor 1 Gene

Srebf1

20787

60

1

10

8.13E-7

ST3 beta-galactoside alpha-2,3-sialyltransferase 5 Gene

St3gal5

20454

41

7

1

6.74E-5

SH3 and cysteine rich domain 3 Gene

Stac3

237611

15

0

4

2.75E-4

sulfotransferase family 1A, phenol-preferring, member 1 Gene

Sult1a1

20887

37

6

0

3.01E-4

sulfotransferase family, cytosolic, 1C, member 2 Gene

Sult1c2

69083

27

6

1

4.75E-5

sulfotransferase family 1D, member 1 Gene

Sult1d1

53315

45

9

3

1.57E-6

sulfotransferase family 3A, member 1 Gene

Sult3a1

57430

23

5

1

2.32E-4

Sad1 and UNC84 domain containing 2 Gene

Sun2

223697

34

6

1

1.86E-4

tensin like C1 domain-containing phosphatase Gene

Tenc1

209039

60

10

0

2.41E-6

transmembrane protein 132D Gene

Tmem132d

243274

4

0

3

4.34E-5

transmembrane protein 218 Gene

Tmem218

66279

21

6

0

9.91E-6

tumor necrosis factor (ligand) superfamily, member 10 Gene

Tnfsf10

22035

19

0

5

4.89E-5

transducer of ErbB-2.1 Gene

Tob1

22057

40

6

0

4.66E-4

transformation related protein 53 inducible protein 13 Gene

Trp53i13

216964

29

7

1

6.10E-6

TSC22 domain family, member 3 Gene

Tsc22d3

14605

26

6

0

3.77E-5

tubulin tyrosine ligase-like family, member 12 Gene

Ttll12

223723

21

0

5

8.25E-5

ubiquitin specific peptidase 2 Gene

Usp2

53376

60

11

0

2.79E-7

WEE 1 homolog 1 (S. pombe) Gene

Wee1

22390

37

8

2

3.22E-6

zinc finger and BTB domain containing 16 Gene

Zbtb16

235320

19

7

0

2.46E-7

zinc finger protein 354A Gene

Zfp354a

21408

54

7

0

4.00E-4

zinc finger protein 64 Gene

Zfp64

22722

34

1

8

6.52E-7

RIKEN cDNA 1110051M20 gene Gene

1110051M20Rik

228356

33

0

6

8.03E-5

RIKEN cDNA 1110054M08 gene

1110054M08Rik

68841

16

1

4

3.60E-4

RIKEN cDNA 2810051F02 gene

2810051F02Rik

72704

7

0

3

3.61E-4

RIKEN cDNA 2900086B20 gene

2900086B20Rik

73074

15

0

4

2.75E-4

4432414F05Rik RIKEN cDNA 4432414F05 gene

4432414F05Rik

77027

4

3

0

6.24E-5

4833417J20Rik RIKEN cDNA 4833417J20 gene

4833417J20Rik

74604

4

3

0

6.24E-5

Reference: HAGR