Anti-longevity genes in Saccharomyces Cerevisiae

Name

Symbol

Entrez ID

Max average lifespan change

Acyl-CoA-Binding

ACB1

852925

Upregulated

Adenine AminoHydrolase

AAH1

855581

Upregulated

Adenine PhosphoribosylTransferase

APT1

854986

Upregulated

Adenine requiring

ADE1

851272

Upregulated

Adenine requiring

ADE12

855501

Upregulated

Adenine requiring

ADE2

854295

Upregulated

Adenine requiring

ADE4

855346

Upregulated

Adenine requiring

ADE5,7

852617

Upregulated

Adenine requiring

ADE6

852952

Upregulated

Adenylate cyclase

CYR1

853452

90%  Upregulated

Adenylyl-sulfate kinase

MET14

853869

Upregulated

ADP/ATP Carrier

AAC3

852380

15%  Upregulated

Alcohol DeHydrogenase

ADH1

854068

20%  Upregulated

ALdehyde Dehydrogenase

ALD4

854556

50%  Upregulated

Aldehyde dehydrogenase (NADP(+)) ALD6

ALD6

856044

Upregulated

Alpha-1,2-mannosyltransferase MNN2

MNN2

852303

16%  Upregulated

Alpha-1,3-mannosyltransferase MNN1

MNN1

856718

15%  Upregulated

AMP Deaminase

AMD1

854973

Upregulated

Arginine permease CAN1

CAN1

856646

30%  Upregulated

Ark family Kinase-Like protein

AKL1

852351

20%  Upregulated

Aromatic amino acid transmembrane transporter TAT2

TAT2

854139

23%  Upregulated

Asparagine-Linked Glycosylation

ALG12

855764

25%  Upregulated

Asparagine-Linked Glycosylation

ALG5

855874

50%  Upregulated

Aspartate-Glutamate Carrier

AGC1

856132

30%  Upregulated

ATP synthase

ATP3

852327

50%  Upregulated

ATPase Family Gene

AFG3

856737

20%  Upregulated

BASal

BAS1

853974

30%  Upregulated

Bem1 (One) Interacting protein

BOI2

856850

25%  Upregulated

Bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17

MET17

851010

100%  Upregulated

Bile Pigment Transporter

BPT1

850645

20%  Upregulated

Biosynthesis of Nicotinic Acid

BNA2

853541

Upregulated

Bst1p

BST1

850519

25%  Upregulated

Bypass of Stop Codon

BSC2

851868

20%  Upregulated

Bypass of Stop Codon

BSC1

851524

20%  Upregulated

CaRnitine Carrier

CRC1

854267

25%  Upregulated

Casein Kinase Alpha' subunit

CKA2

854227

Upregulated

CaTalase A

CTA1

851843

Upregulated and Downregulated

Cbp6p

CBP6

852417

25%  Upregulated

Cbs1p

CBS1

851491

37%  Upregulated

Cdc25p

CDC25

851019

50%  Upregulated

Cell division cycle

CDC6

853244

20%  Upregulated

Ceramide synthase component

LAG1

856386

50%  Upregulated

Chromosome STability

CST26

852330

40%  Upregulated

Cln3p

CLN3

851191

Downregulated

Csr2p

CSR2

856142

Upregulated

CYStathionine beta-synthase

CYS4

853059

50%  Upregulated

Cysteine-Three-Histidine

CTH1

851729

20%  Upregulated

Cytoplasmic pre-60S factor

REI1

852569

40%  Upregulated

Dead Box Protein

DBP3

852802

35%  Upregulated

Defective Cell Wall

DCW1

853820

Upregulated

Deficient in Utilization of Glutathione

DUG1

850605

Upregulated

Der1p

DER1

852500

16%  Upregulated

Derepression of ITR1 Expression

DIE2

853142

50%  Upregulated

Dls1p

DLS1

853381

20%  Upregulated

Dnm1p

DNM1

850686

Upregulated

dolichyl-diphosphooligosaccharide--protein glycotransferase OST3

OST3

854252

20%  Upregulated

dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase

ALG6

854163

15%  Upregulated

dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase

ALG3

852196

10%  Upregulated

Drs2 Neo1 Family

DNF1

856913

50%  Upregulated

Dst1-delta 6-Azauracil Sensitivity

DAS2

851583

25%  Upregulated

ELongator Protein

ELP3

856019

Upregulated

ELongator Protein

ELP4

856002

30%  Upregulated

Eos1p

EOS1

855644

24%  Upregulated

ER oxidoreductin

ERO1

854909

28%  Upregulated

Essential for Respiration and Viability

ERV2

856152

Upregulated

Factor ARrest

FAR10

850939

Upregulated

Factor ARrest

FAR8

855044

Upregulated

Ferric REductase 6

FRE6

850675

14%  Upregulated

Five Zinc Fingers

FZF1

852638

66%  Upregulated

FluoroCYtosine resistance

FCY2

856783

Upregulated

FluoroCYtosine resistance

FCY21

856788

Upregulated

FluoroCYtosine resistance

FCY1

856175

Upregulated

Fob1p

FOB1

851688

50%  Upregulated

Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for gluc

FBP1

851092

Downregulated

GDP/GTP exchange protein (GEP) for Rho1p and Rho2p

ROM2

851086

50%  Upregulated

GIg1-2 Suppressor

GIS1

851670

25%  Upregulated

gluconokinase

YDR248C

851835

20%  Upregulated

glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2

TDH2

853465

29%  Upregulated

Gpr1p

GPR1

851527

50%  Upregulated

GTPase involved in G-protein signaling in the adenylate cyclase activating pathway

RAS1

854268

23%  Upregulated

Hes1p

HES1

854412

25%  Downregulated

hexokinase 2

HXK2

852639

50%  Upregulated

high-Affinity Glutamine Permease

AGP1

850333

Upregulated

Histone deacetylase

RPD3

855386

41%  Upregulated

Histone DeAcetylase

HDA1

855710

Upregulated

HnRNP MethylTransferase

HMT1

852322

50%  Upregulated

homolog of S. pombe SDS23

SDS23

852824

Upregulated

Homologous to RAD4

RAD34

851909

30%  Upregulated

Hsp70 family ATPase SSC1

SSC1

853503

40%  Upregulated

Hyper-resistance to Nitrogen Mustard

HNM1

852803

Upregulated

hypothetical protein

YBR238C

852540

30%  Upregulated

hypothetical protein

YLR422W

851141

25%  Upregulated

hypothetical protein

YMR018W

855032

35%  Upregulated

hypothetical protein

YGR130C

853031

30%  Upregulated

hypothetical protein

YOR012W

854177

Upregulated

hypothetical protein

YER186C

856935

30%  Upregulated

hypothetical protein

YER187W

856937

30%  Upregulated

hypothetical protein

YMR010W

855022

30%  Upregulated

Hypothetical RNA-Binding protein

HRB1

855728

20%  Upregulated

Hypoxanthine guanine PhosphoribosylTransferase

HPT1

852008

Upregulated

Idh2p

IDH2

854303

30%  Upregulated

INositol polyphosphate 5-Phosphatase

INP51

854815

10%  Upregulated

Inositol Polyphosphate Kinase

IPK1

851910

40%  Upregulated

Insensitive to KIller toxin

IKI3

851100

Upregulated

Iron-sulfur cluster assembly factor for Biotin synthase and Aconitase-like mitochondrial proteins

IBA57

853586

50%  Upregulated

Isocitrate dehydrogenase

LYS12

854714

Upregulated

Isocitrate DeHydrogenase

IDH1

855691

15%  Upregulated

Isocitrate Dehydrogenase, NADP-specific

IDP1

851493

15%  Upregulated

Isw2p

ISW2

854480

24%  Upregulated

Itc1p

ITC1

852744

18%  Upregulated

KARyogamy

KAR3

856263

55%  Upregulated

Las Seventeen Binding protein

LSB3

850580

40%  Upregulated

Las Seventeen Binding protein

LSB1

853037

30%  Upregulated

Las Seventeen Binding protein

LSB6

853345

50%  Upregulated

LEUcine biosynthesis

LEU2

850342

Upregulated

LEUcine biosynthesis

LEU3

851172

Upregulated

LINk

LIN1

856561

40%  Upregulated

LOCalization of ASH1 mRNA

LOC1

850551

40%  Upregulated

Long Chronological Lifespan

LCL1

856051

Upregulated

Long Chronological Lifespan 2

LCL2

850794

Upregulated

Long Chronological Lifespan 3

LCL3

852795

Upregulated

Long-Chain Base

LCB3

853307

Upregulated

lysine--tRNA ligase MSK1

MSK1

855651

12%  Upregulated

mannosyltransferase YUR1

YUR1

853302

19%  Upregulated

Mep2p

MEP2

855580

Upregulated

Mep3p

MEP3

856260

Upregulated

Methylene Tetrahydrafolate Dehydrogenase

MTD1

853955

Upregulated

Mir1p

MIR1

853540

25%  Upregulated

mitochondrial 54S ribosomal protein IMG1

IMG1

850413

23%  Upregulated

mitochondrial 54S ribosomal protein IMG2

IMG2

850434

28%  Upregulated

mitochondrial 54S ribosomal protein YmL33

MRPL33

855330

16%  Upregulated

mitochondrial 54S ribosomal protein YmL40

MRPL40

855930

21%  Upregulated

mitochondrial 54S ribosomal protein YmL49

MRPL49

853349

25%  Upregulated

Mitotic Arrest-Deficient

MAD2

853422

50%  Upregulated

Mns1p

MNS1

853595

Upregulated

Mub1p

MUB1

855126

29%  Upregulated

MUddled Meiosis

MUM2

852348

Upregulated

N-Myristoyl Transferase

NMT1

850892

50%  Upregulated

Nat4p

NAT4

855091

21%  Upregulated

Nitrogen Network Kinase

NNK1

853683

Upregulated

OligoPeptide Transporter 2

OPT2

856324

23%  Upregulated

Outer Membrane

OM45

854670

Upregulated

p53 Regulatory Kinase

PRK1

854713

30%  Upregulated

Pachytene CHeckpoint

PCH2

852484

50%  Upregulated

PaXillin-Like protein

PXL1

853965

Upregulated

PEroXisome related

PEX25

855991

Upregulated

Pet127p

PET127

854182

35%  Upregulated

Pet309p

PET309

850756

25%  Upregulated

Pho85 CycLin

PCL7

854761

Upregulated

PHOsphate metabolism

PHO89

852599

50%  Upregulated

PhosphatidylInositol(3)-phosphate Binding

PIB1

851908

25%  Upregulated

phosphoadenylyl-sulfate reductase (thioredoxin)

MET16

856296

Upregulated

PhosphoRibosylpyrophosphate Synthetase

PRS3

856375

50%  Upregulated

PIK-related protein kinase and rapamycin target

TOR1

853529

30%  Upregulated

Pkb-activating Kinase Homolog

PKH1

852101

15%  Upregulated

Pkb-activating Kinase Homolog

PKH3

852077

10%  Upregulated

Pkb-activating Kinase Homolog

PKH2

854053

20%  Upregulated

Plasma Membrane ATPase Related

PMR1

852709

40%  Upregulated

Pleiotropic Drug Resistance

PDR18

855807

Upregulated

Pmt7p

PMT7

851902

30%  Upregulated

protein disulfide isomerase MPD1

MPD1

854462

17%  Upregulated

Protein kinase activator found in a complex containing Snf1p and members of the Sip1p/Sip2p/Gal83p f

SNF4

852763

20%  Upregulated

Protein kinase that regulates signal transduction activity and G1 progression

SCH9

856612

300%  Upregulated

PseudoHyphal Determinant

PHD1

853823

20%  Upregulated

Psi+ INducibility

PIN3

856277

15%  Upregulated

Pst2p

PST2

851596

36%  Upregulated

putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5

PMT5

851464

21%  Upregulated

putative mitochondrial 54S ribosomal protein

MRX14

851692

12%  Upregulated

putative ubiquitin-protein ligase UBR2

UBR2

850711

67%  Upregulated

PyriDoXine auxotrophy

PDX3

852323

50%  Upregulated

Rcm1p

RCM1

855709

Upregulated

Rcy1p

RCY1

853226

Upregulated

Rec8p

REC8

856115

20%  Upregulated

Regulator of heterotrimeric G protein Signaling

RGS2

854274

35%  Upregulated

Replication In Mitochondria

RIM1

850395

20%  Upregulated

Resistance to Congo Red 2

RCR2

851566

18%  Upregulated

Restores Glucose Transport

RGT1

853828

Upregulated

Restores Glucose Transport

RGT2

851417

Upregulated

Rfx1p

RFX1

850873

20%  Upregulated

ribosomal 40S subunit protein S10B

RPS10B

855270

Upregulated

ribosomal 40S subunit protein S12

RPS12

854551

38%  Upregulated

ribosomal 40S subunit protein S18A

RPS18A

852061

15%  Upregulated

ribosomal 40S subunit protein S18B

RPS18B

854982

15%  Upregulated

ribosomal 40S subunit protein S6B

RPS6B

852479

45%  Upregulated

ribosomal 60S subunit protein L10

RPL10

850764

24%  Upregulated

ribosomal 60S subunit protein L16B

RPL16B

855655

23%  Upregulated

ribosomal 60S subunit protein L26A

RPL26A

851058

22%  Upregulated

ribosomal 60S subunit protein L2B

RPL2B

854794

38%  Upregulated

ribosomal 60S subunit protein L35A

RPL35A

851336

41%  Upregulated

ribosomal 60S subunit protein L6B

RPL6B

851169

40%  Upregulated

Ribosomal Protein of the Large subunit

RPL33B

854409

15%  Upregulated

Ribosomal Protein of the Large subunit

RPL35B

851419

25%  Upregulated

Ribosomal Protein of the Large subunit

RPL8B

850682

25%  Upregulated

Ribosomal Protein of the Large subunit

RPL12A

856656

35%  Upregulated

Ribosomal Protein of the Large subunit

RPL37B

852111

35%  Upregulated

Ribosomal Protein of the Large subunit

RPL19A

852379

50%  Upregulated

Ribosomal Protein of the Large subunit

RPL9A

852730

30%  Upregulated

Ribosomal Protein of the Large subunit

RPL9B

855658

30%  Upregulated

Ribosomal Protein of the Large subunit

RPL20B

854489

50%  Upregulated

Ribosomal Protein of the Large subunit

RPL19B

852254

20%  Upregulated

Ribosomal Protein of the Large subunit

RPL12B

852026

20%  Upregulated

Ribosomal Protein of the Large subunit

RPL1B

852742

20%  Upregulated

Ribosomal Protein of the Large subunit

RPL4A

852319

20%  Upregulated

Ribosomal Protein of the Large subunit

RPL21B

856026

50%  Upregulated

Ribosomal Protein of the Large subunit

RPL22A

850750

90%  Upregulated

Ribosomal Protein of the Large subunit

RPL23A

852191

40%  Upregulated

Ribosomal Protein of the Large subunit

RPL29

850592

35%  Upregulated

Ribosomal Protein of the Large subunit

RPL34B

854759

60%  Upregulated

Ribosomal Protein of the Large subunit

RPL43B

853557

30%  Upregulated

Ribosomal Protein of the Large subunit

RPL7A

852804

40%  Upregulated

Ribosomal Protein of the Large subunit

RPL13A

851477

30%  Upregulated

Ribosomal Protein of the Large subunit

RPL21A

852489

30%  Upregulated

Ribosomal Protein of the Small subunit

RPS11A

851589

30%  Upregulated

Ribosomal Protein of the Small subunit

RPS6A

856015

30%  Upregulated

Ribosomal Protein of the Small subunit

RPS26B

856868

20%  Upregulated

Ribosomal Protein P1 Beta

RPP1B

851427

40%  Upregulated

Ribosomal Protein P2 Beta

RPP2B

851990

55%  Upregulated

Rieske Iron-sulfur Protein

RIP1

856689

15%  Upregulated

RNase H

RNH201

855652

50%  Upregulated

RPO31

RPO31

854283

Upregulated

Rtg3p

RTG3

852171

Upregulated

S-AdenosylMethionine requiring

SAM1

850877

20%  Upregulated

SAGA histone acetyltransferase complex subunit SGF11

SGF11

856060

26%  Upregulated

Scp1p

SCP1

854549

65%  Upregulated

SECretory

SEC28

854734

20%  Upregulated

Silent information regulator

SIR4

851813

Upregulated and Downregulated

similar to the mammalian TPA Induced Sequence gene family

TIS11

850827

30%  Upregulated

SIt4 Suppressor

SIS2

853946

50%  Upregulated

Sna3p

SNA3

853290

27%  Upregulated

Something About Silencing

SAS3

852228

Upregulated

Something About Silencing

SAS4

851762

Upregulated

Sorting NeXin

SNX3

854539

Upregulated

Sorting NeXin

SNX41

852035

Upregulated

Sov1p

SOV1

855088

30%  Upregulated

SPOrulation

SPO22

854737

Upregulated

SPorulation Specific

SPS1

852135

25%  Upregulated

Stability of Eisosomes Guaranteed

SEG2

853756

20%  Upregulated

Stress-inducible Dual specificity Phosphatase

SDP1

854693

25%  Upregulated

Stress-Seventy subfamily A

SSA3

852203

50%  Upregulated

succinate dehydrogenase assembly factor SDH5

SDH5

854083

28%  Upregulated

succinate dehydrogenase flavoprotein subunit SDH1

SDH1

853709

25%  Upregulated

succinate dehydrogenase iron-sulfur protein subunit SDH2

SDH2

850685

21%  Upregulated

Sucrose NonFermenting

SNF3

851333

Upregulated

Suppressor gene for FLocculation

SFL1

854307

Upregulated

Suppressor Of Kinase

SOK1

851569

50%  Upregulated

Suppressor of Kre Null

SKN1

853045

60%  Upregulated

SuPpressor of Ty's

SPT4

852955

40%  Upregulated

Suv3p

SUV3

856078

25%  Upregulated

SWItching deficient

SWI5

851724

20%  Upregulated

Tcb3p

TCB3

854903

18%  Upregulated

Temperature dependent Organization in Mitotic nucleus

TOM1

852068

30%  Upregulated

Tpk2p

TPK2

855898

25%  Upregulated

TransALdolase

TAL1

851068

20%  Upregulated

transcription factor MIG1

MIG1

852848

Downregulated

Translation Initiation Factor

TIF4631

853071

20%  Upregulated

Translation Initiation Factor

TIF4632

852833

20%  Upregulated

Translation Machinery Associated

TMA19

853809

30%  Upregulated

TriacylGlycerol Lipase

TGL3

855361

Upregulated

trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))

GRE3

856504

100%  Upregulated

TRna Methyltransferase

TRM9

854994

Upregulated

UBiquitin-Conjugating

UBC12

851015

50%  Upregulated

Ubx2p

UBX2

854995

24%  Upregulated

Up in StarVation

USV1

855871

Upregulated

Upstream Activation Factor subunit

UAF30

854470

Upregulated

Ure2p

URE2

855492

20%  Upregulated

URidine Hydrolase

URH1

852009

24%  Upregulated

Uth1p

UTH1

853916

15%  Upregulated

Utilization of GAba

UGA1

852902

50%  Upregulated

Utilization of GAba

UGA3

851384

75%  Upregulated

Vacuolar Basic Amino acid transporter

VBA5

853980

Upregulated

Vacuolar Protein Sorting

VPS5

854235

Upregulated

Vacuolar Protein Sorting

VPS70

853590

Upregulated

Vacuolar Protein Sorting

VPS75

855475

Upregulated

Yeast Protein Two

YPT6

850966

30%  Upregulated

Yeast Tat-binding Analog

YTA7

853186

50%  Upregulated

Yeast vaccinia virus VH1 Homolog

YVH1

854844

50%  Upregulated

Ysc84p

YSC84

856409

25%  Upregulated

Zds1p

ZDS1

855316

37%  Upregulated

ZWischenFerment

ZWF1

855480

Upregulated

Reference: HAGR