[Frontiers in Bioscience S5, 766-773, January 1, 2013]
STIM1 and Orai in cardiac hypertrophy and vascular proliferative diseases
Anne-Marie Lompre1,2,3, Ludovic Benard4, Youakim Saliba1,2,3, Fleur Aubart1,2,3, Jeremy Fauconnier5, Jean-Sebastien Hulot1,2,3,4
1Inserm UMRS 956- Paris, F75013, France, 2Universite Pierre et Marie Curie UMRS956, Paris, F75013, France, 3Institute for Cardiac Metabolism and Nutrition-Paris,75013,France, 4Cardiovascular Research Institute, Mount Sinai School of Medicine, New York, 5Inserm U1046, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F34000, France
TABLE OF CONTENTS
Cardiac hypertrophy and vascular proliferative diseases are associated with major alterations in calcium homeostasis and calcium signaling. The recent discovery of STIM and Orai has generated great enthusiasm concerning the role of these proteins in the cardiovascular system. We will review the major results concerning the existence and the role of these proteins in the cardiovascular system in normal and pathological situations and their implication in cardiovascular remodeling.