[Frontiers in Bioscience S5, 396-411, January 1, 2013]

Genomic stability disorders: from budding yeast to humans

Nicolas Carlos Hoch1,2, Xianning Lai1,2, Jorg Heierhorst1,2

1St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia, 2Department of Medicine (St. Vincent's Hospital), University of Melbourne, Fitzroy, VIC, Australia


1. Abstract
2. Introduction
3. Budding yeast and DNA repair
3.1 .Saccharomyces cerevisiae as a model organism
3.2 .DNA damage
3.3 .DNA repair and telomere maintenance pathways
4. Yeast rad, human XP and NER
5. Matching MMR and HNPCC
6. Checking on cancer
7. Happy endings
8. Conclusion
9. References


Fundamental aspects of eukaryotic molecular and cellular biology are extensively studied in the budding yeast Saccharomyces cerevisiae. Genome maintenance pathways are highly conserved and research into a number of human genetic disorders with increased genome instability and cancer predisposition have benefited greatly from studies in budding yeast. Here, we present some of the examples where yeast research into DNA damage responses and telomere maintenance pathways paved the way to understanding these processes, and their involvement in selected human diseases.