[Frontiers in Bioscience E5, 602-609, January 1, 2013]

Two-photon polymerization microstructuring in regenerative medicine

Shaun Davis Gittard1, Anastasia Koroleva1, Alexander Nguyen1,2, Elena Fadeeva1, Arune Gaidukeviciute1, Sabrina Schlie1, Roger Jagdish Narayan2, Boris Chichkov1

1Nanotechnology Department, Laser Zentrum Hannover eV, Hollerithallee 8, 30419 Hannover, Germany, 2 Joint Department of Biomedical Engineering, North Carolina State University, Campus Box 7115, Raleigh, NC 27695, USA


1. Abstract
2. Introduction
3. Micro- and nanoscale aspects of tissue engineering
3.1. Effects of Scaffold Architecture and Surface Morphology on Tissue Engineering
3.2. Mass Transport in Tissue Engineering Scaffolds
4. Two-photon polymerization in regenerative medicine
5. Future applications of two-photon polymerization in regenerative medicine
6. Conclusions
7. References


Two-photon polymerization has developed as a powerful tool for making micro- and nanoscale structures for regenerative medicine applications. This review discusses micro- and nanoscale aspects of tissue engineering, which are followed by a brief description of the two-photon polymerization process and how it has been used thus far in tissue engineering and other regenerative medicine applications. Lastly, potential future applications of two-photon polymerization in regenerative medicine are presented. This review provides a comprehensive summary of the uses of two-photon polymerization thus far in regenerative medicine and a look into how this technique will be used in the future.