[Frontiers in Bioscience E5, 500-508, January 1, 2013]

(Pro)renin receptor: subcellular localizations and functions

Gabin Sihn1, Celine Burckle2, Anthony Rousselle1, Tatiana Reimer1, Michael Bader1

1Max-Delbrueck-Center for Molecular Medicine (MDC), Robert-Roessle-Strasse 10, D-13125 Berlin-Buch, Germany, 2INSERM U983, Tour Lavoisier, Hopital Necker-Enfants Malades, 149 rue de Sevres, Paris, France


1. Abstract
2. Introduction
3. (P)RR structure and subcellular localization
4. Role of (P)RR as a cell surface receptor?
5. Role of (P)RR in intracellular vesicle trafficking?
6. Conclusion
7. Acknowledgement
8. References


Since its first report in 1996, the concept of the so-called (Pro)renin receptor ((P)RR/ATP6ap2) has dramactically evolved from a receptor mediating cellular effects of (pro)renin, to a protein with more basic and potentially essential intracellular functions. Among the arguments urging to reconsider the role of (P)RR was the observation that its localization appears mainly intracellular, although this does not preclude potential functions at the cell surface. However, despite about 10 years of research boosted by the generation of genetically modified animal models, the basic mechanisms of action of this protein at the cellular level remain elusive. This review aims at discussing the functions described for (P)RR in relation to its subcellular localization(s).