[Frontiers in Bioscience 18, 788-794, January 1, 2013]

The miRNAs in the pathgenesis of osteosarcoma

Wenqing Liang1, Bo Gao2, Peng Fu3, Shuogui Xu4, Yu Qian1Qingge Fu4

1Department of Orthopedics, Shaoxing People's Hospital, Zhejiang 312000, China, 2Department of Orthopedics, The 306th Hospital of PLA, Beijing 100101, China, 3Department of Nephrology, Tongji Hospital of Tongji University, Shanghai 200065, China, 4Department of Orthopedics, Changhai Hospital of Second Military Medical University, Shanghai 200433, China


1. Abstract
2. Introduction
3. The miRNAs expression profile in the Osteosarcoma
4. The role of miRNA played in the Osteosarcoma
5. miRNAs function as tumor suppressor genes (targeting Fas,Bcl-2)
6. miRNA founction as oncogenes (target p53 and p21)
7. miRNAs and metastasis (as regulator of cell invision and proliferation)
8. miRNA and Chemotherapeutic Response
9. Conclusions
10. Acknowledgments
11. References


Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. MicroRNAs (miRNAs) are non-coding small RNAs, usually 18-25 nucleotides in length, which repress translation and cleave mRNA by base-pairing to the 3 untranslated region of the target genes. miRNAs have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. A number of reports have investigated the role of microRNAs in osteosarcoma. This review summeizes the recent research progress of miRNA in the osteosarcome.