[Frontiers in Bioscience 18, 716-724, January 1, 2013]

Confronting JC virus and Homo sapiens biological signatures

Guglielmo Lucchese1,2

1Department of Biochemistry and Molecular Biology, University of Bari, Italy, 2Department of Neurological and Psychiatric Sciences, University of Bari, Italy


1. Abstract
2. Introduction
3. Methods
4. Results
4.1. Peptide sharing between JCV and human proteins involved in cell-cell adhesion/repulsion
4.2. Examples of peptide sharing between JCV and the neural network
4.3. JCV LT429-437IDSGKTTLA sequence and human EFG, FANCJ, and NRK1 proteins
4.4. JCV VP2295-302 MLPLLLGL sequence and human protein signal peptides
5. Conclusion
6. Acknowledgements
7. References


The present report describes the peptide commonality between JC virus (JCV) and the human proteome at the heptamer level. In total, 53 viral heptapeptides occur in functionally important human proteins with potential consequences for host functions and JCV pathogenesis. A paradigmatic example of a crucial peptide match is the SGKTTLA sequence, shared by JCV LT antigen and human nicotinamide/nicotinic acid riboside kinase, an enzyme involved in myelination processes. In general, the JCV-versus-host heptapeptide overlap may result in a competition between viral sequences and identical motifs in host enzymic active sites, adhesive domains, regulatory signaling motifs, etc., thus interfering with essential reactions and posing disadvantages to the cell. Overall, this study provides a starting point for investigating the role of peptide commonality in host-pathogen interactions.