[Frontiers in Bioscience 18, 608-615, January 1, 2013]

MicroRNAs in the regeneration of skeletal muscle

Xinkai Yu1, Qun Zuo1

1Shanghai University of Sport, Key Laboratory of Exercise and Health Sciences, Shanghai University of Sport, Ministry of Education, Shanghai, China 200438


1. Abstract
2. Introduction
3. Skeletal muscle-specific miR-206 in the regeneration of skeletal muscle
3.1. Expression of miR-206 in skeletal muscle 3.2 .MicroRNA-206 in the regulation of satellite cells 3.3 .MiR-206 related signalings in the regeneration of skeletal muscle
4. Other microRNAs
5. MicroRNAs in keletal muscle regeneration through regulating MyoD and Pax genes
6. Pathways and microRNAs in keletal muscle regeneration
7. Conclusions
8. Acknowledgments
9. References


MicroRNAs (miRNAs) have emerged as critical regulators of numerous biological processes by modulating gene expression at the post-transcriptional level. The discovery of miRNAs as new and important regulators of gene expression is expected to broaden our biological understanding of the regulatory mechanism in muscle by adding another dimension of regulation to the diversity and complexity of gene-regulatory networks. Exercise-induced skeletal muscle injury and repair have always been among the highlights of research in sports medicine. However, many mechanism problems that occur during regeneration and repair in the aftermath of skeletal muscle injury remain unsolved. It has become increasingly clear that the regeneration of skeletal muscle development involve regulation by miRNAs. In the last few years the field has seen a rapid expansion of our knowledge of miRNAs in the regeneration of skeletal muscle. This study reviews the miRNAs related with regeneration of skeletal muscle, and discuss the regulation of their expression in muscles, and emerging themes of miRNA regulation.