[Frontiers in Bioscience 18, 441-446, January 1, 2013]

MicroRNA in the molecular mechanism of the circadian clock in mammals

Cheng Chu1,2, Zhongxin Zhao1

1Department of Neurology, Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China, 2Department of Neurology, The First People's Hospital of Yangzhou, 45 Taizhou Road, Yangzhou 225001, Jiangsu Province, China


1. Abstract
2. Introduction
3. Molecular control through microRNA
3.1. MicroRNAs and SCN clock 3.2 .MicroRNAs and peripheral circadian oscillators
4. Conclusion
5. References


The biochemical activity of mammals is controlled by an internal timekeeping mechanism driving a clock to run in approximate 24-hour (circadian) cycles. In mammals, this circadian clock is located both in the suprachiasmatic nuclei (SCN) and peripheral oscillators. Recently, microRNAs have emerged as significant players in circadian clock timing. The biological implications of miRNAs are extended further by recent studies that microRNAs are expressed in the SCN and peripheral circadian oscillators. In this study, we review recent work revealing the role of microRNAs in the molecular mechanism of circadian clock in mammals.