[Frontiers in Bioscience 18, 279-288, January 1, 2013]

Role of TSG101 in cancer

Yun Jiang1, Yu Ou1, Xiaodong Cheng2

1School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China, 2Department of Pharmacology and Toxicology, The University of Texas Medical Brach, Galveston, Texas 77555-0615, USA


1. Abstract
2. Introduction: Initial discovery and controversy
3. TSG101 structure and function
3.1. The UEV domain
3.2. The proline-rich region (PRR)
3.3. The coiled-coil (CC) region
3.4. The C-terminal α-helical/steadiness box (SB) domain
4. TSG101 role in cancers
4.1. TSG101 and breast cancer
4.2. TSG101 and ovarian cancer
4.3. TSG101 and cervical cancer
4.4. TSG101 and prostate cancer
4.5. TSG101 and lung cancer
5. Conclusion and perspectives
6. Acknowledgement
7. References


The tumor susceptibility gene 101 (TSG101) encodes a multidomain protein that contains a UEV (ubiquitin e2 variant) domain at is N-terminus and a putative DNA-binding motif at its C-terminus. In addition to being a bona fide component of the ESCRT (endosomal sorting complexes required for transport) complex 1 and playing a critical role in endosomal sorting and trafficking, TSG101 has also been implicated in an array of cellular functions including, cytokinesis, protein ubiquitination, transcriptional regulation, cell cycle and proliferation, as well as viral budding. The major focus of this article is on the role of TSG101 in tumorigenesis.