[Frontiers in Bioscience S4, 831-839, January 1, 2012]

Modulation of cell cycle regulators by HDACs

Elphine Telles1, Edward Seto1

1Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612


1. Abstract
2. Introduction
3. HDACs and the G1-S transition
3.1. E2F and HDAC
4. Sin3-HDAC corepressor complex and the cell cycle
5. Loss of HDACs and cell cycle progression
6. HDACs and cancer cell division
7. HDACs and p53
8. Conclusions and perspectives
9. Acknowledgements
10. References


Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues on histones and non-histone proteins. HDACs have been shown to control the functions of key cell cycle proteins. Consistent with this, the overexpression of HDACs has been observed in multiple cancers, resulting in deregulation of the cell cycle and uncontrolled proliferation. This review focuses on the impact that HDACs have on cell cycle control through the deacetylation of proteins.