[Frontiers in Bioscience 17, 2691-2697, June 1, 2012]

Phage in the diagnosis and treatment of tuberculosis

Shuliang Guo1, Zhi Ao1

1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital, Chongqing Medical University, 400016, China


1. Abstract
2. Introduction
3. Biological characteristics of mycobacterium phage
4. The use of mycobacterium phage in tb diagnosis and drug resistance testing
5. Fastplaque tbÔ kit
6. Luciferase reporter phage (lrp)
7. Fluoromycobacteriophage
8. Mycobacterium phage in tb therapy
9. Early studies of tb therapy
10. Appropriate phage for tb therapy
11. Protective carrier
12. Single- or multi-phage agents
13. Delivery method, frequency and dose
14. The therapeutic effect of lyase 
15. Conclusion
16. Reference


The serious global TB epidemic coupled with limited diagnostic and therapeutic technologies necessitate the study of the role phage in TB treatment. Mycobacterium phage have been used for TB diagnosis, but the accuracy of such methods needs to be improved. Phage have various advantages in treating many kinds of bacterial infection, and coupled with the abuse and misuse of antibiotics, and the increasing prevalence of drug-resistant bacteria, they have been studied as a novel therapy to support antibiotics. The study of phage in TB therapy has developed from the selection of appropriate phage to the simultaneous use of multiple phage and even the use of purified lyase proteins. Though phage have great potential in TB therapy, the technology is still in the in vitro and animal experiment stages, and needs further study.