[Frontiers in Bioscience 17, 2675-2683, June 1, 2012]

Abnormal bone metabolism in Crohn's disease

Tao Wu1,2, Haiyan Song1, Guang Ji1

1Institute of Digestive Disease, Longhua Hospital,Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China, 2Center of Chinese medicine therapy and systems biology, shanghai university of Traditional Chinese Medicine, Shanghai 201203, China


1. Abstract
2. Introduction
3. Related indicators in bone metabolism studies
3.1. General indicators
3.2. Bone turnover indicators
3.3. Indicators of PBMC function and hormones evaluating bone turnover
4. Factors influencing abnormal bone metabolism
4.1. Common factors affecting bone turnover
4.2. Disease region and duration
4.3. Corticosteroid therapy in CD
4.4. Disequilibrium of calcium and VitD
4.5. Gene polymorphisms
4.6. Endocrine hormone level
4.7. Skin-fold thickness (SFT)
4.8. Serum bone sialoprotein
4.9. Muscular mass and activity
4.10. Complications or extra-intestinal involvement
5. Treatment of abnormal bone metabolism
5.1. Anti-tumor necrosis factor-alpha antibody Hormones
5.2. Anti-resorptive agents
5.3. Altered function of PBMC
5.4. Granulocyte-macrophage colony-stimulating factor
5.5. Nutrition
6. Problems and prospection
7. Acknowledgements
8. References


Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a major impact on the health of individuals and population. These diseases result from an inappropriate immune response, in genetically susceptible individuals, to microbial antigens of commensal microorganisms. This paper reviews the abnormal bone metabolism associated with CD, in order to elucidate the mechanism of bone loss.