[Frontiers in Bioscience 17, 2391-2395, June 1, 2012]
Transdifferentiation of hepatic oval cells into pancreatic islet beta-cells
Ying Li1, Li-Juan Zhao1, Fang-Zhen Xia1, Yan-Xiang Li1, Ying-li Lu1
1Institute and Department of Endocrinology and Metabolism of Shanghai Ninth People's Hospital Affiliated Shanghai Jiaotong University School of Medicine
TABLE OF CONTENTS
Insulin production by beta-cells derived from hepatic oval cells is a promising new approach for the treatment of diabetes. Hepatic oval cells can be redirected to the beta-cell linage by an appropriate combination of high extracellular glucose, specific extracellular matrix proteins (laminin and fibronectin), cytokines (activin A), and the expression of several differentiation-related transcription factors (Pdx-1, Ngn-3, MafA). We review the process of hepatic oval cell transdifferentiation into pancreatic islet beta-cells and the cellular signaling pathways involved.