[Frontiers in Bioscience 17, 2284-2294, June 1, 2012]

Th17 related cytokines in acute myeloid leukemia

Peng Li1, Min Ji1,3, Jino Park3, Kevin D. Bunting2, Chunyan Ji1, William Tse3

1Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China, 2Aflac Cancer Center of Children's Heathcare of Atlanta and Emory University Department of Pediatrics, Atlanta, GA 30345, 3Mary Babb Randolph Cancer Center, West Virginia University Health Science Center, Morgantown, WV 26506


1. Abstract
2. Introduction
3. Th17 related cytokines
3.1. Cytokines participate in the generation of Th17 cells
3.2. Cytokines secreted by Th17 cells
4. Th17 related cytokines in acute myeloid leukemia
4.1. IL-23
4.2. TGF-beta
4.3. IL-1beta
4.4. IL-6
4.5. IL-17
4.6. IL-21
5. Perspective
6. References


Acute myeloid leukemia (AML) is the most common hematological malignancy in adults, characterized by distorted proliferation and development of myeloid cells and their precursors in blood and bone marrow. Impressive biologic advances have increased our understanding of leukemogenesis, however, little is known about the pathogenic events which lead to the initiation and progression of AML. T helper type 17 (Th17) cells are a unique subset of CD4+ T cells. They play important roles in the pathogenesis of many diseases, including inflammatory diseases, autoimmune diseases, and cancers. A range of cytokines, such as interleukin (IL)-23, transforming growth factor-beta (TGF-beta), IL-1beta, IL-6, IL-17, IL-22, and IL-21, have been shown related to Th17 cells. Some researchers have reported that the levels of Th17 and its related cytokines were different between normal cells and malignant AML cells, suggesting that Th17 might be involved in AML pathogenesis. In this review, we summarize current progress in the mechanisms of Th17 related cytokines in AML pathogenesis.