[Frontiers in Bioscience 17, 1020-1034, January 1, 2012]
Bacterial chromosome segregation
Christophe Possoz1, Ivan Junier2,3, Olivier Espeli1
1Centre de Genetique Moleculaire, CGM-CNRS-UPR3404, Avenue de la terrasse, 91198 Gif sur Yvette, France, 2iSSB, Institute of Systems and Synthetic Biology, University of Evry, Genopole, Campus 1, Genavenir 6, 5 rue Heny Desbrueres, 91030 Evry cedex, France, 3Institut des systemes complexes, 57-59 rue Lhomond, 75005 Paris, France
TABLE OF CONTENTS
Dividing cells have mechanisms to ensure that their genomes are faithfully segregated into daughter cells. In bacteria, the description of these mechanisms has been considerably improved in the recent years. This review focuses on the different aspects of bacterial chromosome segregation that can be understood thanks to the studies performed with model organisms: Escherichia coli, Bacillus subtilis, Caulobacter crescentus and Vibrio cholerae. We describe the global positionning of the nucleoid in the cell and the specific localization and dynamics of different chromosomal loci, kinetic and biophysic aspects of chromosome segregation are presented. Finally, a presentation of the key proteins involved in the chromosome segregation is made.