[Frontiers in Bioscience E3, 1092-1099, June 1, 2011]

Non-coding RNAs and embryo implantation

Ji-Long Liu1, Zeng-Ming Yang1,2

1College of Life Science, Northeast Agricultural University, Harbin 150030, China, 2 School of Life Science, Xiamen University, Xiamen 361005, China


1. Abstract
2. Introduction
3. Role of ncRNAs in the uterus during embryo implantation 3.1. miRNAs
3.2.1. miR-21
3.2.2. miR-101a and miR-199a*
3.2.3. miR-222
3.2. Long ncRNAs
3.2.1. HOXA11-AS
3.2.2. Scx-AS
3.2.3. EMX2-OS
3.2.4. FGF2-AS
3.2.4. SRA
4. Conclusions and perspectives
5. Acknowledgement
6. References


In mammals, thousands of non-protein-coding RNAs (ncRNAs), including microRNAs, endogenous small interfering RNAs, PIWI-interacting RNAs and mRNA-like long ncRNAs, have been identified. These RNAs modulate gene expression at transcriptional, post-transcriptional and epigenetic levels in many developmental and metabolic processes. Increasing evidence shows that ncRNAs are also linked to embryo implantation through regulating the expression of certain key genes and pathways. In this paper, we summarized the recent literatures on the ncRNAs involved in embryo implantation.