|[Frontiers in Bioscience 1, d59-71, March 1, 1996]|
THE ANDROGEN RECEPTOR: A MEDIATOR OF DIVERSE RESPONSES
Evan T. Keller, William B. Ershler, and Chawnshang Chang
The Institute on Aging and the Department of Human Oncology, University of Wisconsin, Madison, WI 53706, USA.
Received 01/16/96; Accepted 02/22/96; On-line 03/01/96
We have reviewed several critical issues concerning the cellular and molecular biology of androgen regulation. Androgens, working via the AR, afford multiple levels of regulation. The levels of control include hormone metabolism, AR affinity for ligands, HRE, and mesenchymal-epithelial interactions. The overall effect of these phenomena may be the basis for the diverse response of tissues to androgen. Future studies on androgens and AR should elucidate the importance of protein-protein interactions and the role of ARE in imparting control over gene expression specificity. Other areas of research including analysis of receptor phosphorylation, cell cycle biology, and gene methylation will undoubtedly contribute to our understanding of the androgens' effect on expression of diverse androgen responsive genes.