November 22, 1999

• Timothy J. Richmond of Swiss Federal Institute of Technology discusses the mutator phenotype hypothesis for cancer
• Maria Grazia Roncarolo of the Telethon Institute of Gene Therapy discusses graft-versus-host disease.

November 8, 1999

• Scott W. Lowe of Cold Spring Harbor Lab discusses oncogene ooperation
• Robert L. Nussbaum of the National Human Genome Research Institute discusses genetics in Parkinson's disease

October 25, 1999

• Manuel Perucho and Nicholas Rampino of the Burnham Institute discuss the mutator phenotype hypothesis for cancer;
• Joseph S. Takahashi of Northwestern University discusses the genetics of circadian rhythms

October 11, 1999

• Robert A. Weinberg of Massachusetts Institute of Technology and Thomas R. Cech of the University of Colorado Health Sciences Center discuss the telomerase enzyme in cancer formation.

September 27, 1999

• Frank Kunst of Institut Pasteur discusses the sequencing of Bacillus subtilis
• Paul M. Ridker of Brigham and Women's Hospital discusses vascular inflammation as a sign of cardiovascular disease

September 13, 1999

• Neil Aronin of Massachusetts Medical Center discusses huntingtin, the protein, and Huntington's, the disease
• Dennis J. Selkoe of Harvard Medical School and Brigham and Women's Hospital discusses the role of plaque deposits on the brain in Alzheimer's disease

August 30, 1999

• David Wallach of the Weizmann Institute, Zhaodan Cao of Tularik Inc., Michael Karin of the University of California, San Diego, and Ebrahim Zandi of the University of Southern California, Norris Cancer Center, discuss how protein kinases regulate NF-KappaB activity

August 16, 1999

• Miriam J. Alter of the Centers for Disease Control and Prevention and Harvey J. Alter of the National Institutes of Health discuss the hepatitis G virus.

July 19, 1999

• Jean-Francois Tomb of DuPont Research and Development discusses sequencing of the Helicobacter pylori genome;
• Fred R. Blattner of the University of Wisconsin, Madison, discusses sequencing of Escherichia coli K-12.

July 5, 1999

• Hans Clevers of Utrecht University, Paul Polakis of Genentech Inc., and Kenneth W. Kinzler of Johns Hopkins University Medical School discuss the role of ß-catenin in cancer.

June 21, 1999

• Henrik Nielsen of The Technical University of Denmark discusses SignalP, a server for predicting the presence and location of signal cleavage sites in amino acid sequences

• Bertram Pitt of the University of Michigan and Robert Segal of Merck Research Laboratories discuss the effects of losartan on heart-failure patients

• Jan-Åke Gustafsson of Karolinska Institute and Huddinge University Hospital, Sweden, discusses a novel estrogen receptor

• Francis S. Collins and Settara C. Chandrasekharappa of the National Human Genetics Research Institute and Allen M. Spiegel and Stephen J. Marx of the National Institute of Diabetes and Digestive and Kidney Diseases discuss the search for MEN1, a tumor suppressor gene.

June 7, 1999

Moshe Oren of the Weizman Institute of Science and Karen H. Vousden of The Frederich Cancer Research and Development Center discuss the Mdm2-p53 relationship.

May 24, 1999

Henryk Dudek of Ontogeny Inc., Michael E. Greenberg of Harvard Medical School, Thomas F. Franke of Columbia University, and Alex Toker of Boston Biomedical Research Institute discuss the role of protein kinase Akt in cellular processes.

May 10, 1999

• Michael J. Eck of Dana-Farber Cancer Institute and John Kuriyan of Rockefeller University discuss the Src-family kinases

April 26, 1999

• Cheng Chi Lee of Baylor College of Medicine and S.H. Subramony of the University of Mississippi School of Medicine discuss gene identification related to ataxia;
• David M. Livingston of Harvard Medical School discusses the BRCA1 gene

April 12, 1999

• Stephen Altschul, senior investigator at the National Center for Biotechnology Research, discusses protein database search programs
• Walter Birchmeier, professor of cell biology at Max Delbrück Center for Molecular Medicine, discusses the wnt pathway

March 29, 1999

• Ramon Parsons of Columbia University Cancer Center, Peter A. Steck of M.D. Anderson Cancer Center, and Sean V. Tavtigian of Myriad Inc. discuss their search for a tumor suppressor gene

March 15, 1999

• Richard D. Palmiter of the University of Washington discusses the role of neuropeptide Y; Steve Oliver of the University of Manchester Institute of Science and Technology and Andre Goffeau of the Universite Catholique de Lovain, Belgium, discuss whole-genome sequencing

March 1, 1999

• C. David Allis of the University of Virginia and Stuart L. Schreiber of Harvard University discuss the enzymes that regulate and activate histones.

February 15, 1999

• Greg Lennon of Gene Logic in Gaithersburg, Md., discusses the world's largest public collection of genes
• David A. Katzenstein of Stanford University discusses AIDS drug therapies

February 1, 1999

• Andras Nagy of Mount Sinai Hospital, Toronto, Napoleone Ferrara of Genentech Inc., South San Francisco, and Mark W. Moore of Deltagen, San Carlos, Calif., discuss vascular endothelial growth factor in embryonic development

January 18, 1999

• Andras Nagy of Mount Sinai Hospital, Toronto, Napoleone Ferrara of Genentech Inc., South San Francisco, and Mark W. Moore of Deltagen, San Carlos, Calif., discuss vascular endothelial growth factor in embryonic development

January 18, 1999

• Donald D. Newmeyer of the La Jolla Institute for Allergy and Immunology in La Jolla, Calif., and Xiaodong Wang of the University of Texas Southwestern Medical Center in Dallas, discuss the role of mitochondria in apoptosis
• Phyllis A. Wingo of the American Cancer Society in Atlanta discusses cancer-statistics calculation

January 4, 1999

Richard M. Harland, Choh Hao Li professor of biochemistry and molecular biology, University of California, Berkeley Eddy M. De Robertis, Investigator, Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, discuss the Spemann organizer's role in cell development; Source: The scientist