TNF receptor I
Normal fertility
Unaltered development of thymocyte and lymphocyte populations
Alteration of signalling to specific (p55/60) stimuli
Pfeffer et al., 1993
Rothe et al., 1993
TNF Receptor 1
Resistant to the lethal effect of low doses of lipopolysaccharide after sensitization with D-galactosamine
Sensitivity to high doses of lipopolysaccharide
Increased susceptibility to infection with the facultative intracellular bacterium Listeria monocytogenes
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Rothe, 1993
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Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes.
Nature 364, 798-802 (1993) [93361144]
Development of greatly accelerated lymphadenopathy
Development of greatly accelerated autoantibody production
Early onset autoimmune disease
Massive mononuclear cell infiltration in the liver, kidney, lung, and knee joints
High mortalityZhou, C. K. Edwards III, P. Yang, Z. Wang, H. Bluethmann & J. D. Mountz: Greatly Accelerated Lymphadenopathy and Autoimmune Disease in Ipr Mice Lacking Tumor Necrosis Factor Receptor I1. The Journal of Immunology 156, 2661-2665 (1996)
| Line Name | DNA Construct | |
|---|---|---|
| 1. | TNF-R2 (-/-) | A genomic clone was isolated from a mouse 129 library. A 9-kb subclone was used to construct the targeting vector. A neomycin-resistance gene under control of the Pgk.... |
| 2. | TNFR1(0)/TNFR1(0) ( | For the targeting vector used to generate mice lacking a functional tumor necrosis factor receptor 1 (TNFR1), a genomic fragment containing exons ll and lll and 5' seque.... |
| 3. | TNFRp55 (-/-) | The TNFRp55 targeting vector was constructed from a 3.2kb DNA fragment derived from a genomic clone isolated from a BALB/c EMBL3 library. The coding sequence was disrup.... |
| 4. | TNF-R2 (+/-) | A genomic clone was isolated from a mouse 129 library. A 9-kb subclone was used to construct the targeting vector. A neomycin-resistance gene under control of the Pgk.... |
| 5. | TNFR1/TNFR1(0) (+/- | For the targeting vector used to generate mice lacking a functional tumor necrosis factor receptor 1 (TNFR1), a genomic fragment containing exons ll and lll and 5' seque.... |
| 6. | TNFRp55 (+/-) | The TNFRp55 targeting vector was constructed from a 3.2kb DNA fragment derived from a genomic clone isolated from a BALB/c EMBL3 library. The coding sequence was disrup.... |
