SP-B
Heterozygous mice
Normal Homozygous mice
Normal development of lungs but atelectatic
Lack of tubular myelin figures
Lack of fully formed lamellar bodies in Type II cells
Markedly decreased number of fully processed SPC peptide in lung homogenates
Death immediately after birth due to respiratory failure
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Clark, 1995
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Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice.
Proc Natl Acad Sci U S A 92, 7794-7798 (1995) [95372365]
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| Line Name | DNA Construct | |
|---|---|---|
| 1. | SP-B (+/-) | A 129J mouse genomic library made in lambda DASH II (Promega) was kindly provided by M. Shull (G00-099-276) and was screened for SP-B (surfactant protein B) by using ~30.... |
| 2. | SP-B (-/-) | A 129J mouse genomic library made in lambda DASH II (Promega) was kindly provided by M. Shull (G00-099-276) and was screened for SP-B (surfactant protein B) by using ~30.... |
| 3. | GR (-/-) | Genomic clones from isogenic DNA containing the 5' end of the mouse glucocorticoid receptor gene were obtained by screening an amplified mouse 129/Sv-C-P Sl/ + library i.... |
