P- and E- selectins
Single gene deficient mice exhibit mild phenotypes
Double gene deficient show leukocytosis, elevated cytokines levels, and hematopoiesis alteration
Increased granulocytopoiesis in bone marrow and spleen
Erythropoiesis partially translocated to spleen
Virtual lack of leukocyte rolling
Low extravasation at sites of inflammation
Lack of endothelial selections affects leukocyte homeostasis
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Frenette, 1996
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Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins.
Cell 84, 563-574 (1996) [96178469]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations)
Near Complete inhibition of cerbrospinal fluid leukocyte influx.Tang, P. S. Frenette, R. O. Hynes, D. D. Wagner & T. N. Mayadas: Cytokine-induced Meningitis Is Dramatically Attenuated in Mice Deficient in Endothelial Selectins. J. Clin. Invest. 97, 2485-90 (1996)
| Line Name | DNA Construct | |
|---|---|---|
| 1. | P-selectin (+/-) | An amplified mouse genomic library constructed from the liver DNA of black agouti 129Sv mouse strain (kindly provided by Drs. H. Wu and R. Jaenisch (G00-100-762) was scr.... |
| 2. | P-selectin (-/-) | An amplified mouse genomic library constructed from the liver DNA of black agouti 129Sv mouse strain (kindly provided by Drs. H. Wu and R. Jaenisch (G00-100-762) was scr.... |
| 3. | Sele (+/-) | Murine E-selectin genomic clones were isolated from lambda libraries derived from either 129SV DNA (Stratagene, Incorporated) or BALB/c DNA (Clonetec, Incorporated). In.... |
| 4. | Sele (-/-) | Murine E-selectin genomic clones were isolated from lambda libraries derived from either 129SV DNA (Stratagene, Incorporated) or BALB/c DNA (Clonetec, Incorporated). In.... |
