Joyner AL, Herrup K, Auerbach BA, Davis CA, Rossant J:
Subtle cerebellar phenotype in mice homozygous for a targeted
deletion of the En-2 homeobox.
Science 1991 Mar 8;251(4998):1239-43
ABSTRACT
The two mouse genes, En-1 and En-2, that are homologs of the
Drosophila segmentation gene engrailed, show overlapping spatially
restricted patterns of expression in the neural tube during
embryogenesis, suggestive of a role in regional specification. Mice
homozygous for a targeted mutation that deletes the homeobox were
viable and showed no obvious defects in embryonic development. This
may be due to functional redundancy of En-2 and the related En-1
gene product during embryogenesis. Consistent with this hypothesis,
the mutant mice showed abnormal foliation in the adult cerebellum,
where En-2, and not En-1, is normally expressed.
